Jia Zhou, Yuchen Wang, Yangxin Fu, Zhe Lin, He Lin, Guangfu Lv, Ning Kong, Guo Xin, Fang Zhou, Zhidong Qiu, Xiaowei Huang
Ovarian cancer is a prevalent malignancy in the female reproductive system, representing a significantly fatal and incurable tumor. Chelerythrine (CHE), a natural benzopyridine alkaloid, has demonstrated a broad spectrum of anticancer activities. Nevertheless, the ovarian cancer inhibitory impact of CHE remains unclear. In this study, we investigated the cytotoxic mechanism and potential targets of CHE on in vitro cultures of A2780 and SKOV3 cells derived from ovarian cancer. Additionally, in vivo experiments were conducted to confirm the suppressive impact of CHE on tumor growth in nude mice...
March 31, 2024: Cellular and Molecular Biology