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Disruptive Mood Dysregulation Disorder

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https://www.readbyqxmd.com/read/28207918/disruptive-mood-dysregulation-disorder-and-its-effect-on-bipolar-disorder
#1
Shama Faheem, Victoria Petti, George Mellos
BACKGROUND: In the last few decades, a noticeable increase in the diagnosis of bipolar disorder (BD) in youth has raised concerns, particularly because of a consequent increase in the use of psychotropic medications with adverse side effects. After observing the development of those youth into adulthood, clinicians and researchers have questioned the notion of expanding the diagnostic boundaries of BD to encapsulate these youth. METHODS: Our research is aimed at gleaning further information on disruptive mood dysregulation disorder (DMDD) and to observe whether its introduction has affected the rates of BD in children and adolescents...
February 1, 2017: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/28192774/irritability-in-child-and-adolescent-psychopathology-an-integrative-review-for-icd-11
#2
REVIEW
Spencer C Evans, Jeffrey D Burke, Michael C Roberts, Paula J Fite, John E Lochman, Francisco R de la Peña, Geoffrey M Reed
In preparation for the World Health Organization's development of the Eleventh Revision of the International Classification of Diseases and Related Health Problems (ICD-11) chapter on Mental and Behavioral Disorders, this article reviews the literature pertaining to severe irritability in child and adolescent psychopathology. First, research on severe mood dysregulation suggests that youth with irritability and temper outbursts, among other features of hyperactivity and arousal, demonstrate cross-sectional correlates and developmental outcomes that distinguish them from youth with bipolar disorder...
January 17, 2017: Clinical Psychology Review
https://www.readbyqxmd.com/read/28186315/sleep-study-in-disruptive-mood-dysregulation-disorder-and-bipolar-children
#3
Xavier Estrada-Prat, Ion Álvarez-Guerrico, María J Bleda-Hernández, Ester Camprodon-Rosanas, Santiago Batlle-Vila, Elena Pujals-Altes, María T Nascimento-Osorio, Luís M Martín-López, Enric Álvarez-Martínez, Víctor Pérez-Solá, Soledad Romero-Cela
INTRODUCTION: Decreased need for sleep has been proposed as a core symptom of mania and it has been associated with the pathogenesis of Bipolar Disorder. The emergence of Disruptive Mood Dysregulation Disorder (DMDD) as a new diagnostic has been controversial and much has been speculated about its relationship with the bipolar spectrum. REM sleep fragmentation could be a biomarker of affective disorders and it would help us to differentiate them from other disorders. METHOD: Polysomnographic cross-sectional study of children with DMDD, bipolar disorder and Attention Deficit Hyperactivity Disorder (ADHD)...
January 2017: Actas Españolas de Psiquiatría
https://www.readbyqxmd.com/read/27902832/association-of-irritability-and-anxiety-with-the-neural-mechanisms-of-implicit-face-emotion-processing-in-youths-with-psychopathology
#4
Joel Stoddard, Wan-Ling Tseng, Pilyoung Kim, Gang Chen, Jennifer Yi, Laura Donahue, Melissa A Brotman, Kenneth E Towbin, Daniel S Pine, Ellen Leibenluft
Importance: Psychiatric comorbidity complicates clinical care and confounds efforts to elucidate the pathophysiology of commonly occurring symptoms in youths. To our knowledge, few studies have simultaneously assessed the effect of 2 continuously distributed traits on brain-behavior relationships in children with psychopathology. Objective: To determine shared and unique effects of 2 major dimensions of child psychopathology, irritability and anxiety, on neural responses to facial emotions during functional magnetic resonance imaging...
January 1, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/27871637/comparing-brain-morphometry-across-multiple-childhood-psychiatric-disorders
#5
Andrea L Gold, Melissa A Brotman, Nancy E Adleman, Sara N Lever, Elizabeth R Steuber, Stephen J Fromm, Sven C Mueller, Daniel S Pine, Ellen Leibenluft
OBJECTIVE: In both children and adults, psychiatric illness is associated with structural brain alterations, particularly in the prefrontal cortex (PFC). However, most studies compare gray matter volume (GMV) in healthy volunteers (HVs) to one psychiatric group. We compared GMV among youth with anxiety disorders, bipolar disorder (BD), disruptive mood dysregulation disorder (DMDD), attention-deficit/hyperactivity disorder (ADHD), and HVs. METHOD: 3-Tesla T1-weighted magnetic resonance imaging scans were acquired in 184 youths (39 anxious, 20 BD, 52 DMDD, 20 ADHD, and 53 HV)...
