keyword
MENU ▼
Read by QxMD icon Read
search

He-Feng Huang

keyword
https://www.readbyqxmd.com/read/29677520/stable-black-phosphorus-bi-2-o-3-heterostructures-for-synergistic-cancer-radiotherapy
#1
Hao Huang, Lizhen He, Wenhua Zhou, Guangbo Qu, Jiahong Wang, Na Yang, Jie Gao, Tianfeng Chen, Paul K Chu, Xue-Feng Yu
X-ray induced photodynamic therapy (X-ray-PDT) is a promising approach for synergistic cancer radiotherapy and development of suitable radiosensitizers is highly desired. In this paper, we propose black phosphorus/Bi2 O3 (BP/Bi2 O3 ) heterostructures as efficient and biocompatible radiosensitizers for synergistic cancer radiotherapy. The heterostructures are synthesized by growth of ultrasmall Bi2 O3 nanoparticles onto BP nanosheets. The Bi2 O3 decoration inhibits the rapid degradation of BP nanosheets by occupation of the defect sites, and the synergistic effects of BP and Bi2 O3 enable 1 O2 overproduction under X-ray irradiation...
April 13, 2018: Biomaterials
https://www.readbyqxmd.com/read/29673220/ultrasensitive-mach-zehnder-interferometric-temperature-sensor-based-on-liquid-filled-d-shaped-fiber-cavity
#2
Hui Zhang, Shecheng Gao, Yunhan Luo, Zhenshi Chen, Songsong Xiong, Lei Wan, Xincheng Huang, Bingsen Huang, Yuanhua Feng, Miao He, Weiping Liu, Zhe Chen, Zhaohui Li
A liquid-filled D-shaped fiber (DF) cavity serving as an in-fiber Mach–Zehnder interferometer (MZI) has been proposed and experimentally demonstrated for temperature sensing with ultrahigh sensitivity. The miniature MZI is constructed by splicing a segment of DF between two single-mode fibers (SMFs) to form a microcavity (MC) for filling and replacement of various refractive index (RI) liquids. By adjusting the effective RI difference between the DF and MC (the two interference arms), experimental and calculated results indicate that the interference spectra show different degrees of temperature dependence...
April 17, 2018: Sensors
https://www.readbyqxmd.com/read/29671787/proteomic-identification-of-the-galectin-1-involved-molecular-pathways-in-urinary-bladder-urothelial-carcinoma
#3
Chien-Feng Li, Kun-Hung Shen, Lan-Hsiang Chien, Cheng-Hao Huang, Ting-Feng Wu, Hong-Lin He
Among various heterogeneous types of bladder tumors, urothelial carcinoma is the most prevalent lesion. Some of the urinary bladder urothelial carcinomas (UBUCs) develop local recurrence and may cause distal invasion. Galectin-1 de-regulation significantly affects cell transformation, cell proliferation, angiogenesis, and cell invasiveness. In continuation of our previous investigation on the role of galectin-1 in UBUC tumorigenesis, in this study, proteomics strategies were implemented in order to find more galectin-1-associated signaling pathways...
April 19, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29665722/vibralactones-u-w-three-vibralactone-derivatives-from-cultures-of-the-basidiomycete-boreostereum-vibrans
#4
Kai-Ting Duan, Zheng-Hui Li, Wen-Xuan Wang, He-Ping Chen, Huan Sun, Rong Huang, Tao Feng, Ji-Kai Liu
Three new vibralactone derivatives, namely vibralactones U-W (1-3), together with vibralactone (4), have been isolated from cultures of the basidiomycete Boreostereum vibrans. Their structures were determined on the basis of spectroscopic methods and literature data. All compounds showed no activities to five human cancer cell lines.
April 18, 2018: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/29664296/ppar%C3%AE-mediates-the-hepatoprotective-effects-of-nutmeg
#5
Xiao Nan Yang, Xue-Mei Liu, JIan-He Fang, Xu Zhu, Xiu-Wei Yang, Xue-Rong Xiao, Jian-Feng Huang, Frank J Gonzalez, Fei Li
Nutmeg is a traditional Chinese medicine used to treat gastrointestinal diseases. Some reports indicated that nutmeg has hepatoprotective activity. In this study, a thioacetamide (TAA)-induced acute liver injury model in mice was used to explore the mechanism of the protective effects of nutmeg extract (NME), including its major bioactive component myrislignan. The results indicated that NME could effectively protect TAA-induced liver damage as assessed by recovery of increased serum liver transaminases, decrease hepatic oxidative stress and lower hepatic inflammation...
