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Cholecalciferol

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https://www.readbyqxmd.com/read/28429905/maintenance-vitamin-d3-dosage-requirements-in-chinese-women-with-post-menopausal-osteoporosis-living-in-the-tropics
#1
Yogeswari Venugopal, Sharifah F Wan Muhamad Hatta, Nurbazlin Musa, Siti Abdul Rahman, Jeyakantha Ratnasingam, Sharmila Sunita Paramasivam, Lee Ling Lim, Luqman Ibrahim, Karen Choong, Alexander Tb Tan, Karuthan Chinna, Siew Pheng Chan, Shireene R Vethakkan
BACKGROUND AND OBJECTIVES: Vitamin D3 (cholecalciferol) dose required to maintain sufficiency in non- Caucasian women with postmenopausal osteoporosis (PMO) inthe tropics has not been well studied. Some guidelines mandate 800-1000 IU vitamin D/day but the Endocrine Society (US) advocates 1500-2000 IU/day to maintain 25-hydroxyvitamin-D (25(OH)D) concentration at >75 nmol/L. We aimed to establish oral cholecalciferol dose required to maintain 25(OH)D concentration at >75 nmol/L in PMO Chinese Malaysian women, postulating lower dose requirements amongst light-skinned subjects in the tropics...
May 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28425575/high-dose-supplementation-of-vitamin-d-affects-measures-of-systemic-inflammation-reductions-in-high-sensitivity-c-reactive-protein-level-and-neutrophil-to-lymphocyte-ratio-nlr-distribution
#2
Seyed-Amir Tabatabaeizadeh, Amir Avan, Afsane Bahrami, Ezzat Khodashenas, Habibollah Esmaeili, Gordon A Ferns, Mojtaba Fattahi Abdizadeh, Majid Ghayour-Mobarhan
BACKGROUND: The prevalence of Vitamin D deficiency is increasing worldwide, which has be shown to be associated with increased risk of cardiovascular disease (CVD), autoimmune disease and metabolic syndrome. These conditions are also associated with a heightened state of inflammation. The aim of the current study was to evaluate the effect of vitamin D supplementation on serum C - reactive protein (CRP) level and Neutrophil-to-lymphocyte ratio (NLR) distribution in a large cohort of adolescent girls...
April 20, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28421358/vitamin-d-supplementation-for-the-management-of-knee-osteoarthritis-a-systematic-review-of-randomized-controlled-trials
#3
Salman Hussain, Ambrish Singh, Mohd Akhtar, Abul Kalam Najmi
Conflicting evidence exists concerning the supplementation of vitamin D in knee osteoarthritis condition. This systematic literature review was done to explore the effects of vitamin D supplementation in the management of knee osteoarthritis. Electronic literature search was done in databases like PubMed(®), Embase(®), and Cochrane CENTRAL from inception to 6th July 2016. The quality of included Randomized Controlled Trials (RCTs) was assessed using Cochrane risk of bias tool. We considered change in Western Ontario and McMaster Universities (WOMAC) index, Visual Analog Scale (VAS) and Functional Pain Score (FPS) as the primary outcome measure...
April 18, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28409320/vitamin-d-sub-inflammation-and-insulin-resistance-a-window-on-a-potential-role-for-the-interaction-between-bone-and-glucose-metabolism
#4
REVIEW
Stefania Giuliana Garbossa, Franco Folli
Vitamin D is a key hormone involved in the regulation of calcium/phosphorous balance and recently it has been implicated in the pathogenesis of sub-inflammation, insulin resistance and obesity. The two main forms of vitamin D are cholecalciferol (Vitamin D3) and ergocalciferol (Vitamin D2): the active form (1,25-dihydroxyvitamin D) is the result of two hydroxylations that take place in liver, kidney, pancreas and immune cells. Vitamin D increases the production of some anti-inflammatory cytokines and reduces the release of some pro-inflammatory cytokines...
