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https://www.readbyqxmd.com/read/28454469/regulation-of-cytotoxicity-and-apoptosis-associated-pathways-contributes-to-the-enhancement-of-efficacy-of-cisplatin-by-baicalein-adjuvant-in-human-a549-lung-cancer-cells
#1
Suparata Kiartivich, Ying Wei, Jiaqi Liu, Rungtip Soiampornkul, Mihui Li, Hongying Zhang, Jingcheng Dong
Scutellaria baicalensis (SB; Chinese name, huangqin) is widely used in Chinese medicine as a traditional adjuvant in the chemotherapy of lung and liver cancer. Baicalein is one of the bioactive flavonoid components isolated from the root of SB. The present study aimed to observe the effect of baicalein, in combination with platin-based systemic chemotherapy (cisplatin), on cytotoxicity and apoptosis of human A549 lung cancer cells. The cell cultures were treated with baicalein, cisplatin, or a combination of the two...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454464/metastasis-from-a-primary-hepatic-angiosarcoma-to-the-colon-a-case-report-and-literature-review
#2
Yukako Mokutani, Taishi Hata, Yuichiro Miyake, Hideki Kuroda, Hidekazu Takahashi, Naotsugu Haraguchi, Junichi Nishimura, Tsunekazu Mizushima, Hirofumi Yamamoto, Yuichiro Doki, Masaki Mori
Primary hepatic angiosarcoma is a rare type of tumor with a poor prognosis. To the best of our knowledge, curative surgery of a metastatic gastrointestinal angiosarcoma from a hepatic angiosarcoma has not been reported previously. In the present report, a case of colonic metastasis from a primary hepatic angiosarcoma is discussed. A rapidly growing mass was identified in the liver of an 84-year-old Japanese male who underwent a subsegmentectomy of the liver. Microscopic examination determined that the mass was an angiosarcoma composed of sheets of spindle cells...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454444/anterior-mediastinum-invasion-by-multiple-myeloma-a-case-report
#3
Ying-Hui Xu, Lu-Guo Sun, Chao Sun, Ou Bai, Ting-Ting Liang, Ke-Wei Ma
Multiple myeloma (MM) is a clonal proliferation of malignant plasma cells in the bone marrow (BM) that secretes monoclonal paraproteins in the blood serum and urine. Bone marrow MM cells can invade and damage the functions of other tissues and organs, such as the lungs, spleen, liver, pancreas, kidneys and lymph nodes. However, the invasion of MM cells primarily located in the BM to the anterior mediastinum at the site of the thymus is an extremely rare event. The current study reports the case of a 53-year-old female who presented with MM with involvement of the anterior mediastinum...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454406/carcinoid-syndrome-from-a-carcinoid-tumor-of-the-pancreas-without-liver-metastases-a-case-report-and-literature-review
#4
Nikolaos Zavras, Demetrios Schizas, Nikolaos Machairas, Vasileia Damaskou, Nikolaos Economopoulos, Anastasios Machairas
A carcinoid tumor of the pancreas (CTP) is a rare pancreatic neoplasm, and usually presents with carcinoid syndrome (CS). CS consists of the classic symptom triad of cutaneous flushing, diarrhea and valvular disease, and occurs in the majority of patients with liver metastases. In the present study, the patient presented with symptoms of CS. A diagnosis of CTP with CS was suspected due to high levels of urine 5-hydroxyindolacetic acid, and this was confirmed by a fine-needle aspiration biopsy. Computed tomography showed extended lymphadenopathy, but no liver metastases...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454405/expression-of-b-cell-translocation-gene-2-is-associated-with-favorable-prognosis-in-hepatocellular-carcinoma-patients-and-sensitizes-irradiation-induced-hepatocellular-carcinoma-cell-apoptosis-in-vitro-and-in-nude-mice
#5
Yuanyuan Chen, Chuan Chen, Zhimin Zhang, He Xiao, Bijing Mao, Huan Huang, Chenchen Ding, Lin Lei, Hui Zhang, Jian Li, Mei Jiang, Ge Wang
B-cell translocation gene 2 (BTG2) proteins have been reported to be putative tumor suppressors in various cancer types. The present study first assessed BTG2 expression in 44 human liver cancer tissue specimens, then investigated BTG2 expression in the regulation of hepatocellular carcinoma (HCC) cell apoptosis with or without radiotherapy in vitro and in vivo. The results revealed that BTG2 protein expression was significantly reduced in HCC tissues, and associated with better survival for HCC patients (P=0...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454376/expression-and-function-of-mutt-homolog-1-in-distinct-subtypes-of-breast-cancer
