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https://www.readbyqxmd.com/read/29775967/bilateral-breast-calciphylaxis-in-a-patient-who-survived-earlier-extensive-tissue-necrosis-5-years-previously-a-case-report
#1
E M J Verstappen, A J G Maaskant-Braat, M R Scheltinga
INTRODUCTION: Calciphylaxis is a rare condition including patchy dermal necrosis that mostly affects chronic hemodialysis patients. The syndrome usually heralds impending death although patients may survive following a set of measures including an adapted dialysis regimen. The present case is a unique patient who recovered from an earlier episode of upper leg calciphylaxis 5 years previously but developed fatal bilateral breast necrosis. PRESENTATION OF CASE: A 69 year old Caucasian woman with a history of atrial fibrillation, hypertension, CVA, hyperparathyroidectomy for secondary hyperparathyroidism and end stage renal disease with hemodialysis recovered in 2012 from extensive symptomatic left upper leg necrosis due to calciphylaxis...
May 7, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29775218/unilateral-movement-preparation-causes-task-specific-modulation-of-tms-responses-in-the-passive-opposite-limb
#2
Lilian Chye, Stephan Riek, Aymar de Rugy, Richard G Carson, Timothy J Carroll
Corticospinal excitability is modulated for muscles on both sides of the body during unilateral movement preparation. For the effector, there is a progressive increase in excitability, and a shift in direction of muscle twitches evoked by transcranial magnetic stimulation (TMS) toward the impending movement. By contrast, the directional characteristics of excitability changes in the opposite (passive) limb have not been fully characterized. Here we assessed how preparation of voluntary forces towards four spatially distinct visual targets with the left wrist alters muscle twitches and motor evoked potentials (MEPs) elicited by TMS of left motor cortex...
May 18, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29770571/using-poly-l-lactic-acid-and-poly-%C3%A9-caprolactone-blends-to-fabricate-self-expanding-watertight-and-biodegradable-surgical-patches-for-potential-fetoscopic-myelomeningocele-repair
#3
Rigwed Tatu, Marc Oria, Sarah Pulliam, Lorenzo Signey, Marepalli B Rao, Jose L Peiro, Chia-Ying Lin
Our study focuses on the development and characterization of a self-expanding, watertight and biodegradable patch for fetoscopic myelomeningocele (MMC) prenatal repair. We fabricated poly(l-lactic acid) (PLA) and poly(ɛ-caprolactone) (PCL) blend films by solution casting. Formulation c with average glass transition temperature of 37.6 ± 1.2°C was chosen for temporospatial recovery. Favorable results from surface studies reflected homogeneous dispersion of polymers in the blend. The cytotoxicity was studied in human foreskin fibroblasts...
May 16, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29761882/the-prevalence-of-obesity-in-children-and-young-people-with-down-syndrome
#4
Muireann O' Shea, Carol O' Shea, Louise Gibson, Jennifer Leo, Catherine Carty
BACKGROUND: Overweight and obesity is a growing concern among individuals with intellectual disabilities; however, little is known about the prevalence among children and youth with Down syndrome (CYDS). The purpose of this study was to determine the prevalence of overweight/obesity among CYDS in South West Ireland. METHODS: This cross-sectional study measured height and weight of 61 CYDS aged 4-16 years. Body mass index (BMI) was calculated and percentage body fat (PBF) was measured using bio-electrical impendence analysis (BIA)...
May 15, 2018: Journal of Applied Research in Intellectual Disabilities: JARID
https://www.readbyqxmd.com/read/29757265/application-and-comparison-of-the-modis-derived-enhanced-vegetation-index-to-viirs-landsat-5-tm-and-landsat-8-oli-platforms-a-case-study-in-the-arid-colorado-river-delta-mexico
#5
Christopher J Jarchow, Kamel Didan, Armando Barreto-Muñoz, Pamela L Nagler, Edward P Glenn
The Enhanced Vegetation Index (EVI) is a key Earth science parameter used to assess vegetation, originally developed and calibrated for the Moderate Resolution Imaging Spectroradiometer (MODIS) aboard the Terra and Aqua satellites. With the impending decommissioning of the MODIS sensors by the year 2020/2022, alternative platforms will need to be used to estimate EVI. We compared Landsat 5 (2000⁻2011), 8 (2013⁻2016) and the Visible Infrared Imaging Radiometer Suite (VIIRS; 2013⁻2016) to MODIS EVI (2000⁻2016) over a 420,083-ha area of the arid lower Colorado River Delta in Mexico...
