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Cholecalciferol

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https://www.readbyqxmd.com/read/28335514/the-association-between-vitamin-d-deficiency-and-diabetic-retinopathy-in-type-2-diabetes-a-meta-analysis-of-observational-studies
#1
Bang-An Luo, Fan Gao, Lu-Lu Qin
Emerging evidence from in vivo and in vitro studies have shown that vitamin D may play an important role in the development of diabetic retinopathy (DR), but individually published studies showed inconclusive results. The aim of this study was to quantitatively summarize the association between vitamin D and the risk of diabetic retinopathy. We conducted a systematic literature search of Pubmed, Medline, and EMBASE updated in September 2016 with the following keywords: "vitamin D" or "cholecalciferol" or "25-hydroxyvitamin D" or "25(OH)D" in combination with "diabetic retinopathy" or "DR"...
March 20, 2017: Nutrients
https://www.readbyqxmd.com/read/28327260/vitamin-d-and-dental-caries-in-primary-dentition
#2
Ana Lucia Seminario, Elizabet Velan
Traditionally classified as a vitamin, vitamin D represents a group of fat-soluble secosteroids with D2 (ergocalciferol) and D3 (cholecalciferol) being the most relevant of the group. The importance of this prohormone exceeds its known ability to maintain intra- and extracellular calcium and phosphate concentrations, thereby preserving essential metabolic functions such as the promotion of mineralization and maintenance and remodeling of the bone. Current observational research recognizes the potential antiproliferative, prodifferentiative, and immunomodulatory effects of vitamin D and its metabolites in the human body...
September 15, 2016: Journal of Dentistry for Children
https://www.readbyqxmd.com/read/28293271/a-mouse-model-of-vitamin-d-insufficiency-is-there-a-relationship-between-25-oh-vitamin-d-levels-and-obesity
#3
Kenneth L Seldeen, Manhui Pang, Maria Rodríguez-Gonzalez, Mireya Hernandez, Zachary Sheridan, Ping Yu, Bruce R Troen
BACKGROUND: Vitamin D insufficiency (serum 25-OH vitamin D > 10 ng/ml and < 30 ng/ml) is prevalent in the obese (body mass index (BMI) > 30 kg/m(2)), yet relationships between the two are poorly understood. Objectives of this study include identification of the impact of obesity on reducing serum 25-OH vitamin D concentration, particularly in response to altered vitamin D3 supplementation, and to elucidate the longitudinal impact of serum 25-OH vitamin D on body mass index...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28267045/supplementation-with-2000-iu-of-cholecalciferol-is-associated-with-improvement-of-trabecular-bone-mineral-density-and-muscle-power-in-pediatric-patients-with-ibd
#4
Ondrej Hradsky, Ondrej Soucek, Klara Maratova, Jana Matyskova, Ivana Copova, Kristyna Zarubova, Jiri Bronsky, Zdenek Sumnik
BACKGROUND: Inflammatory bowel diseases (IBD) are associated with altered bone health and increased risk for fractures. Vitamin D deficiency is frequently found in IBD; however, the effect of vitamin D supplementation on bone health of children with IBD is poorly understood. We aimed to observe the changes in volumetric bone density and dynamic muscle functions after vitamin D substitution in a cohort of pediatric patients with IBD. METHODS: This was a prospective observational study of 55 patients (aged 5-19 years) with IBD...
April 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28247363/atypical-fracture-of-the-sternum-after-long-term-alendronate-plus-cholecalciferol-treatment-a-case-report
#5
Luis H Martín Arias, Pilar García Ortega, María Sáinz Gil, Ester Navarro García, Carlos Treceño Lobato, Virginia Delgado Armas
A 55-year-old woman developed an atraumatic sternum fracture during treatment with alendronate for osteoporosis. The woman received alendronate 70 mg in combination with cholecalciferol 5600 IU once weekly, as well as nonsteroidal anti-inflammatory drugs. After 4 years of treatment, following a dorsal flexion with no direct thoracic trauma, the patient suffered a fracture of the sternum, with an X-ray revealing sternal body fracture. This fracture was seen to be transverse, noncomminuted and without displacement...
