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Quality use of pathology

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https://www.readbyqxmd.com/read/28731040/er-stress-and-the-unfolded-protein-response-in-neurodegeneration
#1
REVIEW
Claudio Hetz, Smita Saxena
The clinical manifestation of neurodegenerative diseases is initiated by the selective alteration in the functionality of distinct neuronal populations. The pathology of many neurodegenerative diseases includes accumulation of misfolded proteins in the brain. In physiological conditions, the proteostasis network maintains normal protein folding, trafficking and degradation; alterations in this network - particularly disturbances to the function of endoplasmic reticulum (ER) - are thought to contribute to abnormal protein aggregation...
July 21, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28730301/biopsychosocial-factors-predict-quality-of-life-in-thoracolumbar-spine-surgery
#2
Dean A Tripp, Edward Abraham, Maude Lambert, Kate Wagg, Erin Bigney, Eden Daly, Phylicia Verreault, Neil Manson
PURPOSE: Surgical intervention is a treatment option for various spinal pathology but many patients report no improvement or even an exacerbation of symptoms like pain. This study examined the association of preoperative (pre-op) biopsychosocial risk factors with poor quality of life at 2 and 6 months using hierarchical models controlling demographic and medical variables. METHOD: Participants undergoing thoracolumbar spine surgery (N = 214) were provided with questionnaire packages to complete pre-op, at 2 and at 6-month postoperative clinical follow-ups (i...
July 20, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28730090/critical-pathway-for-primary-open-angle-glaucoma-diagnosis
#3
Alejandro R Allocco, Julia A Ponce, Maria J Riera, Mauricio G Magurno
AIM: To develop a critical pathway for primary open angle glaucoma (POAG) diagnosis intended to be efficient, to unify criteria, reduce resource use and minimize costs to the health system. METHODS: We performed a systematic search on PubMed, Cochrane, Embase and ClinicalTrials.org databases and classified the quality of evidence from level I through III. RESULTS: A critical pathway was designed by setting a key-decision step by step model on the basis of the best current evidence...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28726532/local-to-global-working-together-to-meet-the-needs-of-vulnerable-communities
#4
Anne Dressel, Lucy Mkandawire-Valhmu, Ann Dietrich, Ellen Chirwa, Florence Mgawadere, Sylvia Kambalametore, Peninnah Kako
Since 2012, the University of Wisconsin-Milwaukee (UWM) faculty from nursing and physical therapy (PT) have been working together towards a common goal: to meet the healthcare needs of vulnerable populations in Malawi and Milwaukee. Sharing valuable knowledge and understanding one another's professions have allowed us to develop interprofessional education (IPE) learning experiences for students to help identify how quality of life could be improved or enhanced for children and their families across two different geographic spaces, one in rural Malawi and the other in urban Milwaukee...
July 20, 2017: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/28726120/magnetic-resonance-imaging-for-detection-of-parametrial-invasion-in-cervical-cancer-an-updated-systematic-review-and-meta-analysis-of-the-literature-between-2012-and-2016
#5
Sungmin Woo, Chong Hyun Suh, Sang Youn Kim, Jeong Yeon Cho, Seung Hyup Kim
OBJECTIVE: To review the diagnostic performance of MRI for detection of parametrial invasion (PMI) in cervical cancer patients. METHODS: MEDLINE and EMBASE databases were searched for studies providing diagnostic performance of MRI for detecting PMI in patients with cervical cancer. Studies published between 2012 and 2016 using surgico-pathological results as reference standard were included. Study quality was evaluated using QUADAS-2. Sensitivity and specificity of all studies were calculated...
