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A Bachir Cherif, M Temmar, S Bennouar, A Bouamra, A Taleb, A Bouraghda, M T Bouafia
OBJECTIVE: To evaluate the effect of 25 (OH) vitamin D supplementation on blood pressure (BP) variability in hypertensive women in the pre-menopausal and post-menopausal periods. MATERIALS AND METHODS: 881 hypertensive women prospectively followed for an interventional study between January 2016 and September 2017, in specialized consultation at the department of internal medicine at the Blida University Hospital (Algeria). Four hundred and thiry nine premenopausal women (group I) and 442 menopausal women (group II)...
May 8, 2018: Annales de Cardiologie et D'angéiologie
Katarzyna Tyśkiewicz, Roman Gieysztor, Izabela Maziarczyk, Paweł Hodurek, Edward Rój, Krystyna Skalicka-Woźniak
In the presented study for the first time a new, optimized, fast SFC (supercritical fluid chromatography) method was applied to separate in one run fat-soluble vitamins from waste fish oil, including cis -and tran s-retinyl palmitate, cis - and trans -retinyl acetate, retinol, α-tocopherol, β-tocopherol, γ‑tocopherol, δ-tocopherol, ergocalciferol (D₂), cholecalciferol (D₃), cis - and trans -phylloquinone (K₁) and menaquinone-4 (K₂-MK4). Vitamins were baseline separated on an Acquity UPC² (ultra performance convergence chromatography) HSS C18 SB (highly strength chemically modified silica) column within 13 min...
May 10, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Mayur Garg, Philip Hendy, John Nik Ding, Sophie Shaw, Georgina Hold, Ailsa Hart
Background and Aims: There is evidence vitamin D may be immunomodulatory and alter faecal microbiota, but results from clinical studies in humans to date have been inconclusive. This study aimed to assess the effect of vitamin D replacement in vitamin D deficient patients with and without ulcerative colitis (UC) on inflammation and faecal microbiota. Methods: Vitamin D was replaced over 8 weeks in patients with active UC (defined by faecal calprotectin ≥100 µg/g), inactive UC (faecal calprotectin <100 µg/g), and non-IBD controls with baseline 25(OH) vitamin D <50 nmol/L, and markers of inflammation and faecal microbiota analysed...
May 3, 2018: Journal of Crohn's & Colitis
Jae Wook Kim, Seung Won Park, Young Baeg Kim, Myeong Jin Ko
Objective: The loosening of pedicle screws (PS) is one of the frequent problems of spinal surgery in the patients with osteoporosis. Previous studies had revealed that intermittent injection of teriparatide could reduce PS loosening by improving bone mass and quality when their patients took parathyroid hormone for a considerable duration before surgery. However, although the teriparatide is usually used after spine surgery in most clinical situations, there was no report on the efficacy of teriparatide treatment started after spine surgery...
May 4, 2018: Journal of Korean Neurosurgical Society
J M Quesada-Gomez, R Bouillon
Modest and even severe vitamin D deficiency is widely prevalent around the world. There is consensus that a good vitamin D status is necessary for bone and general health. Similarly, a better vitamin D status is essential for optimal efficacy of antiresorptive treatments. Supplementation of food with vitamin D or using vitamin D supplements is the most widely used strategy to improve the vitamin status. Cholecalciferol (vitamin D3 ) and ergocalciferol (vitamin D2 ) are the most widely used compounds and the relative use of both products depends on historical or practical reasons...
April 30, 2018: Osteoporosis International
Murugan Sumathra, Murugan A Munusamy, Abdulla A Alarfaj, Mariappan Rajan
Composite materials hold cellulose(C) established network and biomimetic Hydroxyapatite (HAP) are potentially appropriate for bone formation and protect the external organisms. Tissue engineering scaffolds with unified porous and enhanced biological properties can be fabricated using a small quantity of porous additives. In this study we synthesizd a Cholecalciferol (VD3) loaded, cellulose functionalized hydroxyapatite nanocomposites with different concentration of Mesoporous silica nanoparticles (MSNs). VD3 plays an important role in the bone formation by regulating extracellular levels of calcium and phosphorus...
April 21, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Janelle M Guirguis-Blake, Yvonne L Michael, Leslie A Perdue, Erin L Coppola, Tracy L Beil
Importance: Falls are the most common cause of injury-related morbidity and mortality among older adults. Objective: To systematically review literature on the effectiveness and harms of fall prevention interventions in community-dwelling older adults to inform the US Preventive Services Task Force. Data Sources: MEDLINE, PubMed, Cumulative Index for Nursing and Allied Health Literature, and Cochrane Central Register of Controlled Trials for relevant English-language literature published through August 2016, with ongoing surveillance through February 7, 2018...
