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https://www.readbyqxmd.com/read/28526096/pvgama-reticulocyte-binding-activity-predicting-conserved-functional-regions-by-natural-selection-analysis
#1
Luis A Baquero, Darwin A Moreno-Pérez, Diego Garzón-Ospina, Johanna Forero-Rodríguez, Heidy D Ortiz-Suárez, Manuel A Patarroyo
BACKGROUND: Adhesin proteins are used by Plasmodium parasites to bind and invade target cells. Hence, characterising molecules that participate in reticulocyte interaction is key to understanding the molecular basis of Plasmodium vivax invasion. This study focused on predicting functionally restricted regions of the P. vivax GPI-anchored micronemal antigen (PvGAMA) and characterising their reticulocyte binding activity. RESULTS: The pvgama gene was initially found in P...
May 19, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28521840/characterising-pvrbsa-an-exclusive-protein-from-plasmodium-species-infecting-reticulocytes
#2
Darwin A Moreno-Pérez, Luis A Baquero, Diana M Chitiva-Ardila, Manuel A Patarroyo
BACKGROUND: Plasmodium vivax uses multiple ligand-receptor interactions for preferential invasion of human reticulocytes. Several of these ligands have been identified by in silico approaches based on the role displayed by their orthologs in other Plasmodium species during initial adhesion or invasion. However, the cell adhesion role of proteins that are exclusive to species that specifically invade reticulocytes (as P. vivax and P. cynomolgi) has not been evaluated to date. This study aimed to characterise an antigen shared between Plasmodium species that preferentially infect reticulocytes with a focus on assessing its binding activity to target cells...
May 18, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28513983/book-review-the-foundations-of-immunology-and-their-pertinence-to-medicine
#3
REVIEW
A Corthay
We are in the era cursed with overspecialization. Charles Darwin's foundational Origin of Species, published in 1859 was accessible to the broadly educated individual. Starting with this statement, Peter Bretscher in his new book aims at explaining foundational concepts of immunology to a broad public. His standpoint is that foundational ideas usually can be simply expressed. This book describes first how foundational concepts of immunology have evolved over the last two and a half centuries. The importance of self-nonself discrimination by the immune system is acknowledged and models for immunological tolerance are compared...
May 17, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28505666/acute-pancreatitis-how-soon-should-we-feed-patients
#4
Kristen M Roberts, Darwin Conwell
No abstract text is available yet for this article.
May 16, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28496202/inhibition-of-jak-stat-signaling-reduces-the-activation-of-pancreatic-stellate-cells-in-vitro-and-limits-caerulein-induced-chronic-pancreatitis-in-vivo
#5
Hannah M Komar, Gregory Serpa, Claire Kerscher, Erin Schwoegl, Thomas A Mace, Ming Jin, Ming-Chen Yang, Ching-Shih Chen, Mark Bloomston, Michael C Ostrowski, Phil A Hart, Darwin L Conwell, Gregory B Lesinski
Chronic pancreatitis (CP) is a fibro-inflammatory disease leading to pain, maldigestion, and pancreatic insufficiency. No therapeutic options exist due to a limited understanding of the biology of CP pathology. Recent findings implicate pancreatic stellate cells (PSC) as prominent mediators of inflammatory and fibrotic processes during CP. Here, we utilized primary and immortalized PSC obtained from mice and patients with CP or pancreatic cancer to examine the effect of Jak/STAT and MAPK pathway inhibition in vitro...
May 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28494937/msc-derived-extracellular-vesicles-attenuate-immune-responses-in-two-autoimmune-murine-models-type-1-diabetes-and-uveoretinitis
#6
Taeko Shigemoto-Kuroda, Joo Youn Oh, Dong-Ki Kim, Hyun Jeong Jeong, Se Yeon Park, Hyun Ju Lee, Jong Woo Park, Tae Wan Kim, Su Yeon An, Darwin J Prockop, Ryang Hwa Lee
Accumulating evidence shows that extracellular vesicles (EVs) produced by mesenchymal stem/stromal cells (MSCs) exert their therapeutic effects in several disease models. We previously demonstrated that MSCs suppress autoimmunity in models of type 1 diabetes (T1D) and experimental autoimmune uveoretinitis (EAU). Therefore, here, we investigated the therapeutic potential of MSC-derived EVs using our established mouse models for autoimmune diseases affecting the pancreas and the eye: T1D and EAU. The data demonstrate that MSC-derived EVs effectively prevent the onset of disease in both T1D and EAU...
May 9, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28492270/diy-gene-engineering-an-attack-on-darwinism-and-a-probe-into-nazi-science
#7
(no author information available yet)
No abstract text is available yet for this article.
