Kaira C P Tomaz, Tatyana A Tavella, Joyce V B Borba, Luis C Salazar-Alvarez, João E Levandoski, Melina Mottin, Bruna K P Sousa, José T Moreira-Filho, Vitor M Almeida, Leandro C Clementino, Catarina Bourgard, Katlin B Massirer, Rafael M Couñago, Carolina H Andrade, Per Sunnerhagen, Elizabeth Bilsland, Gustavo C Cassiano, Fabio T M Costa
Drug resistance to commercially available antimalarials is a major obstacle in malaria control and elimination, creating the need to find new antiparasitic compounds with novel mechanisms of action. The success of kinase inhibitors for oncological treatments has paved the way for the exploitation of protein kinases as drug targets in various diseases, including malaria. Casein kinases are ubiquitous serine/threonine kinases involved in a wide range of cellular processes such as mitotic checkpoint signaling, DNA damage response, and circadian rhythm...
October 11, 2023: Antimicrobial Agents and Chemotherapy