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https://www.readbyqxmd.com/read/28330812/molecular-evidence-for-differential-long-term-outcomes-of-early-life-severe-acute-malnutrition
#1
Allan Sheppard, Sherry Ngo, Xiaoling Li, Michael Boyne, Debbie Thompson, Anthony Pleasants, Peter Gluckman, Terrence Forrester
BACKGROUND: Severe acute malnutrition (SAM) in infants may present as one of two distinct syndromic forms: non-edematous (marasmus), with severe wasting and no nutritional edema; or edematous (kwashiorkor) with moderately severe wasting. These differences may be related to developmental changes prior to the exposure to SAM and phenotypic changes appear to persist into adulthood with differences between the two groups. We examined whether the different response to SAM and subsequent trajectories may be explained by developmentally-induced epigenetic differences...
March 8, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28279227/treatment-outcomes-of-severe-acute-malnutrition-in-children-treated-within-outpatient-therapeutic-program-otp-at-wolaita-zone-southern-ethiopia-retrospective-cross-sectional-study
#2
Mulugeta Yohannis Kabalo, Canaan Negash Seifu
BACKGROUND: Children in third world countries suffer from severe acute malnutrition (SAM) in an extent of public health important. SAM management protocol available this time brought the approach from facility-based to community-based by Outpatient Therapeutic Program (OTP). But, little was known about the treatment outcomes of the program in Ethiopia. Thus, this study was aimed to assess treatment outcomes of SAM and identify factors associated among children treated at OTP in Wolaita Zone...
March 9, 2017: Journal of Health, Population, and Nutrition
https://www.readbyqxmd.com/read/28164028/the-clinical-spectrum-of-severe-acute-malnutrition-in-children-in-cameroon-a-hospital-based-study-in-yaounde-cameroon
#3
Andreas Chiabi, Berthe Malangue, Seraphin Nguefack, Félicitée Nguefack Dongmo, Florence Fru, Virginie Takou, Fru Angwafo
BACKGROUND: Severe acute malnutrition (SAM) is a major health problem, and the cause of more than half of childhood deaths in children less than 5 years in developing countries. Globally, 20 million children under 5 years of age are severely malnourished according to the World Health Organization (WHO). In Cameroon, the prevalence of SAM remains high and estimated at 1.9% in 2011 and 1.3% in 2014. The aim of this study was to determine the epidemiology, clinical aspects and outcome of SAM at the Yaounde Gynaeco-Obstetric and Pediatric Hospital (YGOPH)...
January 2017: Translational pediatrics
https://www.readbyqxmd.com/read/27882009/functional-and-structural-abnormalities-of-the-kidney-and-urinary-tract-in-severely-malnourished-children-a-hospital-based-study
#4
Misbah Anjum, Khemchand N Moorani, Ifra Sameen, Muhammad Ayaz Mustufa, Shazia Kulsoom
OBJECTIVES: The association of malnutrition and systemic diseases like chronic kidney disease (CKD) is well known. Various urinary tract abnormalities may be associated with malnutrition. So objective of current study was to determine the frequency of functional and structural urinary tract abnormalities in severely malnourished children admitted in Nutritional Rehabilitation Unit (NRU) of a tertiary care facility, Karachi. METHODS: This descriptive cases series of 78 children was conducted in NRU from October 2014 - March 2015...
September 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27877011/analysis-of-clinical-characteristics-and-treatment-of-pancreatic-cystic-tumors
#5
Lei You, Jianchun Xiao, Zhe Cao, Wanying Zhang, Quan Liao, Menghua Dai, Taiping Zhang, Yupei Zhao
OBJECTIVE: To summarize experience in the diagnosis and treatment of pancreatic cystic neoplasms. METHODS: This is a retrospective study of 207 patients who were diagnosed with pancreatic cystic tumors at Peking Union Medical College Hospital between Jan 2009 and Mar 2014. Clinical data, such as clinical manifestations, radiological and pathological images and surgical recordings, were collected. RESULTS: Of the 207 included patients, females accounted for 76...
