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https://www.readbyqxmd.com/read/29679432/an-rct-with-the-combination-of-varenicline-and-bupropion-for-smoking-cessation-clinical-implications-for-front-line-use
#1
Paul M Cinciripini, Jennifer A Minnix, Charles E Green, Jason D Robinson, Jeffrey M Engelmann, Francesco Versace, David W Wetter, Sanjay Shete, Maher Karam-Hage
BACKGROUND AND AIMS: Despite the availability of several efficacious smoking cessation treatments, less than 25% of smokers who quit remain abstinent 1 year post treatment. This study aimed to determine if varenicline and bupropion combination treatment would result in higher abstinence rates than varenicline alone. DESIGN: A double-blind, randomized, parallel groups smoking cessation clinical trial in which participants were exposed to 12 weeks of treatment and followed for 12 months...
April 21, 2018: Addiction
https://www.readbyqxmd.com/read/29678772/minocycline-adjunctive-treatment-to-risperidone-for-negative-symptoms-in-schizophrenia-association-with-pro-inflammatory-cytokine-levels
#2
Lulu Zhang, Hongbo Zheng, Rengrong Wu, Furong Zhu, Thomas R Kosten, Xiang-Yang Zhang, Jingping Zhao
BACKGROUND: We attempted to replicate the efficacy of minocycline, a second-generation tetracycline, as adjunctive therapy for the negative symptoms of schizophrenia, and to investigate its association with pro-inflammatory cytokine levels. METHODS: Seventy-five schizophrenia patients with negative symptoms entered a 3-month, double blind, randomized, placebo-controlled clinical trial. Subjects were assigned low dose (100 mg per day) or high dose minocycline (200 mg per day) or placebo combined with risperidone...
April 17, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29678471/hematologic-toxicity-from-radium-223-therapy-for-bone-metastases-in-castration-resistant-prostate-cancer-risk-factors-and-practical-considerations
#3
REVIEW
Heather Jacene, Leonard Gomella, Evan Y Yu, Eric M Rohren
Radium-223 dichloride is an α-emitting radiopharmaceutical that localizes to bone matrix and is approved for the treatment of patients with metastatic castration-resistant prostate cancer (CRPC) and symptomatic bone metastases. The cumulative impact of Ra-223 and other therapeutic agents for metastatic CRPC on myelosuppression in bone marrow is unknown. The phase 3 randomized, double-blind, placebo-controlled ALSYMPCA trial of Ra-223 in patients with CRPC and symptomatic bone metastases demonstrated a significant improvement in overall survival...
March 23, 2018: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29677895/re-intravenous-mannitol-versus-placebo-during-partial-nephrectomy-in-patients-with-normal-kidney-function-a-double-blind-clinically-integrated-randomized-trial
#4
https://www.readbyqxmd.com/read/29676968/effects-of-daily-intake-of-calcium-and-vitamin-d-enriched-milk-in-healthy-postmenopausal-women-a-randomized-controlled-double-blind-nutritional-study
#5
Rebeca Reyes-Garcia, Nicolas Mendoza, Santiago Palacios, Nancy Salas, Miguel Quesada-Charneco, Antonia Garcia-Martin, Juristo Fonolla, Federico Lara-Villoslada, Manuel Muñoz-Torres
OBJECTIVE: To determine the effect of the daily intake of calcium and vitamin D-enriched milk (with or without fructooligosaccharides [FOS]) on vitamin D, bone metabolism, and cardiovascular risk factors. MATERIALS AND METHODS: Two-year randomized controlled study, including 500 healthy postmenopausal women, assigned to 500 mL/day of skimmed milk to one of three groups: Low-dose (L): (120 mg/100 mL calcium, vitamin D3 30 UI/100 mL), group A: calcium and vitamin D (180 mg/100 mL and 120 UI/100 mL), and group B: calcium and vitamin D (180 mg/100 mL and 120 UI/100 mL) and FOS (5 g/L)...
April 20, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29676824/the-safety-effectiveness-and-cost-effectiveness-of-cytisine-in-achieving-six-month-continuous-smoking-abstinence-in-tuberculosis-patients-protocol-for-a-double-blind-placebo-controlled-randomised-trial
#6
Omara Dogar, Deepa Barua, Melanie Boeckmann, Helen Elsey, Razia Fatima, Rhian Gabe, Rumana Huque, Ada Keding, Amina Khan, Daniel Kotz, Eva Kralikova, James N Newell, Iveta Nohavova, Steve Parrott, Anne Readshaw, Lottie Renwick, Aziz Sheikh, Kamran Siddiqi
BACKGROUND AND AIMS: Tuberculosis (TB) patients who quit smoking have much better disease outcomes than those who continue to smoke. Behavioural support combined with pharmacotherapy is the most effective strategy in helping people to quit, in general populations. However, there is no evidence for the effectiveness of this strategy in TB patients who smoke. We will assess the safety, effectiveness and cost-effectiveness of cytisine - a low-cost plant-derived nicotine substitute - for smoking cessation in TB patients compared with placebo, over and above brief behavioural support...
