keyword
MENU ▼
Read by QxMD icon Read
search

Hyperuricemia

keyword
https://www.readbyqxmd.com/read/29324308/antacids-side-effect-hyperuricaemia-could-be-alleviated-by-long-term-aerobic-exercise-via-accelerating-atp-turnover-rate
#1
Shu Yuan, Zhong-Wei Zhang, Zi-Lin Li
Hyperuricemia is the term for an abnormally high serum uric acid level. Many factors contribute to hyperuricemia, however no definite correlation between proton pump inhibitors (PPIs) and hyperuricemia has been reported before. Physical exercise also decreases serum uric acid levels. However, the detailed biochemical-regulatory mechanisms remain unknown. Here we found that adenylate deaminase activities are much higher in hyperuricemia patients than in the healthy people. Therefore, the patients have higher levels of adenosine metabolites hypoxanthine and uric acid...
January 8, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29320555/chronic-kidney-disease-associated-with-decreased-bone-mineral-density-uric-acid-and-metabolic-syndrome
#2
Bo-Lin Pan, Song-Seng Loke
OBJECTIVE: The relationship between decreased bone mineral density (BMD) and chronic kidney disease (CKD) is controversial. The associations among metabolic syndrome (MetS), serum uric acid and CKD are also unclear. We aimed to investigate the relationship between decreased BMD, MetS, serum uric acid and CKD in a general population. METHODS: A total of 802 subjects who visited a medical center in Southern Taiwan and underwent a BMD measured by dual-energy X-ray absorptiometry (DEXA) during a health examination were enrolled in this retrospective cross-sectional study...
2018: PloS One
https://www.readbyqxmd.com/read/29318274/lesinurad-allopurinol-duzallo-for-gout-associated-hyperuricemia
#3
(no author information available yet)
No abstract text is available yet for this article.
January 9, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29317200/hyperuricemia-enhances-intracellular-urate-accumulation-via-down-regulation-of-cell-surface-bcrp-abcg2-expression-in-vascular-endothelial-cells
#4
Hisakazu Komori, Kazuyuki Yamada, Ikumi Tamai
Hyperuricemia has been recognized as an independent risk factor for cardiovascular disease. Urate stimulates NADPH oxidase and induces production of reactive oxygen species (ROS); consequently, intracellular urate accumulation can induce oxidative stress leading to endothelial dysfunction. Here, we studied the mechanism involved, using human umbilical vascular endothelial cells (HUVEC) as a model. Pretreatment with 15mg/dL unlabeled uric acid (corresponding to hyperuricemia) resulted in increased uptake of [14C]uric acid at steady-state by HUVEC, whereas pretreatment with 5mg/dL uric acid (in the normal serum concentration range) did not...
January 6, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29305119/weicao-capsule-ameliorates-renal-injury-through-increasing-autophagy-and-nlrp3-degradation-in-uan-rats
#5
Jiacai Hu, Hao Wu, Daochun Wang, Zhijie Yang, Lihua Zhuang, Na Yang, Junjun Dong
Uric acid nephropathy (UAN) is one of the most common metabolic diseases and leads to kidney damage. This study aimed to evaluate the effect of Weicao capsule on renal injury of UAN rats and to examine whether the mechanism was associated with induction of autophagy and degradation of nucleotide binding oligomerization domain (Nod)-like receptor (NLR) protein 3 (NLRP3) inflammasome. Sixty Sprague-Dawley rats were randomly allocated into 6 groups: Control, Model, Allopurinol, and Weicao (0.55/1.1/2.2 g/kg) group...
January 2, 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29302463/prevalence-and-correlates-of-chronic-kidney-disease-in-a-group-of-patients-with-hypertension-in-the-savanah-zone-of-cameroon-a-cross-sectional-study-in-sub-saharan-africa
#6
Ba Hamadou, Jérôme Boombhi, Félicité Kamdem, Adeline Fitame, Sylvie Ndongo Amougou, Liliane Kuate Mfeukeu, Chris Nadège Nganou, Alain Menanga, Gloria Ashuntantang
Background: The prevalence of chronic kidney disease (CKD) is increasing worldwide due to an increase in the risk factors such as hypertension. The greatest burden is in low-income settings, coupled with late diagnosis and limited management resources. This work aimed at studying the prevalence and risk factors of CKD in a group of patients with hypertension in the Savanah zone in Sub-Saharan Africa (SSA). Methods: We carried out a cross-sectional study between January and May 2016 in the regional Hospital of Garoua-Cameroon...
