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https://www.readbyqxmd.com/read/29778383/in-vitro-fertilization-interpregnancy-interval-and-risk-of-adverse-perinatal-outcomes
#1
Kristin Palmsten, Michael V Homer, Yujia Zhang, Sara Crawford, Russell S Kirby, Glenn Copeland, Christina D Chambers, Dmitry M Kissin, H Irene Su
OBJECTIVE: To compare associations between interpregnancy intervals (IPIs) and adverse perinatal outcomes in deliveries following IVF with deliveries following spontaneous conception or other (non-IVF) fertility treatments. DESIGN: Cohort using linked birth certificate and assisted reproductive technology surveillance data from Massachusetts and Michigan. SETTING: Not applicable. PATIENT(S): 1,225,718 deliveries. INTERVENTION(S): None...
May 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29778069/differential-correlations-between-maternal-hair-levels-of-tobacco-and-alcohol-with-fetal-growth-restriction-clinical-subtypes
#2
Sally Sabra, Ebba Malmqvist, Laura Almeida, Eduard Gratacos, Maria Dolores Gomez Roig
Maternal exposure to tobacco and alcohol is a known cause, among others, for fetal growth restriction (FGR). Clinically, FGR can be subclassified into two forms: intrauterine growth restriction (IUGR) and small for gestational age (SGA), based on the severity of the growth retardation, and abnormal uterine artery Doppler or cerebro-placental ratio. This study aimed at investigating any differential correlation between maternal exposures to these toxins with the two clinical forms of FGR. Therefore, a case-control study was conducted in Barcelona, Spain...
January 4, 2018: Alcohol
https://www.readbyqxmd.com/read/29775476/maternal-asthma-is-associated-with-increased-risk-of-perinatal-mortality
#3
Mari Kemppainen, Anna-Maria Lahesmaa-Korpinen, Paula Kauppi, Martti Virtanen, Suvi M Virtanen, Riitta Karikoski, Mika Gissler, Turkka Kirjavainen
BACKGROUND: Asthma is the most common chronic disease during pregnancy and it may have influence on pregnancy outcome. OBJECTIVES: Our goal was to assess the association between maternal asthma and the perinatal risks as well as possible effects of asthma medication. METHODS: The study was based on a nationwide Finnish register-based cohort between the years 1996 and 2012 in the Drug and Pregnancy Database. The register data comprised 962 405 singleton live and stillbirths, 898 333 (93...
2018: PloS One
https://www.readbyqxmd.com/read/29769421/low-placental-visfatin-expression-is-related-to-impaired-glycaemic-control-and-fetal-macrosmia-in-pregnancies-complicated-by-type-1-diabetes
#4
R Iciek, M Brazert, E Wender-Ozegowska, M Pietryga, J Brazert
Type 1 diabetes mellitus (T1DM) is still related to altered fetal growth and severe maternal complications. We studied the possible role of placental visfatin/nicotinamide phosphoribosyltransferase (NAMPT) in fetal development in T1DM pregnancies, the possible role of placental visfatin in fetal macrosomia. Sixty five pregnant women with T1DM and singleton pregnancy were qualified into the study. Placental visfatin expression was by analysed by RT-PCR. We demonstrated the lowest expression of placental visfatin in women who delivered neonates with birth weight NBW > 4000 g (0...
February 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/29765081/new-birthweight-percentiles-by-sex-and-gestational-age-in-southern-china-and-its-comparison-with-the-intergrowth-21st-standard
#5
Fei Yao, Huazhang Miao, Bing Li, Yuntao Wu, Qingguo Zhao
We first showed the sex- and gestational age (week)-specific birthweight distributions from primiparous and multiparous mothers. Birthweight percentiles were created by using the Lambda Mu Sigma (LMS) method. We established the birthweight percentiles in Southern China and provide clinicians and researchers with up-to-date population norms of birthweight percentiles. Then we use the data from Birth Certificate System between Jan 1st, 2017 and Oct 31st, 2017, which included 1,245,364 live births to calculate SGA and LGA ratio by these three birthweight references- the new INTERGROWTH-21st standard, China's 2015 research standard and our birthweight percentiles...