April 24, 2018: JAMA: the Journal of the American Medical Association
Iolanda Chinellato, Michele Piazza, Marco Sandri, Giulia Paiola, Giovanna Tezza, Attilio L Boner
OBJECTIVE: To establish the relationship between vitamin D serum levels, pulmonary function, asthma control, and passive smoking exposure in children with asthma. METHODS: We studied the relationship between 25-hydroxy cholecalciferol (25[OH]D) concentrations and baseline spirometry and levels of asthma control, and the effect of parental tobacco smoke exposure in 152 white children (84 boys [55.3%]) with a mean age ± standard deviation of 9.9 ± 2.0 years (range 5-15 years) in a cross-sectional study carried out during the winter and early spring...
May 1, 2018: Allergy and Asthma Proceedings:
Kristen M Williams, Margaret T Lee, Maureen Licursi, Gary M Brittenham, Ilene Fennoy
Patients with sickle cell disease (SCD) are at risk for bone fragility from multiple factors including vitamin D deficiency. To date, no studies have evaluated the efficacy and safety of long-term vitamin D therapy for bone disease in children with SCD. We report a cohort of 4 children with SCD found to have severe vitamin D deficiency, secondary hyperparathyroidism, and abnormal bone mineral density treated with monthly high-dose oral cholecalciferol over 2 years. All patients exhibited a positive response to therapy without hypervitaminosis D or hypercalcemia...
April 17, 2018: Journal of Pediatric Hematology/oncology
Jean-Marie Oberson, Esther Campos-Giménez, Johann Rivière, Frédéric Martin
In the present manuscript, we describe a fully optimized and validated method suitable to analyse nine compounds (retinyl acetate, retinyl palmitate, retinol, α-tocopherol, α-tocopheryl acetate, cholecalciferol, ergocalciferol, phylloquinone, menaquinone-4) representing the major contributors to the fat-soluble vitamin activity of selected food products (infant formulas, adult nutritionals, infant cereals and mixed meals). Sample preparation involves direct solvent extraction using enzyme-assisted matrix disintegration and methanolic protein precipitation...
April 10, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Shallu Kutlehria, Imran Vhora, Arvind Bagde, Nusrat Chowdhury, Gautam Behl, Ketan Patel, Mandip Singh
PURPOSE: Poor corneal permeability, nasolacrimal drainage and requirement of chronic administration are major drawbacks of existing therapies for ocular inflammation. Hence, we designed topical micelles of PEG2000 conjugated with cholecalciferol (PEGCCF). METHODS: Integrin targeted tacrolimus loaded PEGCCF micelles (TTM) were prepared by solvent diffusion evaporation method and characterized for particle size, osmolality, encapsulation efficiency and drug loading...
April 16, 2018: Pharmaceutical Research
R M Rodney, N P Martinez, P Celi, E Block, P C Thomson, G Wijffels, D R Fraser, J E P Santos, I J Lean
Bone-derived hormones play an important role in metabolism. This study examined the hypothesis that interactions between bone and energy metabolism, particularly those involving osteocalcin, are present in dairy cattle and have feedback mechanisms over time. Associations between metabolites in blood were examined in 32 Holstein cows blocked by parity and milk yield and randomly allocated to diets containing either 0.27 mg/kg dry matter (DM) calcidiol or cholecalciferol for an anticipated intake of 3 mg/d (120,000 IU/d) at 11 kg of DM, and positive (+130 mEq/kg DM) or negative (-130 mEq/kg DM) dietary cation-anion difference (DCAD) from 252 d of gestation to calving...
April 11, 2018: Journal of Dairy Science
Ewelina Witkowska-Sędek, Anna Stelmaszczyk-Emmel, Anna Majcher, Urszula Demkow, Beata Pyrżak
The relationships between bone turnover, the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis and vitamin D are complex, but still not fully explained. The GH/IGF-1 axis and vitamin D can mutually modulate each other's metabolism and influence the activation of cell proliferation, maturation, and mineralization as well as bone resorption. The aim of this study was to evaluate the reciprocal associations between bone formation markers [alkaline phosphatase (ALP), bone alkaline phosphatase (BALP)], the GH/IGF-1 axis and 25-hydroxyvitamin D [25(OH)D] in children with growth hormone deficiency at baseline and during recombinant human growth hormone (rhGH) therapy...
April 13, 2018: Acta Biochimica Polonica
Carlo Crepaldi, Alessandro Possidoni, Flavia Caputo, Roberto Dell'Aquila, Emilio Giulio Galli, Anna Maria Costanzo, Giuliana Gualberti, Umberto di Luzio Paparatti, Roberto Russo
Background: In Italy, few studies have examined the clinical management of peritoneal dialysis (PD) patients, resulting in a lack of information and awareness. Methods: A total of 378 PD patients (64.7 ± 14.3 years, 58.9% males) were enrolled across 15 centres in a 12-month retrospective and 6-month prospective study. The primary objective was to evaluate the achievement of Kidney Disease Outcomes Quality Initiative and Kidney Disease Improving Global Outcomes guidelines on recommended target values for anaemia, high blood pressure and mineral metabolism...