December 2016: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/27783068/re-evaluating-the-link-between-neuropsychiatric-disorders-and-dysregulated-adult-neurogenesis
#6
Sanghee Yun, Ryan P Reynolds, Irene Masiulis, Amelia J Eisch
People diagnosed with neuropsychiatric disorders such as depression, anxiety, addiction or schizophrenia often have dysregulated memory, mood, pattern separation and/or reward processing. These symptoms are indicative of a disrupted function of the dentate gyrus (DG) subregion of the brain, and they improve with treatment and remission. The dysfunction of the DG is accompanied by structural maladaptations, including dysregulation of adult-generated neurons. An increasing number of studies using modern inducible approaches to manipulate new neurons show that the behavioral symptoms in animal models of neuropsychiatric disorders can be produced or exacerbated by the inhibition of DG neurogenesis...
October 26, 2016: Nature Medicine
https://www.readbyqxmd.com/read/27742912/disruptive-mood-dysregulation-disorder-severe-mood-dysregulation-and-chronic-irritability-in-youth-at-high-familial-risk-of-bipolar-disorder
#7
Tania Perich, Andrew Frankland, Gloria Roberts, Florence Levy, Rhoshel Lenroot, Philip B Mitchell
OBJECTIVE: Disruptive mood dysregulation disorder is a newly proposed childhood disorder included in Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition to describe children ⩽18 years of age with chronic irritability/temper outbursts. This study aimed to examine the prevalence of disruptive mood dysregulation disorder, severe mood dysregulation and chronic irritability in an Australian study of young people at increased familial risk of developing bipolar disorder ('HR' group) and controls ('CON' group)...
October 14, 2016: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/27735972/pediatric-bipolar-disorder
#8
Terry Lee
The diagnosis of bipolar disorder (BD) in youth is confusing and controversial. Controversy notwithstanding, youth diagnosed with BD have high behavioral health needs and are at elevated risk for problematic long-term psychosocial functioning and complex psychiatric medication regimens. Pediatricians and other primary care providers (PCPs) can play an important role in the assessment and treatment of youth diagnosed with BD and the recently created and also controversial diagnosis of disruptive mood dysregulation disorder (DMDD)...
October 1, 2016: Pediatric Annals
https://www.readbyqxmd.com/read/27685191/proper-emotion-recognition-dysfunctional-emotion-regulation
#9
Tanja Legenbauer, Jan Hübner, Marlies Pinnow, Anna Ball, Benjamin Pniewski, Martin Holtmann
 Objective: A considerable number of adolescents exhibit severe self-regulation deficits in affect and behavior, which are referred to as affective dysregulation (AD). AD may be conceptualized as a dimensional trait that, in its extreme form, resembles the diagnostic categories of severe mood dysregulation (SMD) or disruptive mood dysregulation disorder (DMDD). Assuming a shared pathway of psychopathology in AD and SMD, similar underlying dysfunctional mechanisms in emotion processing, particularly emotion recognition (RECOG) and regulation (REGUL), may be postulated...
September 29, 2016: Zeitschrift Für Kinder- und Jugendpsychiatrie und Psychotherapie
https://www.readbyqxmd.com/read/27662894/evidence-based-treatments-for-youths-with-severely-dysregulated-mood-a-qualitative-systematic-review-of-trials-for-smd-and-dmdd
#10
REVIEW
Xavier Benarous, Angèle Consoli, Jean-Marc Guilé, Sébastien Garny de La Rivière, David Cohen, Bertrand Olliac
The aim of this literature review was to examine the evidence for psychotherapeutic and pharmacological treatments in subjects with severely dysregulated mood and to identify potential areas for improvements in research designs. A literature search was conducted using several databases for published (PubMed, PsycINFO) and ongoing (clinical trial registries) studies conducted in youths who met NIMH's criteria for Severe Mood Dysregulation (SMD) or the DSM-5 diagnosis of Disruptive Mood Dysregulation Disorder (DMDD)...