December 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/29298537/pharmacological-effects-of-chatuphalatika-in-hyperuricemia-of-gout
#7
Vilasinee Hirunpanich Sato, Bunleu Sungthong, Prasob-Orn Rinthong, Narawat Nuamnaichati, Supachoke Mangmool, Savita Chewchida, Hitoshi Sato
CONTEXT: Chatuphalatika (CTPT), is a Thai herbal formulation mixture of Phyllanthus emblica Linn. (Euphorbiaceae), Terminalia belerica Linn. (Combretaceae), T. chebula and the fruit of T. arjuna (Roxb.) Wight & Arn. CTPT is considered to exert anti-inflammatory and antihyperuricemic effects, but there have been no reports to demonstrate these pharmacological effects in a quantitative manner. OBJECTIVES: To investigate the antioxidative, anti-inflammatory and antihyperuricemic effects of CTPT...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29288369/assessment-of-cardiovascular-risk-profile-based-on-measurement-of-tophus-volume-in-patients-with-gout
#8
Kyung-Ann Lee, Se-Ri Ryu, Seong-Jun Park, Hae-Rim Kim, Sang-Heon Lee
Hyperuricemia and gout are associated with increased risk of cardiovascular disease and metabolic syndrome. The aim of this study was to evaluate the correlation of total tophus volumes, measured using dual-energy computed tomography, with cardiovascular risk and the presence of metabolic syndrome. Dual-energy computed tomography datasets from 91 patients with a diagnosis of gout were analyzed retrospectively. Patients who received urate lowering therapy were excluded to avoid the effect on tophus volume. The total volumes of tophaceous deposition were quantified using automated volume assessment software...
December 29, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29285741/effects-of-polygonum-cuspidatum-on-ampk-foxo3%C3%AE-signaling-pathway-in-a-rat-model-of-uric-acid-induced-renal-damage
#9
Wei-Guo Ma, Jie Wang, Xiang-Wei Bu, Hong-Hong Zhang, Jian-Ping Zhang, Xiao-Xu Zhang, Yu-Xi He, Da-Li Wang, Zheng-Ju Zhang, Feng-Xian Meng
OBJECTIVE: To observe the effects of Polygonum cuspidatum (PC) on adenosine 5'-monophosphateactivated protein kinase (AMPK), forkhead box O3α (FOXO3α), Toll-like receptor-4 (TLR4), NACHT, LRR and PYD domains-containing protein 3 (NLRP3), and monocyte chemoattractant protein-1 (MCP-1) expression in a rat model of uric acid-induced renal damage and to determine the molecular mechanism. METHODS: A rat model of uric acid-induced renal damage was established, and rats were randomly divided into a model group, a positive drug group, and high-, medium-, and low-dose Chinese medicine (CM) PC groups (n=12 per group)...
December 28, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29285429/relationship-between-serum-uric-acid-and-mortality-among-hemodialysis-patients-retrospective-analysis-of-korean-end-stage-renal-disease-registry-data
#10
Chang Seong Kim, Dong-Chan Jin, Young Cheol Yun, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim
Background: It is thought that hyperuricemia might lower the risk of mortality among hemodialysis patients, unlike in the general population, but the evidence is controversial. The aim of the current study was to evaluate the impact of serum uric acid level on the long-term clinical outcomes of hemodialysis patients in Korea. Methods: Retrospective analysis was performed on data from the End-Stage Renal Disease Registry of the Korean Society of Nephrology. This included data for 7,333 patients (mean age, 61 ± 14 years; 61% male) who received hemodialysis from January 2001 through April 2015...
