Ari D Kappel, Rohan Jha, Saibaba Guggilapu, William J Smith, Abdullah H Feroze, Adam A Dmytriw, Juan Vicenty-Padilla, Rodolfo E Alcedo Guardia, Florian A Gessler, Nirav J Patel, Rose Du, Alfred P See, Pier Paolo Peruzzi, Mohammad A Aziz-Sultan, Joshua D Bernstock
High-grade gliomas (HGGs) have a poor prognosis and are difficult to treat. This review examines the evolving landscape of endovascular therapies for HGGs. Recent advances in endovascular catheter technology and delivery methods allow for super-selective intra-arterial cerebral infusion (SSIACI) with increasing precision. This treatment modality may offer the ability to deliver anti-tumoral therapies directly to tumor regions while minimizing systemic toxicity. However, challenges persist, including blood-brain barrier (BBB) penetration, hemodynamic complexities, and drug-tumor residence time...
April 22, 2024: Cancers