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Cholecalciferol

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https://www.readbyqxmd.com/read/28726185/raising-awareness-on-the-therapeutic-role-of-cholecalciferol-in-ckd-a-multidisciplinary-based-opinion
#1
REVIEW
Sandro Giannini, Sandro Mazzaferro, Salvatore Minisola, Luca De Nicola, Maurizio Rossini, Mario Cozzolino
Vitamin D is recognized to play an essential role in health and disease. In kidney disease, vitamin D analogs have gained recognition for their involvement and potential therapeutic importance. Nephrologists are aware of the use of oral native vitamin D supplementation, however, uncertainty still exists with regard to the use of this treatment option in chronic kidney disease as well as clinical settings related to chronic kidney disease, where vitamin D supplementation may be an appropriate therapeutic choice...
July 19, 2017: Endocrine
https://www.readbyqxmd.com/read/28704190/modulating-effects-of-cholecalciferol-treatment-on-estrogen-deficiency-induced-anxiety-like-behavior-of-adult-female-rats
#2
Julia Fedotova, Daria Zarembo, Jozef Dragasek, Martin Caprnda, Peter Kruzliak, Tatyana Dudnichenko
BACKGROUND: Vitamin D can be one of the candidate substances that are used as additional supplementation in the treatment of anxiety-related disorders in women with estrogen imbalance. MATERIALS AND METHODS: The aim of the present study was to examine the effects of chronic cholecalciferol administration (1.0, 2.5 or 5.0 mg/kg/day, s.c.) on the anxiety-like behavior and monoamines levels in the rat hippocampus following ovariectomy in female rats. Cholecalciferol was given to ovariectomized (OVX) rats and OVX rats treated with 17β-estradiol (17β-E2, 0...
June 1, 2017: Folia Medica
https://www.readbyqxmd.com/read/28670529/a-prospective-study-on-role-of-supplemental-oral-calcium-and-vitamin-d-in-prevention-of-postthyroidectomy-hypocalcemia
#3
Krishnan Ravikumar, Dhalapathy Sadacharan, Sankaran Muthukumar, Thalavai Sundarram, Selladurai Periyasamy, R V Suresh
BACKGROUND: Postoperative transient hypocalcemia is sequelae of total thyroidectomy (TT), which is observed in up to 50% of patients. Routine oral calcium and Vitamin D supplementation have been proposed to prevent symptomatic hypocalcemia preventing morbidity and facilitating early discharge. PATIENTS AND METHODS: A total of 208 patients with nontoxic benign thyroid disorders, undergoing TT, were serially randomized into four groups: Group A (no supplements were given), Group B (oral calcium - 2 g/day given), Group C (calcium and calcitriol - 1 mcg/day are given), and Group D (calcium, calcitriol, and cholecalciferol - 60,000 IU/day are given)...
July 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28667080/a-randomized-trial-of-vitamin-d-supplementation-on-vascular-function-in-ckd
#4
Vivek Kumar, Ashok Kumar Yadav, Anupam Lal, Vinod Kumar, Manphool Singhal, Laurent Billot, Krishan Lal Gupta, Debasish Banerjee, Vivekanand Jha
Vitamin D deficiency associates with mortality in patients with CKD, and vitamin D supplementation might mitigate cardiovascular disease risk in CKD. In this randomized, double-blind, placebo-controlled trial, we investigated the effect of cholecalciferol supplementation on vascular function in 120 patients of either sex, aged 18-70 years, with nondiabetic CKD stage 3-4 and vitamin D deficiency (serum 25-hydroxyvitamin D ≤20 ng/ml). We randomized patients using a 1:1 ratio to receive either two directly observed oral doses of cholecalciferol (300,000 IU) or matching placebo at baseline and 8 weeks...
June 30, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28665937/cholecalciferol-decreases-inflammation-and-improves-vitamin-d-regulatory-enzymes-in-lymphocytes-in-the-uremic-environment-a-randomized-controlled-pilot-trial
#5
José Tarcisio G Carvalho, Marion Schneider, Lilian Cuppari, Caren C Grabulosa, Danilo T Aoike, Beata Marie Q Redublo, Marcelo C Batista, Miguel Cendoroglo, Rosa Maria Moyses, Maria Aparecida Dalboni
It has been reported that vitamin D regulates the immune system. However, whether vitamin D repletion modulates inflammatory responses in lymphocytes from dialysis patients is unclear. In the clinical trial, thirty-two (32) dialysis patients with 25 vitamin D ≤ 20ng/mL were randomized to receive either supplementation of cholecalciferol 100,000 UI/week/3 months (16 patients) or placebo (16 patients). In the in vitro study, B and T lymphocytes from 12 healthy volunteers (HV) were incubated with or without uremic serum in the presence or absence of 25 or 1,25 vitamin D...
