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https://www.readbyqxmd.com/read/29656611/modified-breath-hold-compressed-sensing-3d-mr-cholangiopancreatography-with-a-small-field-of-view-and-high-resolution-acquisition-clinical-feasibility-in-biliary-and-pancreatic-disorders
#1
Liang Zhu, Huadan Xue, Zhaoyong Sun, Tianyi Qian, Elisabeth Weiland, Bernd Kuehn, Patrick Asbach, Bernd Hamm, Zhengyu Jin
BACKGROUND: Compressed-sensing (CS) accelerated 3D MR cholangiopancreatography (MRCP) could be acquired in both navigator-triggered (NT) and breath-hold (BH) mode, but the latter has been considered inferior in depicting pancreatic duct and diagnosing pancreatic duct-related diseases. PURPOSE: To prospectively evaluate the clinical feasibility of a modified 3D BH-CS-MRCP prototype protocol with small field-of-view (FOV) and higher spatial resolution, and to compare its performance to the original BH-CS-MRCP and NT-CS-MRCP...
April 14, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29653359/the-role-of-the-gut-microbiota-in-the-pathology-and-prevention-of-liver-disease
#2
REVIEW
Alejandra Altamirano-Barrera, Misael Uribe, Norberto C Chávez-Tapia, Natalia Nuño-Lámbarri
Several microorganisms belonging to the intestinal microbiota act in an ecosystem responsible for maintaining the homeostasis and vital functions of human beings. From birth to old age the diversity of the intestinal microbiota may change due to environmental factors such as nutrition, immunity, diseases or the use of antibiotics leading to dysbiosis. Improvement in microbiota diversity can be achieved by modifying related risk factors through changes in lifestyle and a healthy diet. Besides, the addition of probiotics, prebiotics or the combination of both (symbiotics), can result in the improvement of the intestinal permeability, inflammatory pathways and the immune system...
March 16, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29645349/endoscopic-and-external-approaches-for-orbital-decompression-an-analysis-of-trends-from-a-u-s-perspective
#3
Peter F Svider, Khashayar Arianpour, Brandon Nguyen, Wayne D Hsueh, Paul D Langer, Jean Anderson Eloy, Adam J Folbe
BACKGROUND: Although the endoscopic approach has been increasingly utilized for a variety of sinonasal and skull base pathologies, there has been little inquiry into its adoption in the surgical management of orbital disease. Our objective was to evaluate nationwide temporal and geographic trends in approaches for orbital decompression. METHODS: Data available from the Centers for Medicare and Medicaid Services (CMS) were evaluated, focusing on the use of open and endoscopic approaches for orbital decompression (CPT codes 67414, 67445, 31292, and 31293) among Medicare beneficiaries over a 10-year period...
April 12, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29630047/simple-and-rapid-method-to-obtain-high-quality-tumor-dna-from-clinical-pathological-specimens-using-touch-imprint-cytology
#4
Kenji Amemiya, Yosuke Hirotsu, Toshio Oyama, Masao Omata
It is critical to determine the mutational status in cancer before administration and treatment of specific molecular targeted drugs for cancer patients. In the clinical setting, formalin-fixed paraffin-embedded (FFPE) tissues are widely used for genetic testing. However, FFPE DNA is generally damaged and fragmented during the fixation process with formalin. Therefore, FFPE DNA is sometimes not adequate for genetic testing because of low quality and quantity of DNA. Here we present a method of touch imprint cytology (TIC) to obtain genomic DNA from cancer cells, which can be observed under a microscope...
March 21, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29628723/prevalence-of-postmenopausal-symptoms-its-effect-on-quality-of-life-and-coping-in-rural-couple
#5
Radha Shukla, Jaishree Ganjiwale, Rakhee Patel
Aim: Menopause is a physiological process, with potential to lead to various pathological/psychological complications, leading to change in quality of life (QOL). Although literature suggests the effect of menopause on various aspects of life, there is scarcity of studies from rural setup in this regard. Thus, it is essential to assess extent of menopause-related changes, its awareness, and coping mechanisms in rural couple. This study aimed to find the prevalence of postmenopausal symptoms, its severity, and effect on QOL of rural women and the couples' coping mechanisms...
January 2018: Journal of Mid-life Health
https://www.readbyqxmd.com/read/29625584/temporomandibular-joint-regeneration-proposal-of-a-novel-treatment-for-condylar-resorption-after-orthognathic-surgery-using-transplantation-of-autologous-nasal-septum-chondrocytes-and-the-first-human-case-report
#6
Ricardo de Souza Tesch, Esther Rieko Takamori, Karla Menezes, Rosana Bizon Vieira Carias, Cláudio Leonardo Milione Dutra, Marcelo de Freitas Aguiar, Tânia Salgado de Sousa Torraca, Alexandra Cristina Senegaglia, Cármen Lúcia Kuniyoshi Rebelatto, Debora Regina Daga, Paulo Roberto Slud Brofman, Radovan Borojevic
BACKGROUND: Upon orthognathic mandibular advancement surgery the adjacent soft tissues can displace the distal bone segment and increase the load on the temporomandibular joint causing loss of its integrity. Remodeling of the condyle and temporal fossa with destruction of condylar cartilage and subchondral bone leads to postsurgical condylar resorption, with arthralgia and functional limitations. Patients with severe lesions are refractory to conservative treatments, leading to more invasive therapies that range from simple arthrocentesis to open surgery and prosthesis...
