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Disruptive Mood Dysregulation Disorder

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https://www.readbyqxmd.com/read/27902832/association-of-irritability-and-anxiety-with-the-neural-mechanisms-of-implicit-face-emotion-processing-in-youths-with-psychopathology
#1
Joel Stoddard, Wan-Ling Tseng, Pilyoung Kim, Gang Chen, Jennifer Yi, Laura Donahue, Melissa A Brotman, Kenneth E Towbin, Daniel S Pine, Ellen Leibenluft
Importance: Psychiatric comorbidity complicates clinical care and confounds efforts to elucidate the pathophysiology of commonly occurring symptoms in youths. To our knowledge, few studies have simultaneously assessed the effect of 2 continuously distributed traits on brain-behavior relationships in children with psychopathology. Objective: To determine shared and unique effects of 2 major dimensions of child psychopathology, irritability and anxiety, on neural responses to facial emotions during functional magnetic resonance imaging...
November 30, 2016: JAMA Psychiatry
https://www.readbyqxmd.com/read/27871637/comparing-brain-morphometry-across-multiple-childhood-psychiatric-disorders
#2
Andrea L Gold, Melissa A Brotman, Nancy E Adleman, Sara N Lever, Elizabeth R Steuber, Stephen J Fromm, Sven C Mueller, Daniel S Pine, Ellen Leibenluft
OBJECTIVE: In both children and adults, psychiatric illness is associated with structural brain alterations, particularly in the prefrontal cortex (PFC). However, most studies compare gray matter volume (GMV) in healthy volunteers (HVs) to one psychiatric group. We compared GMV among youth with anxiety disorders, bipolar disorder (BD), disruptive mood dysregulation disorder (DMDD), attention-deficit/hyperactivity disorder (ADHD), and HVs. METHOD: 3-Tesla T1-weighted magnetic resonance imaging scans were acquired in 184 youths (39 anxious, 20 BD, 52 DMDD, 20 ADHD, and 53 HV)...
December 2016: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/27783068/re-evaluating-the-link-between-neuropsychiatric-disorders-and-dysregulated-adult-neurogenesis
#3
Sanghee Yun, Ryan P Reynolds, Irene Masiulis, Amelia J Eisch
People diagnosed with neuropsychiatric disorders such as depression, anxiety, addiction or schizophrenia often have dysregulated memory, mood, pattern separation and/or reward processing. These symptoms are indicative of a disrupted function of the dentate gyrus (DG) subregion of the brain, and they improve with treatment and remission. The dysfunction of the DG is accompanied by structural maladaptations, including dysregulation of adult-generated neurons. An increasing number of studies using modern inducible approaches to manipulate new neurons show that the behavioral symptoms in animal models of neuropsychiatric disorders can be produced or exacerbated by the inhibition of DG neurogenesis...
October 26, 2016: Nature Medicine
https://www.readbyqxmd.com/read/27742912/disruptive-mood-dysregulation-disorder-severe-mood-dysregulation-and-chronic-irritability-in-youth-at-high-familial-risk-of-bipolar-disorder
#4
Tania Perich, Andrew Frankland, Gloria Roberts, Florence Levy, Rhoshel Lenroot, Philip B Mitchell
OBJECTIVE: Disruptive mood dysregulation disorder is a newly proposed childhood disorder included in Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition to describe children ⩽18 years of age with chronic irritability/temper outbursts. This study aimed to examine the prevalence of disruptive mood dysregulation disorder, severe mood dysregulation and chronic irritability in an Australian study of young people at increased familial risk of developing bipolar disorder ('HR' group) and controls ('CON' group)...
October 14, 2016: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/27735972/pediatric-bipolar-disorder
#5
Terry Lee
The diagnosis of bipolar disorder (BD) in youth is confusing and controversial. Controversy notwithstanding, youth diagnosed with BD have high behavioral health needs and are at elevated risk for problematic long-term psychosocial functioning and complex psychiatric medication regimens. Pediatricians and other primary care providers (PCPs) can play an important role in the assessment and treatment of youth diagnosed with BD and the recently created and also controversial diagnosis of disruptive mood dysregulation disorder (DMDD)...
