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https://www.readbyqxmd.com/read/28230980/chitosan-modified-filter-paper-for-nucleic-acid-extraction-and-in-situ-pcr-on-a-thermoplastic-microchip
#1
Wupeng Gan, Yin Gu, Junping Han, Caixia Li, Jing Sun, Peng Liu
Plastic microfluidic devices with embedded chitosan-modified Fusion 5 filter paper (unmodified one purchased from GE Healthcare) have been successfully developed for DNA extraction and concentration, utilizing two different mechanisms for DNA capture: the physical entanglement of long-chain DNA molecules with the fiber matrix of the filter paper and the electrostatic adsorption of DNA to the chitosan-modified filter fibers. This new method not only provided a high DNA extraction efficiency at a pH of 5 by synergistically combining these two capture mechanisms together, but also resisted the elution of DNA from filters at a pH >8 due to the entanglement of DNA with fibers...
February 23, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28230979/simple-expendable-3d-printed-microfluidic-systems-for-sample-preparation-of-petroleum
#2
Erica Megumi Kataoka, Rui Cesar Murer, Jandyson Machado Santos, Rogerio Mesquita de Carvalho, Marcos Nogueira Eberlin, Fabio Augusto, Ronei Jesus Poppi, Angelo Luiz Gobbi, Leandro Wang Hantao
In this study, we introduce a simple protocol to manufacture disposable, 3D-printed microfluidic systems for sample preparation of petroleum. Such platform is produced with a consumer-grade 3D-printer, using fused deposition modeling. Successful incorporation of solid-phase extraction (SPE) to microchip was ensured by facile 3D element integration using proposed approach. This 3D-printed μSPE device was applied to challenging matrices in oil & gas industry, such as crude oil and oil-brine emulsions. Case studies investigated important limitations of non-silicon and non-glass microchips, namely, resistance to nonpolar solvents and conservation of sample integrity...
February 23, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28227816/a-wide-range-and-high-sensitivity-four-channel-compact-electrochemical-biosensor-for-neurotransmitter-detection-on-a-microfluidic-platform
#3
Elnaz Ghodsevali, Hamza Landari, Mounir Boukadoum, Benoit Gosselin, Amine Miled, Elnaz Ghodsevali, Hamza Landari, Mounir Boukadoum, Benoit Gosselin, Amine Miled, Benoit Gosselin, Amine Miled, Elnaz Ghodsevali, Mounir Boukadoum, Hamza Landari
We present a four-channel, high-sensitivity and linearity electrochemical biosensor for neurotransmitter (NT) detection and measurement. Using a multi-channel microfluidic platform makes this biosensor capable of detecting NT-related currents going from nanoamperes to milliamperes, with a sensitivity of the order of picoamperes. Moreover, by using a fully differential potentiostat architecture, the biosensor offers a high common-mode rejection ratio (90 dB), making it appropriate for low-noise and high-sensitive applications...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227815/lab-on-chips-for-manipulation-of-small-scale-organisms-to-facilitate-imaging-of-neurons-and-organs
#4
Ramtin Ardeshiri, Pouya Rezai, Ramtin Ardeshiri, Pouya Rezai, Ramtin Ardeshiri, Pouya Rezai
Caenorhabditis elegans (C. elegans) and Drosophila melanogaster (D. melanogaster) are widely-used model organisms for neurological and cardiac studies due to their simple neuronal (302 neurons in C. elegans) and cardiac (simple tubular organ in D. melanogaster) systems. However, their small sizes and continuous mobility impede their precise and timely manipulation, hence, limiting the assays that can be done using conventional manual methods. This has resulted in a need for technologies that allow multidirectional manipulation of model organisms to enable studies on target neurons and organs throughout the body...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227794/a-numerical-and-experimental-study-of-acoustic-micromixing-in-3d-microchannels-for-lab-on-a-chip-devices
#5
Susana O Catarino, Vania C Pinto, Paulo J Sousa, Rui Lima, Joao M Miranda, Graca Minas, Susana O Catarino, Vania C Pinto, Paulo J Sousa, Rui Lima, Joao M Miranda, Graca Minas, Joao M Miranda, Paulo J Sousa, Susana O Catarino, Rui Lima, Vania C Pinto, Graca Minas
This paper reports a numerical and experimental study of acoustic streaming and micromixing in polydimethylsiloxane microchannels. The mixing between two fluids flowing in microchannels was evaluated through the following conditions: (1) using a 28 μm thick β-poly(vinylidene fluoride) (β-PVDF) as a piezoelectric transducer actuated with a 24 Vpp and 40 MHz sinusoidal voltage; (2) using different flow rates. The results suggest that the mixing length increases as the flow rate increases and that the acoustic streaming phenomenon leads to a reduction on the mixing length...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227150/integration-of-optical-and-electrochemical-sensors-on-a-microfluidic-platform-using-organic-optoelectronic-components-and-silver-nanowires