2017: PloS One
https://www.readbyqxmd.com/read/28644529/reciprocal-cooperation-of-phytochemicals-and-micronutrients-against-typical-and-atypical-forms-of-borrelia-spp
#6
Anna Goc, Alexandra Niedzwiecki, Matthias Rath
AIMS: Borrelia spp., a causative pathogenic factor of Lyme disease, has become a major public health threat. Current treatments based on antibiotics often lead to relapse after their withdrawal. Naturally derived substances that could work synergistically to display higher efficacy compared to the individual components may serve as a resource for the development of novel approaches to combat both active and latent forms of Borrelia spp. METHODS AND RESULTS: Using checkerboard assay, we investigated the anti-borreliae reciprocal cooperation of phytochemicals and micronutrients against two species of Borrelia selected as prevalent causes of Lyme disease in the US and Europe...
June 23, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28629804/zero-order-controlled-release-delivery-of-cholecalciferol-from-injectable-biodegradable-microsphere-in-vitro-characterization-and-in-vivo-pharmacokinetic-studies
#7
Lalit Vora, Sita V G, Pradeep Vavia
Poly(lactic-co-glycolic acid) microspheres loaded with cholecalciferol (CL), more bioactive form of vitamin D was developed as an injectable controlled drug release system and was evaluated for its feasibility of once a month delivery. The CL loaded microspheres (CL-MS) were prepared by simple oil in water (O/W) emulsion-solvent evaporation technique incorporated with a stabilizer, Tocopherol Succinate (TS). Different formulation as well as process parameters were investigated namely concentration of emulsifier, concentration of stabilizer and drug: polymer mass ratios...
June 16, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28618984/glycemic-variability-and-insulin-needs-in-patients-with-type-1-diabetes-mellitus-supplemented-with-vitamin-d-a-pilot-study-using-continuous-glucose-monitoring-system
#8
Karem Miléo Felício, Ana Carolina Contente Braga de Souza, João Felício Abrahão Neto, Franciane Trindade Cunha de Melo, Carolina Tavares Carvalho, Thaís Pontes Arbage, Hana Andrade de Rider Brito, Amanda Soares Peixoto, Alana Ferreira de Oliveira, Fabricio de Souza Resende, Scarlatt Sousa Reis, Ana Regina Motta, Henrique da Costa Miranda, Luísa Corrêa Janaú, Elizabeth Sumi Yamada, João Soares Felício
BACKGROUND: Recent studies suggest that glycemic variability could influence the risk of complications in type 1 diabetes mellitus (T1DM). There are no data about the action of vitamin D (VD) on glycemic variability. Our pilot study aims to evaluate glycemic variability and insulin needs in patients with T1DM supplemented with VD. METHODS: 22 patients received doses of 4000 and 10000 IU/day of cholecalciferol for 12 weeks, according to the patient's baseline VD levels and underwent continuous glucose monitoring system...
June 15, 2017: Current Diabetes Reviews
https://www.readbyqxmd.com/read/28595683/cholecalciferol-d%C3%A2-versus-ergocalciferol-d%C3%A2-in-older-adults
#9
Simona Dereje, Ilan Muradov, Samira Nazzal, Timothy Nguyen
Vitamin D is a fat-soluble vitamin that is naturally found in very few food sources. It is produced endogenously from ultraviolet light from the sun striking the skin and then triggering vitamin D synthesis and activation. Vitamin D helps promote calcium absorption in the gut, maintains adequate serum calcium and phosphate levels, promotes bone growth, modulates cell growth, and has many other roles. There have been an increasing number of people, especially in older adults, with vitamin D deficiency. This is in part a result of a reduction of sun exposure as people age, increase in use of sunscreen, and other factors...
June 1, 2017: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/28590909/comparing-monolithic-and-fused-core-hplc-columns-for-fast-chromatographic-analysis-of-fat-soluble-vitamins
#10
Said El Kurdi, Dina Abu Muaileq, Hassan A Alhazmi, Mohammed Al Bratty, Sami El Deeb
HPLC stationary phases of monolithic and fused core type can be used to achieve fast chromatographic separation as an alternative to UPLC. In this study, monolithic and fused core stationary phases are compared for fast separation of four fat-soluble vitamins. Three new methods on the first and second generation monolithic silica RP-18e columns and a fused core pentafluoro-phenyl propyl column were developed. Application of three fused core columns offered comparable separations of retinyl palmitate, DL-α-tocopheryl acetate, cholecalciferol and menadione in terms of elution speed and separation efficiency...