October 2016: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/27807038/metabolomic-changes-in-serum-of-children-with-different-clinical-diagnoses-of-malnutrition
#6
Valeria Di Giovanni, Celine Bourdon, Dominic X Wang, Swapna Seshadri, Edward Senga, Christian J Versloot, Wieger Voskuijl, Richard D Semba, Indi Trehan, Ruin Moaddel, M Isabel Ordiz, Ling Zhang, John Parkinson, Mark J Manary, Robert Hj Bandsma
BACKGROUND: Mortality in children with severe acute malnutrition (SAM) remains high despite standardized rehabilitation protocols. Two forms of SAM are classically distinguished: kwashiorkor and marasmus. Children with kwashiorkor have nutritional edema and metabolic disturbances, including hypoalbuminemia and hepatic steatosis, whereas marasmus is characterized by severe wasting. The metabolic changes underlying these phenotypes have been poorly characterized, and whether homeostasis is achieved during hospital stay is unclear...
December 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27651550/prevalence-and-outcome-of-severe-malnutrition-in-children-less-than-five-year-old-in-omdurman-paediatric-hospital-sudan
#7
Shaza O H Kanan, Mohammed Osman Swar
This is a retrospective observational hospital-based study aimed to determine the prevalence and outcome of severe acute malnutrition in children less than five years admitted to Omdurman Paediatric Hospital during the period January 2014 to December 2014. Data was collected from patient's hospital records during the study period. Ethical approval and permission to access patients' record were obtained. A total of 593 children with severe malnutrition were identified; 305 of cases were male (51.4%) with a male: female ratio of 1:0...
2016: Sudanese Journal of Paediatrics
https://www.readbyqxmd.com/read/27396484/treatment-outcome-and-factors-affecting-time-to-recovery-in-children-with-severe-acute-malnutrition-treated-at-outpatient-therapeutic-care-program
#8
Melkamu Merid Mengesha, Negussie Deyessa, Balewgizie Sileshi Tegegne, Yadeta Dessie
BACKGROUND: The outpatient therapeutic care program (OTP) of children with severe acute malnutrition (SAM) has been decentralized to health post level in Ethiopia since 2008-2009. However, there is a lack of evidence regarding treatment outcomes and factors related to the duration of stay on treatment after its decentralization to health post level. OBJECTIVE: This study was aimed to assess treatment outcome and factors affecting time to recovery in children with SAM treated at OTP...
2016: Global Health Action
https://www.readbyqxmd.com/read/26990240/a-successful-case-of-deceased-donor-liver-transplantation-for-a-patient-with-intrahepatic-arterioportal-fistula
#9
Kosei Takagi, Takahito Yagi, Ryuichi Yoshida, Susumu Shinoura, Yuzo Umeda, Daisuke Nobuoka, Nobuyuki Watanabe, Takashi Kuise, Kenta Sui, Akira Hirose, Makiko Tsuboi, Mitsunari Ogasawara, Shinji Iwasaki, Toshiji Saibara, Toshiyoshi Fujiwara
Intrahepatic arterioportal fistula (IAPF) is a rare cause of portal hypertension that is often difficult to treat with interventional radiology or surgery. Liver transplantation for IAPF is extremely rare. We report a case of bilateral diffuse IAPF with severe portal hypertension requiring deceased donor liver transplantation (DDLT). A 51-year-old woman with no past medical history was admitted to another hospital complaining of abdominal distension and marasmus. A computed tomography scan and digital subtraction angiography indicated a massive pleural effusion, ascites, and a very large IAPF...
December 2016: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/26817484/developmental-contributions-to-macronutrient-selection-a-randomized-controlled-trial-in-adult-survivors-of-malnutrition
#10
Claudia P Campbell, David Raubenheimer, Asha V Badaloo, Peter D Gluckman, Claudia Martinez, Alison Gosby, Stephen J Simpson, Clive Osmond, Michael S Boyne, Terrence E Forrester
BACKGROUND AND OBJECTIVES: Birthweight differences between kwashiorkor and marasmus suggest that intrauterine factors influence the development of these syndromes of malnutrition and may modulate risk of obesity through dietary intake. We tested the hypotheses that the target protein intake in adulthood is associated with birthweight, and that protein leveraging to maintain this target protein intake would influence energy intake (EI) and body weight in adult survivors of malnutrition...