October 1, 2016: Pediatric Annals
https://www.readbyqxmd.com/read/27685191/proper-emotion-recognition-dysfunctional-emotion-regulation
#6
Tanja Legenbauer, Jan Hübner, Marlies Pinnow, Anna Ball, Benjamin Pniewski, Martin Holtmann
 Objective: A considerable number of adolescents exhibit severe self-regulation deficits in affect and behavior, which are referred to as affective dysregulation (AD). AD may be conceptualized as a dimensional trait that, in its extreme form, resembles the diagnostic categories of severe mood dysregulation (SMD) or disruptive mood dysregulation disorder (DMDD). Assuming a shared pathway of psychopathology in AD and SMD, similar underlying dysfunctional mechanisms in emotion processing, particularly emotion recognition (RECOG) and regulation (REGUL), may be postulated...
September 29, 2016: Zeitschrift Für Kinder- und Jugendpsychiatrie und Psychotherapie
https://www.readbyqxmd.com/read/27662894/evidence-based-treatments-for-youths-with-severely-dysregulated-mood-a-qualitative-systematic-review-of-trials-for-smd-and-dmdd
#7
Xavier Benarous, Angèle Consoli, Jean-Marc Guilé, Sébastien Garny de La Rivière, David Cohen, Bertrand Olliac
The aim of this literature review was to examine the evidence for psychotherapeutic and pharmacological treatments in subjects with severely dysregulated mood and to identify potential areas for improvements in research designs. A literature search was conducted using several databases for published (PubMed, PsycINFO) and ongoing (clinical trial registries) studies conducted in youths who met NIMH's criteria for Severe Mood Dysregulation (SMD) or the DSM-5 diagnosis of Disruptive Mood Dysregulation Disorder (DMDD)...
September 23, 2016: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/27638044/diagnosing-disruptive-mood-dysregulation-disorder-integrating-semi-structured-and-unstructured-interviews
#8
Emily A McTate, Jarrod M Leffler
The newest iteration of the Diagnostic and Statistical Manual-fifth edition (DSM-5), is the first to include the diagnosis of disruptive mood dysregulation disorder (DMDD). The assessment and diagnosis of psychopathology in children are complicated, particularly for mood disorders. Practice can be guided by the use of well-validated instruments. However, as this is a new diagnosis existing instruments have not yet been evaluated for the diagnosis of DMDD. This study seeks to provide a method for using existing structured interview instruments to assess for this contemporary diagnosis...
September 15, 2016: Clinical Child Psychology and Psychiatry
https://www.readbyqxmd.com/read/27601906/disruptive-mood-dysregulation-disorder-current-insights
#9
REVIEW
Raman Baweja, Susan D Mayes, Usman Hameed, James G Waxmonsky
Disruptive mood dysregulation disorder (DMDD) was introduced as a new diagnostic entity under the category of depressive disorders in Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). It was included in DSM-5 primarily to address concerns about the misdiagnosis and consequent overtreatment of bipolar disorder in children and adolescents. DMDD does provide a home for a large percentage of referred children with severe persistent irritability that did not fit well into any DSM, Fourth Edition (DSM-IV) diagnostic category...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27554606/disruptive-mood-dysregulation-disorder-dmdd-an-rdoc-perspective
#10
Erica Meyers, Mariah DeSerisy, Amy Krain Roy
In recent years, there has been much debate regarding the most appropriate diagnostic classification of children exhibiting emotion dysregulation in the form of irritability and severe temper outbursts. Most recently, this has resulted in the addition of a new diagnosis, Disruptive Mood Dysregulation Disorder (DMDD) in the DSM 5. The impetus for including this new disorder was to reduce the number of diagnoses that these children would typically receive; however, there is concern that it has only complicated matters rather than simplifying them...