May 13, 2018: Sensors
https://www.readbyqxmd.com/read/29756744/monitoring-the-oxygen-reserve-index-can-contribute-to-the-early-detection-of-deterioration-in-blood-oxygenation-during-one-lung-ventilation
#6
Wakana Koishi, Motoi Kumagai, Shohei Ogawa, Shuhei Hongo, Kenji Suzuki
BACKGROUND: Hypoxemia can occur during one-lung ventilation (OLV), but monitoring blood oxygenation using percutaneous oxygen saturation (SpO2) can be limited by detection latency, and SpO2 sometimes does not change during OLV. The Oxygen Reserve Index (ORiTM) is a novel index reported to detect impending desaturation before this is observed with SpO2 monitoring. This study assessed whether the ORi decreased earlier than SpO2 during OLV and evaluated its correlation with the partial pressure of arterial oxygen (PaO2) during OLV...
May 14, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29754843/revision-of-failed-hemiarthroplasty-for-painful-glenoid-arthrosis-to-anatomic-total-shoulder-arthroplasty
#7
Mihir M Sheth, Daniel Sholder, Joseph Abboud, Mark D Lazarus, Matthew L Ramsey, Gerald R Williams, Surena Namdari
BACKGROUND: The impending burden of revision shoulder arthroplasty has increased interest in outcomes of revision procedures. Painful glenoid arthrosis following hemiarthroplasty is a common cause of reoperation, and conversion to anatomic total shoulder arthroplasty is one option. METHODS: We identified patients who underwent revision of painful hemiarthroplasty to total shoulder arthroplasty over a 15-year period in a single tertiary-care health system. Presurgical and operative data were analyzed for 28 patients who met the inclusion and exclusion criteria...
May 10, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29754196/painful-stimulation-of-a-sensitized-site-in-the-forearm-inhibits-ipsilateral-trigeminal-nociceptive-blink-reflexes
#8
Peter D Drummond, Ashlea Bell, Lechi Vo
Exposure to moderate levels of ultraviolet B radiation (UVB) is painless but nevertheless induces an inflammatory response that sensitizes primary afferent nociceptors. Subsequently, heating the UVB-treated site can sensitize spinal nociceptors. We used a repeated-measures design to determine whether heating the UVB-treated site also triggers ipsilateral inhibitory controls. Specifically, a 2-cm diameter site on the forearm of 20 participants was exposed to UVB at twice the minimum erythema dose. 48 h later mechanical and thermal sensitivity had increased at the UVB-treated site, indicating primary hyperalgesia...
May 12, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29748570/network-recovery-based-on-system-crash-early-warning-in-a-cascading-failure-model
#9
Dong Zhou, Ahmed Elmokashfi
This paper investigates the possibility of saving a network that is predicted to have a cascading failure that will eventually lead to a total collapse. We model cascading failures using the recently proposed KQ model. Then predict an impending total collapse by monitoring critical slowing down indicators and subsequently attempt to prevent the total collapse of the network by adding new nodes. To this end, we systematically evaluate five node addition rules, the effect of intervention delay and network degree heterogeneity...
May 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29734172/preemptive-delivery-and-immediate-resection-for-fetuses-with-high-risk-sacrococcygeal-teratomas
#10
Heron D Baumgarten, Juliana S Gebb, Nahla Khalek, Julie S Moldenhauer, Mark P Johnson, William H Peranteau, Holly L Hedrick, N Scott Adzick, Alan W Flake
INTRODUCTION: Fetuses with "high-risk" sacrococcygeal teratoma (SCT) have a mortality rate of 40-50%. While fetal surgery may benefit select fetuses prior to 27 weeks' gestation, many fetuses die due to consequences of rapid tumor growth after 27 weeks. Here we report our experience applying "preemptive" delivery to fetuses who manifest signs of decompensation between 27 and 32 weeks. METHODS: A retrospective review of SCT fetuses delivered between 2010 and 2016 at ≤32 weeks' gestation was performed...