December 2017: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/28237727/tolerance-to-1-25-dihydroxyvitamin-d3-glycosides-from-solanum-glaucophyllum-by-the-growing-pig
#6
P Schlegel, D Guggisberg, A Gutzwiller
Solanum glaucophyllum leaves contain high levels of glycosidically bound 1,25 dihydroxyvitamin D3, the most important vitamin D metabolite. The tolerance to this source was evaluated during six weeks with fifty weaned pigs fed increasing levels (0, 2.5, 5, 10 and 20μg 1,25(OH)2D3/kg diet). The diet contained, per kg, 9.7g Ca, 3.5g digestible P and 2000IU cholecalciferol. Ten additional pigs were fed a diet containing 1000IU cholecalciferol/kg, without 1,25(OH)2D3. Weekly plasma and final kidney, bone and urinary mineral contents, bone density and breaking strength served as indicators for possible adverse effects of the supplement...
February 16, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28231782/differential-effects-of-vitamin-d2-and-d3-supplements-on-25-hydroxyvitamin-d-level-are-dose-sex-and-time-dependent-a-randomized-controlled-trial
#7
RANDOMIZED CONTROLLED TRIAL
Muhammad M Hammami, Ahmed Yusuf
BACKGROUND: Vitamin D (D) supplements are indispensable for its world-wide deficiency. Controversy continues on ergocalciferol (D2) and cholecalciferol (D3) relative potency as well as on dosing-schedule and sex role in raising 25-hydroxy D (25(OH)D) level, the best indicator of D status. METHODS: We randomized 279 adults to daily D2, D3, D2/D3, or placebo; 2-weekly D2 or D3; or 4-weekly D2 or D3 (250,000 IU over/140 days). Randomization sequence, stratified by body-mass-index (BMI) and sex, was concealed from study coordinators and participants who were then blinded to capsules' content...
February 24, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28228790/successful-neridronate-therapy-in-pregnancy-associated-osteoporosis
#8
Agostino Gaudio, Carmelo Erio Fiore
Pregnancy-associated osteoporosis is a rare condition. The pathogenesis is probably multifactorial but has not yet been completely clarified. In this case report, a 38-year-old woman was referred to hospital after suffering an acute, non-traumatic back pain one month after delivering her first child. The radiological examination revealed four vertebral fractures. Bone mineral density was reduced, particularly at spine level. Biochemical tests were within normal range, except for increased urinary deoxypyridinoline and a slight reduction of the serum 25-OH vitamin D level...
September 2016: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/28222027/vitamin-d-modulates-the-expression-of-hla-dr-and-cd38-after-in-vitro-activation-of-t-cells
#9
Simon Villegas-Ospina, Wbeimar Aguilar-Jimenez, Sandra M Gonzalez, María T Rugeles
OBJECTIVE: Vitamin D (VitD) is an anti-inflammatory hormone; however, some evidence shows that VitD may induce the expression of activation markers, such as CD38 and HLA-DR. We explored its effect on the expression of these markers on CD4+ and CD8+ T-cells in vitro, and their potential correlations in vivo. MATERIALS AND METHODS: CD38 and HLA-DR expression was measured by flow cytometry in PHA/IL-2-activated mononuclear cells cultured under VitD precursors: three cholecalciferol (10-11M, 10-9M, 10-7M; n=11) and two calcidiol (40 ng/mL, 80 ng/mL; n=9) concentrations...
March 1, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28219093/-impact-of-vitamin-d-in-sports-does-vitamin-d-insufficiency-compromise-athletic-performance
#10
Sebastian Butscheidt, Tim Rolvien, Peter Ueblacker, Michael Amling, Florian Barvencik
Introduction Vitamin D is essential for calcium homeostasis and regulates the expression of over 900 genes. It thereby influences musculoskeletal health and function. Additionally, multiple other effects were observed through the detection of vitamin D receptors (VDR) in numerous tissues of the human body. Material and Methods We reviewed the literature regarding evidence of the impact of vitamin D on musculoskeletal health and peak athletic performance. Results and Discussion It is well known that there is a high prevalence of vitamin D deficiency in the average European population...
