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He-Feng Huang

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https://www.readbyqxmd.com/read/29239144/smg-1-inhibition-by-mir-192-215-causes-epithelial-mesenchymal-transition-in-gastric-carcinogenesis-via-activation-of-wnt-signaling
#1
Xiaojing Zhang, Yin Peng, Yong Huang, Mengting Yang, Ruibin Yan, Yanqiu Zhao, Yulan Cheng, Xi Liu, Shiqi Deng, Xianling Feng, Huijuan Lin, Huimin Yu, Si Chen, Zhenfu Zhao, Shanni Li, Kuan Li, Liang Wang, Yanjie Wei, Zhendan He, Xinmin Fan, Stephen J Meltzer, Song Li, Zhe Jin
SMG-1,a member of the phosphoinositide kinase-like kinase family, functioned as a tumor suppressor gene. However, the role of SMG-1 in GC remain uncharacterized. In this study, regulation of SMG-1 by miR-192 and-215, along with the biological effects of this modulation, were studied in GC. We used gene microarrays to screening and luciferase reporter assays were to verify the potential targets of miR-192 and-215. Tissue microarrays analyses were applied to measure the levels of SMG-1 in GC tissues. Western blot assays were used to assess the signaling pathway of SMG-1 regulated by miR-192 and-215 in GC...
December 13, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/29235730/smart-design-of-a-bulk-capped-supramolecular-segment-for-the-assembly-into-organic-interdigital-lipid-bilayer-like-ilb-nanosheets
#2
Yin-Xiang Li, Sha-Sha Wang, Yang Yu, He Zhang, Wu-You Wang, Ru-Qian Yang, Ling-Hai Xie, Feng Liu, Zong-Qiong Lin, Nai-En Shi, Li-Tao Sun, Wei Huang
Rational molecular design for the organic nanocrystal morphology still remains a challenge due to the structural diversity and complicated weak intermolecular interactions. In this work, a typical attractor-repulsor molecule N,N-diphenyl-4-(9-phenyl-fluoren-9-yl) phenylamine (TPA-PF) is designed to explore a general assembly strategy for 2D nanocrystals. Via an interdigital lipid bilayer-like (ILB) molecular packing mode, large-sized lamellar 2D nanosheets are obtained with a length:width:thickness ratio as ≈2500:1000:1...
December 13, 2017: Small
https://www.readbyqxmd.com/read/29234428/network-pharmacology-based-approach-to-investigate-the-analgesic-efficacy-and-molecular-targets-of-xuangui-dropping-pill-for-treating-primary-dysmenorrhea
#3
Jihan Huang, Lei Li, Fan Cheung, Ning Wang, Yunfei Li, Zhenyu Fan, Fang Yin, Juan Yang, Rui Gao, Yingchun He, Yibin Feng
This study aimed to evaluate the clinical analgesic efficacy and identify the molecular targets of XGDP for treating primary dysmenorrhea (PD) by a network pharmacology approach. Analysis of pain disappearance rate of XGDP in PD treatment was conducted based on data from phase II and III randomized, double-blind, double-simulation, and positive parallel controlled clinical trials. The bioactive compounds were obtained by the absorption, distribution, metabolism, and excretion processes with oral bioavailability (OB) and drug-likeness (DL) evaluation...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29230718/anemhupehins-a-c-podocarpane-diterpenoids-from-anemone-hupehensis
#4
Xing Yu, Kai-Ting Duan, Zhen-Xiong Wang, He-Ping Chen, Xiao-Qing Gan, Rong Huang, Zheng-Hui Li, Tao Feng, Ji-Kai Liu
Three new podocarpane diterpenoids, namely anemhupehins A-C (1-3), together with four known analogues (4-7), have been isolated from aerial parts of Anemone hupehensis. Their structures were characterized based on extensive spectroscopic data. Compounds 1 and 4 showed certain cytotoxicities against human cancer cell lines.
