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https://www.readbyqxmd.com/read/28759475/component-resolved-diagnostics-for-hymenoptera-venom-allergy
#1
Thilo Jakob, Ulrich Müller, Arthur Helbling, Edzard Spillner
PURPOSE OF REVIEW: Component-resolved diagnostics makes use of defined allergen molecules to analyse IgE-mediated sensitizations at a molecular level. Here, we review recent studies on the use of component-resolved diagnostics in the field of Hymenoptera venom allergy (HVA) and discuss its benefits and limitations. RECENT FINDINGS: Component resolution in HVA has moved from single molecules to panels of allergens. Detection of specific immunoglobulin E (sIgE) to marker and cross-reactive venom allergens has been reported to facilitate the discrimination between primary sensitization and cross-reactivity and thus, to provide a better rationale for prescribing venom immunotherapy (VIT), particularly in patients sensitized to both honeybee and vespid venom...
October 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28748641/eaaci-guidelines-on-allergen-immunotherapy-hymenoptera-venom-allergy
#2
Gunter J Sturm, Eva-Maria Varga, Graham Roberts, Holger Mosbech, M Beatrice Bilò, Cezmi A Akdis, Darío Antolín-Amérigo, Ewa Cichocka-Jarosz, Radoslaw Gawlik, Thilo Jakob, Mitja Kosnik, Joanna Lange, Ervin Mingomataj, Dimitris I Mitsias, Markus Ollert, Joanna N G Oude Elberink, Oliver Pfaar, Constantinos Pitsios, Valerio Pravettoni, Franziska Ruëff, Betül Ayşe Sin, Ioana Agache, Elizabeth Angier, Stefania Arasi, Moises A Calderón, Montserrat Fernandez-Rivas, Susanne Halken, Marek Jutel, Susanne Lau, Giovanni B Pajno, Ronald van Ree, Dermot Ryan, Otto Spranger, Roy Gerth van Wijk, Sangeeta Dhami, Hadar Zaman, Aziz Sheikh, Antonella Muraro
Hymenoptera venom allergy is a potentially life-threatening allergic reaction following a honeybee, vespid or ant sting. Systemic allergic sting reactions have been reported in up to 7.5% of adults and up to 3.4% of children. They can be mild and restricted to the skin or moderate-to-severe with a risk of life-threatening anaphylaxis. Patients should carry an emergency kit containing an adrenaline autoinjector, H1 -antihistamines, and corticosteroids depending on the severity of their previous sting reaction(s)...
July 27, 2017: Allergy
https://www.readbyqxmd.com/read/28497674/the-vespid-allergy-quality-of-life-questionnaire-cultural-adaptation-and-translation-to-portuguese
#3
D Silva, A M Pereira, N Santos, L Amaral, L Delgado, J N Oude Elberink, A Coimbra
A cross-cultural translation of the Vespid Allergy Quality of Life Questionnaire (VQLQ) to the Portuguese population (VQLQ-P) was performed, assessing its applicability in wasp and in non-beekeeper bee venom allergic patients. Additionally, we evaluated a Visual Analogue Scale (VAS) to estimate hymenoptera allergy interference with daily life. Methods. Cross-cultural translation was performed according to recommendations. The final VQLQ-P version, the Expectation of Outcome questionnaire (EoQ), EQ-5D and VAS were applied to wasp (n = 19) and non-beekeeper bee venom allergic patients (n = 30)...
May 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28380475/long-term-follow-up-of-children-after-venom-immunotherapy-low-adherence-to-anaphylaxis-guidelines
#4
Claudia Fiedler, Ulrich Miehe, Regina Treudler, Wieland Kiess, Freerk Prenzel
BACKGROUND: Data on the long-term outcome of children after specific venom immunotherapy (VIT) are limited. Therefore, we assessed sting recurrence and anaphylaxis relapse rates as well as adherence to anaphylaxis guidelines with regard to the availability of emergency equipment and education status. METHODS: For this long-term survey, data of 311 children with a history of anaphylactic reactions to hymenoptera stings were collected by chart review. We included patients who were treated with a 3-year VIT between 1993 and 2009 and had completed a questionnaire...