February 20, 2017: Sportverletzung Sportschaden: Organ der Gesellschaft Für Orthopädisch-Traumatologische Sportmedizin
https://www.readbyqxmd.com/read/28217512/effect-of-oral-versus-intramuscular-vitamin-d-replacement-in-apparently-healthy-adults-with-vitamin-d-deficiency
#11
Nitin Gupta, Khalid J Farooqui, Chandar M Batra, Raman K Marwaha, Ambrish Mithal
CONTEXT: A number of controversies exist regarding appropriate treatment strategy for Vitamin D deficiency. AIMS: The aim of this study was to investigate the efficacy of equivalent doses of oral cholecalciferol (60,000 IU weekly for 5 weeks) versus intramuscular (IM) cholecalciferol (300,000 IU) in correcting Vitamin D deficiency in apparently healthy volunteers working in a hospital. SETTINGS AND DESIGN: Prospective randomized open-label single institution study...
January 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28187226/effects-of-cholecalciferol-vs-calcifediol-on-total-and-free-25-hydroxyvitamin-d-and-parathyroid-hormone
#12
Albert Shieh, Christina Ma, Rene F Chun, Sten Witzel, Brandon Rafison, Hannah Tm Contreras, Jonas Wittwer-Schegg, Leon Swinkels, Tonnie Huijs, Martin Hewison, John S Adams
No abstract text is available yet for this article.
February 10, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28183335/efficacy-of-vitamin-d3-supplementation-in-reducing-incidence-of-pulmonary-tuberculosis-and-mortality-among-hiv-infected-tanzanian-adults-initiating-antiretroviral-therapy-study-protocol-for-a-randomized-controlled-trial
#13
Christopher R Sudfeld, Ferdinand Mugusi, Said Aboud, Tumaini J Nagu, Molin Wang, Wafaie W Fawzi
BACKGROUND: HIV-infected adults initiating antiretroviral therapy (ART) in sub-Saharan Africa continue to experience high rates of morbidity and mortality during the initial months of treatment. Observational studies in high-income and resource-limited settings indicate that HIV-infected adults with low vitamin D levels may be at increased risk of mortality, HIV disease progression, and incidence of pulmonary tuberculosis (TB). As a result, vitamin D3 supplementation may improve survival and treatment outcomes for HIV-infected adults initiating ART...
February 10, 2017: Trials
https://www.readbyqxmd.com/read/28167237/does-high-dose-vitamin-d-supplementation-enhance-cognition-a-randomized-trial-in-healthy-adults
#14
Jacqueline A Pettersen
BACKGROUND: Insufficiency of 25-hydroxyvitamin D [25(OH)D] has been associated with dementia and cognitive decline. However, the effects of vitamin D supplementation on cognition are unclear. It was hypothesized that high dose vitamin D3 supplementation would result in enhanced cognitive functioning, particularly among adults whose 25(OH)D levels were insufficient (<75nmol/L) at baseline. METHODS: Healthy adults (n=82) from northern British Columbia, Canada (54° north latitude) with baseline 25(OH)D levels ≤100nmol/L were randomized and blinded to High Dose (4000IU/d) versus Low Dose (400IU/d) vitamin D3 (cholecalciferol) for 18weeks...
April 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28164126/the-involvement-of-mir-29b-3p-in-arterial-calcification-by-targeting-matrix-metalloproteinase-2
#15
Wenhong Jiang, Zhanman Zhang, Han Yang, Qiuning Lin, Chuangye Han, Xiao Qin
Vascular calcification is a risk predictor and common pathological change in cardiovascular diseases that are associated with elastin degradation and phenotypic transformation of vascular smooth muscle cells via gelatinase matrix metalloproteinase-2 (MMP2). However, the mechanisms involved in this process remain unclear. In this study, we investigated the relationships between miR-29b-3p and MMP2, to confirm miR-29b-3p-mediated MMP2 expression at the posttranscriptional level in arterial calcification. In male Sprague Dawley rats, arterial calcification was induced by subcutaneous injection of a toxic dose of cholecalciferol...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28161530/effects-of-cholecalciferol-supplementation-on-serum-and-urinary-vitamin-d-metabolites-and-binding-protein-in-hiv-infected-youth
#16
Allison Ross Eckard, Myrtle Thierry-Palmer, Natalia Silvestrov, Julia C Rosebush, Mary Ann O'Riordan, Julie E Daniels, Monika Uribe-Leitz, Danielle Labbato, Joshua H Ruff, Ravinder J Singh, Vin Tangpricha, Grace A McComsey
Vitamin D insufficiency is widespread in HIV-infected patients. HIV and/or antiretroviral therapy (ART), particularly efavirenz (EFV), may interfere with vitamin D metabolism. However, few data from randomized, controlled trials exist. Here, we investigate changes in vitamin D metabolites and binding protein (VDBP) after 6 months of supplementation in a randomized, active-control, double-blind trial investigating 2 different monthly cholecalciferol (vitamin D3) doses [60,000 (medium) or 120,000 (high) IU/month] vs...