August 13, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27549781/demographic-differences-in-disruptive-mood-dysregulation-disorder-symptoms-in-adhd-autism-and-general-population-samples
#11
Susan D Mayes, Susan L Calhoun, James G Waxmonsky, Cari Kokotovich, Raman Baweja, Robin Lockridge, Edward O Bixler
OBJECTIVE: Diagnostic and Statistical Manual of Mental Disorders (5th ed.; DSM-5) disruptive mood dysregulation disorder (DMDD) is a controversial new diagnosis. No studies have investigated DMDD symptoms (irritable-angry mood and temper outbursts) and demographics in general population and psychiatric samples. METHOD: Maternal ratings of DMDD symptoms and diagnoses, age, gender, IQ, race, and parent occupation were analyzed in general population (n = 665, 6-12 years) and psychiatric samples (n = 2,256, 2-16 years)...
August 22, 2016: Journal of Attention Disorders
https://www.readbyqxmd.com/read/27536785/increased-serum-levels-of-oxytocin-in-treatment-resistant-depression-in-adolescents-trdia-group
#12
Tsuyoshi Sasaki, Kenji Hashimoto, Yasunori Oda, Tamaki Ishima, Madoka Yakita, Tsutomu Kurata, Masaru Kunou, Jumpei Takahashi, Yu Kamata, Atsushi Kimura, Tomihisa Niitsu, Hideki Komatsu, Tadashi Hasegawa, Akihiro Shiina, Tasuku Hashimoto, Nobuhisa Kanahara, Eiji Shimizu, Masaomi Iyo
OBJECTIVE: 'Treatment-resistant depression' is depression that does not respond to an adequate regimen of evidence-based treatment. Treatment-resistant depression frequently becomes chronic. Children with treatment-resistant depression might also develop bipolar disorder (BD). The objective of this study was to determine whether serum levels of oxytocin (OXT) in treatment-resistant depression in adolescents (TRDIA) differ from non-treatment-resistant depression in adolescents (non-TRDIA) or controls...
2016: PloS One
https://www.readbyqxmd.com/read/27510439/temper-loss-and-persistent-irritability-in-preschoolers-implications-for-diagnosing-disruptive-mood-dysregulation-disorder-in-early-childhood
#13
Sarah E Martin, Jeffrey I Hunt, Lauren R Mernick, Mia DeMarco, Heather L Hunter, Maria Teresa Coutinho, John R Boekamp
Disruptive Mood Dysregulation Disorder (DMDD) is a new and controversial child psychiatric disorder characterized by persistent irritability and frequent temper loss. Among the controversies surrounding DMDD is whether the age of onset criterion-that DMDD may not be diagnosed before age 6 years-is justified. This study examined DMDD symptoms and associated patterns of psychiatric comorbidity, behavioral, and family functioning in a sample of 139 preschoolers (ages 4-0 to 5-11 years) admitted to an early childhood psychiatric day treatment program...
August 10, 2016: Child Psychiatry and Human Development
https://www.readbyqxmd.com/read/27474908/acute-cortisol-reactivity-attenuates-engagement-of-fronto-parietal-and-striatal-regions-during-emotion-processing-in-negative-mood-disorders
#14
Amy T Peters, Anna Van Meter, Patrick J Pruitt, Emily M Briceño, Kelly A Ryan, Melissa Hagan, Anne L Weldon, Michelle T Kassel, Aaron Vederman, Jon-Kar Zubieta, Melvin McInnis, Sara L Weisenbach, Scott A Langenecker
OBJECTIVE: Depression and bipolar disorder (negative mood disorders, NMD) are associated with dysregulated hypothalamic-pituitary-adrenal (HPA)-axis function and disrupted emotion processing. The neural networks involved in attenuation of HPA-axis reactivity overlap with the circuitry involved in perception and modulation of emotion; however, direct links between these systems are understudied. This study investigated whether cortisol activity prior to undergoing fMRI was related to neural processing of emotional information in participants with NMD...
November 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27418862/the-role-of-sleep-in-bipolar-disorder
#15
REVIEW
Alexandra K Gold, Louisa G Sylvia
Bipolar disorder is a serious mental illness characterized by alternating periods of elevated and depressed mood. Sleep disturbances in bipolar disorder are present during all stages of the condition and exert a negative impact on overall course, quality of life, and treatment outcomes. We examine the partnership between circadian system (process C) functioning and sleep-wake homeostasis (process S) on optimal sleep functioning and explore the role of disruptions in both systems on sleep disturbances in bipolar disorder...