2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/27790249/cloning-structural-modelling-and-characterization-of-vest2s-a-wasp-venom-hyaluronidase-haase-from-vespa-tropica
#5
Prapenpuksiri Rungsa, Paroonkorn Incamnoi, Sophida Sukprasert, Nunthawun Uawonggul, Sompong Klaynongsruang, Jureerut Daduang, Rina Patramanon, Sittiruk Roytrakul, Sakda Daduang
BACKGROUND: Wasp venom is a complex mixture containing proteins, enzymes and small molecules, including some of the most dangerous allergens. The greater banded wasp (Vespa tropica) is well-known for its lethal venom, whose one of the major components is a hyaluronidase (HAase). It is believed that the high protein proportion and activity of this enzyme is responsible for the venom potency. METHODS: In the present study, cDNA cloning, sequencing and 3D-structure of Vespa tropica venom HAase were described...
2016: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/27496543/application-of-recombinant-antigen-5-allergens-from-seven-allergy-relevant-hymenoptera-species-in-diagnostics
#6
M Schiener, B Eberlein, C Moreno-Aguilar, G Pietsch, P Serrano, M McIntyre, L Schwarze, D Russkamp, T Biedermann, E Spillner, U Darsow, M Ollert, C B Schmidt-Weber, S Blank
BACKGROUND: Hymenoptera stings can cause severe anaphylaxis in untreated venom-allergic patients. A correct diagnosis regarding the relevant species for immunotherapy is often hampered by clinically irrelevant cross-reactivity. In vespid venom allergy, cross-reactivity between venoms of different species can be a diagnostic challenge. To address immunological IgE cross-reactivity on molecular level, seven recombinant antigens 5 of the most important Vespoidea groups were assessed by different diagnostic setups...
January 2017: Allergy
https://www.readbyqxmd.com/read/27247880/quality-of-life-in-insect-venom-allergy-validation-of-the-turkish-version-of-the-vespid-allergy-quality-of-life-questionnaire-vqlq-t
#7
Betül Ayşe Sin, Derya Öztuna, Aslı Gelincik, Feridun Gürlek, Abdullah Baysan, Aytül Zerrin Sin, Ömür Aydın, Zeynep Mısırlıgil
PURPOSE: "Vespid Allergy Quality of Life Questionnaire (VQLQ)" has been used to assess psychological burden of disease. The aim of this study was to evaluate validity, reliability and responsiveness to interventions of the Turkish version. METHODS: The Turkish language Questionnaire (VQLQ-T) was administered to 81 patients with bee allergy and 65 patients with vespid allergy from different groups to achieve cross-sectional validation. To establish longitudinal validity, the questionnaire was administered to 36 patients treated with venom immunotherapy...
2016: SpringerPlus
https://www.readbyqxmd.com/read/26641698/current-advances-in-ant-venom-proteins-causing-hypersensitivity-reactions-in-the-asia-pacific-region
#8
REVIEW
Hathairat Srisong, Sakda Daduang, Andreas L Lopata
The main insects causing allergy reactions to stinging insect in humans are Apidae (bees), Vespidae (wasps, yellow jackets and hornets) and Formicidae (ants). Their venom stings are composed of various biologically active peptides and protein components, some of which can cause toxicity or anaphylaxis in humans. The protein venom demonstrate some common allergenic activity such as for fire ants and vespids, which have two common allergens that are phospholipase A1 (enzymatic activity) and antigen 5 with unknown biological activity...
January 2016: Molecular Immunology
https://www.readbyqxmd.com/read/26520578/venom-allergy-testing-is-a-graded-approach-necessary
#9
Jaclyn A Quirt, Xia Wen, Jonathan Kim, Angel Jimenez Herrero, Harold L Kim
BACKGROUND: Many institutions recommend a stepwise approach to intradermal testing for venom allergy. This is costly and uncomfortable for the patient. The rationale for this approach is the risk of potential adverse reactions to testing with the maximal dose alone. OBJECTIVE: To evaluate the safety of a single-step approach to venom allergy testing. METHODS: The authors retrospectively reviewed the charts of 300 consecutive patients with suspected hymenoptera venom allergy based on history who underwent venom allergy testing in a single allergist's clinic where a single-step protocol had been adopted...
January 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/26378996/evaluation-of-the-quality-of-life-in-subjects-with-a-history-of-severe-anaphylactic-reaction-to-the-hymenoptera-venom
#10
Natalia Nowak, Stanisława Bazan-Socha, Grażyna Pulka, Karolina Pełka, Paulina Latra
INTRODUCTION: Sensitization to the Hymenoptera venom is one of the main causes of anaphylaxis in Poland. Venom immunotherapy is the only effective treatment in such cases. Comprehensive patient care includes also education. The aim of our study was to assess the state of knowledge and to evaluate the quality of life and the anxiety level in patients allergic to the Hymenoptera venom after anaphylactic reaction. MATERIAL AND METHODS: The survey was carried out in the period of the insects flight in 61 adult subjects (35 wasp and 26 bee allergic), using a validated Vespid Allergy Quality of Life Questionnaire (VQLQ), Hospital Anxiety and Depression Scale, and subjective assessment of anxiety level...