May 10, 2017: Nature
https://www.readbyqxmd.com/read/28490623/genetics-based-interactions-of-foundation-species-affect-community-diversity-stability-and-network-structure
#8
Arthur R Keith, Joseph K Bailey, Matthew K Lau, Thomas G Whitham
We examined the hypothesis that genetics-based interactions between strongly interacting foundation species, the tree Populus angustifolia and the aphid Pemphigus betae, affect arthropod community diversity, stability and species interaction networks of which little is known. In a 2-year experimental manipulation of the tree and its aphid herbivore four major findings emerged: (i) the interactions of these two species determined the composition of an arthropod community of 139 species; (ii) both tree genotype and aphid presence significantly predicted community diversity; (iii) the presence of aphids on genetically susceptible trees increased the stability of arthropod communities across years; and (iv) the experimental removal of aphids affected community network structure (network degree, modularity and tree genotype contribution to modularity)...
May 17, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28482370/dietary-isoflavone-dependent-and-estradiol-replacement-effects-on-body-weight-in-the-ovariectomized-ovx-rat
#9
Ashley L Russell, Jamie Moran Grimes, Danette F Cruthirds, Joanna Westerfield, Lawren Wooten, Margaret Keil, Michael J Weiser, Michael R Landauer, Robert J Handa, T John Wu, Darwin O Larco
17β-Estradiol is known to regulate energy metabolism and body weight. Ovariectomy results in body weight gain while estradiol administration results in a reversal of weight gain. Isoflavones, found in rodent chow, can mimic estrogenic effects making it crucial to understand the role of these compounds on metabolic regulation. The goal of this study is to examine the effect of dietary isoflavones on body weight regulation in the ovariectomized rat. This study will examine how dietary isoflavones can interact with estradiol treatment to affect body weight...
May 8, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28480022/long-term-continental-changes-in-wing-length-but-not-bill-length-of-a-long-distance-migratory-shorebird
#10
David B Lank, Cailin Xu, Brian A Harrington, Richard I Guy Morrison, Cheri L Gratto-Trevor, Peter W Hicklin, Brett K Sandercock, Paul Allen Smith, Eunbi Kwon, Jennie Rausch, Lisa D Pirie Dominix, Diana J Hamilton, Julie Paquet, Sydney E Bliss, Sarah G Neima, Christian Friis, Scott A Flemming, Alexandra M Anderson, Ronald C Ydenberg
We compiled a >50-year record of morphometrics for semipalmated sandpipers (Calidris pusilla), a shorebird species with a Nearctic breeding distribution and intercontinental migration to South America. Our data included >57,000 individuals captured 1972-2015 at five breeding locations and three major stopover sites, plus 139 museum specimens collected in earlier decades. Wing length increased by ca. 1.5 mm (>1%) prior to 1980, followed by a decrease of 3.85 mm (nearly 4%) over the subsequent 35 years...
May 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28476308/magnetic-resonance-elastography-of-the-pancreas-measurement-reproducibility-and-relationship-with-age
#11
Arunark Kolipaka, Samuel Schroeder, Xiaokui Mo, Zarine Shah, Phil A Hart, Darwin L Conwell
PURPOSE: To determine magnetic resonance elastography (MRE)-derived stiffness of pancreas in healthy volunteers with emphasis on: 1) short term and midterm repeatability; and 2) variance as a function of age. METHODS: Pancreatic MRE was performed on 22 healthy volunteers (age range:20-64years) in a 3T-scanner. For evaluation of reproducibility of stiffness estimates, the scans were repeated per volunteer on the same day (short term) and one month apart (midterm)...
May 2, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28475225/the-adaptive-genomic-landscape-of-beak-morphology-in-darwin-s-finches
#12
Lucinda P Lawson, Kenneth Petren
Beak shape in Darwin's ground finches (Geospiza) is emblematic of natural selection and adaptive radiation, yet our understanding of the genetic basis of beak shape variation, and thus the genetic target of natural selection, is still evolving. Here we reveal the genomic architecture of beak shape variation using genome-wide comparisons of four closely related and hybridizing species across 13 islands subject to parallel natural selection. Pairwise contrasts among species were used to identify a large number of genomic loci that are consistently related to species differences across a complex landscape...
May 5, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28474181/sexual-selection-on-receptor-organ-traits-younger-females-attract-males-with-longer-antennae
#13
Tamara L Johnson, Matthew R E Symonds, Mark A Elgar
Sexual selection theory predicts that female choice may favour the evolution of elaborate male signals. Darwin also suggested that sexual selection can favour elaborate receiver structures in order to better detect sexual signals, an idea that has been largely ignored. We evaluated this unorthodox perspective by documenting the antennal lengths of male Uraba lugens Walker (Lepidoptera: Nolidae) moths that were attracted to experimentally manipulated emissions of female sex pheromone. Either one or two females were placed in field traps for the duration of their adult lives in order to create differences in the quantity of pheromone emissions from the traps...
June 2017: Die Naturwissenschaften
https://www.readbyqxmd.com/read/28468022/from-conflict-and-misunderstanding-to-respect
#14
Ivan Cvitković
Sociologists of the 19(th) and the 20(th) centuries were tackling the relation between science and religion. A few models of these relations were offered, by which the monopoly over the truth by any one of those is crashed. Therefore, there are a few models but each is with lots of limitations. None is sufficient to explain the relation between the science and religion, but each contributes to certain extent to better understanding of those relations. Almost every one of the interpretations was under the influence of the social (particularly ideological and political) conditions in which they were emerging...
