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Jie Zhou, Aisha Roshan Mohamed Wali, Shengnan Ma, Yiyan He, Dong Yue, James Zhenggui Tang, Zhongwei Gu
In the progress of designing a gene carrier system, what is urgently needed is a balance of excellent safety and satisfactory efficiency. Herein, a straightforward and versatile synthesis of a cationic guanidine-decorated dendronized pullulan (OGG3P) for efficient genetic photodynamic therapy was proposed. OGG3P was able to block the mobility of DNA from a weight ratio of 2. However, G3P lacking guanidine residues could not block DNA migration until at a weight ratio of 15, revealing guanidination could facilitate DNA condensation via specific guanidinium-phosphate interactions...
April 24, 2018: Biomacromolecules
Yongwoo Lee, Jungmin Han, Bongsik Choi, Jinsu Yoon, Jinhee Park, Yeamin Kim, Jieun Lee, Dae Hwan Kim, Dong Myong Kim, Meehyun Lim, Min-Ho Kang, Sungho Kim, Sung-Jin Choi
Three-dimensional (3D) printers have attracted considerable attention from both industry and academia and especially in recent years due to their ability to overcome the limitations of two-dimensional (2D) processes and to enable large-scale facile integration techniques. With 3D printing technologies, complex structures can be created using only a computer-aided design (CAD) file as a reference; consequently, complex shapes can be manufactured in a single step with little dependence on manufacturer technologies...
April 24, 2018: ACS Applied Materials & Interfaces
Jeremy B Reeves, Rachael K Jayne, Thomas J Stark, Lawrence K Barrett, Alice E White, David J Bishop
The fabrication of metallic electromagnetic meta-atoms on a soft microstructured polymer scaffold using a MEMS-based stencil lithography technique is demonstrated. Using this technique, complex metasurfaces that are generally impossible to fabricate with traditional photolithographic techniques are created. By engineering the mechanical deformation of the polymer scaffold, the metasurface reflectivity in the mid-infrared can be tuned by the application of moderate strains.
April 23, 2018: Nano Letters
Donghwan Kim, Hyunsuk Lee, Joohyeon Bae, Hyomin Jeong, Byeongkeun Choi, Taehyun Nam, Jungpil Noh
Ti-Ni shape memory alloy (SMA) thin films are very attractive material for industrial and medical applications such as micro-actuator, micro-sensors, and stents for blood vessels. An important property besides shape memory effect in the application of SMA thin films is the adhesion between the film and the substrate. When using thin films as micro-actuators or micro-sensors in MEMS, the film must be strongly adhered to the substrate. On the other hand, when using SMA thin films in medical devices such as stents, the deposited alloy thin film must be easily separable from the substrate for efficient processing...
September 1, 2018: Journal of Nanoscience and Nanotechnology
Ramin Mirzazadeh, Saeed Eftekhar Azam, Stefano Mariani
Microscale uncertainties related to the geometry and morphology of polycrystalline silicon films, constituting the movable structures of micro electro-mechanical systems (MEMS), were investigated through a joint numerical/experimental approach. An on-chip testing device was designed and fabricated to deform a compliant polysilicon beam. In previous studies, we showed that the scattering in the input–output characteristics of the device can be properly described only if statistical features related to the morphology of the columnar polysilicon film and to the etching process adopted to release the movable structure are taken into account...
April 17, 2018: Sensors
Zhibo Ma, Yinan Wang, Qiang Shen, Han Zhang, Xuetao Guo
MEMS fabrication that is based on the silicon-on-glass (SOG) process requires many steps, including patterning, anodic bonding, deep reactive ion etching (DRIE), and chemical mechanical polishing (CMP). The effects of the process parameters of CMP and DRIE are investigated in this study. The process parameters of CMP, such as abrasive size, load pressure, and pH value of SF1 solution are examined to optimize the total thickness variation in the structure and the surface quality. The ratio of etching and passivation cycle time and the process pressure are also adjusted to achieve satisfactory performance during DRIE...
April 17, 2018: Sensors
Heng Guo, Qian Chen, Weizhi Qi, Xingxing Chen, Lei Xi
Brain imaging is an important technique in cognitive neuroscience. In this paper, we designed a stereotaxic-apparatus-compatible photoacoustic microscope for studies of rat cortical hemodynamics. Compared with existing OR-PAM systems, the probe owns feature of fast, light, and miniature. In this microscope, we integrated a miniaturized ultrasound transducer with a center frequency of 10 MHz to detect photoacoustic signals and a two-dimensional (2D) micro-electro-mechanical system (MEMS) scanner to achieve raster scanning of the optical focus...