2015: Pneumonologia i Alergologia Polska
https://www.readbyqxmd.com/read/26259841/rapi-m-3-and-rapi-m-10-improve-detection-of-honey-bee-sensitization-in-hymenoptera-venom-allergic-patients-with-double-sensitization-to-honey-bee-and-yellow-jacket-venom
#11
M Frick, S Müller, F Bantleon, J Huss-Marp, J Lidholm, E Spillner, T Jakob
Recombinant allergens improve the diagnostic precision in Hymenoptera venom allergy (HVA), in particular in patients with double sensitization to both honey bee (HBV) and yellow jacket venom (YJV). While currently available vespid allergens allow the detection of >95% of YJV-allergic patients, the sensitization frequency to the only available HBV marker allergen rApi m 1 in HBV-allergic patients is lower. Here, we demonstrate that sIgE to additional HBV marker allergens rApi m 3 and rApi m 10 allows the detection of genuine HBV sensitization in 46-65% of Api m 1 negative sera...
December 2015: Allergy
https://www.readbyqxmd.com/read/26182683/cross-sectional-validation-of-a-quality-of-life-questionnaire-in-spanish-for-patients-allergic-to-hymenoptera-venom
#12
MULTICENTER STUDY
M Armisén, R Guspi, T Alfaya, S Cruz, S Fernández, C Domínguez-Noche, A Alonso, G Dalmau, L Marqués, A Vega
INTRODUCTION AND OBJECTIVES: The first quality of life questionnaire for Vespula-allergic patients (Vespid Allergy Quality of Life Questionnaire [VQLQ) was developed in 2002. Our objective was to perform the cross-sectional validation of the Spanish version of this questionnaire. PATIENTS AND METHODS: Using the original English-language version of the VQLQ as a starting point, the Spanish translation and cultural adaptation were performed and the first Spanish version was backtranslated into English and discussed with the authors of the original version...
2015: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/26078379/sex-related-clinical-aspects-in-insect-venom-anaphylaxis
#13
Marita Nittner-Marszalska, Jerzy Liebhart, Anna Dor-Wojnarowska
Experimental studies, epidemiological data, and clinical observations suggest that the gender factor is involved in the development and manifestation of IgE-dependent allergic diseases. We intend to answer the question if sex-related factors may play a role in Hymenoptera venom allergy (HVA). In the majority of recent studies the frequency of HVA symptoms with respect to both LL and SYS reactions is similar for men and women, while proven sensitization to insect venom is less frequent in women. Studies assessing clinical reactivity in HVA indicate that male sex and vespid venom allergy are factors increasing the risk of severe allergic reactions...
June 2015: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/25956311/when-can-immunotherapy-for-insect-sting-allergy-be-stopped
#14
REVIEW
Ulrich R Müller, Johannes Ring
BACKGROUND: Stings by Hymenoptera (honey bees, vespids, ants) can cause systemic allergic reactions (SARs). Venom immunotherapy (VIT) is highly effective and reduces an allergic patient's risk of a recurrent SAR to less than 5-20%. The risk of a recurrent SAR to a re-sting decreases the longer VIT is continued. The recommended duration of VIT is at least 3 to 5 years. RISK FACTORS: Risk factors for recurrent SARs to a sting after stopping VIT have been identified and discussed: Recommendations concerning stopping VIT: For patients without any of the identified risk factors, VIT should be continued for 5 rather than 3 years...
May 2015: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/25219104/tolerated-sting-challenge-in-patients-on-hymenoptera-venom-immunotherapy-improves-health-related-quality-of-life
#15
D S Koschel, M Schmies, C Nink Weber, G Höffken, F Balck
BACKGROUND: Sting challenge with a live insect remains the best test for proving the efficacy of immunotherapy in Hymenoptera allergy. OBJECTIVE: We studied the impact of tolerated sting challenge on quality of life. PATIENTS AND METHODS: In this prospective study, data were collected via self-report questionnaires completed by consenting patients with Hymenoptera venom allergy on venom immunotherapy before and after a sting challenge. RESULTS: The study population comprised 100 adult patients (82 with yellow jacket allergy and 18 with honeybee allergy) who participated between September 2009 and November 2010...