December 2017: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/29278921/management-of-hyperuricemia-through-dietary-polyphenols-as-a-natural-medicament-a-comprehensive-review
#11
Arshad Mehmood, Lei Zhao, Chengtao Wang, Muhammad Nadeem, Ali Raza, Nawazish Ali, Amjad Abbas Shah
Hyperuricemia, a condition due to high serum uric acid level and is notorious to health. It is considered to be a potent risk factor for gout and dramatically associated in the development of many chronic diseases such as malignant tumor, cardiovascular disorders and renal failure. Modern innovative medicinal and therapeutic interventions are underlying these days to combat hyperuricemia. Previously reported studies revealed the significant impact of dietary polyphenols (e.g. anthocyanins, phenolic acids, flavonoids etc...
December 26, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29274704/synthesis-structure-activity-relationships-and-mechanistic-studies-of-5-arylazo-tropolone-derivatives-as-novel-xanthine-oxidase-xo-inhibitors
#12
Daisuke Sato, Takuya Kisen, Mina Kumagai, Kiminori Ohta
Xanthine oxidase (XO) is an enzyme that contains molybdenum at the active site and catalyzes the oxidation of purine bases to uric acid. Even though XO inhibitors are widely used for the treatment of hyperuricemia and gout, only very few such compounds are clinically used as drugs for the treatment of these diseases. Given the unique physicochemical properties of tropolone, i.e., its chelating effect and the pKa value that is similar to that of carboxylic acid, we have synthesized 22 5-arylazotropolone derivatives as potential XO inhibitors...
December 13, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29273728/allopurinol-and-risk-of-benign-prostatic-hyperplasia-in-a-finnish-population-based-cohort
#13
Ville Kukko, Antti Kaipia, Kirsi Talala, Kimmo Taari, Teuvo L J Tammela, Anssi Auvinen, Teemu J Murtola
BACKGROUND: Metabolic syndrome and obesity are linked with hyperuricemia, and it has also been proposed that oxidative stress associated with hyperuricemia may promote benign prostatic hyperplasia (BPH). However, it is currently unknown whether use of antihyperuricemic medication is associated with risk of developing BPH. We studied the association between BPH and use of antihyperuricemic allopurinol in a Finnish population-based cohort. METHODS: The study cohort consisted of 74,754 men originally identified for the Finnish Randomized Study of Screening for Prostate Cancer (FinRSPC)...
December 22, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29247200/association-of-plasma-free-amino-acids-with-hyperuricemia-in-relation-to-diabetes-mellitus-dyslipidemia-hypertension-and-metabolic-syndrome
#14
M H Mahbub, Natsu Yamaguchi, Hidekazu Takahashi, Ryosuke Hase, Yasutaka Ishimaru, Hiroshi Sunagawa, Hiroki Amano, Mikiko Kobayashi-Miura, Hideyuki Kanda, Yasuyuki Fujita, Hiroshi Yamamoto, Mai Yamamoto, Shinya Kikuchi, Atsuko Ikeda, Naoko Kageyama, Mina Nakamura, Tsuyoshi Tanabe
Previous studies demonstrated independent contributions of plasma free amino acids (PFAAs) and high uric acid (UA) concentrations to increased risks of lifestyle-related diseases (LSRDs), but the important associations between these factors and LSRDs remain unknown. We quantified PFAAs and UA amongst Japanese subjects without LSRDs (no-LSRD, n = 2805), and with diabetes mellitus (DM, n = 415), dyslipidemia (n = 3207), hypertension (n = 2736) and metabolic syndrome (MetS, n = 717). The concentrations of most amino acids differed significantly between the subjects with and without hyperuricemia (HU) and also between the no-LSRD and LSRD groups (p < 0...
December 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29246027/recent-advances-on-uric-acid-transporters
#15
REVIEW
Liuqing Xu, Yingfeng Shi, Shougang Zhuang, Na Liu
Uric acid is the product of purine metabolism and its increased levels result in hyperuricemia. A number of epidemiological reports link hyperuricemia with multiple disorders, such as kidney diseases, cardiovascular diseases and diabetes. Recent studies also showed that expression and functional changes of urate transporters are associated with hyperuricemia. Uric acid transporters are divided into two categories: urate reabsorption transporters, including urate anion transporter 1 (URAT1), organic anion transporter 4 (OAT4) and glucose transporter 9 (GLUT9), and urate excretion transporetrs, including OAT1, OAT3, urate transporter (UAT), multidrug resistance protein 4 (MRP4/ABCC4), ABCG-2 and sodium-dependent phosphate transport protein...