2016: Nature and Science of Sleep
https://www.readbyqxmd.com/read/27411910/affective-disturbance-in-rheumatoid-arthritis-psychological-and-disease-related-pathways
#16
REVIEW
John A Sturgeon, Patrick H Finan, Alex J Zautra
In addition to recurrent pain, fatigue, and increased rates of physical disability, individuals with rheumatoid arthritis (RA) have an increased prevalence of some mental health disorders, particularly those involving affective or mood disturbances. This narrative Review provides an overview of mental health comorbidities in RA, and discusses how these comorbidities interact with disease processes, including dysregulation of inflammatory responses, prolonged difficulties with pain and fatigue, and the development of cognitive and behavioural responses that could exacerbate the physical and psychological difficulties associated with RA...
September 2016: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/27208455/an-exploratory-clinical-study-of-disruptive-mood-dysregulation-disorder-in-children-and-adolescents-from-india
#17
Rashmi Tiwari, Vivek Agarwal, Amit Arya, Pawan Kumar Gupta, Pooja Mahour
BACKGROUND: Children with chronic non-episodic irritability were frequently diagnosed as suffering from pediatric bipolar disorder. Therefore in DSM-5 a new diagnosis of Disruptive Mood Dysregulation Disorder (DMDD) was included for such children. AIMS: This study aimed to identify DMDD in children and adolescents in Indian child and adolescent psychiatry clinic and elicit its phenomenology and co-morbidities. METHODS: Children of 6-16 years, presenting with irritability for more than one year were assessed using DSM 5 diagnostic criteria to make a diagnosis of DMDD...
June 2016: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/27188635/anger-in-psychological-disorders-prevalence-presentation-etiology-and-prognostic-implications
#18
REVIEW
Ephrem Fernandez, Sheri L Johnson
Anger is present as a key criterion in five diagnoses within DSM-5: Intermittent Explosive Disorder, Oppositional Defiant Disorder, Disruptive Mood Dysregulation Disorder, Borderline Personality Disorder and Bipolar Disorder. This review amasses scientific literature demonstrating that within each of these disorders, anger is a central clinical feature that is highly prevalent and predictive of important outcomes. For each disorder, we also discuss the phenomenology and etiology of anger. Although models of anger have been quite distinct across these disorders, few empirical studies have truly tested whether anger stems from different etiological factors across these different conditions...
June 2016: Clinical Psychology Review
https://www.readbyqxmd.com/read/27177299/state-dependent-cortico-amygdala-circuit-dysfunction-in-bipolar-disorder
#19
Roscoe O Brady, Grace A Masters, Ian T Mathew, Allison Margolis, Bruce M Cohen, Dost Öngür, Matcheri Keshavan
BACKGROUND: Existing models of the pathophysiology of bipolar disorder posit disruption in neural circuits of emotion regulation and reward processing. However, few fMRI studies have compared regional brain activity and connectivity in different mood states in bipolar disorder to determine if manic symptomatology is reflected in specific circuit abnormalities. The purpose of this study was to test the hypothesis that bipolar mania is associated with altered connectivity between cortical regions thought to regulate subcortical structures such as the amygdala and striatum...
September 1, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27168046/distinguishing-disruptive-mood-dysregulation-disorder-from-pediatric-bipolar-disorder
#20
Diana T Noller
This article outlines diagnostic criteria and features of the newly established diagnosis disruptive mood dysregulation disorder (DMDD), and discusses how this disorder differs from bipolar disorder in childhood. The chronic, severe, nonepisodic irritability seen in patients with DMDD contrasts with the characteristic episodic mood swing symptoms of bipolar disorder. Differentiating between the two diagnoses is important in regard to prognostic and treatment considerations, as children with DMDD are more likely to develop a mood disorder later in life rather than to develop classic bipolar disorder...
June 2016: JAAPA: Official Journal of the American Academy of Physician Assistants
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