2014: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/25198560/prevalence-and-incidence-of-reactions-to-insect-stings-in-children-a-reappraisal
#16
O Quercia, C Incorvaia, G L Marseglia, P Puccinelli, I Dell'albani, F Emiliani, F Frati, G F Stefanini
AIM: The prevalence of systemic reactions (SR) to Hymenoptera stings in children was estimated in values lower than 1% in early studies but much higher in recent surveys. We evaluated the current prevalence and the incidence of SR and large local reactions (LLR) to Hymenoptera stings in children in Italy. METHODS: The data on children were collected from the database of the population study on the city of Cotignola, analyzing the answers to the part of the questionnaire about Hymenoptera stings, that concerned if the subject was ever stung by apids or vespids, if there has been a SR or a LLR, and if subjects with reactions received a diagnostic evaluation and a medical treatment...
August 2014: Minerva Pediatrica
https://www.readbyqxmd.com/read/24915545/new-directions-in-diagnostic-evaluation-of-insect-allergy
#17
REVIEW
David B K Golden
PURPOSE OF REVIEW: Diagnosis of insect sting allergy and prediction of risk of sting anaphylaxis are often difficult because tests for venom-specific IgE antibodies have a limited positive predictive value and do not reliably predict the severity of sting reactions. RECENT FINDINGS: Component-resolved diagnosis using recombinant venom allergens has shown promise in improving the specificity of diagnostic testing for insect sting allergy. Basophil activation tests have been explored as more sensitive assays for identification of patients with insect allergy and for prediction of clinical outcomes...
August 2014: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/24447114/predictors-of-clinical-effectiveness-of-hymenoptera-venom-immunotherapy
#18
F Ruëff, B Vos, J Oude Elberink, A Bender, R Chatelain, S Dugas-Breit, H-P Horny, H Küchenhoff, A Linhardt, S Mastnik, K Sotlar, E Stretz, R Vollrath, B Przybilla, M Flaig
BACKGROUND: Treatment failure during venom immunotherapy (VIT) may be associated with a variety of risk factors, of which the relative importance is unknown. OBJECTIVE: Our aim was to evaluate the association of baseline serum tryptase concentration (BTC), mastocytosis in the skin (MIS) and of other parameters with the frequency of objective systemic reactions during in-hospital sting challenge (SC). METHODS: In this observational retrospective study, we enrolled 1532 patients (1609 cases due to double SC) with established honeybee or vespid venom allergy who had undergone VIT and a subsequent SC...
2014: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/24308509/using-proteomic-strategies-for-sequencing-and-post-translational-modifications-assignment-of-antigen-5-a-major-allergen-from-the-venom-of-the-social-wasp-polybia-paulista
#19
José Roberto Aparecido Dos Santos-Pinto, Lucilene Delazari Dos Santos, Helen Andrade Arcuri, Fábio Morato Castro, Jorge Elias Kalil, Mario Sergio Palma
Antigen-5 is one of the major allergens identified in wasp venoms, and despite the fact that its biological function is still unknown, many studies have demonstrated its allergenicity. In this study, the biochemical and structural characterization of antigen-5 from the venom of the social wasp Polybia paulista are reported. A gel-based mass spectrometry strategy with CID fragmentation methods and classical protocols of protein chemistry, which included N- and C-terminal sequencing, were used to assign the complete sequence and determine the presence/location of the post-translational modifications (PTMs) of this protein...
February 7, 2014: Journal of Proteome Research
https://www.readbyqxmd.com/read/23750435/-influence-of-venom-immunotherapy-on-anxiety-level-of-being-re-stung
#20
Małgorzata Sacha, Ewa Czarnobilska, Marcin Stobiecki, Wojciech Dyga
UNLABELLED: Hymenoptera venom allergy is related to higher risk of potential life -threatening anaphylactic reactions, which leads to anxiety and decreased quality of life. AIM: The aim of this paper was: 1) estimation of fear level of being re-stung among venom allergy adults treated with venom specific immunotherapy (VIT)--before and during treatment; 2) estimation of expectation of outcome of VIT as compared to level of anxiety of being re-strug, in the Visual Analogue Scale--VAS score; 3) identification of factors influencing changes in the fear level among patients during VIT...
2012: Przegla̧d Lekarski
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