April 7, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29623883/evaluation-of-the-coagulometer-sta-r-max-%C3%A2-stago-for-routine-coagulation-parameters
#7
Justine Brulé, Thomas Sinegre, Bruno Pereira, Marc G Berger, Anne-Françoise Serre-Sapin, Aurélien Lebreton
The STA R Max® is a fully automated multiparameter coagulometer using clotting (viscosity-based detection system), chromogenic and immunologic assays. STA R Max® is equipped with an innovative software (STA Coag Expert® ) designed to assist laboratory in accreditation. The aim of this study was to evaluate its performances for the certification according to ISO 15189 quality standard in the haemostasis unit of our university hospital. The following tests were evaluated: prothrombin time (PT), activated partial thromboplastin time (aPTT), kaolin cephalin clotting time (KCCT), fibrinogen, anti-Xa assay and D-dimers...
April 1, 2018: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/29621128/can-teamwork-and-high-volume-experience-overcome-challenges-of-lymphadenectomy-in-morbidly-obese-patients-body-mass-index-of-40-kg-m2-or-greater-with-endometrial-cancer-a-cohort-study-of-robotics-and-laparotomy-and-review-of-literature
#8
Hubert Fornalik, Temeka Zore, Nicole Fornalik, Todd Foster, Adrian Katschke, Gary Wright
OBJECTIVE: This study aimed to compare surgical outcomes and the adequacy of surgical staging in morbidly obese women with a body mass index (BMI) of 40 kg/m or greater who underwent robotic surgery or laparotomy for the staging of endometrioid-type endometrial cancer. METHODS: This is a retrospective cohort study of patients who underwent surgical staging between May 2011 and June 2014. Patients' demographics, surgical outcomes, intraoperative and postoperative complications, and pathological outcomes were compared...
April 4, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29609366/effect-of-backscattering-in-phase-contrast-imaging-of-the-retina
#9
Dino Carpentras, Timothé Laforest, Mathieu Künzi, Christophe Moser
The observation of retinal cellular structures is fundamental to the understanding of eye pathologies. However, except for rods and cones, most of the retinal microstructures are weakly reflective and thus difficult to image with state of the art reflective optical imaging techniques such as optical coherence tomography. Recently, we demonstrated the possibility of obtaining the phase contrast of retinal cells in the eye using oblique illumination of the retina. Indeed, by illuminating the eye with incoherent oblique illumination, we obtain a secondary oblique illumination from the backscattered light which can then be used to obtain phase contrast in an effective transmission-like configuration...
March 19, 2018: Optics Express
https://www.readbyqxmd.com/read/29608913/shallow-whole-genome-sequencing-for-robust-copy-number-profiling-of-formalin-fixed-paraffin-embedded-breast-cancers
#10
Suet-Feung Chin, Angela Santonja, Marta Grzelak, Soomin Ahn, Stephen-John Sammut, Harry Clifford, Oscar M Rueda, Michelle Pugh, Mae A Goldgraben, Helen A Bardwell, Eun Yoon Cho, Elena Provenzano, Federico Rojo, Emilio Alba, Carlos Caldas
Pathology archives with linked clinical data are an invaluable resource for translational research, with the limitation that most cancer samples are formalin-fixed paraffin-embedded (FFPE) tissues. Therefore, FFPE tissues are an important resource for genomic profiling studies but are under-utilised due to the low amount and quality of extracted nucleic acids. We profiled the copy number landscape of 356 breast cancer patients using DNA extracted FFPE tissues by shallow whole genome sequencing. We generated a total of 491 sequencing libraries from 2 kits and obtained data from 98...
March 30, 2018: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/29607863/total-hip-replacement-in-sickle-cell-disorder-a-preliminary-report-of-challenges-and-early-outcome-of-21-consecutive-patients
#11
A U Katchy, U E Anyaehie, C U Nwadinigwe, G O Eyichukwu
Objective: The aim of this study is to describe the pattern of presentation osteoarthritic patients with sickle cell disorder (SCD) in our environment, determine the implant sizes taking the peculiar nature of the pathology and our operating environment into consideration, highlight the challenges and technical difficulties encountered during the procedure, measure the functional outcome and observe complications of treatment, recommend ways of improving outcome. Patients and Methods: Between November 2008 and November 2012, 29 consecutive primary total hip replacements (THRs) were performed on 21 patients with avascular necrosis of the head of femur secondary to SCD...
April 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29607819/profile-of-high-grade-gliomas-a-single-center-experience
#12
Basharat Mujtaba Jan, Arif Hussain Sarmast, Abdul Rashid Bhat, Altaf Rehman Kirmani
INTRODUCTION: The term high grade glioma (HGG), is usually used to describe WHO grade III and IV tumours. There has been a recent increase in incidence of HGGs in the Western world, particularly in the elderly population. This probably reflects the easy availability of vastly improved diagnostic imaging. A five year retroprospective study was planned to study demography, clinical presentation, imaging, surgical intervention, histopathological examination of specimens and postoperative outcome of patients of high grade gliomas...
January 2018: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/29605443/are-the-electronic-and-paper-questionnaires-equivalent-in-assessing-patients-with-overactive-bladder
#13
Cristina Palmer, