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https://www.readbyqxmd.com/read/29905972/feeling-the-force-how-pollen-tubes-deal-with-obstacles
#1
Jan T Burri, Hannes Vogler, Nino F Läubli, Chengzhi Hu, Ueli Grossniklaus, Bradley J Nelson
Physical forces are involved in the regulation of plant development and morphogenesis by translating mechanical stress into the modification of physiological processes, which, in turn, can affect cellular growth. Pollen tubes respond rapidly to external stimuli and provide an ideal system to study the effect of mechanical cues at the single-cell level. Here, pollen tubes were exposed to mechanical stress while monitoring the reconfiguration of their growth and recording the generated forces in real-time. We combined a lab-on-a-chip device with a microelectromechanical systems (MEMS)-based capacitive force sensor to mimic and quantify the forces that are involved in pollen tube navigation upon confronting mechanical obstacles...
June 15, 2018: New Phytologist
https://www.readbyqxmd.com/read/29905008/the-combined-effects-of-three-dimensional-cell-culture-and-natural-tissue-extract-on-neural-differentiation-of-p19-embryonal-carcinoma-stem-cells
#2
F Azizi, H R Jalil, Z Nasiri, J Moshtaghian, F Esmaeili, A Doostmohammadi, L Shabani, E Ebrahimie
Tissue engineering, as a novel transplantation therapy, aims to create biomaterial scaffolds resembling the extracellular matrix in order to regenerate the damaged tissues. Adding bioactive factors to the scaffold would improve cell-tissue interactions. In this study, the effect of chitosan poly vinyl alcohol nanofibers containing carbon nanotube scaffold with or without active bioglass (BG+ /BG- ), in combination with neonatal rat brain extract (NRBE) on cell viability, proliferation and neural differentiation of P19 embryonic carcinoma (EC) stem cells was investigated...
June 14, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29901247/joint-contracture-is-reduced-by-intra-articular-implantation-of-rosiglitazone-loaded-hydrogels-in-a-rabbit-model-of-arthrofibrosis
#3
Diren Arsoy, Christopher G Salib, William H Trousdale, Meagan E Tibbo, Afton K Limberg, Anthony Viste, Eric A Lewallen, Nicolas Reina, Michael J Yaszemski, Daniel J Berry, Andre J van Wijnen, Mark E Morrey, Joaquin Sanchez-Sotelo, Matthew P Abdel
Trauma, surgery, and other inflammatory conditions can lead to debilitating joint contractures. Adjunct pharmacologic modalities may permit clinical prevention and treatment of recalcitrant joint contractures. We investigated the therapeutic potential of rosiglitazone by intra-articular delivery via oligo[poly(ethylene glycol)fumarate] (OPF) hydrogels in an established rabbit model of arthrofibrosis. OPF hydrogels loaded with rosiglitazone were characterized for drug elution properties upon soaking in minimum essential media (MEM) with 10% fetal bovine serum and measurements of drug concentrations via High Performance Liquid Chromatography (HPLC)...
June 14, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29897358/additive-manufacturing-of-three-dimensional-3d-microfluidic-based-microelectromechanical-systems-mems-for-acoustofluidic-applications
#4
Ellen Cesewski, Alexander P Haring, Yuxin Tong, Manjot Singh, Rajan Thakur, Sahil Laheri, Kaitlin A Read, Michael D Powell, Kenneth J Oestreich, Blake N Johnson
Three-dimensional (3D) printing now enables the fabrication of 3D structural electronics and microfluidics. Further, conventional subtractive manufacturing processes for microelectromechanical systems (MEMS) relatively limit device structure to two dimensions and require post-processing steps for interface with microfluidics. Thus, the objective of this work is to create an additive manufacturing approach for fabrication of 3D microfluidic-based MEMS devices that enables 3D configurations of electromechanical systems and simultaneous integration of microfluidics...
June 13, 2018: Lab on a Chip
https://www.readbyqxmd.com/read/29897341/core-shell-cuo-al-nanorods-thermite-film-based-on-electrochemical-anodization
#5
Chunpei Yu, Wenchao Zhang, Bin Hu, Debin Ni, Zilong Zheng, Jingping Liu, Kefeng Ma, Wei Ren
In this study, a new method was reported for the fabrication of the nanostructured CuO/Al thermite film on the Cu substrate. The CuO nanorods (NRs) arrays vertically grew from the Cu surfaces by electrochemical anodization processes, followed by the deposition of an Al layer on the CuO NRs via magnetron sputtering to form a core/shell CuO/Al nanothermite film, whose component, structure and morphology were subsequently characterized. In addition, the energy-release characteristics of the obtained nanothermite film was investigated using thermal analyses and laser ignition tests...