April 17, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29657718/endotracheal-tube-clamping-and-extracorporeal-membrane-oxygenation-to-resuscitate-massive-pulmonary-haemorrhage
#6
Chien-Feng Lee, Chun-Ta Huang, Sheng-Yuan Ruan
Massive pulmonary haemorrhage is a life-threatening and difficult-to-manage condition. In certain circumstances, traditional approaches for haemoptysis may not be effective. Here, we report a 64-year-old man presenting with dyspnoea and leg oedema. He was diagnosed with microscopic polyangiitis due to positive perinuclear anti-neutrophil cytoplasmic antibody and other supportive evidence. His hospital course was complicated with massive pulmonary haemorrhage, which led to hypoxic respiratory failure, shock, and pulseless electrical activity...
July 2018: Respirology Case Reports
https://www.readbyqxmd.com/read/29655692/effects-of-xin-ji-er-kang-on-heart-failure-induced-by-myocardial-infarction-role-of-inflammation-oxidative-stress-and-endothelial-dysfunction
#7
Juan Hu, Pan Cheng, Guang-Yao Huang, Guo-Wei Cai, Feng-Zhen Lian, Xiao-Yun Wang, Shan Gao
BACKGROUND: Xin-Ji-Er-Kang (XJEK) is a Chinese herbal formula, which has been reported to exert effective protection on cardiovascular diseases like hypertension and myocarditis. PURPOSE: To elucidate the protective effects of XJEK on heart failure (HF) induced by myocardial infarction (MI) through the amelioration of inflammation, oxidative stress (OS) and endothelial dysfunction(ED). MATERIALS AND METHODS: Fifty-seven male KM mice were randomized into the following six groups (n = 9-10 for each): control group, model group, MI+XJEK low dose group(XJEKL) group, MI+XJEK middle dose group(XJEKM), MI+XJEK high dose group(XJEKH), and MI+fosinopril group (positive control group)...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29653010/-transformation-from-promyelocytic-leukemia-with-t-15-17-q22-q21-to-acute-monocytic-leukemia-with-t-11-17-q23-q21-in-a-case
#8
Zheng Wang, Ye Li, Hui Dang, Yan Shi, Qi He, Lin Feng, Li Bao, Yazhen Qin, Yanrong Liu, Xiaojun Huang, Yueyun Lai
OBJECTIVE: To report on a case of therapy-related acute monocytic leukemia(t-AML) with t(11;17) (q23;q21)/MLL-AF17q after successful treatment for acute promyelocytic leukemia(APL) with t(15;17) (q22;q21)/PML-RARα. METHODS: A MICM method (bone marrow morphology(M), immunophenotype(I), cytogenetics(C), and molecular biology(M)) was used for the diagnosis and classification of the disease at the time of onset and transformation. RESULTS: The patient was initially identified with typical morphology and immunophenotype of APL...
April 10, 2018: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/29628309/jmjd6-licenses-er%C3%AE-dependent-enhancer-and-coding-gene-activation-by-modulating-the-recruitment-of-the-carm1-med12-co-activator-complex
#9
Wei-Wei Gao, Rong-Quan Xiao, Wen-Juan Zhang, Yi-Ren Hu, Bing-Ling Peng, Wen-Juan Li, Yao-Hui He, Hai-Feng Shen, Jian-Cheng Ding, Qi-Xuan Huang, Tian-Yi Ye, Ying Li, Zhi-Ying Liu, Rong Ding, Michael G Rosenfeld, Wen Liu
Whereas the actions of enhancers in gene transcriptional regulation are well established, roles of JmjC-domain-containing proteins in mediating enhancer activation remain poorly understood. Here, we report that recruitment of the JmjC-domain-containing protein 6 (JMJD6) to estrogen receptor alpha (ERα)-bound active enhancers is required for RNA polymerase II recruitment and enhancer RNA production on enhancers, resulting in transcriptional pause release of cognate estrogen target genes. JMJD6 is found to interact with MED12 in the mediator complex to regulate its recruitment...