#6
Sujittra Poorahong, Florent Lefevre, Marie-Claude Perron, Philippe Juneau, Ricardo Izquierdo, Sujittra Poorahong, Florent Lefevre, Marie-Claude Perron, Philippe Juneau, Ricardo Izquierdo, Sujittra Poorahong, Ricardo Izquierdo, Florent Lefevre, Philippe Juneau, Marie-Claude Perron
Since the emergence of microfluidic platforms sensors integration has been a major challenge. With the advances in miniaturization of these platforms, there is a need for solutions to integrate various optical components in order to build sensors, which will offer different detection characteristics such as several emission and sensing wavelengths. Moreover, the integration of an electrochemical sensor including a transparent electrode that will be compatible with the optical sensor represents an additional challenge...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227149/automated-and-reconfigurable-platform-for-niosome-generation-based-on-a-microfluidic-architecture
#7
Frederic Tessier, Myriam Laprise-Pelletier, Eric Boilard, Marc-Andre Fortin, Amine Miled, Frederic Tessier, Myriam Laprise-Pelletier, Eric Boilard, Marc-Andre Fortin, Amine Miled, Marc-Andre Fortin, Eric Boilard, Amine Miled, Frederic Tessier, Myriam Laprise-Pelletier
Drug delivery at the nano-scale is becoming an important topic in nano and regenerative medicine as it can offer a very localized therapy. Therefore, niosomes are one of the most important vehicles to release drug at the nanoscale. In this paper, we present a new automated microsystem for niosome generation on-demand. Used niosome were based on a mixture of cholesterol and dicetyl phosphate with chloroform. Three compact micropumps are connected to a microfluidic substrate in order to generate 100 nm noisome vesicles...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227148/towards-a-multi-wavelength-spectroscopy-platform-for-blood-characterization-and-analysis
#8
Alireza Avakh Kisomi, Hamza Landari, Mounir Boukadoum, Amine Miled, Benoit Gosselin, Alireza Avakh Kisomi, Hamza Landari, Mounir Boukadoum, Amine Miled, Benoit Gosselin, Hamza Landari, Benoit Gosselin, Amine Miled, Mounir Boukadoum
Passing multiple light wavelengths through a blood sample makes it possible to investigate the presence and composition of cells, metabolytes and analytes such as blood cells, glucose, lactate and oxygen, providing valuable indications for diagnostic and health monitoring. In this paper, we present a test prototype of a multi-wavelength blood spectroscopy platform integrated with a microfluidic substrate to collect and convey blood samples through a series of micro-LEDs and a photo-detector. This spectroscopy platform is a proof of concept for a system that can collect absorbance and transmittance parameters of blood samples at several wavelengths within the visible and NIR spectrum, and transmit them wirelessly to a base station for real-time calculation and analysis...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227146/power-management-design-for-lab-on-chip-biosensors
#9
Xiaojian Yu, Kambiz Moez, I-Chyn Wey, Jie Chen, Xiaojian Yu, Kambiz Moez, I-Chyn Wey, Jie Chen, Kambiz Moez, Xiaojian Yu, I-Chyn Wey, Jie Chen
Over the past decades, we have witnessed the growth demands of portable lab-on-chip biosensors. These lab-on-chip devices are mostly powered by battery, and intelligent power management systems are required to provide supply voltage for different functional units on biosensors (e.g. a microfluidic control system might require higher voltage than the rest working units of biosensors). In this paper, a fully integrated multiple-stage voltage multiplier is proposed to provide high-voltage power needs. The proposed design was implemented with the IBM's 0...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226930/highly-sensitive-detection-of-human-cancer-antigens-by-an-immunogold-silver-assay-chip-coupled-with-a-polythiophene-based-optical-sensor
#10
Nuno M M Pires, Tao Dong, Nuno M M Pires, Tao Dong, Nuno M M Pires, Tao Dong
This work presents a novel method for protein or cancer antigen detection in clinical samples by an immunogold-silver assay microfluidic biochip coupled with a polythiophene-based organic photodetector. The method has showed a detection limit below 1ng/mL and the low cost and high sensitivity of both organic photodetector and immunogold-silver assay make this method amenable for realization in a portable handheld probe tip biosensor.
