keyword
https://read.qxmd.com/read/38536958/assessing-the-interaction-effects-of-mitochondrial-dna-polymorphisms-and-lifestyle-on-heel-bone-mineral-density
#1
JOURNAL ARTICLE
Dan He, Huan Liu, Yijing Zhao, Wenming Wei, Qingqing Cai, Sirong Shi, Xiaoge Chu, Na Zhang, Xiaoyue Qin, Yumeng Jia, Yan Wen, Bolun Cheng, Feng Zhang
BACKGROUND: Bone mineral density (BMD) is a major predictor of osteoporotic fractures, and previous studies have reported the effects of mitochondrial dysfunction and lifestyle on BMD, respectively. However, their interaction effects on BMD are still unclear. Therefore, we aimed to investigate the possible interaction of mitochondrial DNA (mtDNA) and common lifestyles contributing to osteoporosis. METHODS: Our analysis included 119,120 white participants (Nfemale=65,949 and Nmale=53,171) from the UK Biobank with heel BMD phenotype data...
March 27, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38536498/effect-of-vitamin-d3-supplementation-on-blood-parameters-and-liver-gene-expression-in-female-rats
#2
JOURNAL ARTICLE
Maria Oczkowicz, Beata Szymczyk, Małgorzata Świątkiewicz, Alicja Wierzbicka, Anna Steg, Tomasz Szmatoła
BACKGROUND: To better understand the molecular mechanism responsible for the therapeutic potential of vitamin D, we conducted an analysis of the liver transcriptomes of adult female rats. METHODS: Adult female rats (n = 18) were divided into three groups, receiving different doses of vitamin D: group I, 0; group II, 1000 U/kg; and group III, 5000 U/kg. Growth, body weight, the weight of main organs, blood haematological and biochemical parameters were evaluated...
March 27, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38535850/effect-of-the-season-on-blood-changes-of-oxidative-stress-index-in-the-italian-mediterranean-buffalo-bubalis-bubalis
#3
JOURNAL ARTICLE
Giovanna De Matteis, Susana Flores-Villalva, Emanuela Rossi, Maria Chiara La Mantia, Roberto Steri, Vittoria Lucia Barile, David Meo Zilio
Studies in cattle have shown that high temperatures increase the production of reactive oxygen species (ROS) causing an imbalance between ROS and the ability of antioxidant systems to detoxify and remove the reactive intermediates. As such studies remain limited in buffalo, the effect of temperature on oxidative stress was investigated through the oxidative stress index (OSi). Blood samples were collected from 40 buffaloes over 12 time points distributed over two years (2021, 2022). Samples were taken monthly during the hot and cold seasons...
March 4, 2024: Veterinary Sciences
https://read.qxmd.com/read/38535845/influence-of-maternal-supplementation-with-vitamins-minerals-and-or-protein-energy-on-placental-development-and-angiogenic-factors-in-beef-heifers-during-pregnancy
#4
JOURNAL ARTICLE
Bethania J Dávila Ruiz, Carl R Dahlen, Kacie L McCarthy, Joel S Caton, Jennifer L Hurlbert, Friederike Baumgaertner, Ana Clara B Menezes, Wellison J S Diniz, Sarah R Underdahl, James D Kirsch, Kevin K Sedivec, Kerri A Bochantin, Pawel P Borowicz, Sebastián Canovas, Lawrence P Reynolds
The effect of vitamins and minerals supplementation (VTM) and/or two rates of body weight gain (GAIN) on bovine placental vascular development and angiogenic factors gene expression were evaluated in two experiments: In Exp. 1, crossbred Angus heifers ( n = 34) were assigned to VTM/NoVTM treatments at least 71 days before breeding to allow changes in the mineral status. At breeding, through artificial insemination (AI), heifers were assigned to low-gain (LG) 0.28 kg/d or moderate-gain (MG) 0.79 kg/d treatments, resulting in NoVTM-LG (Control; n = 8), NoVTM-MG ( n = 8), VTM-LG ( n = 9), and VTM-MG ( n = 9) until day 83 of gestation; In Exp...
March 2, 2024: Veterinary Sciences
https://read.qxmd.com/read/38535086/osteoporosis-is-associated-with-an-increased-risk-of-colorectal-neoplasms-regardless-of-sex-nationwide-population-based-cohort-study
#5
JOURNAL ARTICLE
Seung Heon Yoo, Ji Hyung Nam, Dong Jun Oh, Geun U Park, Sang Hoon Kim, Hyoun Woo Kang, Jae Hak Kim, Yun Jeong Lim
Vitamin D may have anticancer effects against colorectal cancer (CRC). Bone mineral density (BMD) reflects the long-term vitamin D status. This study investigated the association between osteoporosis and colorectal neoplasms (CRN). The data were obtained from the National Health Insurance Service sample cohort, which included 60,386 osteoporosis patients and 8224 controls who underwent BMD in 2002-2019. The logistic regression models included age, sex, income level, and comorbidity. Sensitivity tests were performed using the data from the National Health Screening Program...