June 13, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29894626/membrane-permeability-characteristic-times-and-lengths-for-oxygen-and-a-simulation-based-test-of-the-inhomogeneous-solubility-diffusion-model
#6
Oriana De Vos, Richard M Venable, Tanja Van Hecke, Gerhard Hummer, Richard Walter Pastor, An Ghysels
The balance of normal and radial (lateral) diffusion of oxygen in phospholipid mem-branes is critical for biological function. Based on the Smoluchowski equation for the inhomogeneous solubility-diffusion model, Bayesian analysis (BA) can be applied to molecular dynamics trajectories of oxygen to extract the free energy, and the normal and radial diffusion profiles. This paper derives a theoretical formalism to convert these profiles into characteristic times and lengths associated with entering, escaping, or completely crossing the membrane...
June 12, 2018: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29881185/electromagnetic-simulation-of-non-invasive-approach-for-the-diagnosis-of-diabetic-foot-ulcers
#7
Roshen Borkar, James Rizkalla, Youngmin Kwon, Paul Salama, Maher Rizkalla
Diabetic foot ulcers are systemic diseases that affect all blood vessels within the human body. From major blood vessels to microvasculature, hardening, thickening, and narrowing of blood vessels ultimately results to diminished blood flow to end organs. The detrimental effects of peripheral vascular disease are well recognized across medicine, particularly with regards to diabetic foot ulcers. Diabetic foot ulcers (DFU) are common across all fields of medicine, including but not limited to: orthopedics, vascular surgery, podiatry, general internal medicine, and infectious disease...
June 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29877828/active-hearing-mechanisms-inspire-adaptive-amplification-in-an-acoustic-sensor-system
#8
Jose Guerreiro, Andrew Reid, Joseph C Jackson, James F C Windmill
Over many millions of years of evolution, nature has developed some of the most adaptable sensors and sensory systems possible, capable of sensing, conditioning and processing signals in a very power- and size-effective manner. By looking into biological sensors and systems as a source of inspiration, this paper presents the study of a bioinspired concept of signal processing at the sensor level. By exploiting a feedback control mechanism between a front-end acoustic receiver and back-end neuronal based computation, a nonlinear amplification with hysteretic behavior is created...
June 2018: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/29877370/transmission-enabled-fiber-fabry-perot-cavity-based-on-a-deeply-etched-slotted-micromirror
#9
Muhammad A Othman, Yasser M Sabry, Mohamed Sadek, Ismail M Nassar, Diaa A Khalil
In this work, we report the analysis, fabrication, and characterization of an optical cavity built using a Bragg-coated fiber (BCF) mirror and a metal-coated microelectromechanical systems (MEMS) slotted micromirror, where the latter allows transmission output from the cavity. Theoretical modeling, using Fourier optics analysis for the cavity response based on tracing the propagation of light back and forth between the mirrors, is presented. Detailed simulation analysis is carried out for the spectral response of the cavity under different design conditions...
June 1, 2018: Applied Optics
https://www.readbyqxmd.com/read/29874856/an-evaluation-system-for-the-contact-electrification-of-a-single-microparticle-using-microelectromechanical-based-actuated-tweezers
#10
Daichi Yamaguchi
The image quality of laser and multi-function printers that make use of electrophotography depends on the amount of surface charge generated by contact electrification on the toner particles. However, because it has been impossible to experimentally evaluate such amounts under controlled contact conditions using macroscopic measurements, theoretical elucidation of the contact electrification mechanism has not progressed sufficiently. In the present study, we have developed a system to experimentally evaluate the contact electrification of a single particle using atomic force microscopy (AFM) and nanotweezers (microelectromechanical systems (MEMS)-based actuated tweezers)...