January 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/27638044/diagnosing-disruptive-mood-dysregulation-disorder-integrating-semi-structured-and-unstructured-interviews
#11
Emily A McTate, Jarrod M Leffler
The newest iteration of the Diagnostic and Statistical Manual-fifth edition (DSM-5), is the first to include the diagnosis of disruptive mood dysregulation disorder (DMDD). The assessment and diagnosis of psychopathology in children are complicated, particularly for mood disorders. Practice can be guided by the use of well-validated instruments. However, as this is a new diagnosis existing instruments have not yet been evaluated for the diagnosis of DMDD. This study seeks to provide a method for using existing structured interview instruments to assess for this contemporary diagnosis...
September 15, 2016: Clinical Child Psychology and Psychiatry
https://www.readbyqxmd.com/read/27601906/disruptive-mood-dysregulation-disorder-current-insights
#12
REVIEW
Raman Baweja, Susan D Mayes, Usman Hameed, James G Waxmonsky
Disruptive mood dysregulation disorder (DMDD) was introduced as a new diagnostic entity under the category of depressive disorders in Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). It was included in DSM-5 primarily to address concerns about the misdiagnosis and consequent overtreatment of bipolar disorder in children and adolescents. DMDD does provide a home for a large percentage of referred children with severe persistent irritability that did not fit well into any DSM, Fourth Edition (DSM-IV) diagnostic category...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27554606/disruptive-mood-dysregulation-disorder-dmdd-an-rdoc-perspective
#13
REVIEW
Erica Meyers, Mariah DeSerisy, Amy Krain Roy
In recent years, there has been much debate regarding the most appropriate diagnostic classification of children exhibiting emotion dysregulation in the form of irritability and severe temper outbursts. Most recently, this has resulted in the addition of a new diagnosis, Disruptive Mood Dysregulation Disorder (DMDD) in the DSM 5. The impetus for including this new disorder was to reduce the number of diagnoses that these children would typically receive; however, there is concern that it has only complicated matters rather than simplifying them...
August 13, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27549781/demographic-differences-in-disruptive-mood-dysregulation-disorder-symptoms-in-adhd-autism-and-general-population-samples
#14
Susan D Mayes, Susan L Calhoun, James G Waxmonsky, Cari Kokotovich, Raman Baweja, Robin Lockridge, Edward O Bixler
OBJECTIVE: Diagnostic and Statistical Manual of Mental Disorders (5th ed.; DSM-5) disruptive mood dysregulation disorder (DMDD) is a controversial new diagnosis. No studies have investigated DMDD symptoms (irritable-angry mood and temper outbursts) and demographics in general population and psychiatric samples. METHOD: Maternal ratings of DMDD symptoms and diagnoses, age, gender, IQ, race, and parent occupation were analyzed in general population (n = 665, 6-12 years) and psychiatric samples (n = 2,256, 2-16 years)...
August 22, 2016: Journal of Attention Disorders
https://www.readbyqxmd.com/read/27536785/increased-serum-levels-of-oxytocin-in-treatment-resistant-depression-in-adolescents-trdia-group
#15
Tsuyoshi Sasaki, Kenji Hashimoto, Yasunori Oda, Tamaki Ishima, Madoka Yakita, Tsutomu Kurata, Masaru Kunou, Jumpei Takahashi, Yu Kamata, Atsushi Kimura, Tomihisa Niitsu, Hideki Komatsu, Tadashi Hasegawa, Akihiro Shiina, Tasuku Hashimoto, Nobuhisa Kanahara, Eiji Shimizu, Masaomi Iyo
OBJECTIVE: 'Treatment-resistant depression' is depression that does not respond to an adequate regimen of evidence-based treatment. Treatment-resistant depression frequently becomes chronic. Children with treatment-resistant depression might also develop bipolar disorder (BD). The objective of this study was to determine whether serum levels of oxytocin (OXT) in treatment-resistant depression in adolescents (TRDIA) differ from non-treatment-resistant depression in adolescents (non-TRDIA) or controls...