April 13, 2017: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/28393662/cholecalciferol-20-000-iu-once-weekly-in-hiv-positive-patients-with-low-vitamin-d-levels-result-from-a-cohort-study
#5
Sebastian Noe, Silke Heldwein, Rita Pascucchi, Celia Oldenbüttel, C Wiese, Ariane von Krosigk, Eva Jägel-Guedes, Hans Jäger, Wolfgang Mayer, Christoph D Spinner, Eva Wolf
PURPOSE: To evaluate efficacy and safety of 20 000 IU cholecalciferol weekly in HIV-infected patients. METHODS: Longitudinal data for 243 HIV-infected patients with paired 25-OH-vitamin D3 values for the same month in 2 consecutive years were stratified by the initiation of supplementation in this retrospective study. RESULTS: After 1 year of administration of cholecalciferol 20 000 IU weekly, about 78% of patients with initial vitamin D level <20 µg/L achieved vitamin D levels >20 µg/L and 42% achieved levels >30 µg/L...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28390394/hypovitaminosis-d-is-associated-with-negative-outcome-in-dogs-with-protein-losing-enteropathy-a-retrospective-study-of-43-cases
#6
K Allenspach, J Rizzo, A E Jergens, Y M Chang
BACKGROUND: Hypovitaminosis D has previously been shown to be prevalent amongst dogs with protein losing enteropathy (PLE). The hypothesis of this study was that Low 25-hydroxyvitamin D (25(OH) D) serum concentrations could be a risk factor for negative outcome in dogs with PLE. Forty-three dogs diagnosed with PLE (2005-2014) and which serum Vitamin D serum concentrations were collected and archived at -80 Degrees C were analyzed. Post-diagnostic communication with referring veterinarians was made to determine outcome of PLE dogss: Dogs which died due to PLE within 4 months after diagnosis (negative outcome group, n = 22) and dogs alive or which died due to another disease at the end point of the study (1 year after diagnosis, good outcome group, n = 21)...
April 8, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28390010/vitamin-d-supplementation-in-the-prevention-and-management-of-major-chronic-diseases-not-related-to-mineral-homeostasis-in-adults-research-for-evidence-and-a-scientific-statement-from-the-european-society-for-clinical-and-economic-aspects-of-osteoporosis-and
#7
Luisella Cianferotti, Francesco Bertoldo, Heike A Bischoff-Ferrari, Olivier Bruyere, Cyrus Cooper, Maurizio Cutolo, John A Kanis, Jean-Marc Kaufman, Jean-Yves Reginster, Rene Rizzoli, Maria Luisa Brandi
INTRODUCTION: Optimal vitamin D status promotes skeletal health and is recommended with specific treatment in individuals at high risk for fragility fractures. A growing body of literature has provided indirect and some direct evidence for possible extraskeletal vitamin D-related effects. PURPOSE AND METHODS: Members of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis have reviewed the main evidence for possible proven benefits of vitamin D supplementation in adults at risk of or with overt chronic extra-skeletal diseases, providing recommendations and guidelines for future studies in this field...
April 7, 2017: Endocrine
https://www.readbyqxmd.com/read/28384856/role-of-vitamin-d-in-the-outcome-of-ischemic-stroke-a-randomized-controlled-trial
#8
Shuba Narasimhan, Prakash Balasubramanian
INTRODUCTION: Vitamin D deficiency has reached epidemic proportions in India with prevalence rates of 70-100% in the general population. Low vitamin D levels are associated with worse outcomes in ischemic strokes. The outcome of stroke after vitamin D replenishment has not been much studied. AIM: To compare the stroke outcome between patients receiving vitamin D supplementation and patients without vitamin D supplementation by Scandinavian Stroke Scale (SSS) and thus, to assess the long term outcome of ischemic stroke patients with low vitamin D level by supplementation of vitamin D...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28381562/a-pilot-interventional-study-to-evaluate-the-impact-of-cholecalciferol-treatment-on-hba1c-in-type-1-diabetes
#9
Reena Perchard, Lucia Magee, Fiona Ivison, Andrew J Whatmore, Philip Murray, Adam Stevens, Sarah Ehtisham, Judith Campbell, Marie Marshall, Susan Ainsworth, Mark Bone, Ian Doughty, M Zulf Mughal, Peter E Clayton
BACKGROUND: Higher 25(OH)D3 levels are associated with lower Hba1c, but there are limited interventional trials assessing the effect of cholecalciferol on Hba1c. AIMS: (1) To assess baseline 25(OH)D3 status in a Manchester paediatric cohort of patients with T1D. (2) To determine the effect of cholecalciferol administration on Hba1c. METHODS: Children with T1D attending routine clinic appointments over three months in late winter/early spring had blood samples taken with consent, and patients with a 25(OH)D3 level <20ng/ml were treated with a one-off cholecalciferol dose of 100 000 (2-10 years) or 160 000 (>10 years) units...