July 19, 2017: European Radiology
https://www.readbyqxmd.com/read/28725791/quality-improvement-intervention-for-reduction-of-redundant-testing
#6
Alan M Ducatman, Danyel H Tacker, Barbara S Ducatman, Dustin Long, Peter L Perrotta, Hannah Lawther, Kelly Pennington, Owen Lander, Mary Warden, Conard Failinger, Kevin Halbritter, Ronald Pellegrino, Marney Treese, Jeffrey A Stead, Eric Glass, Lauren Cianciaruso, Konrad C Nau
Laboratory data are critical to analyzing and improving clinical quality. In the setting of residual use of creatine kinase M and B isoenzyme testing for myocardial infarction, we assessed disease outcomes of discordant creatine kinase M and B isoenzyme +/troponin I (-) test pairs in order to address anticipated clinician concerns about potential loss of case-finding sensitivity following proposed discontinuation of routine creatine kinase and creatine kinase M and B isoenzyme testing. Time-sequenced interventions were introduced...
January 2017: Acad Pathol
https://www.readbyqxmd.com/read/28725788/pathology-residents-comprise-inspection-team-for-a-cap-self-inspection
#7
Stacy G Beal, Jesse L Kresak, Anthony T Yachnis
We report our experience at the University of Florida in which residents and fellows served as the inspection team for a College of American Pathologists (CAP) self-inspection. We aimed to determine whether the CAP self-inspection could serve as a learning opportunity for pathology residents and fellows. To prepare for the inspection, we provided a series of 4 lunchtime seminars covering numerous laboratory management topics relating to inspections and laboratory quality. Preparation for the inspection began approximately 4 months prior to the date of the inspection...
January 2017: Acad Pathol
https://www.readbyqxmd.com/read/28723518/mid-term-outcomes-following-salvage-lymph-node-dissection-for-prostate-cancer-nodal-recurrence-status-post-radical-prostatectomy
#8
Fabio Zattoni, Avinash Nehra, Christopher R Murphy, Laureano Rangel, Lance Mynderse, Val Lowe, Eugene Kwon, R Jeffrey Karnes
BACKGROUND: Patients with oligometastatic prostate cancer lymph node recurrence can be treated with many options including salvage lymph node dissection (sLND). OBJECTIVE: Evaluation of outcomes of sLND and identification of clinicopathologic features in predicting further biochemical and radiological relapse after sLND for prostate cancer. DESIGN, SETTING, AND PARTICIPANTS: Between November 1, 2009 and March 31, 2015, 117 patients with biochemical recurrence (BCR) after radical prostatectomy (RP) underwent sLND by a single surgeon after a standardized 11C-choline positron emission tomography/computed tomography...
December 2016: European Urology Focus
https://www.readbyqxmd.com/read/28719732/genome-wide-association-meta-analysis-reveals-novel-juvenile-idiopathic-arthritis-susceptibility-loci
#9
Laura A McIntosh, Miranda C Marion, Marc Sudman, Mary E Comeau, Mara L Becker, John F Bohnsack, Tasha E Fingerlin, Thomas A Griffin, J Peter Haas, Daniel J Lovell, Lisa A Maier, Peter A Nigrovic, Sampath Prahalad, Marilynn Punaro, Carlos D Rosé, Carol A Wallace, Carol A Wise, Halima Moncrieffe, Timothy D Howard, Carl D Langefeld, Susan D Thompson
OBJECTIVE: Juvenile idiopathic arthritis (JIA) is the most common childhood rheumatic disease and has a strong genomic component. To date, JIA genetic association studies have had limited sample sizes, used heterogeneous patient populations, or included only candidate regions. This study focuses on identifying new associations among oligoarticular and polyarticular rheumatoid factor negative (RF(-) ) JIA, which are clinically similar and the most prevalent JIA disease subtypes. METHODS: Three cohorts totaling 2,751 oligoarticular and polyarticular RF(-) JIA cases were genotyped on the Affymetrix Genome-Wide SNP Array 6...