December 11, 2017: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/29228625/long-noncoding-rna-sfta1p-promoted-apoptosis-and-increased-cisplatin-chemosensitivity-via-regulating-the-hnrnp-u-gadd45a-axis-in-lung-squamous-cell-carcinoma
#5
Ling Li, Ji-Ye Yin, Fa-Zhong He, Ma-Sha Huang, Tao Zhu, Yuan-Feng Gao, Yi-Xin Chen, Dong-Bo Zhou, Xiang Chen, Lun-Quan Sun, Wei Zhang, Hong-Hao Zhou, Zhao-Qian Liu
Chemotherapeutic insensitivity remains one of the major obstacles in clinical treatment of lung squamous cell carcinoma (LSCC). Recently, increasing evidence has suggested that long non-coding RNAs (lncRNAs) promote tumorigenesis in many cancer types. However, the potential biological roles and regulatory mechanisms of lncRNAs in response to cisplatin treatment are poorly understood. Here, we found that lncRNA SFTA1P (surfactant associated 1, pseudogene), highly expressed in lung, was down-regulated in LSCC tissues and could be induced upon cisplatin treatment in LSCC cells...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29212259/metabolomics-reveals-the-effect-of-xuefu-zhuyu-decoction-on-plasma-metabolism-in-rats-with-acute-traumatic-brain-injury
#6
Dandan Feng, Zian Xia, Jing Zhou, Hongmei Lu, Chunhu Zhang, Rong Fan, Xingui Xiong, Hanjin Cui, Pingping Gan, Wei Huang, Weijun Peng, Feng He, Zhiming Wang, Yang Wang, Tao Tang
Xuefu Zhuyu Decoction (XFZY), an important traditional Chinese herbal formula, has been reported effective on traumatic brain injury (TBI) in rats. However, its cerebral protection mechanism has not been clarified at the metabolic level. This work aims to explore the global metabolic characteristics of XFZY in rats during the acute phase of TBI on days 1 and 3. A plasma metabolomics method based on gas chromatography-mass spectrometry coupled with univariate analysis and multivariate statistical analysis was performed in three groups (Sham, Vehicle, XFZY)...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29206300/effects-of-mtor-nf-%C3%AE%C2%BAb-signaling-pathway-and-high-thoracic-epidural-anesthesia-on-myocardial-ischemia-reperfusion-injury-via-autophagy-in-rats
#7
Wei-Qiang Huang, Jian-Lin Wen, Ri-Qi Lin, Peng Wei, Feng Huang
We investigated the role of mammalian target of rapamycin/nuclear factor-kappa B (mTOR/NF-κB) signaling pathway in high thoracic epidural anesthesia (HTEA) against myocardial ischemia-reperfusion (I/R) injury in rats. The rat model of myocardial I/R injury was established. Ninety rats were divided into the normal, sham, I/R, eHTEA, the PDTC and HTEA + PDTC groups. ELISA was applied to detect cardiac function indexes. HE staining was conducted to observe histopathological changes of myocardial tissues, and TTC staining was performed to detect the myocardial infarction size...
December 5, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29203053/insulin-like-growth-factor-1-mediates-adrenal-development-dysfunction-in-offspring-rats-induced-by-prenatal-food-restriction
#8
Zheng He, Feng Lv, Yufeng Ding, Chunyan Zhu, Hegui Huang, Li Zhang, Yu Guo, Hui Wang
BACKGROUND: Our previous study demonstrated that prenatal food restriction (PFR) could induce the dysfunction of the hypothalamic-pituitary-adrenal axis and glucocorticoid-related glucose and lipid metabolic alterations in adult offspring rats. AIM OF THE STUDY: To investigate the intrauterine programming mechanism of adrenal dysfunction in the PFR offspring rats. METHODS: From gestational days (GDs) 11-20, pregnant Wistar rats were fed a restricted diet (50% of the daily food intake of control rats, 60 g/kg·d)...
