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https://www.readbyqxmd.com/read/28432684/characterization-of-interactions-of-metal-containing-nanoparticles-with-biomolecules-by-ce-an-update-2012-2016
#1
REVIEW
Svetlana S Aleksenko, Magdalena Matczuk, Andrei R Timerbaev
The methodological developments and applications of CE related to studying biotransformations of metal-based nanoscale particles of impending medicinal use are overviewed. This is an update to a previous review article (Aleksenko, S. S., Shmykov, A. Y., Oszwałdowski, S., Timerbaev, A. R., Metallomics 2012, 4, 1141-1148) and it covers the research papers published within the last five years. As was anticipated in that review, CE can now be seen as a customary technique in the analysis of biomolecular interactions that exert an impact on the mechanism of action of nanoparticles, comprising metabolism, delivery, cell processing, and targeting...
April 22, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28426345/economic-evaluation-of-ezetimibe-treatment-in-combination-with-statin-therapy-in-the-united-states
#2
Glenn M Davies, Ami Vyas, Carl A Baxter
AIMS: This study assessed the cost-effectiveness of ezetimibe with statin therapy versus statin monotherapy from a United States (US) payer perspective, assuming the impending patent expiration of ezetimibe. METHODS: A Markov-like economic model consisting of 28 distinct health states was used. Model population data were obtained from US linked claims and electronic medical records, with inclusion criteria based on diagnostic guidelines. Inputs came from recent clinical trials, meta-analyses, and cost-effectiveness analyses...
April 20, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28424074/implementation-and-adaptation-of-the-re-engineered-discharge-red-in-five-california-hospitals-a-qualitative-research-study
#3
S E Mitchell, G M Weigel, V Laurens, J Martin, B W Jack
BACKGROUND: Project Re-Engineered Discharge (RED) is an evidence-based strategy to reduce readmissions disseminated and adapted by various health systems across the country. To date, little is known about how adapting Project RED from its original protocol impacts RED implementation and/or sustainability. The goal of this study was to identify and characterize contextual factors influencing how five California hospitals adapted and implemented RED and the subsequent impact on RED program sustainability...
April 19, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28420178/how-older-adults-and-their-families-perceive-family-talk-about-aging-related-eol-issues-a-dialectical-analysis
#4
Nichole Egbert, Jeffrey T Child, Mei-Chen Lin, Carol Savery, Tammy Bosley
For older adults, approaching end-of-life (EOL) brings unique transitions related to family relationships. Unfortunately, most families greatly underestimate the need to discuss these difficult issues. For example, parents approaching EOL issues often struggle with receiving assistance from others, avoiding family conflict, and maintaining their sense of personhood. In addition, discussions of EOL issues force family members to face their parents' mortality, which can be particularly difficult for adult children to process emotionally...
April 17, 2017: Behavioral Sciences
https://www.readbyqxmd.com/read/28405296/consumptive-and-nonconsumptive-effect-ratios-depend-on-interaction-between-plant-quality-and-hunting-behavior-of-omnivorous-predators
#5
Jörg G Stephan, Johan A Stenberg, Christer Björkman
Predators not only consume prey but exert nonconsumptive effects in form of scaring, consequently disturbing feeding or reproduction. However, how alternative food sources and hunting mode interactively affect consumptive and nonconsumptive effects with implications for prey fitness have not been addressed, impending functional understanding of such tritrophic interactions. With a herbivorous beetle, two omnivorous predatory bugs (plant sap as alternative food, contrasting hunting modes), and four willow genotypes (contrasting suitability for beetle/omnivore), we investigated direct and indirect effects of plant quality on the beetles key reproductive traits (oviposition rate, clutch size)...
April 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28402925/time-delays-associated-with-vasoactive-medication-preparation-and-delivery-in-simulated-patients-at-risk-of-cardiac-arrest
#6
P G Brindley, D O'Dochartaigh, C Volney, S Ryan, M J Douma
PURPOSE: To compare, quantify, and describe the time-delays associated with four common methods of adrenaline administration in the simulated setting of impending cardiac arrest. METHODS: Using sham medication and a high-fidelity simulator, experienced Nurses prepared, then delivered, adrenaline by: i) bolus, ii) lower-concentration infusion iii) higher-concentration infusion, and iv) higher-concentration infusion plus carrier-line. We recorded medication preparation and delivery time, plus administration errors and self-reported competence...
April 7, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28397363/improved-time-to-notification-of-impending-brain-death-and-increased-organ-donation-using-an-electronic-clinical-decision-support-system
#7
J L Zier, A B Spaulding, M Finch, T Verschaetse, R Tarrago
Early referral of patients to an organ procurement organization (OPO) may positively impact donation outcomes. We implemented an electronic clinic decision support (CDS) system to automatically notify our OPO of children meeting clinical triggers indicating impending brain death. Medical records of all patients who died in a pediatric critical care unit or were referred for imminent death for three years prior to installation of the initial CDS (pre-CDS) and for one year after implementation of the final CDS (post-CDS) were reviewed...