June 27, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/28576736/oral-vitamin-d-rapidly-attenuates-inflammation-from-sunburn-an-interventional-study
#11
Jeffrey F Scott, Lopa M Das, Sayeeda Ahsanuddin, Yuqi Qiu, Amy M Binko, Zachary P Traylor, Sara M Debanne, Kevin D Cooper, Rebecca Boxer, Kurt Q Lu
The diverse immunomodulatory effects of vitamin D are increasingly being recognized. However, the ability of oral vitamin D to modulate acute inflammation in vivo has not been established in humans. In a double-blinded, placebo-controlled interventional trial, twenty healthy adults were randomized to receive either placebo or a high dose of vitamin D3 (cholecalciferol) one hour after experimental sunburn induced by an erythemogenic dose of ultraviolet radiation. Compared to placebo, participants receiving vitamin D3 (200,000 IU) demonstrated reduced expression of pro-inflammatory mediators TNF-α (p=0...
May 30, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28575224/response-to-antenatal-cholecalciferol-supplementation-is-associated-with-common-vitamin-d-related-genetic-variants
#12
Rebecca J Moon, Nicholas C Harvey, Cyrus Cooper, Stefania D'Angelo, Elizabeth M Curtis, Sarah R Crozier, Sheila J Barton, Sian M Robinson, Keith M Godfrey, Nikki J Graham, John W Holloway, Nicholas J Bishop, Stephen Kennedy, Aris T Papageorghiou, Inez Schoenmakers, Robert Fraser, Saurabh V Gandhi, Ann Prentice, Hazel M Inskip, M Kassim Javaid
Context: Single nucleotide polymorphisms (SNP) in genes related to vitamin D metabolism have been associated with serum 25-hydroxyvitamin D [25(OH)D] concentration, but these relationships have not been examined following antenatal cholecalciferol supplementation. Objective: To determine whether SNPs in DHCR7, CYP2R1, CYP24A1 and GC are associated with the response to gestational cholecalciferol supplementation. Design: Within-randomization-group analysis of the MAVIDOS trial of antenatal cholecalciferol supplementation...
May 29, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28565886/effects-of-cholecalciferol-supplementation-in-patients-with-stable-heart-failure-and-low-vitamin-d-levels-ecsploit-d-a-double-blind-randomized-placebo-controlled-pilot-study
#13
Fabrizio Turrini, Stefania Scarlini, Paolo Giovanardi, Roberto Messora, Laura Roli, Johanna Chester, Chiara Mussi, Marco Bertolotti, Tommaso Trenti, Marco Bondi
BACKGROUND: The aim of this study was to investigate the effects of vitamin D (VD) on the interaction among functional, echocardiographic and hormonal parameters in patients with heart failure (HF) and VD deficiency. METHODS: In a randomized, double blind trial, 35 patients with HF and VD < 20 ng/ml, received either 300,000 U of oral cholecalciferol followed by 50,000 U/month for 6 months, or placebo treatment. RESULTS: Changes in the 6 Minute Walking Test (6MWT) assessed at 3 and 6 months in treatment group was the primary end point...
May 31, 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/28559516/cholecalciferol-for-prophylaxis-against-antituberculosis-therapy-induced-liver-disorders-among-na%C3%A3-ve-patients-with-pulmonary-tuberculosis-a-randomized-comparative-study
#14
Ahmad Farooq Alsayed Hasanain, Ali Abdel-Azeem Hasan Zayed, Reem Ezzat Mahdy, Amany Mohamed Adawi Nafee
BACKGROUND: Patients in countries endemic for chronic viral hepatitis are more vulnerable to antituberculosis therapy-induced liver disorders (ATT-LDs). The aim of this study was to explore the role of cholecalciferol in prophylaxis against ATT-LD among patients with pulmonary tuberculosis (TB) receiving ATT. MATERIAL AND METHODS: We conducted a hospital-based, prospective, randomized, comparative study which included 300 consecutive, naïve patients with pulmonary TB eligible for ATT...