March 21, 2024: Diagnostics
https://read.qxmd.com/read/38534347/vitamin-d-in-cutaneous-t-cell-lymphoma
#6
REVIEW
August-Witte Feentved Ødum, Carsten Geisler
Cutaneous T-cell lymphoma (CTCL) is characterized by the proliferation of malignant T cells in inflamed skin lesions. Mycosis fungoides (MF)-the most common variant of CTCL-often presents with skin lesions around the abdomen and buttocks ("bathing suit" distribution), i.e., in skin areas devoid of sun-induced vitamin D. For decades, sunlight and vitamin D have been connected to CTCL. Thus, vitamin D induces apoptosis and inhibits the expression of cytokines in malignant T cells. Furthermore, CTCL patients often display vitamin D deficiency, whereas phototherapy induces vitamin D and has beneficial effects in CTCL, suggesting that light and vitamin D have beneficial/protective effects in CTCL...
March 13, 2024: Cells
https://read.qxmd.com/read/38534213/vitamin-d-status-in-patients-with-primary-antiphospholipid-syndrome-paps-a-systematic-review-and-meta-analysis
#7
REVIEW
Md Asiful Islam, Saleh Ahmed, Shabiha Sultana, Sayeda Sadia Alam, Tareq Hossan, Wesam Gouda, Faisal Alsaqabi, Rosline Hassan, Przemysław J Kotyla
Primary antiphospholipid syndrome (PAPS) is a systemic autoimmune disorder, characterised by consistently high levels of antiphospholipid antibodies, thrombosis, and/or pregnancy morbidity. Due to various suspected causes, deficient or insufficient levels of vitamin D in the serum have been reported in patients with PAPS; however, the reports have been sporadic and inconclusive. This systematic review and meta-analysis aimed to comprehensively evaluate the serum vitamin D levels in patients with PAPS compared to controls...
March 13, 2024: Antibodies
https://read.qxmd.com/read/38533909/use-of-nonhuman-sera-as-a-highly-cost-effective-internal-standard-for-quantitation-of-multiple-human-proteins-using-species-specific-tryptic-peptides-applicability-in-clinical-lc-ms-analyses
#8
JOURNAL ARTICLE
Geraldine Williams, Lewis Couchman, David R Taylor, Jatinderpal K Sandhu, Oliver C Slingsby, Leong L Ng, Cajetan F Moniz, Donald J L Jones, Colleen B Maxwell
Quantitation of proteins using liquid chromatography-tandem mass spectrometry (LC-MS/MS) is complex, with a multiplicity of options ranging from label-free techniques to chemically and metabolically labeling proteins. Increasingly, for clinically relevant analyses, stable isotope-labeled (SIL) internal standards (ISs) represent the "gold standard" for quantitation due to their similar physiochemical properties to the analyte, wide availability, and ability to multiplex to several peptides. However, the purchase of SIL-ISs is a resource-intensive step in terms of cost and time, particularly for screening putative biomarker panels of hundreds of proteins...
March 27, 2024: Journal of Proteome Research
https://read.qxmd.com/read/38533674/induction-of-autism-related-behavior-in-male-mice-by-early-life-vitamin-d-deficiency-association-with-disruption-of-the-gut-microbial-composition-and-homeostasis
#9
JOURNAL ARTICLE
Jingjing Cui, Shumin Wang, Zidan Zhai, Xiaoyue Song, Ting Qiu, Leilei Yu, Qixiao Zhai, Heng Zhang
Vitamin D deficiency (VDD) during early life emerges as a potential risk factor for autism spectrum disorder (ASD). Individuals with autism commonly exhibit lower vitamin D (VD) levels compared to the general population, and VD deficiency is prevalent during pregnancy and lactation. Moreover, gastrointestinal comorbidity, prevalent in ASD patients, correlates closely with disruptions in the gut microbiota and altered intestinal permeability. Therefore, it is fascinating and significant to explore the effects of maternal VD deficiency during pregnancy and lactation on the maturation of the gut microbiota of the offspring and its relevance to autism spectrum disorders...
