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https://www.readbyqxmd.com/read/29616339/major-hepatectomy-for-primary-hepatolithiasis-a-comparative-study-of-laparoscopic-versus-open-treatment
#1
Jian-Xin Peng, Ling-Zhi Wang, Jing-Fang Diao, Zhi-Jian Tan, Xiao-Sheng Zhong, Zhi-Peng Zhen, Gui-Hao Chen, Jun-Ming He
BACKGROUND: Due to higher technical requirements, laparoscopic major hepatectomy (LMH) for primary hepatolithiasis have been limited to a few institutions. This retrospective study was performed to evaluate the therapeutic safety, and perioperative and long-term outcomes of LMH versus open major hepatectomy (OMH) for hepatolithiasis. METHODS: From January 2012 to December 2016, 61 patients with hepatolithiasis who underwent major hepatectomy were enrolled, including 29 LMH and 32 OMH...
April 3, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29615085/expression-patterns-of-stat3-erk-and-estrogen-receptor-%C3%AE-are-associated-with-development-and-histologic-severity-of-hepatic-steatosis-a-retrospective-study
#2
Euno Choi, Won Kim, Sae Kyung Joo, Sunyoung Park, Jeong Hwan Park, Yun Kyung Kang, So-Young Jin, Mee Soo Chang
BACKGROUND: Hepatic steatosis renders hepatocytes vulnerable to injury, resulting in the progression of preexisting liver disease. Previous animal and cell culture studies implicated mammalian target of rapamycin (mTOR), signal transducer and activator of transcription-3 (STAT3), extracellular signal-regulated kinase (ERK) and estrogen-receptor α in the pathogenesis of hepatic steatosis and disease progression. However, to date there have been few studies performed using human liver tissue to study hepatic steatosis...
April 3, 2018: Diagnostic Pathology
https://www.readbyqxmd.com/read/29575227/peroral-cholangioscopy-guide-laser-lithotripsy-to-treat-regional-hepatolithiasis-without-stricture
#3
Ruohong Liu, Bingyin Zhang, Danqing Liu
Hepatectomy is the golden standard in treating hepatolithiasis. However, when the stones obstructed in certain segment of liver, the hepatectomy is technically difficult. What's more, for patient without significant lessening of liver volume nor stricture of obstructed ducts, a treatment which have the advantage of minimal invasion, faster recovery and most preservation of uninvolved liver is a burning desire. This article is protected by copyright. All rights reserved.
March 25, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29516989/circulating-microrna-21-as-a-prognostic-biological-marker-in-cholangiocarcinoma
#4
Chen-Hai Liu, Qiang Huang, Zhi-Yuan Jin, Fang Xie, Cheng-Lin Zhu, Zhen Liu, Chao Wang
Aims: The prognosis of cholangiocarcinoma (CCA) is generally poor because there is a lack of effective diagnostic tools including laboratory assessments and imageological examination. Therefore, a novel biological marker (biomarker) to effectively diagnose cancer is highly desirable in clinical. Previously, serum microRNAs as biomarkers of cancers have been reported. However, it was still unclear about the clinical significance of serum microRNA-21 (miR-21) expression levels for CCA. Materials and Methods: The serum samples were separately collected from fifty patients of CCA, 15 patients of hepatolithiasis, and 15 healthy volunteers; quantitative real-time polymerase chain reaction was used for measuring miR-21 expression level in serum...
January 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29505000/biliary-exploration-via-the-left-hepatic-duct-orifice-versus-the-common-bile-duct-in-left-sided-hepatolithiasis-patients-with-a-history-of-biliary-tract-surgery-a-randomized-controlled-trial
#5
Yong Zhou, Wen-Zhang Zha, Xu-Dong Wu, Ren-Gen Fan, Biao Zhang, Yong-Hua Xu, Cheng-Lin Qin, Jing Jia
BACKGROUND: Hepatectomy and additional common bile duct exploration are required for the treatment of left-sided hepatolithiasis (LSH). METHODS: Eligible LSH patients (n = 62) scheduled for open left lateral segmentectomy or left hemihepatectomy with intraoperative biliary exploration via the left hepatic duct orifice (LHD group, n = 35) or the common bile duct (CBD group, n = 27) were retrospectively studied. T-tube insertion was performed on selected patients...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29367038/laparoscopic-hepatectomy-produces-better-outcomes-for-hepatolithiasis-than-open-hepatectomy-an-updated-systematic-review-and-meta-analysis
#6
REVIEW
Xiaohong Liu, Xiaocui Min, Zhen Ma, Xiaodong He, Zhixing Du
BACKGROUND: The present meta-analysis focused on comparing the efficacy and safety of laparoscopic hepatectomy (LH) versus open hepatectomy (OH) for hepatolithiasis. In detail, short-term outcomes including operative time, intraoperative blood loss, intraoperative blood transfusion, postoperative time to oral intake, length of hospital stay, overall postoperative complication rate, initial residual stone, and stone recurrence were analyzed systematically. METHODS: PubMed, Embase, Web of Science and Cochrane Library were comprehensively searched for eligible studies up to Jun...