April 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28553593/randomized-control-trial-assessing-impact-of-increased-sunlight-exposure-versus-vitamin-d-supplementation-on-lipid-profile-in-indian-vitamin-d-deficient-men
#15
Vivek G Patwardhan, Zulf M Mughal, Raja Padidela, Shashi A Chiplonkar, Vaman V Khadilkar, Anuradha V Khadilkar
BACKGROUND: Despite abundance of sunshine in India, Vitamin D deficiency is common and therefore there is an increasing trend toward taking Vitamin D supplements either as prescription medicine or as a nutritional supplement. Studies have suggested that duration of sun exposure may influence serum lipid profile. OBJECTIVES: To study the effect of increased sunlight exposure versus Vitamin D supplementation on Vitamin D status and lipid profile in individuals with Vitamin D deficiency (25-hydroxyvitamin-D [25OHD] <50 nmol/L)...
May 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28552878/medium-chain-triglycerides-in-combination-with-leucine-and-vitamin-d-benefit-cognition-in-frail-elderly-adults-a-randomized-controlled-trial
#16
Sakiko Abe, Osamu Ezaki, Motohisa Suzuki
The combined supplementation of medium-chain triglycerides (MCTs), L-leucine-rich amino acids, and cholecalciferol (vitamin D3) increase muscle strength and function in frail elderly individuals. However, their effects on cognition are unknown. We enrolled 38 elderly nursing home residents (mean age±SD, 86.6±4.8 y) in a 3-mo randomized, controlled, parallel group trial. The participants were randomly allocated to 3 groups: the first group received a L-leucine (1.2 g)- and cholecalciferol (20 μg)-enriched supplement with 6 g of MCT (LD+MCT); the second group received the same supplement with 6 g of long-chain triglycerides (LD+LCT); and the third group did not receive any supplements (control)...
2017: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/28546765/vitamin-d-prohormone-in-the-treatment-of-secondary-hyperparathyroidism-in-patients-with-chronic-kidney-disease
#17
REVIEW
Claudia Friedl, Emanuel Zitt
Secondary hyperparathyroidism (sHPT) represents the adaptive and very often, finally, maladaptive response of the organism to control the disturbed homeostasis of calcium, phosphorus, and vitamin D metabolism caused by declining renal function in chronic kidney disease (CKD). sHPT leads to cardiovascular and extravascular calcifications and is directly linked to an increased risk of cardiovascular morbidity and mortality as well as excess all-cause mortality. Vitamin D plays an important role in the development of sHPT...
2017: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/28538382/improvement-of-fatigue-after-vitamin-d-supplementation-in-kidney-transplant-recipients
#18
Bin Han, Xiao Wu, Yong Guo
Low serum levels of vitamin D have been associated with fatigue in both healthy and clinical populations. Our aim was to evaluate the effect of vitamin D supplementation on fatigue in kidney transplant recipients (KTRs). In total, 137 patients after kidney transplant and 119 age- and sex-matched healthy volunteers were recruited. Serum levels of 25-hydroxyvitamin D (25(OH)D) were measured by competitive protein-binding assay. Fatigue was assessed using the subscale fatigue of the Checklist Individual Strength (CIS)...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28537325/association-of-protein-intake-with-bone-mineral-density-and-bone-mineral-content-among-elderly-women-the-ostpre-fracture-prevention-study
#19
M Isanejad, J Sirola, J Mursu, H Kröger, M Tuppurainen, A T Erkkilä
It has been hypothesized that high protein intakes are associated with lower bone mineral content (BMC). Previous studies yield conflicting results and thus far no studies have undertaken the interaction of body mass index (BMI) and physical activity with protein intakes in relation to BMC and bone mineral density (BMD). OBJECTIVE: To evaluate the associations of dietary total protein (TP), animal protein (AP) and plant protein (PP) intakes with BMC and BMD and their changes. We tested also the interactions of protein intake with, obesity (BMI ≤30 vs...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28536054/effect-of-vitamin-d-replacement-on-immunological-biomarkers-in-patients-with-multiple-sclerosis
#20
May F Mrad, Nabil K El Ayoubi, Maria O Esmerian, Jalal M Kazan, Samia J Khoury
We aimed to investigate the immunologic effects of vitamin D replacement in RRMS patients. In a controlled single center study, patients deficient in 25-hydroxyvitamin D (serum level<25ng/ml) received 10,000IU/week cholecalciferol for 3months. Sufficient vitamin D patients (serum level>35ng/ml) were followed for the same period. Assessments were performed at baseline and at 3months. 25-hydroxyvitamin D levels increased significantly from baseline to month-3 in the deficient group after treatment and remained stable in the sufficient group...
May 20, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
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