March 27, 2024: Food & Function
https://read.qxmd.com/read/38533539/lack-of-vitamin-d-signalling-in-mesenchymal-progenitors-causes-fatty-infiltration-in-muscle
#10
JOURNAL ARTICLE
Tohru Hosoyama, Minako Kawai-Takaishi, Hiroki Iida, Yoko Yamamoto, Yuko Nakamichi, Tsuyoshi Watanabe, Marie Takemura, Shigeaki Kato, Akiyoshi Uezumi, Yasumoto Matsui
BACKGROUND: Recent studies have indicated the importance of muscle quality in addition to muscle quantity in sarcopenia pathophysiology. Intramuscular adipose tissue (IMAT), which originates from mesenchymal progenitors (MPs) in adult skeletal muscle, is a key factor affecting muscle quality in older adults, suggesting that controlling IMAT formation is a promising therapeutic strategy for sarcopenia. However, the molecular mechanism underlying IMAT formation in older adults has not been clarified...
March 27, 2024: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/38533276/primary-hyperparathyroidism-in-young-and-adolescents-alike-or-unlike-adult-hyperparathyroidism-a-series-from-south-india
#11
JOURNAL ARTICLE
Dhalapathy Sadacharan, Smitha S Rao, Shriraam Mahadevan, G Shanmugasundar, S Murthy, Shruti Chandrashekaran, Vijay Bhaskar Reddy, Bharath Ramji
BACKGROUND: Primary hyperparathyroidism (PHPT) is a common endocrine condition but rare in the pediatric and adolescent populations. The presentations can be unique, accounting for significant morbidity in the case of untimely detection. AIM: To study surgically treated pediatric PHPT retrospectively. METHODS: Surgically treated children of PHPT up to 20 years of age between 2010 to 2022 were analyzed. All of them were operated on by an endocrine surgeon and team...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38532938/real-world-data-on-treatment-patterns-and-bleeding-in-cancer-associated-thrombosis-data-from-the-troll-registry
#12
JOURNAL ARTICLE
Zygimantas Zaboras, Camilla Tøvik Jørgensen, Andreas Stensvold, Heidi Hassel Pettersen, Aleksandra Galovic Grdinic, Sigrid Kufaas Brækkan, Waleed Ghanima, Mazdak Tavoly
Background  International guidelines are increasingly recommending direct oral anticoagulants (DOACs) as the first-line treatment for cancer-associated thrombosis (CAT). However, data regarding treatment patterns and adherence to guidelines in patients with CAT are scarce. Objectives  This study aimed to explore anticoagulant treatment patterns in patients with CAT and to calculate the incidence rates of bleeding events. Methods  Patients ≥18 years with active cancer and a first-time venous thromboembolism between 2005 and 2020 were identified through the Venous T hrombosis R egistry in Østf OL d Hospita L ...
January 2024: TH Open: Companion Journal to Thrombosis and Haemostasis
https://read.qxmd.com/read/38532850/a-case-report-of-primary-hyperparathyroidism-in-an-adolescent-during-ramadan-fast
#13
Ujunwa Justina Eze, Sundus Elfadil
Primary hyperparathyroidism is rare in children and usually presents with nonspecific symptoms. Ramadan fasting has been reported to unmask the diagnosis of primary hyperparathyroidism. A 15-year-old boy presented to the clinic for an emergency department follow up visit. He had started Ramadan fasting a week before his presentation to the clinic. He reported unintentional weight loss, abdominal pain, constipation, frequent headaches, exercise intolerance, tiredness, and palpitations. Physical examination was unremarkable except that he looked tired...
2024: SAGE Open Medical Case Reports
https://read.qxmd.com/read/38532702/development-and-characterization-of-cranberry-pomace-extract-incorporated-and-vitamin-e-fortified-edible-films-as-an-edible-separation-sheet-for-fruit-leather
#14
JOURNAL ARTICLE
Jooyeoun Jung, Caroline Christandi Loe, Yanyun Zhao
The separation sheets for fruit leather are traditionally made of plastic film or wax paper, which not only leads to environmental issues but also is inconvenience to consumers. This study evaluated edible fruit leather separation sheets using food polymers, including hydroxypropyl methyl cellulose (HPMC) and incorporation of cranberry pomace water extract (CPE) for providing natural fruit pigment, flavor, and phenolics. HPMCCPE film was then further improved by incorporating hydrophobic compound (oleic acid, OA) and vitamin E (VE) via cellulose nanocrystal (CNC) Pickering emulsion (CNCP) for enhancing film hydrophobicity and nutritional benefit, respectively...
March 27, 2024: Journal of Food Science
https://read.qxmd.com/read/38532309/contribution-of-nutritional-lifestyle-and-metabolic-risk-factors-to-parkinson-s-disease
#15
JOURNAL ARTICLE
Nicola Veronese, Andrea Nova, Teresa Fazia, Emilia Riggi, Lin Yang, Laura Piccio, Bo-Huei Huang, Matthew Ahmadi, Mario Barbagallo, Maria Notarnicola, Gianluigi Giannelli, Giovanni De Pergola, Emmanuel Stamatakis, Emanuele Cereda, Luisa Bernardinelli, Luigi Fontana
BACKGROUND: Modifiable risk factors for Parkinson's disease (PD) are poorly known. OBJECTIVES: The aim is to evaluate independent associations of different nutritional components, physical activity, and sedentary behavior and metabolic factors with the risk of PD. METHODS: In this population-based prospective cohort study using the data of the United Kingdom Biobank (from 2006-2010), 502,017 men and women who were free from PD (International Classification of Diseases 10th edition; "G20") at baseline were included...