April 4, 2018: Molecular Cell
https://www.readbyqxmd.com/read/29624717/sirt3-restricts-hbv-transcription-and-replication-via-epigenetic-regulation-of-cccdna-involving-suv39h1-and-setd1a-histone-methyltransferases
#10
Ji-Hua Ren, Jie-Li Hu, Sheng-Tao Cheng, Hai-Bo Yu, Vincent Kam Wai Wong, Betty Yuen Kwan Law, Yong-Feng Yang, Ying Huang, Yi Liu, Wei-Xian Chen, Xue-Fei Cai, Hua Tang, Yuan Hu, Wen-Lu Zhang, Xiang Liu, Quan-Xin Long, Li Zhou, Na-Na Tao, Hong-Zhong Zhou, Qiu-Xia Yang, Fang Ren, Lin He, Rui Gong, Ai-Long Huang, Juan Chen
Hepatitis B virus (HBV) infection remains a major health problem worldwide. Maintenance of the covalently closed circular DNA (cccDNA) which serves as a template for HBV RNA transcription is responsible for the failure of eradicating chronic HBV during current antiviral therapy. cccDNA is assembled with cellular histone proteins into chromatin, but little is known about the regulation of HBV chromatin by histone posttranslational modifications. In this study, we identified SIRT3 as a host factor restricting HBV transcription and replication by screening seven members of Sirtuin family which is the class III histone deacetylase...
April 6, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29618817/fatal-swine-acute-diarrhoea-syndrome-caused-by-an-hku2-related-coronavirus-of-bat-origin
#11
Peng Zhou, Hang Fan, Tian Lan, Xing-Lou Yang, Wei-Feng Shi, Wei Zhang, Yan Zhu, Ya-Wei Zhang, Qing-Mei Xie, Shailendra Mani, Xiao-Shuang Zheng, Bei Li, Jin-Man Li, Hua Guo, Guang-Qian Pei, Xiao-Ping An, Jun-Wei Chen, Ling Zhou, Kai-Jie Mai, Zi-Xian Wu, Di Li, Danielle E Anderson, Li-Biao Zhang, Shi-Yue Li, Zhi-Qiang Mi, Tong-Tong He, Feng Cong, Peng-Ju Guo, Ren Huang, Yun Luo, Xiang-Ling Liu, Jing Chen, Yong Huang, Qiang Sun, Xiang-Li-Lan Zhang, Yuan-Yuan Wang, Shao-Zhen Xing, Yan-Shan Chen, Yuan Sun, Juan Li, Peter Daszak, Lin-Fa Wang, Zheng-Li Shi, Yi-Gang Tong, Jing-Yun Ma
Cross-species transmission of viruses from wildlife animal reservoirs poses a marked threat to human and animal health1 . Bats have been recognized as one of the most important reservoirs for emerging viruses and the transmission of a coronavirus that originated in bats to humans via intermediate hosts was responsible for the high-impact emerging zoonosis, severe acute respiratory syndrome (SARS)2-10 . Here we provide virological, epidemiological, evolutionary and experimental evidence that a novel HKU2-related bat coronavirus, swine acute diarrhoea syndrome coronavirus (SADS-CoV), is the aetiological agent that was responsible for a large-scale outbreak of fatal disease in pigs in China that has caused the death of 24,693 piglets across four farms...