April 2018: Clinical Kidney Journal
Sumaiyah Mat, Mohamad Hasif Jaafar, Sargunan Sockalingam, Jasmin Raja, Shahrul Bahyah Kamaruzzaman, Ai-Vyrn Chin, Azlina Amir Abbas, Chee Ken Chan, Noran Naqiah Hairi, Sajaratulnisah Othman, Robert Cumming, Maw Pin Tan
AIM: To determine the association between vitamin D and knee pain among participants of the Malaysian Elders Longitudinal Research (MELoR) study. METHOD: This was a cross-sectional study from the MELoR study consisting of a representative group of 1011 community-dwelling older persons (57% female), mean age 86.5 (54-94) years; 313 were Malays, 367 Chinese and 330 Indians. Participants were asked if they had knee pain. Levels of serum 25-hydroxy cholecalciferol (25-[OH]D), an indicator of vitamin D status, were measured using routine laboratory techniques...
April 3, 2018: International Journal of Rheumatic Diseases
Sarah K Duffy, John V O'Doherty, Gaurav Rajauria, Louise C Clarke, Aoife Hayes, Kirsten G Dowling, Michael N O'Grady, Joseph P Kerry, Jette Jakobsen, Kevin D Cashman, Alan K Kelly
This study investigates dietary fortification of heifer feeds with cholecalciferol and ergocalciferol sources and effects on beef total vitamin D activity, vitamer, respective 25-hydroxymetabolite contents, and meat quality. Thirty heifers were allocated to one of three dietary treatments [(1) basal diet + 4000 IU of vitamin D3 (Vit D3 ); (2) basal diet + 4000 IU of vitamin D2 (Vit D2 ); and (3) basal diet + 4000 IU of vitamin D2 -enriched mushrooms (Mushroom D2 )] for a 30 day pre-slaughter period...
August 1, 2018: Food Chemistry
Ning Liu, Yalin Zhang, Han Su, Jinrong Wang, Zuwang Liu, Juan Kong
There was evidence that 1,25(OH)2 D3 regulated aquaporin (AQP) 2 and 4 expression while ameliorating renal fibrosis. This study investigated whether cholecalciferol cholesterol emulsion (CCE), a precursor of 1,25(OH)2 D3 , has similar effects. The impact of CCE on renal fibrosis and AQP2 and AQP4 expression were studied in a unilateralureteral obstruction (UUO) mouse nephropathy model. CCE reduced both the extent of fibrosis and transforming growth factor (TGF)-β signaling compared with vehicle-treated UUO model controls...
March 27, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Mohammad Hossein Dabbaghmanesh, Farideh Danafar, Ahad Eshraghian, Gholamhossein Ranjbar Omrani
BACKGROUND: Low serum vitamin D has been associated with metabolic syndrome and Non-alcoholic fatty liver disease (NAFLD). This study aimed to investigate the impact of vitamin D supplementation in treatment of patients with NAFLD. METHODS: In a double blind, randomized, placebo controlled trial patients with NAFLD were randomized to receive one weekly pearl of placebo, 50,000 U vitamin D3 (cholecalciferol) pearl per week and 0.25 mg calcitriol (1,25 dihydroxycholecalciferol) pearl per day for 3 months...
March 16, 2018: Diabetes & Metabolic Syndrome
Edith Angellotti, David D'Alessio, Bess Dawson-Hughes, Jason Nelson, Robert M Cohen, Amalia Gastaldelli, Anastassios G Pittas
Context: Observational data support a role for vitamin D in type 2 diabetes, but evidence from trials is inconclusive. Objective: To evaluate the effect of vitamin D supplementation on β -cell function and hemoglobin A1c (HbA1c) in patients with well-controlled type 2 diabetes. Design: Double-blind, randomized, placebo-controlled clinical trial. Setting: Tufts Medical Center, Boston, MA; VA Medical Center, Cincinnati, OH...
April 1, 2018: Journal of the Endocrine Society
Palraj Kalimuthu, Agnieszka Wojtkiewicz, Maciej Szaleniec, Paul V Bernhardt
We report electrochemically driven catalysis of the complex molybdoenzyme steroid C25 dehydrogenase (S25DH) from the β-Proteobacterium Sterolibacterium denitrificans. S25DH catalyzes the oxygen-independent regioselective hydroxylation of the tertiary C25 atom of sterols and also their derivatives. Cholest-4-en-3-one is a native substrate for S25DH, which produces 25-hydroxy-cholest-4-en-3-one as a product of catalytic turnover. Cholecalciferol (vitD3) is also a substrate. S25DH was immobilized on a modified Au working electrode with the co-adsorbent chitosan...
March 24, 2018: Chemistry: a European Journal
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