May 7, 2018: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/29732380/antimicrobial-agent-shortages-the-new-norm-for-infectious-diseases-physicians
#11
Adi V Gundlapalli, Susan E Beekmann, Donald R Graham, Philip M Polgreen
Background: In 2012, the US Food and Drug Administration (FDA) required drug manufacturers to give advance notice of impending drug shortages. A survey of infectious diseases (ID) physicians was undertaken to determine the impact of this requirement and to follow-up on prior perceptions of ID physicians on shortages of antimicrobial agents. Methods: We used a web-based survey of ID physician members of the Emerging Infections Network in 2016. Results: Of the 701 of 1597 members (44%) who responded, 70% reported the need to modify their antimicrobial choice because of a shortage in the prior 2 years...
April 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29729461/high-risk-surgical-maneuvers-for-impending-true-positive-intraoperative-neurologic-monitoring-alerts-experience-in-3139-consecutive-spine-surgeries
#12
Shujie Wang, Qiyi Li, Jie Zhu, Jianxiong Shen, Ye Tian, Yong Hu, Jianguo Zhang
BACKGROUND: Intraoperative neurologic monitoring (IONM) has become an essential component for decreasing the incidence of spinal cord injury during many spine surgeries. Many high-risk surgical maneuvers that result in significant IONM alerts have not been reported systematically. Our objective in this study was to thoroughly summarize some common high-risk surgical points associated with IONM alerts in various spine surgeries. METHODS: A total of 62 patients with true-positive IONM alerts from 3139 spine surgeries were enrolled between November 2010 and April 2017...
May 2, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29724445/advancing-continuous-predictive-analytics-monitoring-moving-from-implementation-to-clinical-action-in-a-learning-health-system
#13
REVIEW
Jessica Keim-Malpass, Rebecca R Kitzmiller, Angela Skeeles-Worley, Curt Lindberg, Matthew T Clark, Robert Tai, James Forrest Calland, Kevin Sullivan, J Randall Moorman, Ruth A Anderson
In the intensive care unit, clinicians monitor a diverse array of data inputs to detect early signs of impending clinical demise or improvement. Continuous predictive analytics monitoring synthesizes data from a variety of inputs into a risk estimate that clinicians can observe in a streaming environment. For this to be useful, clinicians must engage with the data in a way that makes sense for their clinical workflow in the context of a learning health system (LHS). This article describes the processes needed to evoke clinical action after initiation of continuous predictive analytics monitoring in an LHS...
June 2018: Critical Care Nursing Clinics of North America
https://www.readbyqxmd.com/read/29724200/cigarette-waterpipe-and-e-cigarette-use-among-an-international-sample-of-medical-students-cross-sectional-multicenter-study-in-germany-and-hungary
#14
Erika Balogh, Nóra Faubl, Henna Riemenschneider, Péter Balázs, Antje Bergmann, Károly Cseh, Ferenc Horváth, Jörg Schelling, András Terebessy, Zoltán Wagner, Karen Voigt, Zsuzsanna Füzesi, István Kiss
BACKGROUND: Tobacco use is the leading preventable cause of death worldwide. Besides cigarette smoking, waterpipe and e-cigarettes are gaining popularity among young adults. Medical students' smoking behavior is of particular interest because of their impending role in health promotion as future physicians. Aim of our study is to examine the prevalence and predictors of cigarette, waterpipe and e-cigarette use and the association of tobacco use with self-reported health status in an international sample of medical students...
May 3, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29721920/acquired-peripheral-pulmonary-artery-aneurysms-morphological-spectrum-of-disease-and-multidetector-computed-tomography-angiography-findings-cases-series-and-literature-review
#15
REVIEW
Tullio Valente, Ahmad Abu-Omar, Giacomo Sica, Alfredo Clemente, Massimo Muto, Giorgio Bocchini, Salvatore Cappabianca, Gaetano Rea
BACKGROUND: Acquired peripheral or intraparenchymal pulmonary artery aneurysms (PPAA) are rare entities but are important to recognize because of the associated morbidity. Hemoptysis is their principal complication and is a potentially fatal condition. PURPOSE: To illustrate the causes, multidetector CT angiography (MDCTA) findings and differential diagnosis of acquired PPAA. MATERIALS AND METHODS: The institutional review boards approved this study...