April 4, 2018: Nature
https://www.readbyqxmd.com/read/29610678/increased-mtdna-copy-number-promotes-cancer-progression-by-enhancing-mitochondrial-oxidative-phosphorylation-in-microsatellite-stable-colorectal-cancer
#12
Xiacheng Sun, Lei Zhan, Yibing Chen, Gang Wang, Linjie He, Qian Wang, Feng Zhou, Fang Yang, Jin Wu, Yousheng Wu, Jinliang Xing, Xianli He, Qichao Huang
Colorectal cancer is one of the leading causes of cancer death worldwide. According to global genomic status, colorectal cancer can be classified into two main types: microsatellite-stable and microsatellite-instable tumors. Moreover, the two subtypes also exhibit different responses to chemotherapeutic agents through distinctive molecular mechanisms. Recently, mitochondrial DNA depletion has been shown to induce apoptotic resistance in microsatellite-instable colorectal cancer. However, the effects of altered mitochondrial DNA copy number on the progression of microsatellite-stable colorectal cancer, which accounts for the majority of colorectal cancer, remain unclear...
2018: Signal Transduction and Targeted Therapy
https://www.readbyqxmd.com/read/29593330/ck1%C3%AE-suppresses-lung-tumour-growth-by-stabilizing-pten-and-inducing-autophagy
#13
Junchao Cai, Rong Li, Xiaonan Xu, Le Zhang, Rong Lian, Lishan Fang, Yongbo Huang, Xianming Feng, Ximeng Liu, Xu Li, Xun Zhu, Heng Zhang, Jueheng Wu, Musheng Zeng, Erwei Song, Yukai He, Yuxin Yin, Jun Li, Mengfeng Li
The contribution of autophagy to cancer development remains controversial, largely owing to the fact that autophagy can be tumour suppressive or oncogenic in different biological contexts. Here, we show that in non-small-cell lung cancer (NSCLC), casein kinase 1 alpha 1 (CK1α) suppresses tumour growth by functioning as an autophagy inducer to activate an autophagy-regulating, tumour-suppressive PTEN/AKT/FOXO3a/Atg7 axis. Specifically, CK1α bound the C-terminal tail of PTEN and enhanced both PTEN stability and activity by competitively antagonizing NEDD4-1-induced PTEN polyubiquitination and abrogating PTEN phosphorylation, thereby inhibiting AKT activity and activating FOXO3a-induced transcription of Atg7...
April 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/29589032/enhanced-solar-water-splitting-activity-of-novel-nanostructured-fe-2-tio-5-photoanode-by-electrospray-and-surface-f-modification
#14
Meng Wang, Xiaofeng Wu, Keke Huang, Yu Sun, Yuan Zhang, Hua Zhang, Jingjing He, Huanwen Chen, Jianhua Ding, Shouhua Feng
Fe2TiO5 is recognized as a novel photoanode material for solar water splitting. However, it has been seldom studied as a photoelectrode by itself, and its practical performance still needs to be improved. Herein, nanostructured Fe2TiO5 photoanode is prepared by the electrospray technique. The effects of the synthesis parameters on the photoelectrochemical water splitting activity are studied including the substrate temperature and film thickness. In addition, surface F-modification is applied on pure Fe2TiO5 to further improve its photoelectrochemical performance...
March 28, 2018: Nanoscale
https://www.readbyqxmd.com/read/29578060/complete-genome-sequence-of-bacillus-licheniformis-bl-010
#15
Sheng He, Kai Feng, Tao Ding, Kaihui Huang, Hai Yan, Xiaolu Liu, Zhongbao Zhang
The biodegradation of Aflatoxin B1 (AFB1 ) is an industry of increasing importance. Bacillus licheniformis BL-010 was isolated from the aflatoxin contaminated corn feed storage, and was shown to degrade AFB1 efficiently. Here we present the complete genome sequence of BL-010, the genome comprises 4,287,714 bp in a circular chromosome with a GC content of 46.12% and contains genes encoding AFB1 degrading enzymes. The genome sequence displayed that this strain contains genes involved in production of laccase, aromatic ring-opening dioxygenase which could detoxify AFB1 ...
March 22, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29576057/construction-of-a-mutant-of-actinoplanes-sp-n902-109-that-produces-a-new-rapamycin-analog
#16
He Huang, Ping Gao, Qi Zhao, Hai-Feng Hu
In the present study, we introduced point mutations into Ac_rapA which encodes a polyketide synthase responsible for rapamycin biosynthesis in Actinoplanes sp. N902-109, in order to construct a mutant with an inactivated enoylreductase (ER) domain, which was able to synthesize a new rapamycin analog. Based on the homologous recombination induced by double-strand breaks in chromosome mediated by endonuclease I-SceI, the site-directed mutation in the first ER domain of Ac_rapA was introduced using non-replicating plasmid pLYERIA combined with an I-SceI expression plasmid...
