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https://www.readbyqxmd.com/read/29342293/genetic-analyses-in-small-for-gestational-age-newborns
#1
Susanne E Stalman, Nita Solanky, Miho Ishida, Cristina Alemán-Charlet, Sayeda Abu-Amero, Marielle Alders, Lucas Alvizi, William Baird, Charalambos Demetriou, Peter Henneman, Chela James, Lia C Knegt, Lydia J Leon, Marcel M A M Mannens, Adi N Mul, Nicole A Nibbering, Emma Peskett, Faisal I Rezwan, Carrie Ris-Stalpers, Joris A M van der Post, Gerdine A Kamp, Frans B Plötz, Jan M Wit, Philip Stanier, Gudrun E Moore, Raoul C Hennekam
Context: Small for gestational age (SGA) can be a result of fetal growth restriction, associated with perinatal morbidity and mortality. Mechanisms that control prenatal growth are poorly understood. Objective: The aim of the present study was to gain more insight into prenatal growth failure and determine an effective diagnostic approach in SGA newborns. We hypothesized that one or more CNVs and disturbed methylation and sequence variants may be present in genes known to be associated with fetal growth...
January 12, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29339641/longitudinal-assessment-of-abdominal-circumference-versus-estimated-fetal-weight-in-the-detection-of-late-fetal-growth-restriction
#2
Tri Rahmat Basuki, Javier Caradeux, Elisenda Eixarch, Eduard Gratacós, Francesc Figueras
OBJECTIVES: To perform a longitudinal assessment comparison between estimated fetal weight (EFW) and abdominal circumference (AC) in the prediction of late fetal growth restriction (FGR) as opposed to small for gestational age (SGA). PATIENTS AND METHODS: A cohort of unselected singleton pregnancies scanned at 32±2 and 37±1 weeks was created. Longitudinal growth assessment by calculating the conditional AC and conditional EFW was performed, and both parameters were compared for their prediction capacity for late FGR and SGA...
January 16, 2018: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/29338497/a-prospective-observational-study-comparing-cardiac-function-of-small-for-gestational-age-with-appropriate-for-gestational-age-babies-using-serial-echocardiographic-studies
#3
Manish Kumar, Santhanam Sridhar, Niranjan Thomas
BACKGROUND: Approximately 30% of babies born in India are low birth weight (LBW) and about 70% of LBW babies are small for gestational age (SGA). Though there are several trials that have evaluated cardiac function of intrauterine growth restricted (IUGR) babies in utero, there is limited data about postnatal cardiac function in SGA babies during early neonatal period. This study was conducted to evaluate the cardiac functions of SGA babies by serial echocardiographic measurements and compare this with appropriate for gestational age (AGA) babies during the early postnatal period...
January 16, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29334569/assessment-of-prehospital-hemorrhage-and-airway-care-using-a-simulation-model
#4
Mariya E Skube, Seth Witthuhn, Kristine Mulier, Bonnie Boucher, Elizabeth Lusczek, Greg J Beilman
BACKGROUND: The quality of prehospital care impacts patient outcomes. Military efforts have focused on training revision and the creation of high fidelity simulation models to address potentially survivable injuries. We sought to investigate the applicability of models emphasizing hemorrhage control and airway management to a civilian population. METHODS: Prehospital healthcare providers (PHPs) undergoing their annual training were enrolled. A trauma scenario was simulated with two modules: hemorrhage control and airway management...
January 12, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29334489/association-between-arterial-stiffness-and-wave-reflection-with-subsequent-development-of-placental-mediated-diseases-during-pregnancy-findings-of-a-systematic-review-and-meta-analysis
#5
Mohamed Waseem Osman, Mintu Nath, Eamonn Breslin, Asma Khalil, David R Webb, Thompson G Robinson, Hatem A Mousa
OBJECTIVE: We present a comprehensive systematic review of published literature to examine, whether arterial stiffness and wave reflection measurements during pregnancy differed between healthy patients and patients with placental-mediated diseases including preeclampsia (PET), small for gestational age (SGA), fetal death, and placental abruption, and a quantitative assessment of the findings using the meta-analysis approach. METHODS: We searched Medline, Embase, and The Cochrane Library for studies of arterial stiffness in pregnancy, analyzed pregnancy outcomes and conducted the meta-analysis of data evaluated by trimesters of pregnancy...