November 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/29241747/pathophysiology-of-the-metabolic-syndrome
#16
Emma McCracken, Monica Monaghan, Shiva Sreenivasan
The metabolic syndrome-otherwise called syndrome X, insulin resistance syndrome, Reaven syndrome, and "the deadly quartet"-is the name given to the aggregate of clinical conditions comprising central and abdominal obesity, systemic hypertension, insulin resistance (or type 2 diabetes mellitus), and atherogenic dyslipidemia. It is a prothrombotic and proinflammatory state characterized by increased inflammatory cytokine activity. In addition to inflammatory dermatoses such as psoriasis, lichen planus, and hidradenitis suppurativa, metabolic syndrome is also commonly associated with accelerated atherosclerotic cardiovascular disease, hyperuricemia/gout, chronic kidney disease, and obstructive sleep apnea...
January 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29239351/association-of-serum-uric-acid-levels-with-osteoporosis-and-bone-turnover-markers-in-a-chinese-population
#17
Dan-Dan Yan, Jie Wang, Xu-Hong Hou, Yu-Qian Bao, Zhen-Lin Zhang, Cheng Hu, Wei-Ping Jia
Recent evidence shows that uric acid is protective against some neurological diseases, but can be detrimental in many metabolic and cardiovascular disorders. In this study, we examined the association between serum uric acid levels and bone metabolism in Chinese males and postmenopausal females. A total of 943 males and 4256 postmenopausal females were recruited in Shanghai. The levels of serum uric acid and bone turnover markers (BTMs) were detected along with other biochemical traits. In addition, the fat distribution was calculated through MRI and image analysis software, and bone mineral density (BMD) was determined using dual-energy X-ray absorptiometry...
December 14, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29238304/neck-circumference-a-novel-indicator-for-hyperuricemia
#18
Jiajia Jiang, Jia Cui, Xinghua Yang, Anping Wang, Yiming Mu, Liguang Dong, Shuyu Wang, Herbert Gaisano, Jingtao Dou, Yan He
Background: Waist circumference has been correlated with the risk of hyperuricemia. Whether neck circumference is also associated with hyperuricemia has not been assessed. This study aimed to investigate whether neck circumference is associated with hyperuricemia. Methods: This study population from Beijing is part of the larger China-wide Risk Evaluation of Cancers in Chinese Diabetic Individuals: a lONgitudinal (REACTION) study. For this Beijing sub-center cross-sectional study, a total of 8971 subjects were recruited...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29237999/the-relationships-among-hyperuricemia-body-mass-index-and-impaired-renal-function-in-type-2-diabetic-patients
#19
Yongmei Li, Xing Fan, Chunjun Li, Xinyue Zhi, Liyuan Peng, Hongling Han, Bei Sun
Chronic kidney disease (CKD) is a common chronic microvascular complication and the major cause of death in diabetic patients. This study was conceived to explore the possible mechanisms of how hyperuricemia and obesity contribute to renal function impairment in type 2 diabetic (T2DM) patients. A cross-sectional study in 609 participants recruited from a T2DM population in North China was conducted. The multiplicative interaction between body mass index (BMI) and uric acid (UA) level was assessed using an interaction term in a logistic regression analysis...
December 13, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/29233733/regulation-mechanism-of-dioscin-on-uric-acid-excretion
#20
Yi Zhang, Lijun Jin, Jinchang Liu, Wei Wang, Haiyang Yu, Jian Li, Qian Chen, Tao Wang
ETHNOPHARMACOLOGY RELEVANCE: Dioscin, a spirostane glycoside, the rhizoma of Dioscorea septemloba (Diocoreacea) is used for diuresis, rheumatism, and joints pain. Given the poor solubility and stability of Dioscin, we proposed a hypothesis that Dioscin's metabolite(s) are the active substance(s) in vivo to contribute to the reducing effects on serum uric acid levels. AIM OF THE STUDY: The aim of this study is to identify the active metabolite(s) of Dioscin in vivo and to explore the mechanism of its antihyperuricemic activity...
December 9, 2017: Journal of Ethnopharmacology
keyword
keyword
2372
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"