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226899/nanoporous-membrane-robustness-stability-in-small-form-factor-microfluidic-filtration-system
#11
Dean G Johnson, Sabrina Pan, Andrew Hayden, James L McGrath, Dean G Johnson, Sabrina Pan, Andrew Hayden, James L McGrath, Andrew Hayden, Sabrina Pan, Dean G Johnson, James L McGrath
The development of wearable hemodialysis (HD) devices that replace center-based HD holds the promise to improve both outcomes and quality-of-life for patients with end-stage-renal disease (ERD). A prerequisite for these devices is the development of highly efficient membranes that can achieve high toxin clearance in small footprints. The ultrathin nanoporous membrane material developed by our group is orders of magnitude more permeable than conventional HD membranes. We report on our progress making a prototype wearable dialysis unit...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226540/micro-tube-mass-production-device-for-microbial-culture
#12
K Fujimoto, M Ogawa, K Higashi, N Miki, K Fujimoto, M Ogawa, K Higashi, N Miki, K Higashi, K Fujimoto, M Ogawa, N Miki
This paper describes mass production system of micro-tubes for microbial culture in an open environment. Microbes are used in many fields, such as food, medicine, environmental and energy. We proposed a microbe culture system using hydrogel micro-tubes, which can protect the target microbes inside from competitive microbes outside of the tubes while allow oxygen and nutrition to diffuse through. The hydrogel micro-tubes can be produced by a microfluidic device, which can precisely control the flow and therefore, the tube geometry...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226539/directing-the-spatial-patterning-of-motor-neuron-differentiation-in-engineered-microenvironments
#13
Christopher J Demers, Greg Cox, Scott D Collins, Rosemary L Smith, Christopher J Demers, Greg Cox, Scott D Collins, Rosemary L Smith, Greg Cox, Christopher J Demers, Scott D Collins, Rosemary L Smith
Embryonic development of the spinal cord proceeds through a carefully orchestrated temporal and spatial sequence of chemical cues to provide precise patterning of adult cell types. Recreating this complex microenvironment in a standard cell culture dish is difficult, if not impossible. In this paper, a microfluidic device is used to recapitulate, in vitro, the graded patterning events which occur during early spinal cord development. The microdevice design is developed using COMSOL modeling, with which the spatiotemporal profiles of multiple, diffusible morphogens are simulated...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226538/sheathless-and-high-throughput-sorting-of-paramagnetic-microparticles-in-a-magneto-hydrodynamic-microfluidic-device
#14
Vikash Kumar, Pouya Rezai, Vikash Kumar, Pouya Rezai, Vikash Kumar, Pouya Rezai
Sorting of microorganisms and particles from a mixture is critical for numerous biotechnological and medical applications. Several sorting methods such as pinched flow fractionation (PFF), optical sorting, dielectrophoresis, acoustic separation, magnetophoresis and deterministic lateral displacement (DLD) have been reported in literature. But most of these methods lack ideal characteristics of a sorter such as ability to process at high throughput, simple design, non-complicated fabrication method, sheathless operation and high purity in separation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226535/probing-the-micromechanics-of-the-fastest-growing-plant-cell-the-pollen-tube
#15
Naveen Shamsudhin, Huseyin Baris Atakan, Nino Laubli, Hannes Vogler, Chengzhi Hu, Abu Sebastian, Ueli Grossniklaus, Bradley J Nelson, Naveen Shamsudhin, Huseyin Baris Atakan, Nino Laubli, Hannes Vogler, Chengzhi Hu, Abu Sebastian, Ueli Grossniklaus, Bradley J Nelson, Hannes Vogler, Ueli Grossniklaus, Nino Laubli, Bradley J Nelson, Naveen Shamsudhin, Huseyin Baris Atakan, Abu Sebastian, Chengzhi Hu
The pollen tube is a fast growing cellular protrusion that plays a key role in the reproductive process of flowering plants. It serves as an important model for studying cellular morphogenesis, anisotropic growth mechanisms, and cellular signaling in the plant sciences. The anisotropic growth of pollen tubes is driven by a finely tuned control of the intracellular turgor pressure and the extensibility of the cell wall. To decipher this internal feedback loop and mathematically model the growth process, a quantitative understanding of the mechanical properties of the cell wall is crucial, in addition to biochemical investigations...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226499/origami-microfluidic-paper-analytical-devices-ompad-for-sensing-and-diagnostics
