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https://www.readbyqxmd.com/read/28109466/definitive-proton-beam-therapy-for-adenoid-cystic-carcinoma-of-the-nasopharynx-involving-the-base-of-skull
#1
Michelle S Gentile, Darwin Yip, Norbert J Liebsch, Judith A Adams, Paul M Busse, Annie W Chan
OBJECTIVES: Management of unresectable adenocystic carcinoma (ACC) of the nasopharynx is challenging given the high dose required for tumor control while respecting dose constraints. We evaluated long-term outcomes and toxicity in patients with unresectable ACC of the nasopharynx treated with definitive proton beam therapy. METHODS: Between 2000 and 2013, 14 patients with ACC of the nasopharynx were treated. Ninety-three percent had T4 disease. All had involvement of the skull base...
February 2017: Oral Oncology
https://www.readbyqxmd.com/read/28108172/the-accuracy-of-digital-templating-for-primary-total-hip-arthroplasty-is-there-a-difference-between-direct-anterior-and-posterior-approaches
#2
Shai S Shemesh, Jonathan Robinson, Aakash Keswani, Michael J Bronson, Calin S Moucha, Darwin Chen
BACKGROUND: The direct anterior approach (DAA) has gained recent popularity for total hip arthroplasty (THA), as it provides immediate feedback on cup position and limb length using fluoroscopy. The purpose of this study is to evaluate any differences in the accuracy of digital templating for preoperative planning of THA, performed with 2 different surgical approaches: DAA using a radiolucent table with intraoperative fluoroscopy and the posterior approach (PA). METHODS: One hundred thirty-one consecutive patients (148 hips) underwent a THA by a single surgeon, using the same cup and stem designs...
December 27, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28107052/trait-evolution-in-adaptive-radiations-modeling-and-measuring-interspecific-competition-on-phylogenies
#3
Magnus Clarke, Gavin H Thomas, Robert P Freckleton
The incorporation of ecological processes into models of trait evolution is important for understanding past drivers of evolutionary change. Species interactions have long been thought to be key drivers of trait evolution. However, models for comparative data that account for interactions between species are lacking. One of the challenges is that such models are intractable and difficult to express analytically. Here we present phylogenetic models of trait evolution that include interspecific competition among chosen species...
February 2017: American Naturalist
https://www.readbyqxmd.com/read/28104380/-evolutionary-medicine-a-new-look-on-health-and-disease
#4
F Bauduer
Evolutionary medicine represents an innovative approach deriving from evolutionary biology. It includes the initial Darwin's view, its actualization in the light of progresses in genetics and also dissident theories (i.e. non gene-based) particularly epigenetics. This approach enables us to reconsider the pathophysiology of numerous diseases, as for instance, infection, and our so-called diseases of civilization especially obesity, type 2 diabetes, allergy or cancer. Evolutionary medicine may also improve our knowledge regarding inter-individual variation in susceptibility to disease or drugs...
January 16, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/28101265/prevalence-and-persistence-of-misconceptions-in-tree-thinking
#5
Tyler A Kummer, Clinton J Whipple, Jamie L Jensen
Darwin described evolution as "descent with modification." Descent, however, is not an explicit focus of most evolution instruction and often leaves deeply held misconceptions to dominate student understanding of common ancestry and species relatedness. Evolutionary trees are ways of visually depicting descent by illustrating the relationships between species and groups of species. The ability to properly interpret and use evolutionary trees has become known as "tree thinking." We used a 20-question assessment to measure misconceptions in tree thinking and compare the proportion of students who hold these misconceptions in an introductory biology course with students in two higher-level courses including a senior level biology course...
December 2016: Journal of Microbiology & Biology Education: JMBE
https://www.readbyqxmd.com/read/28100708/the-origin-of-floral-organ-identity-quartets
#6
Philip Ruelens, Zhicheng Zhang, Hilda van Mourik, Steven Maere, Kerstin Kaufmann, Koen Geuten
The origin of flowers has puzzled plant biologists ever since Darwin referred to their sudden appearance in the fossil record as an abominable mystery. Flowers are considered to be an assembly of protective, attractive and reproductive male and female leaf-like organs. Their origin cannot be understood by a morphological comparison to gymnosperms, their closest relatives, which develop separate male or female cones. Despite these morphological differences, gymnosperms and angiosperms possess a similar genetic toolbox consisting of phylogenetically related MADS-domain proteins...
January 18, 2017: Plant Cell
https://www.readbyqxmd.com/read/28099647/reply-to-ralstonia-pickettii-bacteremia-in-hemodialysis-patients-a-report-of-two-cases
#7
Darwin Tejera
No abstract text is available yet for this article.