December 1, 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/29201186/topically-administered-rhgm-csf-affects-ppar%C3%AE-expression-in-the-stasis-zone
#9
Gen-Feng Fu, She-Min Tian, Xin-Jian Cha, Hong-Jun Huang, Ji-He Lou, Ying Wei, Cheng-De Xia, Yong-Lin Li, Xi-Hua Niu
Using a rat comb thermal damage model, we investigated the effects of topically administered recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) on peroxisome proliferator-activated receptor PPARβ expression. We created bilateral comb scald models on the backs of fifty Sprague-Dawley rats. The left sides of the backs served as the experimental group and the right sides served as the control group. The experimental group received topically applied rhGM-CSF hydrogel and the control group did not...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29200950/isolation-and-determination-of-four-potential-antimicrobial-components-from-pseudomonas-aeruginosa-extracts
#10
Ling-Qing Xu, Jian-Wen Zeng, Chong-He Jiang, Huan Wang, Yu-Zhen Li, Wei-Hong Wen, Jie-Hua Li, Feng Wang, Wei-Jen Ting, Zi-Yong Sun, Chih-Yang Huang
Background:Pseudomonas aeruginosa can cause disease and also can be isolated from the skin of healthy people. Additionally, it exhibits certain antimicrobial effects against other microorganisms.Methods: We collected 60 strains of P. aeruginosa and screened their antimicrobial effects against Staphylococcus aureus (ATCC 25923) using the filter paper-disk method, the cross-streaking method and the co-culture method and then evaluated the antimicrobial activity of the chloroform-isolated S. aureus extracts against methicillin-resistant S...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29197540/miscellaneous-lanostane-triterpenoids-with-cytotoxicities-from-fruiting-bodies-of-the-basidiomycete-stereum-sp
#11
Jian-Neng Yao, Lin Chen, He-Ping Chen, Zhen-Zhu Zhao, Shuai-Bing Zhang, Ying Huang, Yang Tang, Masahiko Isaka, Zheng-Hui Li, Tao Feng, Ji-Kai Liu
Ten new highly oxygenated lanostane triterpenoids, stereinones A-J (1-10), were isolated from the fruiting bodies of the basidiomycete Stereum sp. Compounds 3 and 4 are structurally characterized as intact lanostane-type triterpenoids containing unusual 1,2-diketone functionality at C-11 and C-12, while compound 10 is a 24-methylene-lanostane. The structures of these new compounds were established based on detailed 1D and 2D NMR spectroscopic analyses, along with quantum chemical NMR calculations. All isolates were evaluated for their in vitro cytotoxicities against five human tumor cell lines (including HL-60, A-549, SMMC-7721, MCF-7, and SW480 cell lines)...
November 29, 2017: Fitoterapia
https://www.readbyqxmd.com/read/29191973/blocking-the-feedback-loop-between-neuroendocrine-differentiation-and-macrophages-improves-the-therapeutic-effects-of-enzalutamide-mdv3100-on-prostate-cancer
#12
Chao Wang, Guang Peng, Hai Huang, Fei Liu, De-Pei Kong, Ke-Qin Dong, Li-He Dai, Zhe Zhou, Kai-Jian Wang, Jun Yang, Yan-Qiong Cheng, Xu Gao, Min Qu, Hongru Wang, Feng Zhu, Qin-Qin Tian, Dan Liu, Li Cao, Xingang Cui, Chuanliang Xu, Dan-Feng Xu, Yinghao Sun
PURPOSE: Androgen-deprivation therapy (ADT), including enzalutamide, induces resistance in prostate cancer (PCa); ADT resistance is associated with neuroendocrine differentiation (NED) and tumor-associated macrophages (TAMs). This study aimed to investigate the association between enzalutamide-induced NED and TAMs and its mechanism. EXPERIMENTAL DESIGN: The association between enzalutamide-induced NED and TAMs was investigated by immunohistochemistry using PCa tissues, enzalutamide-resistant mouse xenografts and a co-culture system...