#16
Meera Punjiya, Chung Hee Moon, Yu Chen, Sameer Sonkusale, Meera Punjiya, Chung Hee Moon, Yu Chen, Sameer Sonkusale, Yu Chen, Chung Hee Moon, Sameer Sonkusale, Meera Punjiya
Recent research activities in the area of low-cost sensing and diagnostics that are realized on cellulosic paper substrate are presented. First a three-dimensional origami paper-based analytical device (omPAD) with multiple electrochemical sensors, an integrated sample reservoir and tight integration with a custom CMOS potentiostat is presented. Second, an optical sensor array with built-in microfluidic channel for sample delivery is presented. The sensors are fabricated using a combination of wax printing and screen-printing using a solution based approach in ambient conditions without the need for expensive fabrication equipment or a cleanroom...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226495/a-pmma-microfluidic-dielectric-sensor-for-blood-coagulation-monitoring-at-the-point-of-care
#17
Debnath Maji, Michael A Suster, Erdem Kucukal, Umut A Gurkan, Evi X Stavrou, Pedram Mohseni, Debnath Maji, Michael A Suster, Erdem Kucukal, Umut A Gurkan, Evi X Stavrou, Pedram Mohseni, Umut A Gurkan, Pedram Mohseni, Debnath Maji, Erdem Kucukal, Evi X Stavrou, Michael A Suster
This paper describes the design and construct of a fully biocompatible, microfluidic, dielectric sensor targeted at monitoring human whole blood coagulation at the point-of-care (POC). The sensor assembly procedure involves using sputtered electrodes in a microfluidic channel with a physiologically relevant height of 50μm to create a three-dimensional (3D), parallel-plate, capacitive sensing area. The sensor is constructed with biocompatible materials of polymethyl methacrylate (PMMA) for the substrate and titanium nitride (TiN) for the sensing and floating electrodes...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226489/3d-printed-microfluidic-mixer-for-point-of-care-diagnosis-of-anemia
#18
Kimberly Plevniak, Matthew Campbell, Mei He, Kimberly Plevniak, Matthew Campbell, Mei He, Matthew Campbell, Mei He, Kimberly Plevniak
3D printing has been an emerging fabrication tool in prototyping and manufacturing. We demonstrated a 3D microfluidic simulation guided computer design and 3D printer prototyping for quick turnaround development of microfluidic 3D mixers, which allows fast self-mixing of reagents with blood through capillary force. Combined with smartphone, the point-of-care diagnosis of anemia from finger-prick blood has been successfully implemented and showed consistent results with clinical measurements. Capable of 3D fabrication flexibility and smartphone compatibility, this work presents a novel diagnostic strategy for advancing personalized medicine and mobile healthcare...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225617/multiple-line-particle-focusing-under-viscoelastic-flow-in-a-microfluidic-device
#19
Sei Hyun Yang, Doojin Lee, Jae Ryoun Youn, Young Seok Song
Particles in a viscoelastic fluid are typically focused at the center and four corners of a rectangular channel due to the combination of fluid elasticity and inertia forces. In this study, we observe the transition between single-line and multiple-line particle focusing in a microfluidic device induced by the synergetic effect of inertia and viscoelasticity. The elastic and inertial forces acting on suspended particles are manipulated by controlling the concentration of dilute polymer solution and the flow rate of a fluid...
February 22, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28225604/a-microfluidic-device-for-studying-controllable-hydrodynamic-flow-induced-cellular-responses
#20
Chunhong Zheng, Xiannian Zhang, Chunmei Li, Yuhong Pang, Yanyi Huang
Hydrodynamic flow is an essential stimulus in many cellular functions, regulating many mechanical sensitive pathways and closely associating with human health status and diseases. The flow pattern of blood in vessels is the key factor in causing atherosclerosis. Hemodynamics has great effect on endothelial cells' gene expression and biological functions. There are various tools that can be used for studying flow-induced cellular responses but most of them are either bulky or lack of precise controllability...
February 22, 2017: Analytical Chemistry
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