March 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29360613/minimally-invasive-surgery-versus-open-hepatectomy-for-hepatolithiasis-a-systematic-review-and-meta-analysis
#7
REVIEW
Jiao Lei, Junmin Huang, Xiaobo Yang, Yuan Zhang, Kecheng Yao
OBJECTIVE: Hepatectomy for hepatolithiasis can be performed by following an open approach or a minimally invasive surgery (MIS) approach. MIS is associated with theoretical advantages, but there is no consensus regarding to the best treatment method for hepatolithiasis. The objective of this study was to evaluate the clinical outcomes of MIS hepatectomy compared with those of open hepatectomy in hepatolithiasis patients. METHODS: A systematic literature search was performed using PubMed, Embase and Cochrane Library databases...
March 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29328070/nerve-growth-factor-upregulates-sirtuin-1-expression-in-cholestasis-a-potential-therapeutic-target
#8
Ming-Shian Tsai, Po-Huang Lee, Cheuk-Kwan Sun, Ting-Chia Chiu, Yu-Chun Lin, I-Wei Chang, Po-Han Chen, Ying-Hsien Kao
This study investigated the regulatory role of nerve growth factor (NGF) in sirtuin 1 (SIRT1) expression in cholestatic livers. We evaluated the expression of NGF and its cognate receptors in human livers with hepatolithiasis and the effects of NGF therapy on liver injury and hepatic SIRT1 expression in a bile duct ligation (BDL) mouse model. Histopathological and molecular analyses showed that the hepatocytes of human diseased livers expressed NGF, proNGF (a precursor of NGF), TrkA and p75NTR, whereas only p75NTR was upregulated in hepatolithiasis, compared with non-hepatolithiasis livers...
January 12, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29307573/total-laparoscopic-partial-hepatectomy-versus-open-partial-hepatectomy-for-primary-left-sided-hepatolithiasis-a-propensity-long-term-follow-up-analysis-at-a-single-center
#9
Shi Chen, Long Huang, Fu-Nan Qiu, Song-Qiang Zhou, Mao-Lin Yan, Yan-Nan Bai, Zhi-de Lai, Yi-Feng Tian, Yao-Dong Wang
BACKGROUND: This trial was performed to compare short- and long-term outcomes after laparoscopic left-sided hepatectomy and open left-sided hepatectomy. Left-sided hepatectomy is a novel, minimally invasive operative technique for primary left-sided hepatolithiasis, but it has not been accepted widely due to the limited information about short- and long-term outcomes, effectiveness, and safety compared with the open approach. METHODS: Patients who underwent left-sided hepatectomy between January 2007 and December 2016 were reviewed and grouped into the open left-sided hepatectomy and left-sided hepatectomy groups, according to propensity score matching in terms of age, sex, body mass index, liver function, location of stone, hepatitis serology, and comorbidity on a ratio of 1:1...
April 2018: Surgery
https://www.readbyqxmd.com/read/29237899/role-of-surgical-treatment-for-hepatolithiasis-associated-intrahepatic-cholangiocarcinoma-a-retrospective-study-in-a-single-institution
#10
Jian Xiao, Jisheng Zhu, Zhanying Liu, Renhua Wan, Yong Li, Weidong Xiao
CONTEXT: The extent of hepatectomy and lymph node dissection (LND) in the treatment of hepatolithiasis-associated intrahepatic cholangiocarcinoma (HL-iCCA) is still controversial. AIMS: The aim of this retrospective study was to evaluate the role of surgical treatment for HL-iCCA. METHODS: The clinical data of 63 patients with HL-iCCA who undergoing surgery between January 2005 and December 2015 were analyzed retrospectively. STATISTICAL ANALYSIS USED: All data were analyzed by the SPSS 17...