March 26, 2024: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/38532145/the-alarming-rate-of-malnutrition-after-single-anastomosis-sleeve-ileal-bypass-a-single-centre-experience
#16
JOURNAL ARTICLE
Ala Wafa, Ahmad Bashir, Ricardo V Cohen, Ashraf Haddad
BACKGROUND: Single anastomosis sleeve ileal (SASI) bypass is a modification of sleeve gastrectomy with transit bipartition (SG + TB). This study aims to assess the safety and efficacy of SASI as a primary metabolic and bariatric surgery (MBS). METHODS: This is a retrospective case series of 30 patients who underwent SASI bypass from January to December 2021. All patients completed at least 12 months of follow-up. RESULTS: Among the 30 patients, 93...
March 27, 2024: Obesity Surgery
https://read.qxmd.com/read/38531396/practices-in-the-prescription-of-antiseizure-medications-is-it-time-to-change
#17
JOURNAL ARTICLE
Lécio Figueira Pinto, Lucas Scárdua Silva, Rafael Batista João, Vinícius Boldrini, Fernando Cendes, Clarissa Lin Yasuda
The treatment of epilepsy has advanced over the past 30 years through the development of new antiseizure medications (ASMs). Unfortunately, not all of them have been approved yet in Brazil, and many are still underused. When comparing new ASMs to older ones, they are generally not more effective in treating epilepsy. However, they offer better tolerability, with fewer interactions and long-term side effects, especially for patients with comorbidities or those requiring polytherapy. Enzyme induction caused by older ASMs is associated with increased cholesterol levels, drug interactions with decreased effects of statins and other cardiovascular medications, anticoagulants, chemotherapy, immunosuppressors, anti-infective agents (including HIV treatment), antidepressants, and contraceptives...
June 2024: Arquivos de Neuro-psiquiatria
https://read.qxmd.com/read/38530830/low-vitamin-d-levels-accelerates-muscle-mass-loss-in-patients-with-chronic-liver-disease
#18
JOURNAL ARTICLE
Tomomi Okubo, Masanori Atsukawa, Akihito Tsubota, Hiroki Ono, Tadamichi Kawano, Yuji Yoshida, Taeang Arai, Korenobou Hayama, Norio Itokawa, Chisa Kondo, Katsuhiko Iwakiri
Sarcopenia frequently and progressively occurs in patients with chronic liver disease. This study aimed to clarify the relationship between vitamin D levels and muscle mass loss. A total of 166 patients with chronic liver disease were enrolled in this study. Skeletal muscle mass index (SMI) was measured by bioelectrical impedance analysis at baseline and after 1 year. The rate of change in SMI from baseline after 1 year was calculated: ΔSMI (%) = [(1-year SMI - baseline SMI) / baseline SMI] × 100...
2024: PloS One
https://read.qxmd.com/read/38530826/the-relationship-of-low-serum-vitamin-d-and-early-dental-implant-failure
#19
JOURNAL ARTICLE
John R Francis, H Dexter Barber, Douglas Beals, Trever Siu
The aim of this study was to assess the effects of serum vitamin D levels and its relationship to early dental implant failures. A total of 174 implants in 109 patients were placed and serum vitamin D levels of those patients were noted the day of implant placement. Implants were followed up until restoration, approximately 3-6 months later, and any implant failure was noted based on 50% or more bone loss or implant mobility. Eight individuals had an implant fail early and their vitamin D levels had a mean of 42...
March 26, 2024: Journal of Oral Implantology
https://read.qxmd.com/read/38530447/association-of-vitamin-d-with-disease-severity-in-infants-with-bronchiolitis
#20
JOURNAL ARTICLE
Jashan Mittal, Nikhil Rajvanshi, Kkomal Suvarna, Prawin Kumar, Jagdish Prasad Goyal
UNLABELLED: Vitamin D's role in immune system regulation and its contribution to host defenses against respiratory infections may have implications for bronchiolitis pathophysiology. This cross-sectional study aimed to determine the association between the clinical severity of bronchiolitis and serum vitamin D levels in infants. Infants aged 1 month to 12 months, diagnosed with bronchiolitis, and healthy controls attending routine immunization were enrolled. Baseline characteristics were recorded, including clinical details, bronchiolitis severity, and course during hospital stay...
March 26, 2024: European Journal of Pediatrics
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