April 20, 2018: Addiction
https://www.readbyqxmd.com/read/29676689/intravenous-acetaminophen-for-postoperative-supratentorial-craniotomy-pain-a-prospective-randomized-double-blinded-placebo-controlled-trial
#7
Walavan Sivakumar, Michael Jensen, Julie Martinez, Michael Tanana, Nancy Duncan, Robert Hoesch, Jay K Riva-Cambrin, Craig Kilburg, Safdar Ansari, Paul A House
OBJECTIVE Acute pain control after cranial surgery is challenging. Prior research has shown that patients experience inadequate pain control post-craniotomy. The use of oral medications is sometimes delayed because of postoperative nausea, and the use of narcotics can impair the evaluation of brain function and thus are used judiciously. Few nonnarcotic intravenous (IV) analgesics exist. The authors present the results of the first prospective study evaluating the use of IV acetaminophen in patients after elective craniotomy...
April 20, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29676640/a-pilot-study-assessing-the-ability-of-5-aminosalicylic-acid-to-modulate-the-immune-response-in-chronic-beryllium-disease
#8
Brian J Day, Jie Huang, Briana Q Barkes, May Gillespie, Li Li, Lisa A Maier
Chronic beryllium disease is a granulomatous lung disease, characterized by the accumulation of macrophages and beryllium-specific CD4+ T-cells that proliferate and produce T-helper cell type 1 cytokines. Previous studies indicate that beryllium-mediated oxidative stress enhances cytokine response in chronic beryllium disease CD4+ T-cells. 5-Aminosalicylic acid (5-ASA) is currently used to treat inflammatory bowel disease and has both antioxidant and antiinflammatory actions. We hypothesized that 5-ASA therapy may be a beneficial therapy in chronic beryllium disease...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29676592/pulsed-dye-laser-as-an-adjuvant-treatment-for-discoid-lupus-erythematosus-a-randomized-controlled-trial
#9
Pawinee Rerknimitr, Nucharin Tekacharin, Ratchathorn Panchaprateep, Jade Wititsuwannakul, Pattarin Tangtanatakul, Nattiya Hirankarn, Pravit Asawanonda
PURPOSE: To evaluate the efficacy and safety of PDL for DLE in a double blinded, randomized, controlled fashion. METHOD: Forty-eight DLE lesions from nine patients were recruited. The lesions on one side of the body were randomized into the treatment group and the other side served as a control. Treatments with the PDL (595nm) were delivered every 4 weeks for 4 consecutive months. The patients were evaluated at weeks 0, 4, 8, 12, 16 and 24. Erythema index (EI) and Texture index (TI) were obtained by Antera3D®...
April 20, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29676139/-effect-of-xinling-wan-in-treatment-of-stable-angina-pectoris-a-randomized-double-blinded-placebo-parallel-controlled-multicenter-trial
#10
Jian-Wei Gao, Xue-Min Gao, Ting Zou, Tian-Meng Zhao, Dong-Hua Wang, Zong-Gui Wu, Chang-Jie Ren, Xing Wang, Nai-Zhi Geng, Ming-Jun Zhao, Qiu-Ming Liang, Xing Feng, Bai-Song Yang, Jun-Ling Shi, Qi Hua
To evaluate the effectiveness and safety of Xinling Wan on patients with stable angina pectoris, a randomized, double-blinded, placebo parallel-controlled, multicenter clinical trial was conducted. A total of 232 subjects were enrolled and randomly divided into experiment group and placebo group. The experiment group was treated with Xinling Wan (two pills each time, three times daily) for 4 weeks, and the placebo group was treated with placebo. The effectiveness evaluation showed that Xinling Wan could significantly increase the total duration of treadmill exercise among patients with stable angina pectoris...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29676136/-network-meta-analysis-of-chinese-medical-injections-for-heart-failure
#11
Feng-Wen Yang, Jia-Han Zou, Yuan Wang, Chong-Xiang Sun, Long Ge, Jin-Hui Tian, Jun-Hua Zhang
To assess the clinical efficacy of Chinese medical injection (CMI) for heart failure by using network Meta-analysis method. The relative randomized controlled trials (RCTs) of CMI for heart failure were retrieved from China National Knowledge Infrastructure (CNKI), WanFang Database, Chinese Biomedical Literature Database (SinoMed), PubMed, Cochrane Library and EMbase in July 2017. RCTs on the comparison of two kinds of CMIs for heart failure were included. Two researchers independently completed the literature screening, data extraction and quality evaluation according to the pre-determined inclusion and exclusion criteria, and the results were crossed checked...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29675680/a-randomized-double-blind-phase-2-study-of-ruxolitinib-or-placebo-in-combination-with-capecitabine-in-patients-with-advanced-her2-negative-breast-cancer-and-elevated-c-reactive-protein-a-marker-of-systemic-inflammation