2016: Evolution, Medicine, and Public Health
https://www.readbyqxmd.com/read/26164745/the-adverse-effect-of-4-tert-octylphenol-on-fat-metabolism-in-pregnant-rats-via-regulation-of-lipogenic-proteins
#11
Jun Kim, Eun-Jin Kang, Mee-Na Park, Ji-Eun Kim, Seung-Chul Kim, Eui-Bae Jeung, Geun-Shik Lee, Dae-Youn Hwang, Beum-Soo An
Alkylphenols such as 4-tert-octylphenol (OP), nonylphenol, and bisphenol A are classified as endocrine-disrupting chemicals (EDCs). Digestion and metabolism of food are controlled by many endocrine factors, including insulin, glucagon, and estrogen. These factors are differentially regulated during pregnancy. The alteration of nutritional intake and fat metabolism may affect the maintenance of pregnancy and supplementation of nutrients to the fetus, and therefore can cause severe metabolic diseases such as ketosis, marasmus and diabetes mellitus in pregnant individuals...
July 2015: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/26064678/treatment-outcome-of-severe-acute-malnutrition-cases-at-the-tamale-teaching-hospital
#12
Mahama Saaka, Shaibu Mohammed Osman, Anthony Amponsem, Juventus B Ziem, Alhassan Abdul-Mumin, Prosper Akanbong, Ernestina Yirkyio, Eliasu Yakubu, Sean Ervin
Objective. This study investigated the treatment outcomes and determinant factors likely to be associated with recovery rate. Methods. A retrospective chart review (RCR) was performed on 348 patients who were enrolled in the outpatient care (OPC) during the study period. Results. Of the 348 cases, 33.6% recovered (having MUAC ≥125 mm), 49.1% defaulted, and 11.5% transferred to other OPC units to continue with treatment. There were 187 (53.7%) males and 161 (46.3%) females with severe malnutrition. The average weight gain rate was 28 g/kg/day...
2015: Journal of Nutrition and Metabolism
https://www.readbyqxmd.com/read/26039837/the-ontogeny-of-saliva-secretion-in-infants-and-esophagoprotection
#13
REVIEW
Edgard Ferro Collares, Maria Inez Machado Fernandes
BACKGROUND: Several studies have reported that severe reflux esophagitis is rare in infants despite the well known high occurrence of regurgitation in early infancy. There is evidence of the importance of saliva for the pre-epithelial protection of the esophageal mucosa. RESULTS: A longitudinal study conducted on healthy infants indicated that the stimulated capacity of saliva secretion (saliva output per kg of body weight) was significantly higher during their first year of age compared to older children and adults...
April 2015: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/25937927/mortality-and-morbidity-patterns-in-under-five-children-with-severe-acute-malnutrition-sam-in-zambia-a-five-year-retrospective-review-of-hospital-based-records-2009-2013
#14
Tendai Munthali, Choolwe Jacobs, Lungowe Sitali, Rosalia Dambe, Charles Michelo
BACKGROUND: Severe acute malnutrition has continued to be growing problem in Sub Saharan Africa. We investigated the factors associated with morbidity and mortality of under-five children admitted and managed in hospital for severe acute malnutrition. METHODS: It was a retrospective quantitative review of hospital based records using patient files, ward death and discharge registers. It was conducted focussing on demographic, clinical and mortality data which was extracted on all children aged 0-60 months admitted to the University Teaching Hospital in Zambia from 2009 to 2013...
2015: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/25838626/malnutrition-in-acutely-ill-children-at-the-paediatric-emergency-unit-in-a-tertiary-hospital-in-nigeria
#15
Isaac E Ocheke, Puoane Thandi
BACKGROUND: In many developing countries, malnutrition remains an important cause of morbidity and mortality particularly in under-five children. The factors responsible for malnutrition could be immediate, underlying or basic, acting either alone or together. It has been shown that children who are malnourished have poorer outcomes from other illnesses than well-nourished children. It is important therefore to periodically describe the extent and pattern of childhood malnutrition so that effective preventive measures can be put in place...