2016: PloS One
https://www.readbyqxmd.com/read/27510439/temper-loss-and-persistent-irritability-in-preschoolers-implications-for-diagnosing-disruptive-mood-dysregulation-disorder-in-early-childhood
#16
Sarah E Martin, Jeffrey I Hunt, Lauren R Mernick, Mia DeMarco, Heather L Hunter, Maria Teresa Coutinho, John R Boekamp
Disruptive Mood Dysregulation Disorder (DMDD) is a new and controversial child psychiatric disorder characterized by persistent irritability and frequent temper loss. Among the controversies surrounding DMDD is whether the age of onset criterion-that DMDD may not be diagnosed before age 6 years-is justified. This study examined DMDD symptoms and associated patterns of psychiatric comorbidity, behavioral, and family functioning in a sample of 139 preschoolers (ages 4-0 to 5-11 years) admitted to an early childhood psychiatric day treatment program...
August 10, 2016: Child Psychiatry and Human Development
https://www.readbyqxmd.com/read/27474908/acute-cortisol-reactivity-attenuates-engagement-of-fronto-parietal-and-striatal-regions-during-emotion-processing-in-negative-mood-disorders
#17
Amy T Peters, Anna Van Meter, Patrick J Pruitt, Emily M Briceño, Kelly A Ryan, Melissa Hagan, Anne L Weldon, Michelle T Kassel, Aaron Vederman, Jon-Kar Zubieta, Melvin McInnis, Sara L Weisenbach, Scott A Langenecker
OBJECTIVE: Depression and bipolar disorder (negative mood disorders, NMD) are associated with dysregulated hypothalamic-pituitary-adrenal (HPA)-axis function and disrupted emotion processing. The neural networks involved in attenuation of HPA-axis reactivity overlap with the circuitry involved in perception and modulation of emotion; however, direct links between these systems are understudied. This study investigated whether cortisol activity prior to undergoing fMRI was related to neural processing of emotional information in participants with NMD...
November 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27418862/the-role-of-sleep-in-bipolar-disorder
#18
REVIEW
Alexandra K Gold, Louisa G Sylvia
Bipolar disorder is a serious mental illness characterized by alternating periods of elevated and depressed mood. Sleep disturbances in bipolar disorder are present during all stages of the condition and exert a negative impact on overall course, quality of life, and treatment outcomes. We examine the partnership between circadian system (process C) functioning and sleep-wake homeostasis (process S) on optimal sleep functioning and explore the role of disruptions in both systems on sleep disturbances in bipolar disorder...
2016: Nature and Science of Sleep
https://www.readbyqxmd.com/read/27411910/affective-disturbance-in-rheumatoid-arthritis-psychological-and-disease-related-pathways
#19
REVIEW
John A Sturgeon, Patrick H Finan, Alex J Zautra
In addition to recurrent pain, fatigue, and increased rates of physical disability, individuals with rheumatoid arthritis (RA) have an increased prevalence of some mental health disorders, particularly those involving affective or mood disturbances. This narrative Review provides an overview of mental health comorbidities in RA, and discusses how these comorbidities interact with disease processes, including dysregulation of inflammatory responses, prolonged difficulties with pain and fatigue, and the development of cognitive and behavioural responses that could exacerbate the physical and psychological difficulties associated with RA...
September 2016: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/27208455/an-exploratory-clinical-study-of-disruptive-mood-dysregulation-disorder-in-children-and-adolescents-from-india
#20
Rashmi Tiwari, Vivek Agarwal, Amit Arya, Pawan Kumar Gupta, Pooja Mahour
BACKGROUND: Children with chronic non-episodic irritability were frequently diagnosed as suffering from pediatric bipolar disorder. Therefore in DSM-5 a new diagnosis of Disruptive Mood Dysregulation Disorder (DMDD) was included for such children. AIMS: This study aimed to identify DMDD in children and adolescents in Indian child and adolescent psychiatry clinic and elicit its phenomenology and co-morbidities. METHODS: Children of 6-16 years, presenting with irritability for more than one year were assessed using DSM 5 diagnostic criteria to make a diagnosis of DMDD...
June 2016: Asian Journal of Psychiatry
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