#6
Xiaohui Zhang, Wei Song, Yidong Zhou, Feng Mao, Yan Lin, Jinghong Guan, Qiang Sun
Human MutT homolog 1 (MTH1) detoxifies the oxidized DNA precursor 8-oxo-2'-deoxyguanosine-5'-triphosphate and serves a tumor suppressive role in distinct types of cancer. In the present study, the expression of MTH1 was examined in various subtypes of breast cancer, and the effect of its suppression on breast cancer growth was characterized in vitro and in vivo. MTH1 mRNA and protein levels were assessed using the reverse transcription-quantitative polymerase chain reaction and immunohistochemistry. The effect of MTH1 expression on the proliferation of breast cancer cells was investigated in vitro using Cell Counting Kit-8 and colony formation assays, and in vivo using breast cancer cell line xenografts in mice...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454333/a-polysaccharide-component-from-strongylocentrotus-nudus-eggs-inhibited-hepatocellular-carcinoma-in-mice-by-activating-t-lymphocytes
#7
Min Zhang, Yang Liu, Jingwen Li, Mengyun Ke, Jie Yu, Jie Dou, Hui Wang, Changlin Zhou
A component purified from Strongylocentrotus nudus eggs on a diethylaminoethyl cellulose-52 chromatography column and eluted using a NaCl solution gradient (SEP-S), is a homogeneous polysaccharide of α-D-glucan with a reduced molecular weight of 9.33×10(5) Da, compared with that of S. nudus egg polysaccharide (SEP). In an in vivo antitumor assay of histocompatibility-22 hepatocellular carcinoma in tumor-bearing mice, the inhibitory rates at SEP-S doses of 5, 10 and 20 mg/kg/day were 38.8, 50.7 and 70.3%, respectively...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454323/microrna-29a-b-c-targets-inos-and-is-involved-in-protective-remote-ischemic-preconditioning-in-an-ischemia-reperfusion-rat-model-of-non-alcoholic-fatty-liver-disease
#8
Yun-Fei Duan, Dong-Lin Sun, Jing Chen, Feng Zhu, Yong An
Remote ischemic preconditioning (RIPC) protects against the injury that is incurred by ischemia and reperfusion (IR); however, the role of RIPC in liver IR injury in non-alcoholic fatty liver disease (NAFLD) remains unclear. In this study, a NAFLD rat model was utilized in a series of different surgical procedures and molecular experiments. Rats of the IR group and the RIPC+IR group exhibited more severe injury than NAFLD control rats (in which the liver was prodded following a median-incision laparotomy). The liver condition, measured by serum alanine transaminase and aspartate transaminase levels, of the RIPC+IR group was better than that of the IR group...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454310/downregulation-of-lkb1-promotes-tumor-progression-and-predicts-unfavorable-prognosis-in-patients-with-glioma
#9
Jiehao Huang, Hongwu Chen, Quantang Wei, Ziheng Zhang, Zhiwei Zhong, Yimin Xu
The liver kinase B1 (LKB1)/5'-adenosine monophosphate-activated protein kinase pathway has been reported to facilitate glioma cell growth by improving growth conditions. To investigate the clinical significance of LKB1 in human gliomas western blot analysis and quantitative polymerase chain reaction experiments were performed. The present study demonstrated that LKB1 expression was markedly decreased at the messenger RNA and protein levels in 30 freshly prepared glioma tissues, compared with non-neoplastic brain tissues (P<0...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454305/microrna-profile-of-hepatic-epithelioid-hemangioendothelioma-a-case-report
#10
Asahiro Morishita, Hisakazu Iwama, Hirohito Yoneyama, Teppei Sakamoto, Koji Fujita, Takako Nomura, Joji Tani, Hisaaki Miyoshi, Shintaro Fujihara, Noriko Nishiyama, Hideki Kobara, Hirohito Mori, Naoki Yamamoto, Keiichi Okano, Yasuyuki Suzuki, Emi Ibuki, Reiji Haba, Takashi Himoto, Tsutomu Masaki
A 72-year-old female was referred for further evaluation of epigastralgia. Abdominal contrast computed tomography revealed numerous tumors in the two lobes of the liver. Liver biopsy and immunohistochemical staining revealed that the tumor cells were positive for factor VIII-associated antigen, platelet endothelial cell adhesion molecule 1 and human hematopoietic progenitor cell antigen, concordant with a diagnosis of hepatic epithelioid hemangioendothelioma (HEH). To elucidate the etiology of HEH, particularly the microRNA (miRNA) profiles, tissue samples obtained from normal and tumor tissues were analyzed using a miRNA array system...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454301/immunohistochemical-profile-of-ing3-protein-in-normal-and-cancerous-tissues