July 18, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28719707/community-triage-of-otology-patients-using-a-store-and-forward-telemedicine-device-a-feasibility-study
#10
Nishi Gupta, Neeraj Chawla, Digant Gupta, Nidhi Dhawan, Vidya R Janaki
Chronic otitis media is a major contributor to acquired hearing loss in developing countries. Developing countries such as India, with huge populations and poor health infrastructures, have always felt the shortage of trained specialists who can provide quality care to meet the enormous demand for treatment of this disease. This pilot study assessed the feasibility of empowering trained health workers equipped with ENTraview, a store-and-forward telemedicine device that integrates a camera- enabled smart phone with an otoscope...
July 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28716490/-self-evaluation-of-conization-indications-since-the-introduction-of-the-french-colposcopy-and-cervico-vaginal-pathology-quality-charter-in-2%C3%A2-colposcopy-centers
#11
M Lallemant, C Baeza, C Monnin, M Malincenco, C Gay
OBJECTIVES: Analyze the efficiency of the implementation of the colposcopy and cervico-vaginal pathology quality charter. The question was to determine whether the criteria of more than 70% of excisional conizations containing CIN2+ lesions (cervical intraepithelial neoplasia 2 or 3 or carcinoma in situ) had been reached and demonstrate a reduction of the conization rate is possible. METHODS: An epidemiological descriptive, retrospective and multicenter study was performed in "Nord Franche-Comté Hospitals" (Belfort and Montbéliard, France) during the period from November 2013 to January 2015...
July 14, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/28715061/physical-activity-assessment-during-gestation-and-its-outcomes-a-review
#12
Wanda Forczek, Marta Curyło, Barbara Forczek
Background: Physical activity recommendations emphasize a positive influence of exercise on health. It is particularly recognized during pregnancy for both the mother and fetus. Aim: This review aims to identify the main trends of activity undertaken by women during gestation and to find out how it affects the expecting mother and her child. Methods: Review of the literature comprising the following databases: PubMed, Academic Search Complete, Health Source-Consumer Edition, Health Source: Nursing/Academic Edition, EMBASE (2000 to May 2013), used detailed search strategies...
July 2017: Obstetrical & Gynecological Survey
https://www.readbyqxmd.com/read/28714056/quality-control-in-diagnostic-immunohistochemistry-integrated-on-slide-positive-controls
#13
A Bragoni, A Gambella, S Pigozzi, M Grigolini, R Fiocca, L Mastracci, F Grillo
Standardization in immunohistochemistry is a priority in modern pathology and requires strict quality control. Cost containment has also become fundamental and auditing of all procedures must take into account both these principles. Positive controls must be routinely performed so that their positivity guarantees the appropriateness of the immunohistochemical procedure. The aim of this study is to develop a low cost (utilizing a punch biopsy-PB-tool) procedure to construct positive controls which can be integrated in the patient's tissue slide...
July 17, 2017: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/28713238/targeting-cognitive-impairment-in-multiple-sclerosis-the-road-toward-an-imaging-based-biomarker
#14
Jeroen Van Schependom, Guy Nagels
Multiple Sclerosis (MS) is a neuro-degenerative and -inflammatory disease leading to physical and cognitive impairment, pathological fatigue and depression, and affecting patients' quality of life and employment status. The combination of inflammation, demyelination, and neurodegeneration leads to the emergence of MS lesions, reduced white and gray matter brain volumes, a reduced conduction velocity and microstructural changes in the so-called Normal Appearing White Matter (NAWM). Currently, there are very limited options to treat cognitive impairment and its origin is only poorly understood...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28713173/a-standard-mammography-unit-standard-3d-ultrasound-probe-fusion-prototype-first-results
#15
Rüdiger Schulz-Wendtland, Sebastian M Jud, Peter A Fasching, Arndt Hartmann, Marcus Radicke, Claudia Rauh, Michael Uder, Marius Wunderle, Paul Gass, Hanna Langemann, Matthias W Beckmann, Julius Emons
AIM: The combination of different imaging modalities through the use of fusion devices promises significant diagnostic improvement for breast pathology. The aim of this study was to evaluate image quality and clinical feasibility of a prototype fusion device (fusion prototype) constructed from a standard tomosynthesis mammography unit and a standard 3D ultrasound probe using a new method of breast compression. MATERIALS AND METHODS: Imaging was performed on 5 mastectomy specimens from patients with confirmed DCIS or invasive carcinoma (BI-RADS (™) 6)...
