Fernanda Sarquis Jehee, Luis G Alonso, Denise P Cavalcanti, Chong Kim, Steven A Wall, John B Mulliken, Miao Sun, Ethylin Wang Jabs, Simeon A Boyadjiev, Andrew O M Wilkie, Maria Rita Passos-Bueno
OBJECTIVE: Screen the known craniosynostotic related gene, FGFR1 (exon 7), and two new identified potential candidates, CER1 and CDON, in patients with syndromic and nonsyndromic metopic craniosynostosis to determine if they might be causative genes. DESIGN: Using single-strand conformational polymorphisms (SSCPs), denaturing high-performance liquid chromatography, and/or direct sequencing, we analyzed a total of 81 patients for FGFR1 (exon 7), 70 for CER1, and 44 for CDON...
March 2006: Cleft Palate-craniofacial Journal