November 30, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29190083/structure-based-design-of-6-chloro-4-aminoquinazoline-2-carboxamide-derivatives-as-potent-and-selective-p21-activated-kinase-4-pak4-inhibitors
#13
Chenzhou Hao, Fan Zhao, Hong Yan Song, Jing Guo, Xiaodong Li, Xiaolin Jiang, Ran Huan, Shuai Song, Qiaoling Zhang, Ruifeng Wang, Kai Wang, Yu Pang, Tongchao Liu, Tianqi Lu, Wanxu Huang, Jian Wang, Bin Lin, Zhonggui He, Haitao Li, Feng Li, Dongmei Zhao, Maosheng Cheng
Herein, we report the discovery and characterization of a novel class of PAK4 inhibitors with a quinazoline scaffold. Based on the shape and chemical composition of the ATP-binding pocket of PAKs, we chose a 2, 4-diaminoquinazoline series of inhibitors as a starting point. Guided by X-ray crystallography and a structure-based drug design (SBDD) approach, a series of novel 4-aminoquinazoline-2-carboxamide PAK4 inhibitors were designed and synthesized. The inhibitors' selectivity, therapeutic potency, and pharmaceutical properties were optimized...
November 30, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29182304/lightweight-mesoporous-and-highly-absorptive-all-nanofiber-aerogel-for-efficient-solar-steam-generation
#14
Feng Jiang, He Liu, Yiju Li, Yudi Kuang, Xu Xu, Chaoji Chen, Hao Huang, Chao Jia, Xinpeng Zhao, Emily Hitz, Yubing Zhou, Ronggui Yang, Lifeng Cui, Liangbing Hu
Global fresh water shortage has driven enormous endeavors in seawater desalination and wastewater purification; among these, solar steam generation is effective in extracting fresh water by efficient utilization of naturally abundant solar energy. For solar steam generation, primary focus is to design new material with biodegradability, sustainability, low cost and high solar steam generation efficiency. Here, we designed a bilayer aerogel structure employing naturally abundant cellulose nanofibrils (CNFs) as basic building blocks to fulfill sustainability and biodegradability, and carbon nanotube (CNT) layer for efficient solar utilization with over 97...
November 28, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29176261/reduced-vitamin-d-receptor-on-circulating-endothelial-progenitor-cells-a-new-risk-factor-of-coronary-artery-diseases
#15
Sidi Ai, Zhiqing He, Ru Ding, Feng Wu, Zhigang Huang, Jiamei Wang, Shuaibo Huang, Xianliang Dai, Jiayou Zhang, Jing Chen, Linlin Liu, Zonggui Wu, Chun Liang
AIM: Endothelial progenitor cells (EPCs) are shown to participate in the pathological processes of atherosclerosis. While Vitamin D and its receptor axis might exert some effects on EPCs' function. But their exact relationship with clinical patients is still elusive, which inspired us to explore the potential association of vitamin D receptor (VDR) expression on circulating EPCs and serum vitamin D levels among patients with coronary artery disease (CAD). METHODS: Two hundred patients with CAD after their admission to hospital and one hundred healthy controls were enrolled...
November 24, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29170472/interaction-effects-of-afb1-and-mc-lr-co-exposure-with-polymorphism-of-metabolic-genes-on-liver-damage-focusing-on-slco1b1-and-gstp1
#16
Xiaohong Yang, Wenyi Liu, Hui Lin, Hui Zeng, Renping Zhang, Chaowen Pu, Lingqiao Wang, Chuanfen Zheng, Yao Tan, Yang Luo, Xiaobin Feng, Yingqiao Tian, Guosheng Xiao, Jia Wang, Yujing Huang, Jiaohua Luo, Zhiqun Qiu, Ji-An Chen, Liping Wu, Lixiong He, Weiqun Shu
AFB1 and MC-LR are two major environmental risk factors for liver damage worldwide, especially in warm and humid areas, but there are individual differences in health response of the toxin-exposed populations. Therefore, we intended to identify the susceptible genes in transport and metabolic process of AFB1 and MC-LR and find their effects on liver damage. We selected eight related SNPs that may affect liver damage outcomes in AFB1 and MC-LR exposed persons, and enrolled 475 cases with liver damage and 475 controls of healthy people in rural areas of China...