October 2016: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/28099256/diagnosis-of-chronic-pancreatitis-incorporating-endosonographic-features-demographics-and-behavioral-risk
#8
Linda S Lee, Ying P Tabak, Vivek Kadiyala, Xiaowu Sun, Shadeah Suleiman, Richard S Johannes, Peter A Banks, Darwin L Conwell
OBJECTIVES: Diagnosing chronic pancreatitis remains challenging. Endoscopic ultrasound (EUS) is utilized to evaluate pancreatic disease. Abnormal pancreas function test is considered the "nonhistologic" criterion standard for chronic pancreatitis. We derived a prediction model for abnormal endoscopic pancreatic function test (ePFT) by enriching EUS findings with patient demographic and pancreatitis behavioral risk characteristics. METHODS: Demographics, behavioral risk characteristics, EUS findings, and peak bicarbonate results were collected from patients evaluated for pancreatic disease...
January 18, 2017: Pancreas
https://www.readbyqxmd.com/read/28096448/loss-of-function-mutations-in-hspr-rescue-the-growth-defect-of-a-mycobacterium-tuberculosis-proteasome-activator-e-pafe-mutant
#9
Jordan B Jastrab, Marie I Samanovic, Richard Copin, Bo Shopsin, K Heran Darwin
: Mycobacterium tuberculosis uses a proteasome to degrade proteins by both ATP-dependent and -independent pathways. While much has been learned about ATP-dependent degradation, relatively little is understood about the ATP-independent pathway, which is controlled by Mycobacterium tuberculosis proteasome accessory factor E (PafE). Recently, we found that a Mycobacterium tuberculosis pafE mutant has slowed growth in vitro and is sensitive to killing by heat stress. However, we did not know if these phenotypes were caused by an inability to degrade the PafE-proteasome substrate HspR (heat shock protein repressor), an inability to degrade any damaged or misfolded proteins, or a defect in another protein quality control pathway...
January 17, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28095970/cyclic-alternating-pattern-associated-with-catathrenia-and-bruxism-in-a-10-year-old-patient
#10
Brian Villafuerte-Trisolini, Fiorella Adrianzén-Álvarez, Kevin R Duque, Jimmy Palacios-García, Darwin Vizcarra-Escobar
Cyclic alternating pattern (CAP) is widely recognized as an expression of sleep instability in electroencephalogram activity during nonrapid eye movement sleep. We report a case with sequences of CAP followed by bruxism and catathrenia in a 10-y-old male patient with a diagnosis of attention deficit hyperactivity disorder in treatment with methylphenidate. We found CAP in 83.1% of all episodes of catathrenia, and the CAP rate was 12.8%. We propose to consider catathrenia as one of the sleep disorders that may be accompanied by CAP...
January 11, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28089958/heredity-and-environment-a-warning-to-eugenists
#11
Major Leonard Darwin
No abstract text is available yet for this article.
January 15, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28077306/the-interaction-of-dietary-isoflavones-and-estradiol-replacement-on-behavior-and-brain-derived-neurotrophic-factor-in-the-ovariectomized-rat
#12
Ashley L Russell, Jamie Moran Grimes, Darwin O Larco, Danette F Cruthirds, Joanna Westerfield, Lawren Wooten, Margaret Keil, Michael J Weiser, Michael R Landauer, Robert J Handa, T John Wu
Phytoestrogens are plant derived, non-steroidal compounds naturally found in rodent chows that potentially have endocrine-disrupting effects. Isoflavones, the most common phytoestrogens, have a similar structure and molecular weight to 17β-estradiol (E2) and have the ability to bind and activate both isoforms of the estrogen receptor (ER). Most isoflavones have a higher affinity for ERβ, which is involved in sexually dimorphic behavioral regulation. The goal of this study was to examine the interaction of isoflavones and E2 presence in the OVX rat on anxiety- and depressive- like behavior and the related BDNF pathophysiology...
January 8, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28057866/evidence-for-opposing-roles-of-celsr3-and-vangl2-in-glutamatergic-synapse-formation
#13
Sonal Thakar, Liqing Wang, Ting Yu, Mao Ye, Keisuke Onishi, John Scott, Jiaxuan Qi, Catarina Fernandes, Xuemei Han, John R Yates, Darwin K Berg, Yimin Zou
The signaling mechanisms that choreograph the assembly of the highly asymmetric pre- and postsynaptic structures are still poorly defined. Using synaptosome fractionation, immunostaining, and coimmunoprecipitation, we found that Celsr3 and Vangl2, core components of the planar cell polarity (PCP) pathway, are localized at developing glutamatergic synapses and interact with key synaptic proteins. Pyramidal neurons from the hippocampus of Celsr3 knockout mice exhibit loss of ∼50% of glutamatergic synapses, but not inhibitory synapses, in culture...