January 13, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29331157/eccentric-placentae-have-reduced-surface-area-and-are-associated-with-lower-birth-weight-in-babies-small-for-gestational-age
#6
G Ravikumar, J Crasta, J S Prabhu, T Thomas, P Dwarkanath, A Thomas, T S Sridhar, A V Kurpad
Placental structure and function determine birth outcomes. Placental mass does not always correlate with fetal birth weight (BW) in uncomplicated pregnancies which raises the possibility of other variables such as placental shape and cord insertion being the determinants of placental efficiency. In total, 160 women with singleton pregnancy, recruited into a pregnancy cohort were studied. Placental weight (PW) was measured and other data were obtained from clinical records. Birth outcomes were classified as small for gestational age (SGA) and appropriate for gestational age (AGA) based on fetal gender, gestational age (GA) and BW...
January 14, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29325466/the-correlation-between-birth-weight-and-insulin-like-growth-factor-binding-protein-1-igfbp-1-kisspeptin-1-kiss-1-and-three-dimensional-fetal-volume
#7
Gunsu Kimyon Comert, Sertac Esin, Gamze Sinem Caglar, Bulent Yirci, Sedat Ozdemir, Selda Demirtas, Omer Kandemir
PURPOSE: This study aimed to determine the relationship between birth weight, and maternal serum insulin-like growth factor binding protein-1 (IGFBP-1) and kisspeptin-1 (KISS-1) levels, and first-trimester fetal volume (FV) based on three-dimensional ultrasonography. MATERIALS AND METHODS: The study included 142 pregnant women at gestational week 110-136. All fetuses were imaged ultrasonographically by the same physician. Maternal blood samples were collected at the time of ultrasonographic evaluation and analyzed for IGFBP-1 and KISS-1 levels via enzyme-linked immunosorbent assay (ELISA)...
January 11, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29324613/racial-disparities-in-adverse-pregnancy-outcomes-and-psychosocial-stress
#8
William A Grobman, Corette B Parker, Marian Willinger, Deborah A Wing, Robert M Silver, Ronald J Wapner, Hyagriv N Simhan, Samuel Parry, Brian M Mercer, David M Haas, Alan M Peaceman, Shannon Hunter, Pathik Wadhwa, Michal A Elovitz, Tatiana Foroud, George Saade, Uma M Reddy
OBJECTIVE: To assess the relationships between self-reported psychosocial stress and preterm birth, hypertensive disease of pregnancy, and small-for-gestational-age (SGA) birth and to assess the extent to which these relationships account for racial and ethnic disparities in these adverse outcomes. METHODS: Self-reported measures of psychosocial stress (perceived stress, depression, racism, anxiety, resilience, and social support) were collected during pregnancy among a racially and ethnically diverse cohort of women enrolled in a prospective observational study of nulliparous women with singleton pregnancies, from eight clinical sites across the United States, between October 2010 and May 2014...
January 9, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29323608/the-association-between-low-50%C3%A2-g-glucose-challenge-test-values-and-adverse-pregnancy-outcomes
#9
Hayan Kwon, Joonho Lee, Byung-Wan Lee, Ja-Young Kwon, Young-Han Kim
BACKGROUND: The implications of low values on the 50 g glucose challenge test (GCT) in pregnancy are not clearly defined. Few studies have evaluated the influence of maternal low GCT values on obstetrical outcomes. This study aimed to compare pregnancy outcomes between women with low 50 g GCT values and those with normal values. MATERIALS AND METHODS: Women undergoing gestational diabetes mellitus screening at 24-28 weeks of gestational age between January 2010 and December 2016 were retrospectively evaluated...
January 11, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29320948/the-profiles-of-soluble-adhesion-molecules-in-the-great-obstetrical-syndromes
#10
Nikolina Docheva, Roberto Romero, Piya Chaemsaithong, Adi L Tarca, Gaurav Bhatti, Percy Pacora, Bogdan Panaitescu, Noppadol Chaiyasit, Tinnakorn Chaiworapongsa, Eli Maymon, Sonia S Hassan, Offer Erez
OBJECTIVE: The objective of this study was to determine the profiles of maternal plasma soluble adhesion molecules in patients with preeclampsia, small-for-gestational-age (SGA) fetuses, acute pyelonephritis, preterm labor with intact membranes (PTL), preterm prelabor rupture of the membranes (preterm PROM), and fetal death. MATERIALS AND METHODS: A cross-sectional study was conducted to determine maternal plasma concentrations of sE-selectin, sL-selectin, and sP-selectin as well as sICAM-1, sVCAM-1, and sPECAM-1 in patients with 1) an uncomplicated pregnancy (control, n = 100); 2) preeclampsia (n = 94); 3) SGA fetuses (in women without preeclampsia/hypertension, n = 45); 4) acute pyelonephritis (n = 25); 5) PTL (n = 53); 6) preterm PROM (n = 24); and 7) fetal death (n = 34)...