April 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28460255/darwin-revisited-the-vagus-nerve-is-a-causal-element-in-controlling-recognition-of-other-s-emotions
#15
Lorenza S Colzato, Roberta Sellaro, Christian Beste
Charles Darwin proposed that via the vagus nerve, the tenth cranial nerve, emotional facial expressions are evolved, adaptive and serve a crucial communicative function. In line with this idea, the later-developed polyvagal theory assumes that the vagus nerve is the key phylogenetic substrate that regulates emotional and social behavior. The polyvagal theory assumes that optimal social interaction, which includes the recognition of emotion in faces, is modulated by the vagus nerve. So far, in humans, it has not yet been demonstrated that the vagus plays a causal role in emotion recognition...
April 7, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28442558/gene-flow-ancient-polymorphism-and-ecological-adaptation-shape-the-genomic-landscape-of-divergence-among-darwin-s-finches
#16
Fan Han, Sangeet Lamichhaney, B Rosemary Grant, Peter R Grant, Leif Andersson, Matthew T Webster
Genomic comparisons of closely related species have identified "islands" of locally elevated sequence divergence. Genomic islands may contain functional variants involved in local adaptation or reproductive isolation and may therefore play an important role in the speciation process. However, genomic islands can also arise through evolutionary processes unrelated to speciation, and examination of their properties can illuminate how new species evolve. Here, we performed scans for regions of high relative divergence (FST) in 12 species pairs of Darwin's finches at different genetic distances...
April 25, 2017: Genome Research
https://www.readbyqxmd.com/read/28439020/mathematical-model-of-chronic-pancreatitis
#17
Wenrui Hao, Hannah M Komar, Phil A Hart, Darwin L Conwell, Gregory B Lesinski, Avner Friedman
Chronic pancreatitis (CP) is a progressive inflammatory disease of the pancreas, leading to its fibrotic destruction. There are currently no drugs that can stop or slow the progression of the disease. The etiology of the disease is multifactorial, whereas recurrent attacks of acute pancreatitis are thought to precede the development of CP. A better understanding of the pathology of CP is needed to facilitate improved diagnosis and treatment strategies for this disease. The present paper develops a mathematical model of CP based on a dynamic network that includes macrophages, pancreatic stellate cells, and prominent cytokines that are present at high levels in the CP microenvironment...
May 9, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28434184/complex-problems-and-unchallenged-solutions-bringing-ecosystem-governance-to-the-forefront-of-the-un-sustainable-development-goals
#18
Liette Vasseur, Darwin Horning, Mary Thornbush, Emmanuelle Cohen-Shacham, Angela Andrade, Ed Barrow, Steve R Edwards, Piet Wit, Mike Jones
Sustainable development aims at addressing economic, social, and environmental concerns, but the current lack of responsive environmental governance hinders progress. Short-term economic development has led to limited actions, unsustainable resource management, and degraded ecosystems. The UN Sustainable Development Goals (SDGs) may continue to fall short of achieving significant progress without a better understanding of how ecosystems contribute to achieving sustainability for all people. Ecosystem governance is an approach that integrates the social and ecological components for improved sustainability and includes principles such as adaptive ecosystem co-management, subsidiarity, and telecoupling framework, as well as principles of democracy and accountability...
April 22, 2017: Ambio
https://www.readbyqxmd.com/read/28428199/experimental-insights-on-darwin-s-cross-promotion-hypothesis-in-tristylous-purple-loosestrife-lythrum-salicaria
#19
Joana Costa, Sílvia Castro, João Loureiro, Spencer C H Barrett
PREMISE OF THE STUDY: Darwin proposed that the reciprocal arrangement of anthers and stigmas in heterostylous plants promotes cross-pollination through pollen segregation on pollinators' bodies. The floral tube in most heterostylous species constrains the feeding posture of pollinators determining the site of contact with sex organs located at different heights within a flower. Here, we evaluate Darwin's hypothesis in tristylous Lythrum salicaria, a species with a partially tubular corolla, and examine the extent to which the location of sex organs within a flower influence compatible and incompatible pollination...
April 20, 2017: American Journal of Botany
https://www.readbyqxmd.com/read/28426692/what-is-adaptation-by-natural-selection-perspectives-of-an-experimental-microbiologist
#20
REVIEW
Richard E Lenski
Ever since Darwin, the role of natural selection in shaping the morphological, physiological, and behavioral adaptations of animals and plants across generations has been central to understanding life and its diversity. New discoveries have shown with increasing precision how genetic, molecular, and biochemical processes produce and express those organismal features during an individual's lifetime. When it comes to microorganisms, however, understanding the role of natural selection in producing adaptive solutions has historically been, and sometimes continues to be, contentious...
April 2017: PLoS Genetics
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