May 2, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29720799/phrenic-nerve-conduction-study-in-the-early-stage-of-guillain-barre-syndrome-as-a-predictor-of-respiratory-failure
#16
Barun Kumar Sen, Alak Pandit
Background: Guillain-Barré syndrome (GBS) has unpredictable clinical course with severe complication of respiratory failure. Objective: To identify clinical profiles and electrophysiological study particularly non-invasive Phrenic nerve conduction study in patients of early GBS to predict respiratory failure. Methods: 64 adult (age≥18yrs) patients of early GBS (onset ≤ 14 days) during the study period from January 2014 to October 2015 were evaluated by clinical profiles of age, gender, antecedent infection, time to peak disability, single breath counts, cranial nerve involvement, autonomic dysfunction and non-invasive Phrenic nerve conduction study...
January 2018: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/29720647/a-midline-thalamic-circuit-determines-reactions-to-visual-threat
#17
Lindsey D Salay, Nao Ishiko, Andrew D Huberman
How our internal state is merged with our visual perception of an impending threat to drive an adaptive behavioural response is not known. Mice respond to visual threats by either freezing or seeking shelter. Here we show that nuclei of the ventral midline thalamus (vMT), the xiphoid nucleus (Xi) and nucleus reuniens (Re), represent crucial hubs in the network controlling behavioural responses to visual threats. The Xi projects to the basolateral amygdala to promote saliency-reducing responses to threats, such as freezing, whereas the Re projects to the medial prefrontal cortex (Re→mPFC) to promote saliency-enhancing, even confrontational responses to threats, such as tail rattling...
May 2, 2018: Nature
https://www.readbyqxmd.com/read/29718934/r-software-package-based-statistical-optimization-of-process-components-to-simultaneously-enhance-the-bacterial-growth-laccase-production-and-textile-dye-decolorization-with-cytotoxicity-study
#18
Sunil Bhavsar, Pravin Dudhagara, Shantilal Tank
The thermophilic bacterium, Bacillus licheniformis U1 is used for the optimization of bacterial growth (R1), laccase production (R2) and synthetic disperse blue DBR textile dye decolorization (R3) in the present study. Preliminary optimization has been performed by one variable at time (OVAT) approach using four media components viz., dye concentration, copper sulphate concentration, pH, and inoculum size. Based on OVAT result further statistical optimization of R1, R2 and R3 performed by Box-Behnken design (BBD) using response surface methodology (RSM) in R software with R Commander package...
2018: PloS One
https://www.readbyqxmd.com/read/29717793/drug-induced-dysphoria-is-enhanced-following-prolonged-cocaine-abstinence-and-dynamically-tracked-by-nucleus-accumbens-neurons
#19
Rachel M Haake, Elizabeth A West, Xuefei Wang, Regina M Carelli
Negative reinforcement models postulate that addicts use drugs to alleviate negative affective states (e.g. dysphoria) associated with withdrawal. In a pre-clinical model, rats exhibit negative affect to a normally rewarding tastant when it predicts impending, but delayed cocaine, and nucleus accumbens (NAc) neurons dynamically track this state. Here, we examined the effects of short versus prolonged experimenter-imposed cocaine abstinence on negative affect, cocaine seeking and self-administration. Rats were given 14 saccharin-cocaine sessions; NAc activity and affective responses to the taste (i...
May 2, 2018: Addiction Biology
https://www.readbyqxmd.com/read/29717232/global-time-size-distribution-of-volcanic-eruptions-on-earth
#20
Paolo Papale
Volcanic eruptions differ enormously in their size and impacts, ranging from quiet lava flow effusions along the volcano flanks to colossal events with the potential to affect our entire civilization. Knowledge of the time and size distribution of volcanic eruptions is of obvious relevance for understanding the dynamics and behavior of the Earth system, as well as for defining global volcanic risk. From the analysis of recent global databases of volcanic eruptions extending back to more than 2 million years, I show here that the return times of eruptions with similar magnitude follow an exponential distribution...
May 1, 2018: Scientific Reports
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