March 2015: Nigerian Medical Journal: Journal of the Nigeria Medical Association
https://www.readbyqxmd.com/read/25755816/synchronous-of-gastric-adenocarcinoma-and-schwannoma-report-of-a-case-and-review-of-literatures
#16
REVIEW
Lian-He Yang, Jin-Ou Wang, Shuang Ma, Zhi Zhu, Jia-Xing Sun, Si-Lu Ding, Guang Li, Hong-Tao Xu, Liang Wang, Sun-Dong Dai, Yang Liu, Yuan Miao, Gui-Yang Jiang, Chui-Feng Fan, En-Hua Wang
We presented a case of 80-year-old male with long term stomachache, marasmus and anaemia. Endoscopic evaluation suggested the malignant ulcerative tumor on the Gastric antrum, and biopsy confirmed the diagnosis of gastric adenocarcinoma. Surprisingly, in resected specimen the pathologist found a nodule just below the ulcer with clear boundary and gray-yellow section. Histologically, the whole lesion was composed with adenocarcinoma area and spindle tumor cells area. In the spindle tumor cells area, the cells with round or oval nuclei, eosinophilic cytoplasm, and these cells showed bundle or fence-like arrangement...
2015: International Journal of Clinical and Experimental Pathology
https://www.readbyqxmd.com/read/25573807/body-mass-index-body-fat-and-nutritional-status-of-patients-with-heart-failure-the-plica-study
#17
Paloma Gastelurrutia, Josep Lupón, Marta de Antonio, Elisabet Zamora, Mar Domingo, Agustín Urrutia, Salvador Altimir, Ramon Coll, Crisanto Díez, Antoni Bayes-Genis
BACKGROUND & AIMS: Nutritional assessment may help to explain the incompletely understood obesity paradox in patients with heart failure (HF). Currently, obesity is usually identified by body mass index (BMI). Our objective was to assess the prognostic influence of undernourishment in HF outpatients. METHODS: Two published definitions of undernourishment were used to assess 214 ambulatory HF patients. Definition 1 included albumin, total lymphocyte count, tricipital skinfold (TS), subscapular skinfold, and arm muscle circumference (AMC) measurements (≥2 below normal considered undernourishment)...
December 2015: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/25421910/management-of-severe-acute-malnutrition-in-low-income-and-middle-income-countries
#18
Indi Trehan, Mark J Manary
Kwashiorkor and marasmus, collectively termed severe acute malnutrition (SAM), account for at least 10% of all deaths among children under 5 years of age worldwide, virtually all of them in low-income and middle-income countries. A number of risk factors, including seasonal food insecurity, environmental enteropathy, poor complementary feeding practices, and chronic and acute infections, contribute to the development of SAM. Careful anthropometry is key to making an accurate diagnosis of SAM and can be performed by village health workers or even laypeople in rural areas...
March 2015: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/25387494/phototherapy-promotes-healing-of-cutaneous-wounds-in-undernourished-rats
#19
Saulo Nani Leite, Thiago Antônio Moretti de Andrade, Daniela dos Santos Masson-Meyers, Marcel Nani Leite, Chukuka S Enwemeka, Marco Andrey Cipriani Frade
BACKGROUND: Various studies have shown that phototherapy promotes the healing of cutaneous wounds. OBJECTIVE: To investigate the effect of phototherapy on healing of cutaneous wounds in nourished and undernourished rats. METHODS: Forty rats, 20 nourished plus 20 others rendered marasmus with undernourishment, were assigned to four equal groups: nourished sham, nourished Light Emitting Diode treated, undernourished sham and undernourished Light Emitting Diode treated...
November 2014: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/25290719/trace-elements-and-immune-responses
#20
R K Chandra
The common association of malnutrition and infection has led to many studies that have examined the effects of nutritional status on immunocompetence. Children with the syndromes of marasmus and kwaskiorkor show marked impairment of cell-mediated immunity (CMI), complement system, microbicidal function of polymorphonuclear leukocytes (PMN), and secretory IgA antibody response. The extensive literature on this burgeoning field has been summarized(1-5,40) Clinical malnutrition, however, is a complex combination of the deficiencies of many nutrients, including proteins, lipids, carbohydrates, vitamins, macrominerals and trace elements...
November 1983: Immunology Today
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