April 19, 2018: Journal of Biophotonics
Lei Hou, Fei Feng, Wenbin You, Pengcheng Xu, Fan Luo, Bowen Tian, Haimei Zhou, Xinxin Li
Microfabricated semi-packed gas chromatography (GC) columns coated with two kinds of mesoporous silica (MS) stationary phase have been explored and compared in this paper. The micro GC (μGC) columns are fabricated by microelectromechanical system (MEMS) technique. MSs with pore size of 2 and 5 nm are prepared using two different soft-templates and deposited on the inner surface of the μGC columns by dip-coating. For the first time, the influence of pore size of MS stationary phase on the separation performance in a μGC column has been investigated...
April 3, 2018: Journal of Chromatography. A
Richard P Middlemiss, Steven G Bramsiepe, Rebecca Douglas, Stefan Hild, James Hough, Douglas J Paul, Antonio Samarelli, Sheila Rowan, Giles D Hammond
A microelectromechanical system (MEMS) gravimeter has been manufactured with a sensitivity of 40 ppb in an integration time of 1 s. This sensor has been used to measure the Earth tides: the elastic deformation of the globe due to tidal forces. No such measurement has been demonstrated before now with a MEMS gravimeter. Since this measurement, the gravimeter has been miniaturized and tested in the field. Measurements of the free-air and Bouguer effects have been demonstrated by monitoring the change in gravitational acceleration measured while going up and down a lift shaft of 20...
May 28, 2018: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
Andrew M Ayoob, Marcello Peppi, Vishal Tandon, Robert Langer, Jeffrey T Borenstein
Advances in microelectromechanical systems (MEMS) technologies are enhancing the development of intracochlear delivery devices for the treatment of hearing loss with emerging pharmacological therapies. Direct intracochlear delivery addresses the limitations of systemic and intratympanic delivery. However, optimization of delivery parameters for these devices requires pharmacokinetic assessment of the spatiotemporal drug distribution inside the cochlea. Robust methods of measuring drug concentration in the perilymph have been developed, but lack spatial resolution along the tonotopic axis or require complex physiological measurements...
April 5, 2018: Hearing Research
Megan Canavan, Dermot Daly, Andreas Rummel, Eoin K McCarthy, Cathal McAuley, Valeria Nicolosi
In-situ transmission electron microscopy is rapidly emerging as the premier technique for characterising materials in a dynamic state on the atomic scale. The most important aspect of in-situ studies is specimen preparation. Specimens must be electron transparent and representative of the material in its operational state, amongst others. Here, a novel fabrication technique for the facile preparation of lamellae for in-situ transmission electron microscopy experimentation using focused ion beam milling is developed...
March 29, 2018: Ultramicroscopy
Atalie C Thompson, Sandra Woolson, Maren K Olsen, Susanne Danus, Hayden B Bosworth, Kelly W Muir
Objective: To investigate whether electronically measured medication adherence is associated with vision-related quality of life (VRQoL) in patients with open-angle glaucoma. Methods and analysis: This is a 3-year prospective cohort study of 79 subjects with open-angle glaucoma at a Veterans Affairs medical centre. Participants returned a medication event monitoring system (MEMS) for their glaucoma eye-drops and had at least two visits with glaucoma during the study period...
2018: BMJ Open Ophthalmology
Bharat Sharma, Jung-Sik Kim
A low power, dual-gate field-effect transistor (FET) hydrogen gas sensor with graphene decorated Pd-Ag for hydrogen sensing applications was developed. The FET hydrogen sensor was integrated with a graphene-Pd-Ag-gate FET (GPA-FET) as hydrogen sensor coupled with Pt-gate FET as a reference sensor on a single sensor platform. The sensing gate electrode was modified with graphene by an e-spray technique followed by Pd-Ag DC/MF sputtering. Morphological and structural properties were studied by FESEM and Raman spectroscopy...
April 12, 2018: Scientific Reports
Haifeng Xing, Zhiyong Chen, Haotian Yang, Chengbin Wang, Zhihui Lin, Meifeng Guo
The micro-electro-mechanical-system (MEMS) inertial measurement unit (IMU) has been widely used in the field of inertial navigation due to its small size, low cost, and light weight, but aligning MEMS IMUs remains a challenge for researchers. MEMS IMUs have been conventionally aligned on a static base, requiring other sensors, such as magnetometers or satellites, to provide auxiliary information, which limits its application range to some extent. Therefore, improving the alignment accuracy of MEMS IMU as much as possible under swing conditions is of considerable value...