June 5, 2018: Sensors
https://www.readbyqxmd.com/read/29865271/design-of-low-cost-vehicle-roll-angle-estimator-based-on-kalman-filters-and-an-iot-architecture
#11
Javier Garcia Guzman, Lisardo Prieto Gonzalez, Jonatan Pajares Redondo, Susana Sanz Sanchez, Beatriz L Boada
In recent years, there have been many advances in vehicle technologies based on the efficient use of real-time data provided by embedded sensors. Some of these technologies can help you avoid or reduce the severity of a crash such as the Roll Stability Control (RSC) systems for commercial vehicles. In RSC, several critical variables to consider such as sideslip or roll angle can only be directly measured using expensive equipment. These kind of devices would increase the price of commercial vehicles. Nevertheless, sideslip or roll angle or values can be estimated using MEMS sensors in combination with data fusion algorithms...
June 3, 2018: Sensors
https://www.readbyqxmd.com/read/29865079/combination-therapy-of-serotonin-reuptake-inhibitors-and-memantine-for-obsessive-compulsive-disorder-a-meta-analysis-of-double-blind-randomized-placebo-controlled-trials
#12
Taro Kishi, Yuki Matsuda, Nakao Iwata
We performed a meta-analysis to determine whether combination therapy with serotonin reuptake inhibitors (SRIs) and memantine (MEM) was beneficial for the treatment of obsessive- compulsive disorder. This study included three double-blind, randomized, placebo-controlled trials. MEM+SRI was superior to placebo+SRI with regard to response rate [primary outcome, n = 97; risk ratio = 0.22; 95% confidence intervals (CI) = 0.12-0.42; p < 0.00001; I2 = 0%; number needed to treat = 2], the Yale- Brown Obsessive- Compulsive Scale total [standardized mean difference (SMD) = - 4...
May 28, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29862700/-walking-ability-assessment-system-for-parkinson-s-patients-based-on-inertial-sensor
#13
Junli Wen, Xianjun Yang, Shengqiang Xu, Yao Liu, Zheng Tang, Xiaolei Qiu, Nanjyu Xie, Yining Sun
In order to evaluate the ability of Parkinson's patients to walk comprehensively, a system based on MEMS to aid clinical quantification of ability in Parkinson's is established. The inertial units are respectively fixed on the back and the waist of subject to be measured. The Kalman fusion algorithm is used to extract the characteristic parameters of accelerometer and gyroscope data. SVM classifier is designed to train and test the classifier by the feature. The results show that the system possesses a high recognition rate for Parkinson's patients and normal subjects and for the classification of the walking ability of patients with Parkinson's disease...
November 30, 2017: Zhongguo Yi Liao Qi Xie za Zhi, Chinese Journal of Medical Instrumentation
https://www.readbyqxmd.com/read/29851333/detection-of-chemical-engagement-of-solute-carrier-proteins-by-cellular-thermal-shift-assay
#14
Mari Hashimoto, Enrico Girardi, Ruth Eichner, Giulio Superti-Furga
Solute carriers (SLCs) are transmembrane proteins transporting various nutrients, metabolites and drugs across cellular membranes. Despite the relevance of SLCs to cell homeostasis, metabolism and disease states, for the majority of SLCs we lack experimental evidence regarding the nature of the cognate ligands, whether endobiotic or xenobiotic. Moreo-ver, even for the roughly 20 SLCs for which inhibitors have been characterized, engagement assays in cells are limited to accessibility of radiolabeled or fluorescent probes...
May 31, 2018: ACS Chemical Biology
https://www.readbyqxmd.com/read/29846431/anethole-reduces-oxidative-stress-and-improves-in-vitro-survival-and-activation-of-primordial-follicles
#15
N A R Sá, J B Bruno, D D Guerreiro, J Cadenas, B G Alves, F W S Cibin, J H Leal-Cardoso, E L Gastal, J R Figueiredo
Primordial follicles, the main source of oocytes in the ovary, are essential for the maintenance of fertility throughout the reproductive lifespan. To the best of our knowledge, there are no reports describing the effect of anethole on this important ovarian follicle population. The aim of the study was to investigate the effect of different anethole concentrations on the in vitro culture of caprine preantral follicles enclosed in ovarian tissue. Randomized ovarian fragments were fixed immediately (non-cultured treatment) or distributed into five treatments: α-MEM+ (cultured control), α-MEM+ supplemented with ascorbic acid at 50 μg/mL (AA), and anethole at 30 (AN30), 300 (AN300), or 2000 µg/mL (AN2000), for 1 or 7 days...