April 11, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28397177/bankruptcy-prevention-new-effort-to-reflect-on-legal-and-social-changes
#8
Tomas Kliestik, Maria Misankova, Katarina Valaskova, Lucia Svabova
Every corporation has an economic and moral responsibility to its stockholders to perform well financially. However, the number of bankruptcies in Slovakia has been growing for several years without an apparent macroeconomic cause. To prevent a rapid denigration and to prevent the outflow of foreign capital, various efforts are being zealously implemented. Robust analysis using conventional bankruptcy prediction tools revealed that the existing models are adaptable to local conditions, particularly local legislation...
April 10, 2017: Science and Engineering Ethics
https://www.readbyqxmd.com/read/28389464/chromatin-determinants-impart-camptothecin-sensitivity
#9
Fabio Puddu, Israel Salguero, Mareike Herzog, Nicola J Geisler, Vincenzo Costanzo, Stephen P Jackson
Camptothecin-induced locking of topoisomerase 1 on DNA generates a physical barrier to replication fork progression and creates topological stress. By allowing replisome rotation, absence of the Tof1/Csm3 complex promotes the conversion of impending topological stress to DNA catenation and causes camptothecin hypersensitivity. Through synthetic viability screening, we discovered that histone H4 K16 deacetylation drives the sensitivity of yeast cells to camptothecin and that inactivation of this pathway by mutating H4 K16 or the genes SIR1-4 suppresses much of the hypersensitivity of tof1∆ strains towards this agent...
April 7, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28387898/relationship-of-serum-novel-adipokine-chemerin-levels-with-body-composition-insulin-resistance-dyslipidemia-and-diabesity-in-saudi-women
#10
S S Habib, A Eshki, B AlTassan, D Fatani, H Helmi, S AlSaif
OBJECTIVE: Chemerin is believed to be a mediator for the adipose tissue inflammation that occurs in obesity. The present study compared chemerin levels between healthy and type 2 diabetic women matched for age and body composition. We also aimed to assess the relationship of serum chemerin levels with body composition, insulin resistance, dyslipidemia, and diabesity. PATIENTS AND METHODS: This observational case-control study was conducted at the Departments of Physiology and Medicine, Saud University Riyadh, Saudi Arabia, from September 2013 to April 2014...
March 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28386420/interaction-between-stimulus-contrast-and-pre-saccadic-crowding
#11
Mehmet N Agaoglu, Susana T L Chung
Objects that are briefly flashed around the time of saccades are mislocalized. Previously, robust interactions between saccadic perceptual distortions and stimulus contrast have been reported. It is also known that crowding depends on the contrast of the target and flankers. Here, we investigated how stimulus contrast and crowding interact with pre-saccadic perception. We asked observers to report the orientation of a tilted Gabor presented in the periphery, with or without four flanking vertically oriented Gabors...
February 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28383799/facile-synthesis-of-rod-like-cu2-xse-and-insight-into-its-improved-lithium-storage-property
#12
He Li, Jiali Jiang, Feng Wang, Jianxing Huang, Yunhui Wang, Yiyong Zhang, Jinbao Zhao
A rod-like Cu2-xSe is synthesized via a facile water evaporation process. The electrochemical reaction mechanism is investigated with ex-situ X-ray diffraction (XRD) test. By adopting ether-based electrolyte instead of carbonate-based electrolyte, the electrochemical performance of Cu2-xSe electrodes improves significantly. The Cu2-xSe electrodes exhibit outstanding cycle performance, after 1000 cycles, 160 mAh g-1 can be maintained with the retention of 80.3 %. At current density of 100, 200, 500 and 1000 mA g-1, the capacity of Cu2-xSe/Li battery is 208, 202, 200 and 198 mAh g-1, respectively, showing excellent rate capability...
April 6, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28382557/long-acting-injectable-antipsychotics-in-schizophrenia-literature-review-and-practical-perspective-with-a-focus-on-aripiprazole-once-monthly
#13
REVIEW
Enrico Biagi, Enrico Capuzzi, Fabrizia Colmegna, Alessandra Mascarini, Giulia Brambilla, Alessandra Ornaghi, Jacopo Santambrogio, Massimo Clerici
INTRODUCTION: Prevention of relapse is a major challenge in schizophrenia, a disease characterized by poor adherence to antipsychotic medication leading to multiple rehospitalizations and a substantial burden-of-care. METHODS: We narratively review published clinical data from the development of long-acting injectable (LAI) formulations of antipsychotic drugs and examine the comparative effectiveness of oral versus LAIs in schizophrenia, with a focus on the second-generation LAI antipsychotic aripiprazole...