June 2017: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/28713086/intensifying-approach-to-the-therapy-of-patients-with-constellation-of-the-diseases-chronic-obstructive-pulmonary-disease-and-osteoarthritis
#16
Vyacheslav N Zhdan, Maksim М Potyazhenko, Galina S Khaymenova, Nadezhda N Lyulka, Tatyana V Dubrovinskaya, Igor V Ivanitsky
INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is one of 21st century. About 210 million people all over the world are suffering with COPD, and annually 3 million people die of it. Under the influence of different factors, such as smoking, air prolusion, evaporation of chemicals, poisoning effect of chemical firings, inflammation processes take place in lungs, and if it is prolonged and take place simultaneously with morphological changes in the lungs, it it provide the de4velopment of the systemic inflammation process...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28713039/efficacy-of-ankle-foot-orthoses-types-on-walking-in-children-with-cerebral-palsy-a-systematic-review
#17
REVIEW
Atefeh Aboutorabi, Mokhtar Arazpour, Monireh Ahmadi Bani, Hassan Saeedi, John S Head
BACKGROUND: Ankle foot orthoses (AFOs) are orthotic devices that can be used to normalize the walking pattern of children with cerebral palsy (CP). One of the aims of orthotic management is to produce a more normal gait pattern by positioning joints in the proper position to reduce pathological reflex or spasticity. OBJECTIVE: To conduct a systematic review of the literature and establish the effect of treatment with various types of AFOs on gait patterns of children with CP...
July 13, 2017: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28708761/most-red-flags-for-malignancy-in-low-back-pain-guidelines-lack-empirical-support-a-systematic-review
#18
Arianne P Verhagen, Aron Downie, Chris G Maher, Bart W Koes
Clinicians do not want to miss underlying serious pathology, but it is still unclear which red flags are relevant. We aimed to evaluate the origin and evidence on diagnostic accuracy of red flags for malignancy for the management of low back pain in primary care. We performed a comprehensive overview, and searched the literature using snowballing techniques and reference checking for evidence on red flags endorsed in clinical guidelines for identifying patients with higher likelihood of malignancy. We selected studies including people with low back pain without any restriction on study design...
July 11, 2017: Pain
https://www.readbyqxmd.com/read/28707586/an-overview-of-new-possible-treatments-of-alzheimer-s-disease-based-on-natural-products-and-semi-synthetic-compounds
#19
Enrico Zanforlin, Giuseppe Zagotto, Giovanni Ribaud
BACKGROUND: Dementias and all related neurodegenerative diseases of the Central Nervous System (CNS) are a current issue arousing a great deal of interest in the international scientific community. This is due to the increasing number of patients suffering from these diseases. These pathologies represent a serious problem, not only concerning the quality of life of the patient, but in addition, the enormous economic efforts that society has to do for their treatment. There are currently a few strategies that are available in order to prevent the progression or to mitigate symptoms of the aforementioned diseases...
July 12, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28707363/equine-peripheral-dental-caries-an-epidemiological-survey-assessing-the-prevalence-and-possible-risk-factors-in-western-australian-horses
#20
K Jackson, E Kelty, M Tennant
BACKGROUND: Peripheral dental caries is defined as macroscopic destruction of the calcified dental tissues and can be a cause of considerable dental pathology and pain. It appears to have a high prevalence within Western Australian horses and, at present, risk factors for the condition are poorly understood, making treatment and prevention difficult. OBJECTIVES: To assess the prevalence and potential risk factors involved in peripheral caries in horses in Western Australia...
July 14, 2017: Equine Veterinary Journal
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