Anella Saviano, Anna Schettino, Nunzia Iaccarino, Adel Abo Mansour, Jenefa Begum, Noemi Marigliano, Federica Raucci, Francesca Romano, Gelsomina Riccardi, Emma Mitidieri, Roberta d'Emmanuele di Villa Bianca, Ivana Bello, Elisabetta Panza, Martina Smimmo, Valentina Vellecco, Peter Rimmer, Jonathan Cheesbrough, Zhaogong Zhi, Tariq H Iqbal, Stefano Pieretti, Vincenzo Maria D'Amore, Luciana Marinelli, Valeria La Pietra, Raffaella Sorrentino, Luisa Costa, Francesco Caso, Raffaele Scarpa, Giuseppe Cirino, Antonio Randazzo, Mariarosaria Bucci, Helen Michelle McGettrick, Asif Jilani Iqbal, Francesco Maione
Inflammatory bowel diseases (IBDs) are chronic intestinal disorders often characterized by a dysregulation of T cells, specifically T helper (Th) 1, 17 and T regulatory (Treg) repertoire. Increasing evidence demonstrates that dietary polyphenols from Mangifera indica L. extract (MIE, commonly known as mango) mitigate intestinal inflammation and splenic Th17/Treg ratio. In this study, we aimed to dissect the immunomodulatory and anti-inflammatory properties of MIE using a reverse translational approach, by initially using blood from an adult IBD inception cohort and then investigating the mechanism of action in a preclinical model of T cell-driven colitis...
March 23, 2024: Journal of Autoimmunity