#12
Joyce O'Shaughnessy, Angela DeMichele, Cynthia X Ma, Paul Richards, Denise A Yardley, Gail Shaw Wright, Kevin Kalinsky, Ronald Steis, Sami Diab, Gerard Kennealey, Ryan Geschwindt, Wei Jiang, Hope S Rugo
PURPOSE: The Janus-associated kinase (JAK)/signal transducer and activator of transcription pathway is a key regulator of inflammatory signaling, associated with tumorigenesis, cell survival, and progression. This randomized phase 2 trial evaluated the efficacy and safety of the addition of ruxolitinib, a JAK1/JAK2 inhibitor, to capecitabine in patients with HER2-negative advanced breast cancer and high systemic inflammation (modified Glasgow Prognostic Score [mGPS] ≥ 1). METHODS: Patients with ≤ 2 prior chemotherapy regimens for advanced or metastatic disease or hormone receptor-positive patients with disease progression on prior hormonal therapies were randomized 1:1 to 21-day cycles of ruxolitinib (n = 76) or placebo (n = 73) plus capecitabine...
April 19, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29674967/no-acute-effects-of-cannabidiol-on-the-sleep-wake-cycle-of-healthy-subjects-a-randomized-double-blind-placebo-controlled-crossover-study
#13
Ila M P Linares, Francisco S Guimaraes, Alan Eckeli, Ana C S Crippa, Antonio W Zuardi, Jose D S Souza, Jaime E Hallak, José A S Crippa
Cannabidiol (CBD) is a component of Cannabis sativa that has a broad spectrum of potential therapeutic effects in neuropsychiatric and other disorders. However, few studies have investigated the possible interference of CBD on the sleep-wake cycle. The aim of the present study was to evaluate the effect of a clinically anxiolytic dose of CBD on the sleep-wake cycle of healthy subjects in a crossover, double-blind design. Twenty-seven healthy volunteers that fulfilled the eligibility criteria were selected and allocated to receive either CBD (300 mg) or placebo in the first night in a double-blind randomized design (one volunteer withdrew from the study)...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29674270/response-inhibition-and-emotional-cognition-improved-by-atomoxetine-in-children-and-adolescents-with-adhd-the-action-randomized-controlled-trial
#14
Kristi R Griffiths, John E Leikauf, Tracey W Tsang, Simon Clarke, Daniel F Hermens, Daryl Efron, Leanne M Williams, Michael R Kohn
Although the non-stimulant medication atomoxetine is effective for attention-deficit hyperactivity disorder (ADHD) in children and adolescents, there are still significant gaps in our knowledge about whether atomoxetine improves anxiety symptoms or cognition in children. Furthermore, while cognition has been proposed as an intermediate phenotype for ADHD dysfunction, the relationships between clinical and cognitive outcomes are not yet understood. We addressed these knowledge gaps in a controlled trial using objective assessments of both general and emotional cognitive functions implicated in ADHD and in anxiety, which commonly co-occurs with ADHD...
March 27, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29673890/efficacy-and-safety-of-fixed-dose-combination-therapy-with-telmisartan-and-rosuvastatin-in-korean-patients-with-hypertension-and-dyslipidemia-telsta-yu-telmisartan-rosuvastatin-from-yuhan-a-multicenter-randomized-4-arm-double-blind-placebo-controlled-phase
#15
Gyu Chul Oh, Jung-Kyu Han, Ki Hoon Han, Min-Su Hyon, Joon Hyung Doh, Moo Hyun Kim, Jin-Ok Jeong, Jang-Ho Bae, Sang Hyun Kim, Byung-Su Yoo, Sang Hong Baek, Moo-Yong Rhee, Sang-Hyun Ihm, Jung Hoon Sung, Young Jin Choi, Soo-Joong Kim, Kyung-Soon Hong, Byoung Kwon Lee, JangHyun Cho, Eun Seok Shin, Jay Young Rhew, Hyunsu Kim, Hyo-Soo Kim
PURPOSE: Hypertension and dyslipidemia are 2 risk factors of cardiovascular disease that often present simultaneously. Traditionally, treatment of these multiple conditions required separate medications for each disease, which may result in poor compliance and thus lead to possible treatment failure. Fixed-dose combination (FDC) therapy with a single pill may be a solution in these situations. METHODS: This multicenter, 8-week, randomized, double-blind, Phase III study evaluated the efficacy and safety of FDC treatment with telmisartan (80 mg) and rosuvastatin calcium (20 mg) in Korean patients with mild to moderate hypertension and dyslipidemia...