January 10, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29311572/correlative-factors-of-the-deterioration-of-necrotizing-enterocolitis-in-small-for-gestational-age-newborns
#11
Lijuan Luo, Wenbin Dong, Lingping Zhang, Xuesong Zhai, Qingping Li, Xiaoping Lei
Small for gestational age (SGA) infants have an increased risk of necrotizing enterocolitis (NEC), but SGA has been found to not be a risk factor for the deterioration of NEC in previous literature. Few studies have focused on correlative factors of the progression of NEC in SGA newborns. The present retrospective observational study was performed in 64 SGA infants with Bell's stage II NEC. The dependent variable was Bell's stage II NEC that progressed to stage III after diagnosis. A stepwise forward multivariate logistic regression model was used to select potential correlative factors for the progression of NEC in SGA newborns...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29306493/delivery-room-resuscitation-and-short-term-outcomes-in-moderately-preterm-infants
#12
Monika Bajaj, Girija Natarajan, Seetha Shankaran, Myra Wyckoff, Abbot R Laptook, Edward F Bell, Barbara J Stoll, Waldemar A Carlo, Betty R Vohr, Shampa Saha, Krisa P Van Meurs, Pablo J Sanchez, Carl T D'Angio, Rosemary D Higgins, Abhik Das, Nancy Newman, Michele C Walsh
OBJECTIVES: To describe the frequency and extent of delivery room resuscitation and evaluate the association of delivery room resuscitation with neonatal outcomes in moderately preterm (MPT) infants. STUDY DESIGN: This was an observational cohort study of MPT infants delivered at 290/7 to 336/7 weeks' gestational age (GA) enrolled in the Neonatal Research Network MPT registry. Infants were categorized into 5 groups based on the highest level of delivery room intervention: routine care, oxygen and/or continuous positive airway pressure, bag and mask ventilation, endotracheal intubation, and cardiopulmonary resuscitation including chest compressions and/or epinephrine use...
January 3, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29305526/associations-of-neighbourhood-crime-with-adverse-pregnancy-outcomes-among-women-in-chicago-analysis-of-electronic-health-records-from-2009-to-2013
#13
Stephanie L Mayne, Lindsay R Pool, William A Grobman, Kiarri N Kershaw
BACKGROUND: Adverse pregnancy outcomes are associated with higher cardiovascular disease risk among mothers and future health problems of offspring. Neighbourhood crime may contribute to adverse pregnancy outcomes by increasing chronic stress, yet the association has been relatively understudied. METHODS: Electronic health records from 34 383 singleton births at a single hospital in Chicago (2009-2013) were geocoded and linked to 1-year rates of police-recorded crime at the neighbourhood (Chicago community area) level...
January 5, 2018: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/29305123/automated-visualization-and-quantification-of-spiral-artery-blood-flow-entering-the-first-trimester-placenta-using-3-d-power-doppler-ultrasound
#14
Gordon N Stevenson, J Alison Noble, Alec W Welsh, Lawrence Impey, Sally L Collins
The goal of our research was to quantify the placental vascularity in 3-D at 11-13 + 6 wk of pregnancy at precise distances from the utero-placental interface (UPI) using 3-D power Doppler ultrasound. With this automated image analysis technique, differences in vascularity between normal and pathologic pregnancies may be observed. The algorithm was validated using a computer-generated image phantom and applied retrospectively in 143 patients. The following features from the PD data were recorded: The number of spiral artery jets into the inter-villous space, total geometric and PD area...