#11
Wen-Feng Gou, Xue-Feng Yang, Dao-Fu Shen, Shuang Zhao, Hong-Zhi Sun, Jun-Sheng Luo, Hua-Chuan Zheng
The inhibitor of growth family, member 3 (ING3) protein may be capable of blocking the cell cycle via activating p53-transactivated promoters of p21 and Bcl2-associated X protein, and may induce apoptosis via a Fas/caspase-8-dependent signaling pathway. In the present study, immunohistochemistry was performed in order to characterize the expression profile of ING3 protein in tissue microarrays containing mouse and human normal tissue, human hepatocellular (n=62), renal clear cell (n=62), pancreatic (n=62), esophageal squamous cell (n=45), cervical squamous cell (n=31), breast (n=144), gastric (n=196), colorectal (n=96), ovarian (n=208), endometrial (n=96) and lung carcinoma (n=192)...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454295/nima-related-kinase-2-regulates-hepatocellular-carcinoma-cell-growth-and-proliferation
#12
Xiao-Bo Lai, Yu-Qiang Nie, Hong-Li Huang, Ying-Fei Li, Chuang-Yu Cao, Hui Yang, Bo Shen, Zhi-Qiang Feng
NIMA-related kinase 2 (Nek2) is often upregulated in human cancer and is important in regulating the cell cycle and gene expression, and maintaining centrosomal structure and function. The present study aimed to investigate the expression pattern, clinical significance, and biological function of Nek2 in hepatocellular carcinoma (HCC). mRNA and protein levels of Nek2 were examined in HCC and corresponding normal liver tissues. The MTT and soft agar colony formation assays, and flow cytometry were employed to assess the roles of Nek2 in cell proliferation and growth...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454263/investigation-of-the-cytotoxicity-apoptosis-and-pharmacokinetics-of-raddeanin-a
#13
Guiying Gu, Huanhuan Qi, Tianyue Jiang, Bo Ma, Zheng Fang, Hong Xu, Qi Zhang
Raddeanin A, one of the triterpenoid saponins extracted from Anemone raddeana rhizome of the Ranunculaceae family, has demonstrated the ability to inhibit the growth of human hepatic and gastric cancer cells. However, the effects of Raddeanin A on human colon cancer cells have not been investigated extensively. The present study aimed to examine the antiproliferative and apoptosis-inducing effects of Raddeanin A on the HCT-116 human colon cancer cell line in vitro, and evaluate the pharmacokinetic and biodistribution properties of Raddeanin A in mice following a single oral administration...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454262/aberrant-klk4-gene-promoter-hypomethylation-in-pediatric-hepatoblastomas
#14
Baihui Liu, Ximao Cui, Shan Zheng, Kuiran Dong, Rui Dong
DNA methylation has a crucial role in cancer biology and has been recognized as an activator of oncogenes and inactivator of tumor suppressor genes, both of which are mechanisms for tumorigenesis. Kallikrein-related peptidase 4 (KLK4), has been suggested to be an oncogene in various types of cancer. The aim of the present study was to assess the DNA methylation patterns of the KLK4 gene in cancerous samples harvested from patients with hepatoblastoma (HB). KLK4 mRNA expression levels were detected using reverse transcription-quantitative polymerase chain reaction and assessed its DNA methylation patterns using high-throughput mass spectrometry on a matrix-assisted laser desorption/ionization time-of-flight mass array...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454239/downregulation-of-tumor-protein-53-inducible-nuclear-protein-1-expression-in-hepatocellular-carcinoma-correlates-with-poor-prognosis
#15
Yan Deng, Ai-Min Li, Xin-Mei Zhao, Zhang-Juan Song, Si-De Liu
The expression of tumor protein 53-inducible nuclear protein 1 (TP53INP1) is upregulated in certain cancers and downregulated in others. However, its expression in hepatocellular carcinoma (HCC) is not clear. The present study aimed to investigate the expression and prognostic value of TP53INP1 and its association with clinicopathological parameters in HCC. TP53INP1 expression in HCC tissue samples was examined via immunohistochemistry, western blotting and reverse transcription-quantitative polymerase chain reaction...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454235/metabolic-profiling-of-hepatitis-b-virus-related-hepatocellular-carcinoma-with-diverse-differentiation-grades