February 1, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28161119/monthly-oral-ibandronate-reduces-bone-loss-in-korean-women-with-rheumatoid-arthritis-and-osteopenia-receiving-long-term-glucocorticoids-a-48-week-double-blinded-randomized-placebo-controlled-investigator-initiated-trial
#17
Kichul Shin, Sung-Hwan Park, Won Park, Han Joo Baek, Yun Jong Lee, Seong Wook Kang, Jung-Yoon Choe, Wan-Hee Yoo, Yong-Beom Park, Jung-Soo Song, Seung-Geun Lee, Bin Yoo, Dae-Hyun Yoo, Yeong Wook Song
PURPOSE: Our aim was to investigate the efficacy of monthly oral ibandronate in Korean women with rheumatoid arthritis and reduced bone mineral density (BMD) receiving long-term glucocorticoids. METHODS: Patients (n = 167 women) were randomly assigned (1:1) to receive ibandronate 150 mg or placebo every 4 weeks. Patients had taken glucocorticoid (equivalent of daily prednisolone ≥5 mg) for 3 or more consecutive months before enrollment, and had a lumbar spine 1 to 4 (L1-L4) T-score of < -1...
February 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28130182/induction-of-cftr-gene-expression-by-1-25-oh-2-vitamin-d3-25oh-vitamin-d3-and-vitamin-d3-in-cultured-human-airway-epithelial-cells-and-in-mouse-airways
#18
Kristina M DiFranco, Jennifer K Mulligan, Aman S Sumal, Gill Diamond
Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which often leads to protein misfolding and no CFTR surface localization. This then leads to chronic airway infections, inflammation, and tissue damage. Although vitamin D has been explored as a therapy to treat CF due to its antimicrobial-inducing and anti-inflammatory properties, the effect of 1,25-dihydroxyvitamin D3 (1α,25(OH)2D3) on CFTR directly has not been studied...
January 24, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28114352/pharmacokinetic-evaluation-of-a-single-intramuscular-high-dose-versus-an-oral-long-term-supplementation-of-cholecalciferol
#19
Katharina Wylon, Gennadiy Drozdenko, Alexander Krannich, Guido Heine, Sabine Dölle, Margitta Worm
BACKGROUND AND OBJECTIVES: Vitamin D deficiency is frequent during the winter and occurs throughout the year in the elderly or patients suffering from autoimmune diseases. The objective of this study was to evaluate the pharmacokinetic properties of oral supplementation versus a single intramuscular injection of cholecalciferol in healthy individuals. RESEARCH DESIGN AND METHODS: Up to 8,000 I.U. oral cholecalciferol was administered daily for 84 days in a 4 week dose-escalation setting to vitamin D deficient individuals...
2017: PloS One
https://www.readbyqxmd.com/read/28105733/vitamin-d-supplementation-for-sickle-cell-disease
#20
REVIEW
Htoo Htoo Kyaw Soe, Adinegara Bl Abas, Nan Nitra Than, Han Ni, Jaspal Singh, Abdul Razzak Bin Mohd Said, Ifeyinwa Osunkwo
BACKGROUND: Sickle cell disease is a genetic chronic haemolytic and pro-inflammatory disorder. The clinical manifestations of sickle cell disease result from the presence of mutations on the beta globin genes that generate an abnormal haemoglobin product (called haemoglobin S) within the red blood cell. Sickle cell disease can lead to many complications such as acute chest syndrome, stroke, acute and chronic bone complications (including painful vaso-occlusive crisis, osteomyelitis, osteonecrosis and osteoporosis)...
January 20, 2017: Cochrane Database of Systematic Reviews
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