January 2, 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29303059/association-between-endometriosis-and-preterm-birth-in-women-with-spontaneous-conception-or-using-assisted-reproductive-technology-a-systematic-review-and-meta-analysis-of-cohort-studies
#15
Faustino R Pérez-López, Pablo Villagrasa-Boli, María Muñoz-Olarte, Álex Morera-Grau, Pablo Cruz-Andrés, Adrian V Hernandez
OBJECTIVE: To perform a systematic review and meta-analysis to estimate the effect of endometriosis on preterm birth (PB) risk. METHODS: Searches were conducted in PubMed-MEDLINE, Embase, Scopus, Web of Science, Cochrane Library, Google Scholar, and SciELO for studies published in all languages from inception through April 2017. We included cohort studies evaluating pregnant women with and without endometriosis and conception either by spontaneous conception (SC) or with assisted reproductive technology (ART)...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29303058/can-placental-histopathology-lesions-predict-recurrence-of-small-for-gestational-age-neonates
#16
Michal Levy, Yossi Mizrachi, Sophia Leytes, Eran Weiner, Jacob Bar, Letizia Schreiber, Michal Kovo
OBJECTIVE: To study the role of placental pathology in predicting the recurrence of delivery of small for gestational age (SGA) neonates. METHODS: The medical records and placental pathological reports of normotensive women who gave birth at 24 to 42 weeks to neonates with birth weight (BW) <10th percentile were reviewed. Patients were divided according to their subsequent pregnancy into those who developed or did not develop recurrent SGA (BW < 10th percentile)...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29301455/body-mass-index-at-11-13%C3%A2-weeks-gestation-and-pregnancy-complications-in-a-southern-chinese-population-a-retrospective-cohort-study
#17
Piya Chaemsaithong, Tak Yeung Leung, Daljit Sahota, Yvonne Kwun Yue Cheng, Wing Cheong Leung, Tsz Kin Lo, Liona Chiu Yee Poon
OBJECTIVE: To assess the association between body mass index (BMI) and adverse pregnancy outcomes. MATERIALS AND METHODS: A multicentre retrospective cohort study was conducted in three hospitals in Hong Kong including 67 248 women with singleton pregnancy at 11-13 weeks between 2010-2016. The relationship between maternal BMI and [1] miscarriage or stillbirth, [2] development of preeclampsia (PE), [3] gestational hypertension (GH), [4] development of gestational diabetes mellitus (GDM), [5] spontaneous preterm delivery (sPTD) < 34 and < 37 weeks, [6] delivery of a small for gestational age (SGA) or large for gestational age (LGA) neonate, [7] caesarean section (CS) and [8] postpartum haemorrhage (PPH) were examined after adjusting for confounding factors...
January 4, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29298686/a-single-center-experience-with-12-consecutive-cases-of-pregnancy-among-patients-with-membranous-ventricular-septal-aneurysm
#18
Kana Wang, Xiaodong Wang, Haiyan Yu, Xinghui Liu, Aiyun Xing, Yong You
BACKGROUND: Membranous ventricular septal aneurysm (MVSA) is a rare cardiac anomaly that can occur as an isolated entity or being associated with other cardiac malformations. Complications of MVSA include thromboembolism, arrhythmia, rupture, bacterial endocarditis, right ventricular outflow tract obstruction, and atrioventricular valve diseases.The success rate of pregnancy and delivery in patients with MVSA has not been reported in the literature. This study was to assess the clinical implications of this condition from our center's experience...
January 3, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29298330/the-higher-mortality-associated-with-low-serum-albumin-is-dependent-on-systemic-inflammation-in-end-stage-kidney-disease
#19
Filipa Caeiro Alves, Jia Sun, Abdul Rashid Qureshi, Lu Dai, Sunna Snaedal, Peter Bárány, Olof Heimbürger, Bengt Lindholm, Peter Stenvinkel
BACKGROUND: The correlation of low serum albumin with mortality in patients with chronic kidney disease (CKD) is partly linked to its association with systemic inflammation. However, it is not clear to what extent albumin's correlation with mortality depends on concomitant systemic inflammation. Here we addressed this question in patients with CKD stage 5. METHODS: Serum albumin (S-Alb), systemic inflammation (high-sensitive C-reactive protein, hsCRP), cardiovascular disease (CVD) and nutritional status (subjective global assessment, SGA) were assessed at baseline in 822 patients: 523 incident dialysis patients, 212 prevalent hemodialysis (HD) and 87 prevalent peritoneal dialysis (PD) patients...
2018: PloS One
https://www.readbyqxmd.com/read/29297696/second-generation-antipsychotics-in-adolescent-psychiatric-patients-metabolic-effects-and-impact-of-an-early-weight-change-to-predict-longer-term-weight-gain
#20
Frederik Vandenberghe, Alexandra Najar-Giroud, Laurent Holzer, Philippe Conus, Chin B Eap, Anne-Emmanuelle Ambresin
OBJECTIVES: To examine the metabolic profile of adolescents at baseline and to determine the potential predictive power of a 1-month weight gain (WG) on weight changes during longer term second-generation antipsychotic (SGA) treatment. METHODS: A retrospective chart review study, including patients between 13 and 18 years of age and treated with SGA, was conducted. Available data at baseline, 1, 3, and 12 months of treatment were recorded. RESULTS: Four hundred fifty-six patients were included, with a median age of 15 years...
January 3, 2018: Journal of Child and Adolescent Psychopharmacology
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