2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29209120/laparoscopic-vs-open-hepatectomy-for-hepatolithiasis-an-updated-systematic-review-and-meta-analysis
#11
Hui Li, Jun Zheng, Jian-Ye Cai, Shi-Hui Li, Jun-Bin Zhang, Xiao-Ming Wang, Gui-Hua Chen, Yang Yang, Gen-Shu Wang
AIM: To perform a meta-analysis on laparoscopic hepatectomy VS conventional liver resection for treating hepatolithiasis. METHODS: We conducted a systematic literature search on PubMed, Embase, Web of Science and Cochrane Library, and undertook a meta-analysis to compare the efficacy and safety of laparoscopic hepatectomy VS conventional open liver resection for local hepatolithiasis in the left or right lobe. Intraoperative and postoperative outcomes (time, estimated blood loss, blood transfusion rate, postoperative intestinal function recovery time, length of hospital stay, postoperative complication rate, initial residual stone, final residual stone and stone recurrence) were analyzed systematically...
November 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29208867/surgical-treatment-of-hepatolithiasis-our-experience-in-bangabandhu-sheikh-mujib-medical-university
#12
B C Das, M M Rahman, A K Biswas, S Shahriar, A Ahmed, Z R Khan
Recurrent cholangitis and sepsis are common complications after surgical treatment for hepatolithiasis as total clearance is not always possible. This retrospective study is designed to see the effect of our treatment for hepatolithiasis on stone clearance and post operative complications. We have treated 60 patients with hepatolithiasis surgically from September 2010 to September 2016 in the Department of Surgery, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. Various operative procedures were applied on the basis of location of stone and status of biliary tree...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29188532/lipopolysaccharide-stimulates-endogenous-%C3%AE-glucuronidase-via-pkc-nf-%C3%AE%C2%BAb-c-myc-signaling-cascade-a-possible-factor-in-hepatolithiasis-formation
#13
Dianbo Yao, Qianze Dong, Yu Tian, Chaoliu Dai, Shuodong Wu
Hepatolithiasis is commonly encountered in Southeastern and Eastern Asian countries, but the pathogenesis mechanism of stone formation is still not well understood. Now, the role of endogenous β-glucuronidase in pigment stones formation is being gradually recognized. In this study, the mechanism of increased expression and secretion of endogenous β-glucuronidase during hepatolithiasis formation was investigated. We assessed the endogenous β-glucuronidase, c-myc, p-p65, and p-PKC expression in liver specimens with hepatolithiasis by immunohistochemical staining, and found that compared with that in normal liver samples, the expression of endogenous β-glucuronidase, c-myc, p-p65, and p-PKC in liver specimens with hepatolithiasis significantly increased, and their expressions were positively correlated with each other...
November 29, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29174175/imaging-appearances-of-hepatic-tuberculosis-experience-with-12-patients
#14
L S Ch'ng, H Amzar, K C Ghazali, F Siam
AIM: To review computed tomography (CT), ultrasound (US), magnetic resonance cholangiopancreatography (MRCP), endoscopic retrograde cholangiopancreatography (ERCP) and percutaneous transhepatic cholangiogram (PTC) appearances and their diagnostic value in hepatic tuberculosis. MATERIALS AND METHODS: The imaging studies for 12 patients with biopsy-proven hepatic tuberculosis from January 2012 till March 2014 were reviewed retrospectively. These cases were confirmed via ultrasound-guided biopsy...
March 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29168230/routine-guidewire-application-facilitates-cholangioscopy-in-the-management-of-postoperative-residual-hepatolithiasis
#15
Xu-Dong Wen, Le Xiao, Tao Wang, Nalu Navarro-Alvarez, Wei-Hui Liu
BACKGROUND AND AIM: Although postoperative cholangioscopy (POC) is considered to be an effective treatment for residual hepatolithiasis after surgery, its security and validity still need to be improved. This study compared wire-guided POC (WG-POC) versus traditional POC (T-POC) in the management of patients with residual hepatolithiasis. METHODS: This retrospective study included a total of 203 patients who suffered from hepatolithiasis and underwent hepatectomy as initial intervention from 1 January 2016 to 1 January 2017...