May 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29764569/-combined-effect-of-gestational-age-and-birth-weight-on-metabolites-related-to-inherited-metabolic-diseases-in-neonates
#6
Fang Yi, Ling Wang, Mei Wang, Xue-Lian Yuan, Hua-Jing Wan, Jia-Yuan Li
OBJECTIVE: To study the combined effect of gestational age and birth weight on metabolites related to inherited metabolic diseases (IMD). METHODS: A total of 3 381 samples ruled out of IMD by follow-up were randomly selected from 38 931 newborns who participated in the neonatal IMD screening during 2014-2016. The 3 381 neonates were categorized into seven groups according to their gestational age and birth weight: extremely preterm appropriate-for-gestational age (AGA) group (n=12), preterm small-for-gestational age (SGA) group (n=18), preterm AGA group (n=219), preterm large-for-gestational age (LGA) group (n=18), full-term SGA group (n=206), full-term AGA group (n=2 677), and full-term LGA group (n=231)...
May 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29763893/patterns-of-infancy-growth-and-metabolic-hormonal-profile-are-different-in-very-low-birth-weight-preterm-infants-born-small-for-gestational-age-compared-to-those-born-appropriate-for-gestational-age
#7
María Isabel Hernandez, Katherine Rossel, Veronica Peña, Mirna Garcia, Gabriel Cavada, Alejandra Avila, German Iñiguez, Verónica Mericq
BACKGROUND/AIMS: An increased preterm birth survival rate is associated with long-term neurological and metabolic risks; thus, our aim was to evaluate whether early patterns of infancy anthropometry and metabolic hormonal profile differ in preterm infants born small for gestational age (SGA) or appropriate for gestational age (AGA) from birth to 36 months of corrected age (CA). METHODS: We recruited 110 very-low-birth-weight (VLBW) preterm infants (AGA = 60 and SGA = 50) with a mean birth weight of -2...
May 15, 2018: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29759932/examining-the-link-between-placental-pathology-growth-restriction-and-stillbirth
#8
REVIEW
Robert M Silver
Stillbirth, often defined as death of a fetus ≥20 weeks of gestation, is emotionally devastating for families and caregivers. It is often associated with fetal growth restriction (FGR). Indeed, FGR or small-for-gestational age fetus (SGA) is a major risk factor for stillbirth. In rare cases, this is due to genetic abnormalities or infections. However, in most cases, it is linked to placental insufficiency. This may be due to abnormal placental development or placental damage, thereby resulting in decreased blood flow, oxygen, and nutrients to the fetus...
March 26, 2018: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29753845/gestational-di-2-ethylhexyl-phthalate-exposure-causes-fetal-intrauterine-growth-restriction-through-disturbing-placental-thyroid-hormone-receptor-signaling
#9
Zhen Yu, Yan Han, Ru Shen, Kun Huang, Yuan-Yuan Xu, Qu-Nan Wang, Shan-Shan Zhou, De-Xiang Xu, Fang-Biao Tao
Previous study reported that gestational Di-(2-ethylhexyl) phthalate (DEHP) exposure caused fetal intrauterine growth restriction (IUGR). We aimed to investigate the role of placental thyroid hormone receptor (THR) signaling in DEHP-induced IUGR. Dams were treated with DEHP (50 or 200 mg/kg) by gavage daily throughout pregnancy. As expected, gestational DEHP exposure dose-dependently caused fetal IUGR. The mRNA levels of placental Thrα1 and Thrβ1 were reduced and nuclear translocation of placental THRα1 and THRβ1 were suppressed in DEHP-exposed mice even though thyroid hormones in maternal and fetal sera were unaffected...
May 10, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29752776/influence-of-prehospital-airway-management-on-neurological-outcome-in-patients-transferred-to-a-heart-attack-centre-following-out-of-hospital-cardiac-arrest
#10
Timothy Edwards, Julia Williams, Michaela Cottee
OBJECTIVE: To describe the association between prehospital airway management and neurological outcomes in patients transferred by the ambulance service directly to a heart attack centre (HAC) post-return of spontaneous circulation (ROSC). METHODS: A retrospective observational cohort study in which ambulance records were reviewed to determine prehospital airway management strategy and collect physiological and demographic data. HAC notes were obtained to determine in-hospital management and quantify neurological outcome via the cerebral performance category (CPC) scale...