April 16, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29673685/comparison-of-efficacy-of-dental-varnish-containing-fluoride-either-with-cpp-acp-or-bioglass-on-root-caries-ex-vivo-study
#16
A Sleibi, A R Tappuni, Graham R Davis, P Anderson, A Baysan
OBJECTIVES: To compare the efficacy of fluoride varnishes either casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) or bioglass particles on the severity index of root caries. METHODS: Visual-tactile assessments including lesion hardness was carried out to categorise the severity index of 80 extracted teeth with primary root caries. These teeth were randomly divided into four groups; CPP-ACP and fluoride, bioglass and fluoride, fluoride only, and no treatment...
April 16, 2018: Journal of Dentistry
https://www.readbyqxmd.com/read/29673620/effects-of-opioid-and-non-opioid-analgesics-on-responses-to-psychosocial-stress-in-humans
#17
Anya K Bershad, Melissa A Miller, Greg J Norman, Harriet de Wit
Both preclinical and clinical evidence suggests that the endogenous opioid system is involved in responses to stress. For example, in animal models opioid agonists reduce isolation distress whereas opioid antagonists increase isolation distress. We recently reported that the mixed mu agonist and kappa antagonist buprenorphine dampened responses to acute psychosocial stress in humans. Now we extend this to study the effects of a pure mu-opioid agonist, hydromorphone, and a non-opioid analgesic, acetaminophen, on response to social stress...
April 16, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29673544/no-effect-of-creatine-monohydrate-supplementation-on-inflammatory-and-cartilage-degradation-biomarkers-in-individuals-with-knee-osteoarthritis
#18
Stephen M Cornish, Jason D Peeler
The study purpose was to evaluate the effectiveness of creatine monohydrate supplementation (20 grams/day for 1 week and then 5 grams/day for 11 weeks) on inflammation (C-reactive protein, interleukin-1β, interleukin-6, s100 A8/A9, and tumor necrosis factor-α) and cartilage degradation (serum cartilage oligomeric matrix protein) in patients with knee osteoarthritis. We hypothesized that supplementing with creatine monohydrate for 12 weeks would lower biomarkers of inflammation and cartilage degradation in patients with knee osteoarthritis when compared to placebo...
March 2018: Nutrition Research
https://www.readbyqxmd.com/read/29673379/erythropoietin-as-an-add-on-treatment-for-cognitive-side-effects-of-electroconvulsive-therapy-a-study-protocol-for-a-randomized-controlled-trial
#19
Lejla Sjanic Schmidt, Jeff Zarp Petersen, Maj Vinberg, Ida Hageman, Niels Vidiendal Olsen, Lars Vedel Kessing, Martin Balslev Jørgensen, Kamilla Woznica Miskowiak
BACKGROUND: Electroconvulsive therapy (ECT) is the most effective treatment for severe depression, but its use is impeded by its cognitive side effects. Novel treatments that can counteract these side effects may therefore improve current treatment strategies for depression. The present randomized trial investigates (1) whether short-term add-on treatment with erythropoietin (EPO) can reduce the cognitive side -effects of ECT and (2) whether such effects are long-lasting. Further, structural and functional magnetic resonance imaging (MRI) will be used to explore the neural underpinnings of such beneficial effects of EPO...
April 19, 2018: Trials
https://www.readbyqxmd.com/read/29673355/patient-reported-outcomes-in-patients-with-overactive-bladder-treated-with-mirabegron-and-tolterodine-in-a-prospective-double-blind-randomized-two-period-crossover-multicenter-study-prefer
#20
Sender Herschorn, David Staskin, Le Mai Tu, Jonathan Fialkov, Terry Walsh, Katherine Gooch, Carol R Schermer
BACKGROUND: The PREFER study was an assessment of medication tolerability, treatment preference and symptom improvement during treatment with mirabegron (M) and tolterodine (T) extended release (ER) in patients with overactive bladder (OAB). In this analysis of PREFER, patient-reported outcomes (PROs) were assessed during treatment. METHODS: PREFER was a two-period, 8-week crossover, double-blind, phase IV study (NCT02138747) of treatment-naïve adults with OAB ≥3 months randomized to 1 of 4 treatment sequences (M/T; T/M; M/M; T/T), separated by a 2-week washout...
April 19, 2018: Health and Quality of Life Outcomes
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