March 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29567997/nuclear-receptor-binding-protein-1-correlates-with-better-prognosis-and-induces-caspase-dependent-intrinsic-apoptosis-through-the-jnk-signalling-pathway-in-colorectal-cancer
#17
Yi Liao, Zihuan Yang, Jintuan Huang, Hao Chen, Jun Xiang, Senmao Li, Chunyu Chen, Xuan He, Feng Lin, Zuli Yang, Jianping Wang
Nuclear receptor binding protein 1 (NRBP1) is a ubiquitously expressed and highly conserved pseudokinase that has important roles in cellular homoeostasis. Despite recent advances in understanding the biology of NRBP1, the role of NRBP1 and its underlying mechanism in colorectal cancer (CRC) have not been fully elucidated. In the present study, we observed that NRBP1 expression levels were significantly reduced in CRC tissues compared with corresponding adjacent normal tissues, and high NRBP1 expression correlated with better prognosis in CRC...
March 22, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29562462/-effects-of-preexisting-donor-specific-hla-antibodies-for-graft-failure-in-un-manipulated-haploidentical-hematopoietic-stem-cell-transplantation
#18
R L Zhang, X H Zheng, L K Zhou, Y Zhang, S L Chen, D L Yang, E L Jiang, J L Wei, Y Huang, Q L Ma, W H Zhai, S Z Feng, M Z Han, Y He
Objective: To investigate the effects of donor-specific HLA antibodies(DSA) for graft failure in un-manipulated haploidentical hematopoietic stem cell transplantation(haplo-HSCT) and the feasible treatment for DSA. Methods: HLA antibodies were examined using the Luminex-based single Ag assay for 92 patients who were going on haplo-SCT and the correlations of graft failure and DSA among the patients who had finished SCT were analyzed. Results: Of the total 92 patients who were going on haplo-HSCT, sixteen (17...
March 14, 2018: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/29561435/comparison-of-high-and-low-viscosity-cement-in-the-treatment-of-vertebral-compression-fractures-a-systematic-review-and-meta-analysis
#19
Zhao-Fei Zhang, He Huang, Shuai Chen, Dong-Hua Liu, Yong-Hui Feng, Chun-Liang Xie, Feng Jiao
BACKGROUND: High-viscosity cement (HVC) has been gradually applied in percutaneous vertebroplasty (PVP) and percutaneous kyphoplasty (PKP). Although HVC has been reported to reduce cement leakage, different opinions exist. To assess the complications of HVC in cement leakage in the treatment of vertebral compression fractures and to evaluate the clinical effect of HVC compared with low-viscosity cement (LVC). METHODS: EMBASE, PubMed, Science Direct, Google Scholar and Cochrane Library databases were comprehensively searched from their inception to August 2017...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29556345/gelatin-nanoparticle-coated-silicon-beads-for-density-selective-capture-and-release-of-heterogeneous-circulating-tumor-cells-with-high-purity
#20
Qinqin Huang, Fu-Bing Wang, Chun-Hui Yuan, Zhaobo He, Lang Rao, Bo Cai, Bolei Chen, Susu Jiang, Zhiqiang Li, Jincao Chen, Wei Liu, Feng Guo, Zheng Ao, Shi Chen, Xing-Zhong Zhao
Background: Circulating tumor cells (CTCs) are a burgeoning topic in cancer biomarker discovery research with minimal invasive blood draws. CTCs can be used as potential biomarkers for disease prognosis, early cancer diagnosis and pharmacodynamics. However, the extremely low abundance of CTCs limits their clinical utility because of technical challenges such as the isolation and subsequent detailed molecular and functional characterization of rare CTCs from patient blood samples. Methods: In this study, we present a novel density gradient centrifugation method employing biodegradable gelatin nanoparticles coated on silicon beads for the isolation, release, and downstream analysis of CTCs from colorectal and breast cancer patients...
2018: Theranostics
keyword
keyword
23686
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"