April 5, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28381891/using-collaborative-drug-therapy-agreements-to-train-student-pharmacists-to-provide-clinical-patient-care-services
#14
Kimberly C McKeirnan, Julie M Akers, Jennifer C Czapinski, Jennifer D Robinson
Objective. To assess the impact of a new course designed to train student pharmacists to provide clinical patient care services delivered through collaborative drug practice agreements. Design. An intensive two-credit, one-week course with a combined self-study and interactive pedagogical approach was developed. Content from the online Washington State Pharmacy Association Clinical Community Pharmacist training program was integrated with a live, eight-hour seminar. Assessment. Student-pharmacist learning, effectiveness of content presented, and perceived value of the material were evaluated...
March 25, 2017: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28377700/two-types-of-receptive-field-dynamics-in-area-v4-at-the-time-of-eye-movements
#15
Till S Hartmann, Marc Zirnsak, Michael Marquis, Fred H Hamker, Tirin Moore
How we perceive the world as stable despite the frequent disruptions of the retinal image caused by eye movements is one of the fundamental questions in sensory neuroscience. Seemingly convergent evidence points towards a mechanism which dynamically updates representations of visual space in anticipation of a movement (Wurtz, 2008). In particular, receptive fields (RFs) of neurons, predominantly within oculomotor and attention related brain structures (Duhamel et al., 1992; Walker et al., 1995; Umeno and Goldberg, 1997), are thought to "remap" to their future, post-movement location prior to an impending eye movement...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28373759/insights-on-the-use-of-biosimilars-in-the-treatment-of-inflammatory-bowel-disease
#16
REVIEW
Michael K Zheng, David Q Shih, Gary C Chen
Biologic therapy, such as those that target tumor necrosis factor (TNF) signaling, has proven to be an efficacious method of treatment for patients with inflammatory bowel disease (IBD) with regards to symptom management and mucosal healing. However, the rising prevalence of IBD worldwide and the ever-increasing burden of biologic pharmaceuticals in the health care industry is alarming for insurance companies, clinicians, and patients. The impending patent expiry and the relatively high costs of biologics, particularly anti-TNF agents, have paved the way for biosimilar development for IBD...
March 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28373179/dual-incarcerated-internal-hernias-after-laparoscopic-total-gastrectomy-with-roux-en-y-reconstruction-for-gastric-cancer
#17
Zi Qin Ng, Willy Low, Pradeep Subramanian, Joel Stein
Internal hernia postgastrectomy is an exceedingly rare complication especially in the laparoscopic cohort of patients. Different types of internal hernias have been described, of which, Petersen's and jejunojejunostomy mesenteric defect hernias are the most commonly encountered followed by oesophageal defect and transverse colon mesocolic defect hernias. As the early presentation is always non-specific, late diagnosis of internal hernia has significant implication on morbidity and mortality. Here, we present a rare case of a patient with previous laparoscopy-assisted total gastrectomy presented with features of impending bowel obstruction and bowel ischaemia secondary to dual incarcerated internal hernias...
April 3, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28359825/bilateral-simultaneous-infective-keratitis
#18
Lai Hiu On Annie, Manotosh Ray
AIM: To analyze the demographics, risk factors, clinical and microbiological characteristics of cases of bilateral simultaneous infective keratitis. METHODS: In this retrospective case series, patients with clinical evidence of bilateral simultaneous infective keratitis were identified from January 1, 2011 to August 31, 2016. Demographics, risk factors, clinical and microbiological characteristics, and treatment outcomes were analyzed. RESULTS: Five patients (ten eyes) with bilateral simultaneous infective keratitis were identified...
March 27, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28358839/frequency-and-clinical-significance-of-short-cervix-in-patients-with-preterm-premature-rupture-of-membranes
#19
Seung Mi Lee, Kyo Hoon Park, Eun Young Jung, Ji Ae Jang, Ha-Na Yoo
OBJECTIVE: Cervical length measurement has been uggested as a useful tool for predicting intra-amniotic infection/inflammation in preterm labor, but little information is available in the setting of preterm premature rupture of membranes (pPROM). We aimed to determine whether a short cervical length is independently associated with an increased risk of intra-amniotic infection or inflammation and impending preterm delivery in women with pPROM. METHODS: This was a retrospective cohort study involving 171 consecutive singleton pregnant women with pPROM (21+0-33+6 weeks' gestation), who underwent amniocentesis...
2017: PloS One
https://www.readbyqxmd.com/read/28356682/dental-implants-in-children-a-multidisciplinary-perspective-for-long-term-success
#20
REVIEW
Nidhi Agarwal, Dipanshu Kumar, Ashish Anand, Surendrakumar Kaluram Bahetwar
Congenital hypodontia or trauma is a frequent cause of loss of teeth in children. The absence of teeth leads to loss of function and lack of normal alveolar growth, along with unpleasant esthetics that hamper the psychosocial development of the young child. Traditionally, the management of tooth loss in the young child is done by conservative means. None of those methods of treatment are completely satisfactory and have their own drawbacks. Dental implants in a young child would be an ideal mode of treatment for the absence of teeth...
July 2016: National Journal of Maxillofacial Surgery
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