May 11, 2018: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/29751416/household-environmental-exposures-during-gestation-and-birth-outcomes-a-cross-sectional-study-in-shanghai-china
#11
Wei Liu, Chen Huang, Jiao Cai, Xueying Wang, Zhijun Zou, Chanjuan Sun
Several studies have reported that certain aspects of the household environments are associated with adverse birth outcomes, but associations have been inconsistent. Few of these studies have been conducted in China. During 2011-2012, we conducted a retrospective cross-sectional study and collected 13,335 parents-reported questionnaires for 4-6-year-olds children in Shanghai, China. We investigated associations of household environmental factors (environmental tobacco smoke (ETS), cooking fuel, dampness, pet-keeping, and home renovation) during gestation with preterm birth (PTB, gestational age<37weeks), low birth weight (LBW, birth weight<2500g), term low birth weight (T-LBW, LBW when the gestational age was ≥37weeks), and small for gestational age (SGA, birth weight<10th percentile of birth weight for gestational age)...
February 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29747664/adverse-effects-in-children-exposed-to-maternal-hiv-and-antiretroviral-therapy-during-pregnancy-in-brazil-a-cohort-study
#12
Adriane M Delicio, Giuliane J Lajos, Eliana Amaral, Fernanda Cavichiolli, Marina Polydoro, Helaine Milanez
BACKGROUND: Antiretroviral therapy (ART) in pregnancy was associated with a drastic reduction in HIV mother-to-child transmission (MTCT), although it was associated with neonatal adverse effects. The aim of this study was to evaluate the neonatal effects to maternal ART. METHODS: This study was a cohort of newborns from HIV pregnant women followed at the CAISM/UNICAMP Obstetric Clinic from 2000 to 2015. The following adverse effects were evaluated: anemia, thrombocytopenia, liver function tests abnormalities, preterm birth, low birth weight and congenital malformation...
May 10, 2018: Reproductive Health
https://www.readbyqxmd.com/read/29744251/comparison-of-different-cuff-pressure-use-with-the-supreme-laryngeal-mask-airway-on-haemodynamic-response-seal-pressure-and-postoperative-adverse-events-a-prospective-randomized-study
#13
Achmet Ali, Demet Altun, Nukhet Sivrikoz, Mesut Yornuk, Namigar Turgut, İbrahim Özkan Akıncı
Objective: The Supreme™ laryngeal mask airway (SLMA) is a supra glottic airway (SGA) device that is used as an alternative to endotracheal tubes. In the present study, we aimed to compare the use of the SLMA with normal cuff pressure and low cuff pressure, primarily for haemodynamic response. Methods: In the present study, 120 patients diagnosed with hypertension and scheduled for varicose vein or inguinal hernia operation were enrolled and 99 patients finished...
April 2018: Turkish Journal of Anaesthesiology and Reanimation
https://www.readbyqxmd.com/read/29742672/fetal-growth-patterns-in-pregnancies-with-first-trimester-bleeding
#14
Alaina M Bever, Sarah J Pugh, Sungduk Kim, Roger B Newman, William A Grobman, Edward K Chien, Deborah A Wing, Hanyun Li, Paul S Albert, Katherine L Grantz
OBJECTIVE: To assess the relationship between first-trimester vaginal bleeding and fetal growth patterns. METHODS: We conducted a secondary analysis of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Fetal Growth Studies-Singletons, a prospective cohort study of low-risk, nonobese women with healthy lifestyles. Duration of bleeding was self-reported at enrollment (10 0/7 to 13 6/7 weeks of gestation) and categorized as 0, 1, or more than 1 day...
May 7, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29739262/comparison-of-prostaglandin-and-mechanical-cervical-ripening-in-the-setting-of-small-for-gestational-age-neonates
#15
Robert M Rossi, Carri R Warshak, Heather R Masters, Jodi K Regan, Sara A Kritzer, Kristin P Magner
OBJECTIVE: To determine whether cervical ripening with misoprostol (MP) is associated with higher rates of cesarean delivery (CD) (CD) compared to dinoprostone (DP) or Pitocin/Foley balloon (PFB) in infants found to be small for gestational age (SGA). STUDY DESIGN: Single center institution based cohort study of all inductions between 2008-2012 where birth weight was found to be as SGA (< 10th percentile). Maternal demographic, obstetric, and labor characteristics were compared between SGA births where cervical ripening with MP, Mode compares MP to referent group (DP), or PFB was used as the primary agent...