2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29846273/are-we-ready-for-intercultural-cancer-care
#16
Patrick Crombez, Sandra Michiels, Dominique Bron
PURPOSE OF REVIEW: Migration is increasing worldwide, with accumulating evidence of health disparities. At the same time, oncology faces new challenges within a fast-changing care landscape. These two developments raise the question of integration of migrants and ethnic minorities (MEMs) and cultural influences in oncology. RECENT FINDINGS: Perceptions of health and disease differ substantially across and within societies and cultures. However, health needs of MEMs and cultural influences seem often out of the scope of cancer care...
May 24, 2018: Current Opinion in Oncology
https://www.readbyqxmd.com/read/29845788/conditioned-medium-protects-dopaminergic-neurons-in-parkinsonian-rats
#17
Malihe Nakhaeifard, Maryam Haji Ghasem Kashani, Iran Goudarzi, Arezou Rezaei
Objective: Adipose derived stem cells (ASCs) secrete numerous neurotrophic factors and cytokines in conditioned medium (CM), which protect neurons by its antioxidative and trophic effects. This research assesses the neuroprotective effect of ASCCM on neurotrophins genes expressions and tyrosine hydroxylase positive (TH+ ) cell density in male Wistar rats lesioned by 6-hydroxydopamine (6-OHDA). Materials and Methods: In this experimental study, the groups consisted of lesioned and sham rats with unilateral injections of 20 μg of 6-OHDA neurotoxin and phosphate buffered saline (PBS) into the striatum, respectively...
October 2018: Cell Journal
https://www.readbyqxmd.com/read/29844301/vibration-induced-errors-in-mems-tuning-fork-gyroscopes-with-imbalance
#18
Xiang Fang, Linxi Dong, Wen-Sheng Zhao, Haixia Yan, Kwok Siong Teh, Gaofeng Wang
This paper discusses the vibration-induced error in non-ideal MEMS tuning fork gyroscopes (TFGs). Ideal TFGs which are thought to be immune to vibrations do not exist, and imbalance between two gyros of TFGs is an inevitable phenomenon. Three types of fabrication imperfections (i.e., stiffness imbalance, mass imbalance, and damping imbalance) are studied, considering different imbalance radios. We focus on the coupling types of two gyros of TFGs in both drive and sense directions, and the vibration sensitivities of four TFG designs with imbalance are simulated and compared...
May 29, 2018: Sensors
https://www.readbyqxmd.com/read/29843892/insulin-like-growth-factor-1-igf-1-promotes-primordial-follicle-growth-and-reduces-dna-fragmentation-through-the-phosphatidylinositol-3-kinase-protein-kinase-b-pi3k-akt-signalling-pathway
#19
Maria É S Bezerra, Ricássio S Barberino, Vanúzia G Menezes, Bruna B Gouveia, Taís J S Macedo, Jamile M S Santos, Alane P O Monte, Vanessa R P Barros, Maria H T Matos
We investigated the effects of insulin-like growth factor 1 (IGF-1) on the morphology and follicular activation of ovine preantral follicles cultured in situ and whether the phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) pathway is involved in IGF-1 action in the sheep ovary. Ovine ovarian fragments were fixed for histological and terminal deoxynucleotidyl transferase dUTP nick-end labelling (TUNEL) analyses (fresh control) or cultured in supplemented alpha-minimum essential medium (α-MEM+; control) or α-MEM+ with IGF-1 (1, 10, 50, 100 or 200ngmL-1) for 7 days...
May 30, 2018: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/29843688/huatuo-zaizao-pill-ameliorates-cognitive-impairment-of-app-ps1-transgenic-mice-by-improving-synaptic-plasticity-and-reducing-a%C3%AE-deposition
#20
Jing-Hua Zhang, Lin-Jie Yu, Hui Yang, Zhen Hui, Su Jiang, Ling Chen, Yang Zhao, Su-Lei Wang, Yi Liu, Yun Xu
BACKGROUND: It is well known that Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by memory deficits and cognitive decline. Amyloid-β (Aβ) deposition and synaptic dysfunction play important roles in the pathophysiology of Alzheimer's disease (AD). The Huatuo Zaizao pill (HT) is a Traditional Chinese Medicine (TCM) that has been used clinically for many years in China, mainly for post-stroke rehabilitation and cognitive decline; however, the mechanism of cognitive function is not clear...
May 29, 2018: BMC Complementary and Alternative Medicine
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