January 5, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28053063/correction-to-unravelling-darwin-s-entangled-bank-architecture-and-robustness-of-mutualistic-networks-with-multiple-interaction-types
#14
Wesley Dáttilo, Nubia Lara-Rodríguez, Pedro Jordano, Paulo R Guimarães, John N Thompson, Robert J Marquis, Lucas P Medeiros, Raul Ortiz-Pulido, Maria A Marcos-García, Victor Rico-Gray
No abstract text is available yet for this article.
January 11, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28045936/detoxification-of-mitochondrial-oxidants-and-apoptotic-signaling-are-facilitated-by-thioredoxin-2-and-peroxiredoxin-3-during-hyperoxic-injury
#15
Benjamin J Forred, Darwin R Daugaard, Brianna K Titus, Ryan R Wood, Miranda J Floen, Michelle L Booze, Peter F Vitiello
Mitochondria play a fundamental role in the regulation of cell death during accumulation of oxidants. High concentrations of atmospheric oxygen (hyperoxia), used clinically to treat tissue hypoxia in premature newborns, is known to elicit oxidative stress and mitochondrial injury to pulmonary epithelial cells. A consequence of oxidative stress in mitochondria is the accumulation of peroxides which are detoxified by the dedicated mitochondrial thioredoxin system. This system is comprised of the oxidoreductase activities of peroxiredoxin-3 (Prx3), thioredoxin-2 (Trx2), and thioredoxin reductase-2 (TrxR2)...
2017: PloS One
https://www.readbyqxmd.com/read/28044207/limiting-similarity-and-darwin-s-naturalization-hypothesis-understanding-the-drivers-of-biotic-resistance-against-invasive-plant-species
#16
F A Yannelli, C Koch, J M Jeschke, J Kollmann
Several hypotheses have been proposed to explain biotic resistance of a recipient plant community based on reduced niche opportunities for invasive alien plant species. The limiting similarity hypothesis predicts that invasive species are less likely to establish in communities of species holding similar functional traits. Likewise, Darwin's naturalization hypothesis states that invasive species closely related to the native community would be less successful. We tested both using the invasive alien Ambrosia artemisiifolia L...
January 2, 2017: Oecologia
https://www.readbyqxmd.com/read/28033036/nonverbal-communication-of-confidence-in-soccer-referees-an-experimental-test-of-darwin-s-leakage-hypothesis
#17
Philip Furley, Geoffrey Schweizer
The goal of the present paper was to investigate whether soccer referees' nonverbal behavior (NVB) differed based on the difficulty of their decisions and whether perceivers could detect these systematic variations. On the one hand, communicating confidence via NVB is emphasized in referee training. On the other hand, it seems feasible from a theoretical point of view that particularly following relatively difficult decisions referees have problems controlling their NVB. We conducted three experiments in order to investigate into this question...
December 29, 2016: Journal of Sport & Exercise Psychology
https://www.readbyqxmd.com/read/28032530/charles-darwin-and-the-church-of-wordsworth
#18
John Holmes
No abstract text is available yet for this article.
December 29, 2016: Annals of Science
https://www.readbyqxmd.com/read/28012688/darwin-s-body-snatchers
#19
John van Wyhe
For decades creationists have claimed that Charles Darwin sought the skulls of full-blooded Aboriginal Tasmanian people when only four were left alive. It is said that Darwin letters survive which reveal this startling and distasteful truth. Tracing these claims back to their origins, however, reveals a different, if not unfamiliar story.
December 21, 2016: Endeavour
https://www.readbyqxmd.com/read/27994123/the-origins-scaling-and-loss-of-tetrapod-digits
#20
REVIEW
Aditya Saxena, Matthew Towers, Kimberly L Cooper
Many of the great morphologists of the nineteenth century marvelled at similarities between the limbs of diverse species, and Charles Darwin noted these homologies as significant supporting evidence for descent with modification from a common ancestor. Sir Richard Owen also took great care to highlight each of the elements of the forelimb and hindlimb in a multitude of species with focused attention on the homology between the hoof of the horse and the middle digit of man. The ensuing decades brought about a convergence of palaeontology, experimental embryology and molecular biology to lend further support to the homologies of tetrapod limbs and their developmental origins...
February 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
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