April 12, 2018: Sensors
Y D Ma, D Huang, Y F Chen, H Y Jiang, J H Liu, H Q Sun, Z H Li
OBJECTIVE: To explore an electrode suitable for wireless portable sleep monitoring equipment and analyze the result of the signals of electrooculogram (EOG) and electroencephalography (EEG) collected by this kind of flexible electrodes. METHODS: The flexible electrodes were prepared by microelectromechanical systems (MEMS) technology. This kind of electrodes consisted parylene, chromium, and gold. Parylene, the flexible substrate of this kind of flexible electrodes, was of biocompatibility...
April 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Jiaying Du, Christer Gerdtman, Maria Lindén
Motion sensors such as MEMS gyroscopes and accelerometers are characterized by a small size, light weight, high sensitivity, and low cost. They are used in an increasing number of applications. However, they are easily influenced by environmental effects such as temperature change, shock, and vibration. Thus, signal processing is essential for minimizing errors and improving signal quality and system stability. The aim of this work is to investigate and present a systematic review of different signal error reduction algorithms that are used for MEMS gyroscope-based motion analysis systems for human motion analysis or have the potential to be used in this area...
April 6, 2018: Sensors
Wen Chen, Lei Zhang, Zhong-Qi Zhou, Yue-Qin Ren, Li-Na Sun, Yu-Lin Man, Zhong-Wei Ma, Zhi-Kui Wang
BACKGROUND/AIMS: Chronic renal failure (CRF) is usually associated with chronic diseases such as congestive heart failure and diabetes mellitus, the prevalence of which is increased with age. This study is designed to investigate the role of long intergenic non-coding RNA (lincRNA) LINC00963 in renal interstitial fibrosis (RIF) and oxidative stress (OS) of CRF via the forkhead box O (FoxO) signaling pathway. METHODS: Microarray data and annotated probe files related to CRF were downloaded by retrieving Gene Expression Omnibus (GEO) database to screen differentially expressed lncRNA...
March 29, 2018: Cellular Physiology and Biochemistry
S Hoda Moosavi, Danny Kojda, Maximilian Kockert, Saskia F Fischer, Michael Kroener, Peter Woias
In order to study the thermoelectric properties of individual nanowires, a thermoelectric nanowire characterization platform (TNCP) has been previously developed and used in our chair. Here, we report on a redesigned platform aiming to optimize performance, mechanical stability and usability. We compare both platforms for electrical conductivity and the Seebeck coefficient for an individual Ag nanowire of the previously-used batch and for comparable measurement conditions. By this, the measurement performance of both designs can be investigated...
April 5, 2018: Nanomaterials
Courtney N Hemphill, Tryon A Wickersham, Jason E Sawyer, T M Brown-Brandl, Harvey C Freetly, Kristin E Hales
The objective of this study was to determine if feeding monensin would improve diet digestion, energy and nitrogen balance in bred heifers receiving a limit-fed corn stalk-based diet. Sixteen pregnant Meat Animal Research Center (MARC) III composite heifers were used in a 161-d completely randomized design. Heifers were randomly assigned to one of two treatments, no monensin (CON) or 150 mg/d monensin (MON), with eight heifers in each treatment group. Heifers were limit-fed a corn stalk-based diet at 100% of MEm requirements...
April 2, 2018: Journal of Animal Science
Rong-Quan He, Mei-Jiao Qin, Peng Lin, Yi-Huan Luo, Jie Ma, Hong Yang, Xiao-Hua Hu, Gang Chen
BACKGROUND/AIMS: Whether the level of long noncoding RNA plasmacytoma variant translocation 1 gene (lncRNA PVT1) expression influences the clinical development and outcome of human cancers has not been thoroughly elucidated to date. Inconsistencies still exist regarding the associations between PVT1 and the clinicopathological features, including patient survival data. Additionally, the regulatory mechanism of PVT1 among human cancers remains unclear. METHODS: we conducted a comprehensive inquiry to verify the implication of PVT1 expression in cancer patients by conducting a meta-analysis of 19 selected studies and The Cancer Genome Atlas (TCGA) database to examine the relationship between PVT1 expression and both the prognosis and clinicopathological features of cancer patients using STATA 12...
March 28, 2018: Cellular Physiology and Biochemistry
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