#16
Lei Zhang, Ya Huang, Mingjian Lian, Zhijuan Fan, Yaqiong Tian, Yufan Wang, Hua Kang, Shuang Liu, Shuye Liu, Tong Li, Zhongqiang Shan
The most effective diagnostic tool for the majority of hepatocellular carcinoma (HCC) patients is determining the differentiation grade of their tumors. However liver biopsies, which are currently the most effective way of determining tumor differentiation grade, have several limitations. The present study was designed to select serum characteristic metabolites that correlate with the differentiation grades of hepatitis B virus (HBV)-related HCC, and so could be used in the clinic as a non-invasive method of differentiating patients with different grades of HCC...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454103/subchronic-arsenism-induced-oxidative-stress-and-inflammatory-contribute-to-apoptosis-through-mitochondrial-and-death-receptor-dependent-pathways-in-chicken-immune-organs
#17
Hongjing Zhao, Ying He, Siwen Li, Xiao Sun, Yu Wang, Yizhi Shao, Zhijun Hou, Mingwei Xing
In many organ dysfunctions, arsenic and its compounds are well known to induce apoptosis by the mitochondria and death receptor apoptotic pathways in liver and airway. However, it is less reported that which signaling pathways contribute to excessive apoptosis of chicken immune organs, a major target of toxic metals biotransformation, which suffer from subchronic arsenism. In this study, we investigated whether the mitochondria or death receptor apoptotic pathways activated in the immune organs (spleen, thymus and bursa of Fabricius) of one-day-old male Hy-line chickens exposed to arsenic trioxide (As2O3), which were fed on diets supplemented with 0, 0...
April 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28454097/upregulation-of-calprotectin-in-mild-ige-mediated-ovalbumin-hypersensitivity
#18
Qingling Zhu, Feng Li, Junli Wang, Jingqiu Ma, Xiaoyang Sheng
Calprotectin, also known as S100A8/A9, has been linked to gut inflammation caused by IgE-mediated food hypersensitivities, but the pathophysiologic abnormalities it causes remain to be determined. We created a mild food hypersensitivity model through oral gavage of ovalbumin in Norway brown rats without using immune adjuvant. Changes in the levels of calprotectin and inflammation-associated cytokines were then observed over time. We found that fecal calprotectin as well as jejunal and liver TLR4, TNF-α, NF-κB, IL-1β, and IL-6 were upregulated in hypersensitive rats...
April 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28454084/preliminary-biological-evaluation-of-18f-alf-nota-mal-cys-annexin-v-as-a-novel-apoptosis-imaging-agent
#19
Chunxiong Lu, Quanfu Jiang, Minjin Hu, Cheng Tan, Huixin Yu, Zichun Hua
A novel annexin V derivative (Cys-Annexin V) with a single cysteine residue at its C-terminal has been successfully labeled site-specifically with NOTA-maleimide aluminum [18F]fluoride complexation and evaluated it as a novel apoptosis agent in vitro and in vivo. The total synthesis time of 18F-AlF-NOTA-MAL-Cys-Annexin V from [18F]fluoride was about 65 min. The tracer was stable in vitro and it was excreted through renal in normal mice. The rate of the tracer bound to erythrocytes with exposed phosphatidylserine was 89...
April 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28454041/long-term-intake-of-a-high-protein-diet-increases-liver-triacylglycerol-deposition-pathways-and-hepatic-signs-of-injury-in-rats
#20
Rubén Díaz-Rúa, Jaap Keijer, Andreu Palou, Evert M van Schothorst, Paula Oliver
Intake of high-protein (HP) diets has increased over the last years, mainly due to their popularity for body weight control. Liver is the main organ handling ingested macronutrients and it is associated with the beginning of different pathologies. We aimed to deepen our knowledge on molecular pathways affected by long-term intake of an HP diet. We performed a transcriptome analysis on liver of rats chronically fed with a casein-rich HP diet and analyzed molecular parameters related to liver injury. Chronic increase in the dietary protein/carbohydrate ratio up-regulated processes related with amino acid uptake/metabolism and lipid synthesis, promoting a molecular environment indicative of hepatic triacylglycerol (TG) deposition...
April 19, 2017: Journal of Nutritional Biochemistry
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