November 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29168903/black-phosphorus-based-orientation-induced-diodes
#17
Wei Xin, Xiao-Kuan Li, Xin-Ling He, Bao-Wang Su, Xiao-Qiang Jiang, Kai-Xuan Huang, Xiang-Feng Zhou, Zhi-Bo Liu, Jian-Guo Tian
Despite many decades of research of diodes, which are fundamental components of electronic and photoelectronic devices with p-n or Schottky junctions using bulk or 2D materials, stereotyped architectures and complex technological processing (doping and multiple material operations) have limited future development. Here, a novel rectification device, an orientation-induced diode, assembled using only few-layered black phosphorus (BP) is investigated. The key to its realization is to utilize the remarkable anisotropy of BP in low dimensions and change the charge-transport conditions abruptly along the different crystal orientations...
November 23, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29158203/p2x7-receptor-in-spinal-tuberculosis-gene-polymorphisms-and-protein-levels-in-chinese-han-population
#18
Ying Zhou, Chun-Yan Tan, Zhi-Jiang Mo, Qi-le Gao, Dan He, Jiong Li, Rong-Fu Huang, Yan-Bing Li, Chao-Feng Guo, Qiang Guo, Long-Jie Wang, Guan-Teng Yang, Hong-Qi Zhang
Spinal tuberculosis (TB) accounts for 1%-5% of all TB infections. Host genetic variation influences susceptibility to Mycobacterium tuberculosis (MTB). P2X7 receptor (P2X7R) expressed on cells has been identified as a regulatory molecule in cell death/apoptosis, killing of intercellular pathogens, and bone turnover. This study investigated the P2X7 gene polymorphisms and protein levels in spinal TB. P2X7 gene -762C>T and 489C>T polymorphisms were genotyped. The expression of P2X7R in bone or intervertebral disc (ID) tissues was analyzed by Western blot assay...
January 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29156746/tssc3-represses-self-renewal-of-osteosarcoma-stem-cells-and-nanog-expression-by-inhibiting-the-src-akt-pathway
#19
Guang-Ning Yan, Xue-Feng Tang, Xian-Chao Zhang, Ting He, Yu-Sheng Huang, Xi Zhang, Gang Meng, De-Yu Guo, Yang-Fan Lv, Qiao-Nan Guo
Osteosarcoma is the most common type of bone cancer, and the second leading cause of cancer-related death in children and young adults. Osteosarcoma stem cells are essential for osteosarcoma initiation, metastasis, chemoresistance and recurrence. In the present study, we report that: 1) higher TSSC3 expression indicates a better prognosis for osteosarcoma patients, and; 2) overexpression of TSSC3 significantly decreases sphere-forming capacity, tumor initiation, stemness-related surface markers and Nanog expression in osteosarcoma cells...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29155986/prenatal-high-estradiol-exposure-induces-sex-specific-and-dietarily-reversible-insulin-resistance-through-decreased-hypothalamic-insr
#20
Hui-Hui Wang, Cheng-Liang Zhou, Min Lv, Qian Yang, Ju-Xue Li, Min Hou, Jing Lin, Xin-Mei Liu, Yan-Ting Wu, Jian-Zhong Sheng, He-Feng Huang
Adverse intrauterine environment may induce adult disease in offspring, but the mechanisms are not well understood. It is reported that fresh embryo transfer (ET) in assisted reproductive technology presents extra-high maternal estradiol (E2) and prenatal high E2 exposure increases the risk of organ disorders in later life. We found male newborns and children of fresh ET showed increased fasting insulin and the homeostasis model of assessment for insulin resistance index (HOMA-IR). Prenatal high E2 exposed (HE) male mice grew heavier than control and developed insulin resistance, they also showed increased food intake with enhanced orexigenic hypothalamic neuropeptide Y (NPY) expression...
November 15, 2017: Endocrinology
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