November 23, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29147136/step-by-step-strategy-in-the-management-of-residual-hepatolithiasis-using-post-operative-cholangioscopy
#16
REVIEW
Xu-Dong Wen, Tao Wang, Zhu Huang, Hong-Jian Zhang, Bing-Yin Zhang, Li-Jun Tang, Wei-Hui Liu
Hepatolithiasis is the presence of calculi within the intrahepatic bile duct specifically located proximal to the confluence of the left and right hepatic ducts. The ultimate goal of hepatolithiasis treatment is the complete removal of the stone, the correction of the associated strictures and the prevention of recurrent cholangitis. Although hepatectomy could effectively achieve the above goals, it can be restricted by the risk of insufficient residual liver volume, and has a 15.6% rate of residual hepatolithiasis...
November 2017: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/29119290/a-proposed-severity-classification-system-for-hepatolithiasis-based-on-an-analysis-of-prognostic-factors-in-a-japanese-patient-cohort
#17
Yutaka Suzuki, Toshiyuki Mori, Masaaki Yokoyama, Sangchul Kim, Hirokazu Momose, Ryota Matsuki, Masaharu Kogure, Nobutsugu Abe, Hiroyuki Isayama, Takahiro Nakazawa, Kenji Notohara, Atsushi Tanaka, Toshio Tsuyuguchi, Susumu Tazuma, Hajime Takikawa, Masanori Sugiyama
BACKGROUND: Hepatolithiasis frequently results in severe complications. We conducted a cohort study to identify prognostic factors and to establish a hepatolithiasis severity classification system. METHODS: The study cohort comprised 396 patients who were identified through a 1998 nationwide survey and followed up for 18 years or until death. Cox regression analysis was used to identify prognostic factors. RESULTS: Median survival time of the patients was 308 (range 0-462) months...
November 8, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29079113/laparoscopic-versus-open-hepatectomy-approach-for-regional-hepatolithiasis-a-meta-analysis
#18
Hui Jiang, Ou Jiang, Xianming Xia, Song Su, Bo Li
BACKGROUND: In the present study, we aimed to compare laparoscopic hepatectomy (LH) with open hepatectomy (OH) approach in patients with regional hepatolithiasis (RHL) using meta-analytical techniques. METHODS: A systematic review of the literature was performed to identify studies comparing LH and OH in the management of RHL. Operative parameters, postoperative outcomes, and postoperative complications were evaluated. Meta-analysis was performed using Review Manage Version 5...
October 24, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28927985/the-efficacy-of-resection-of-intrahepatic-bile-duct-stenosis-causing-membrane-or-septum-for-preventing-hepatolithiasis-after-choledochal-cyst-excision
#19
Yujiro Tanaka, Takahisa Tainaka, Wataru Sumida, Chiyoe Shirota, Akinari Hinoki, Naruhiko Murase, Kazuo Oshima, Ryo Shirotsuki, Kosuke Chiba, Hiroo Uchida
BACKGROUND/PURPOSE: We previously found that many patients who developed hepatolithiasis after choledochal cyst excisions had intrahepatic bile duct stenosis (IHBDS). In 1992, we started resection of the membrane or septum which was found at the site of IHBDS during choledochal cyst excisions. Since intrahepatic stones usually take years to form, the efficacy of this procedure has not been proved. METHODS: The records of patients who had IHBDS-causing membrane or septum and underwent choledochal cyst excision with Roux-Y hepaticojejunostomy between January 1979 and December 2006 were retrospectively analyzed...
December 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28879598/implications-of-intrahepatic-cholangiocarcinoma-etiology-on-recurrence-and-prognosis-after-curative-intent-resection-a-multi-institutional-study
#20
Xu-Feng Zhang, Jeffery Chakedis, Fabio Bagante, Eliza W Beal, Yi Lv, Matthew Weiss, Irinel Popescu, Hugo P Marques, Luca Aldrighetti, Shishir K Maithel, Carlo Pulitano, Todd W Bauer, Feng Shen, George A Poultsides, Oliver Soubrane, Guillaume Martel, B Groot Koerkamp, Alfredo Guglielmi, Endo Itaru, Timothy M Pawlik
BACKGROUND: We sought to investigate the prognosis of patients following curative-intent surgery for intrahepatic cholangiocarcinoma (ICC) stratified by hepatitis B (HBV-ICC), hepatolithiasis (Stone-ICC), and no identifiable cause (conventional ICC) etiologic subtype. METHODS: 986 patients with HBV-ICC (n = 201), stone-ICC (n = 103), and conventional ICC (n = 682) who underwent curative-intent resection were identified from a multi-institutional database. Propensity score matching (PSM) was used to mitigate residual bias...
September 6, 2017: World Journal of Surgery
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