April 5, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28380322/vitamin-d-in-amyotrophic-lateral-sclerosis
#10
L Libonati, E Onesti, M C Gori, Mauro Ceccanti, C Cambieri, A Fabbri, V Frasca, M Inghilleri
Vitamin D supplementation has been proposed as a potential treatment to delay amyotrophic lateral sclerosis (ALS) progression. The aims of this study were to compare retrospectively vitamin D blood levels in ALS patients with those in healthy subjects; to correlate vitamin D blood levels with clinical functions in patients; and to evaluate whether administration of vitamin D could modify the clinical progression of the disease. Vitamin D blood levels were evaluated in 57ALS patients and in 57 healthy subjects...
January 2017: Functional Neurology
https://www.readbyqxmd.com/read/28367262/an-open-label-evaluator-blinded-study-of-the-efficacy-and-safety-of-a-new-nutritional-supplement-in-androgenetic-alopecia-a-pilot-study
#11
Anna J Nichols, Olivia Bosshardt Hughes, Agnese Canazza, Martin N Zaiac
Objective: To evaluate the effectiveness of a novel oral supplement, Forti5(®), containing green tea extract, omega 3 and 6 fatty acids, cholecalciferol, melatonin, beta-sitosterol, and soy isoflavones, and in the management of subjects with androgenetic alopecia. Design: A prospective case series of 10 subjects. Setting: Open-label, evaluator-blinded, proof-of-concept study. Participants: Ten adult subjects with androgenetic alopecia completed the study. Subjects were not allowed to use oral or topical hair growth products in the 24 weeks preceding the study or during the study...
February 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28365177/high-dose-vitamin-d-after-lung-transplantation-a-randomized-trial
#12
Robin Vos, David Ruttens, Stijn E Verleden, Elly Vandermeulen, Hannelore Bellon, Anke Van Herck, Annelore Sacreas, Tobias Heigl, Veronique Schaevers, Dirk E Van Raemdonck, Eric K Verbeken, Arne P Neyrinck, Lieven J Dupont, Jonas Yserbyt, Bart M Vanaudenaerde, Geert M Verleden
BACKGROUND: Vitamin D may have innate immunomodulatory functions with potentially beneficial therapeutic effects in lung transplant recipients. METHODS: This was a single-center, double blind, randomized, placebo-controlled, prevention trial of once-monthly oral vitamin D (cholecalciferol; 100,000 IU, n = 44) vs placebo (n = 43) during 2 years in adult lung transplant recipients enrolled from October 2010 to August 2013. Primary outcome was prevalence of chronic lung allograft dysfunction (CLAD) 3 years after transplantation...
March 8, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28359820/development-of-medicated-foams-that-combine-incompatible-hydrophilic-and-lipophilic-drugs-for-psoriasis-treatment
#13
Janja Mirtič, Foteini Papathanasiou, Žane Temova Rakuša, Mirjam GosencaMatjaž, Robert Roškar, Julijana Kristl
The focus was on the development of medicated foam for incorporation of two incompatible active agents for psoriasis treatment; i.e., lipophilic cholecalciferol, and hydrophilic salicylic acid. Emphasis was given to formulation of a propellant-free foam, with sufficient foaming properties, physical and chemical stability, and low irritancy potential to maintain relevance for later translation into clinical practice. Various excipients and concentrations were examined to achieve suitable foam stability parameters, viscoelasticity, and bubble-size, which relate to foamability and spreadability...
March 27, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28358909/amelioration-of-cognitive-impairments-in-appswe-ps1de9-mice-is-associated-with-metabolites-alteration-induced-by-total-salvianolic-acid
#14
Li Shen, Bing Han, Yuan Geng, Jinhua Wang, Zhengmin Wang, Mingwei Wang
PURPOSE: Total salvianolic acid (TSA) is extracted from salvia miltiorrhiza; however, to date, there has been limited characterization of its effects on metabolites in Alzheimer's disease model-APPswe/PS1dE9 mice. The main objective of this study was to investigate the metabolic changes in 7-month-old APPswe/PS1dE9 mice treated with TSA, which protects against learning and memory impairment. METHODS: APPswe/PS1dE9 mice were treated with TSA (30 mg/kg·d and 60 mg/kg·d, i...
