Maxime Guéguinou, Romain Felix, Séverine Marionneau-Lambot, Thibauld Oullier, Aubin Penna, Sana Kouba, Audrey Gambade, Yann Fourbon, David Ternant, Christophe Arnoult, Gaëlle Simon, Ana Maria Bouchet, Aurélie Chantôme, Thomas Harnois, Jean-Pierre Haelters, Paul-Alain Jaffrès, Gunther Weber, Philippe Bougnoux, François Carreaux, Olivier Mignen, Christophe Vandier, Marie Potier-Cartereau
The Transient Receptor Potential Vanilloid type 2 (TRPV2) channel is highly selective for Ca2+ and can be activated by lipids, such as LysoPhosphatidylCholine (LPC). LPC analogues, such as the synthetic alkyl-ether-lipid edelfosine or the endogenous alkyl-ether-lipid Platelet Activating Factor (PAF), modulates ion channels in cancer cells. This opens the way to develop alkyl-ether-lipids for the modulation of TRPV2 in cancer. Here, we investigated the role of 2-Acetamido-2-Deoxy-l-O-Hexadecyl-rac-Glycero-3-PhosphatidylCholine (AD-HGPC), a new alkyl-ether-lipid (LPC analogue), on TRPV2 trafficking and its impact on Ca2+ -dependent cell migration...
June 12, 2021: Cell Calcium