May 8, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29738268/low-food-intake-in-hospital-patient-institutional-and-clinical-factors
#16
Lori J Curtis, Renata Valaitis, Celia V Laur, Tara McNicholl, Roseann Nasser, Heather H Keller
In-hospital malnutrition and inadequate food intake have been associated with negative outcomes (e.g., prolonged length of stay, readmission, mortality, and increased hospital costs). Studies examining factors associated with low food intake in hospital, commonly defined as consuming ≤50% of meals, have produced mixed results. We examined the correlates of food intake including patient socioeconomic, demographic, and health characteristics, institutional factors, and common clinical strategies in 1129 medical patients from five Canadian hospitals...
May 8, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29735478/development-and-validation-of-a-multidisciplinary-mobile-care-system-for-patients-with-advanced-gastrointestinal-cancer-interventional-observation-study
#17
Ji Yeong Soh, Won Chul Cha, Dong Kyung Chang, Ji Hye Hwang, Kihyung Kim, Miyong Rha, Hee Kwon
BACKGROUND: Mobile health apps have emerged as supportive tools in the management of advanced cancers. However, only a few apps have self-monitoring features, and they are not standardized and validated. OBJECTIVE: This study aimed to develop and validate a multidisciplinary mobile care system with self-monitoring features that can be useful for patients with advanced gastrointestinal cancer. METHODS: The development of the multidisciplinary mobile health management system was divided into 3 steps...
May 7, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29735370/generation-of-%C3%AE-solanine-free-hairy-roots-of-potato-by-crispr-cas9-mediated-genome-editing-of-the-st16dox-gene
#18
Masaru Nakayasu, Ryota Akiyama, Hyoung Jae Lee, Keishi Osakabe, Yuriko Osakabe, Bunta Watanabe, Yukihiro Sugimoto, Naoyuki Umemoto, Kazuki Saito, Toshiya Muranaka, Masaharu Mizutani
Potato (Solanum tuberosum) is a major food crop, while the most tissues of potato accumulates steroidal glycoalkaloids (SGAs) α-solanine and α-chaconine. Since SGAs confer a bitter taste on human and show the toxicity against various organisms, reducing the SGA content in the tubers is requisite for potato breeding. However, generation of SGA-free potato has not been achieved yet, although silencing of several SGA biosynthetic genes led a decrease in SGAs. Here, we show that the knockout of St16DOX encoding a steroid 16α-hydroxylase in SGA biosynthesis causes the complete abolition of the SGA accumulation in potato hairy roots...
April 24, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29734130/baseline-results-from-the-european-non-interventional-antipsychotic-long-acting-injection-in-schizophrenia-alto-study
#19
Pierre-Michel Llorca, Julio Bobes, W Wolfgang Fleischhacker, Stephan Heres, Nicholas Moore, Nawal Bent-Ennakhil, Christophe Sapin, Jean-Yves Loze, Anna-Greta Nylander, Maxine X Patel
BACKGROUND: The Antipsychotic Long-acTing injection in schizOphrenia (ALTO) study was a non-interventional study across several European countries examining prescription of long-acting injectable (LAI) antipsychotics to identify sociodemographic and clinical characteristics of patients receiving and physicians prescribing LAIs. ALTO was also the first large-scale study in Europe to report on the use of both first- or second-generation antipsychotic (FGA- or SGA-) LAIs. METHODS: Patients with schizophrenia receiving a FGA- or SGA-LAI were enrolled between June 2013 and July 2014 and categorized as incident or prevalent users...
May 4, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29730594/adverse-effects-of-small-for-gestational-age-differ-by-gestational-week-among-very-preterm-infants
#20
Erik A Jensen, Elizabeth E Foglia, Kevin C Dysart, Rebecca A Simmons, Zubair H Aghai, Alison Cook, Jay S Greenspan, Sara B DeMauro
OBJECTIVE: To characterise the excess risk for death, grade 3-4 intraventricular haemorrhage (IVH), bronchopulmonary dysplasia (BPD) and stage 3-5 retinopathy of prematurity independently associated with birth small for gestational age (SGA) among very preterm infants, stratified by completed weeks of gestation. METHODS: Retrospective cohort study using the Optum Neonatal Database. Study infants were born <32 weeks gestation without severe congenital anomalies...
May 5, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
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