2017: PloS One
https://www.readbyqxmd.com/read/28346569/vitamin-d-supplementation-in-nursing-home-residents-randomized-single-cholecalciferol-loading-protocol-vs-individualized-loading-dose-regimen
#15
C Delomas, M Hertzog, T Vogel, P O Lang
OBJECTIVE: To assess the efficacy and safety of a single cholecalciferol loading protocol in nursing home (NH) residents taking no VitD supplementation at regular basis. DESIGN: Randomized single-blind controlled study. SETTING: One NH. PARTICIPANTS: All residents. INTERVENTION: From March 21st to May 19th, 2015, NH residents were randomly assigned to either 4x100'000IU to be taken every 2 weeks (treatment group) or an individualized regimen according to baseline 25(OH)VitD level (control group)...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28346348/vitamin-d-in-chronic-kidney-disease-and-dialysis-patients
#16
REVIEW
Guillaume Jean, Jean Claude Souberbielle, Charles Chazot
Vitamin D deficiency (<20 ng/mL) and insufficiency (20-29 ng/mL) are common among patients with chronic kidney disease (CKD) or undergoing dialysis. In addition to nutritional and sunlight exposure deficits, factors that affect vitamin D deficiency include race, sex, age, obesity and impaired vitamin D synthesis and metabolism. Serum 1,25(OH)₂D levels also decrease progressively because of 25(OH)D deficiency, together with impaired availability of 25(OH)D by renal proximal tubular cells, high fibroblast growth factor (FGF)-23 and decreased functional renal tissue...
March 25, 2017: Nutrients
https://www.readbyqxmd.com/read/28345527/prevalence-and-factors-promoting-the-occurrence-of-vitamin-d-deficiency-in-the-elderly
#17
Magdalena Wyskida, Katarzyna Wieczorowska-Tobis, Jerzy Chudek
Vitamin D deficiency affects a large part of the population of elderly people, especially women, who live in moderate climate countries due to a reduced amount of vitamin D in the diet (small sea fish consumption) and reduced content of 7-dehydrocholesterol, which causes decreased skin synthesis. The lowest seasonal concentration of 25(OH)D3 is usually observed during winter and spring. Sun exposure influences 25(OH)D3 concentration more strongly in men than in women. Sociodemographic factors that increase the risk of vitamin D deficiency in the elderly include poor environmental conditions, low economic status, lower educational level, drug exposure (smoking), reduced physical activity, overall poor health and obesity, which causes reduced skin exposure to sunlight...
March 13, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28341259/effect-of-vitamin-d-supplementation-and-isokinetic-training-on-muscle-strength-explosive-strength-lean-body-mass-and-gait-in-severely-burned-children-a-randomized-controlled-trial
#18
Anwar Abdelgayed Ebid, Shamekh Mohamed El-Shamy, Maysa Abbas Amer
OBJECTIVE: To determine the effects of vitamin D (VD) supplementation and isokinetic training on muscle strength, explosive strength (counter movement jump) (ES), lean body mass (LBM) and gait parameters in severe pediatric burn. METHODS: Forty-eight burned children with circumferential lower extremity burns covering 40-55% of the total body surface area (TBSA), aged 10-16 years (Mean±SD 13.01±1.75), were randomized into the standard of care (n=16), isokinetic (n=17) and VD (n=15) groups...
March 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28339866/relative-biological-value-of-1%C3%AE-hydroxycholecalciferol-to-25-hydroxycholecalciferol-in-broiler-chicken-diets
#19
J C Han, G H Chen, J L Zhang, J G Wang, H X Qu, Y F Yan, X J Yang, Y H Cheng
This study was conducted to evaluate the relative biological value (RBV) of 1α-hydroxycholecalciferol (1α-OH-D3) to 25-hydroxycholecalciferol (25-OH-D3) in one- to 21-day-old broiler chickens fed calcium (Ca)- and phosphorus (P)-deficient diets. On the d of hatch, 450 male Ross 308 broiler chickens were weighed and randomly allotted to 9 treatments with 5 replicates of 10 birds per replicate. The basal diet contained 0.50% Ca and 0.25% non-phytate phosphorus (NPP) but was not supplemented with cholecalciferol (vitamin D3)...
March 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/28335514/the-association-between-vitamin-d-deficiency-and-diabetic-retinopathy-in-type-2-diabetes-a-meta-analysis-of-observational-studies
#20
Bang-An Luo, Fan Gao, Lu-Lu Qin
Emerging evidence from in vivo and in vitro studies have shown that vitamin D may play an important role in the development of diabetic retinopathy (DR), but individually published studies showed inconclusive results. The aim of this study was to quantitatively summarize the association between vitamin D and the risk of diabetic retinopathy. We conducted a systematic literature search of Pubmed, Medline, and EMBASE updated in September 2016 with the following keywords: "vitamin D" or "cholecalciferol" or "25-hydroxyvitamin D" or "25(OH)D" in combination with "diabetic retinopathy" or "DR"...
March 20, 2017: Nutrients
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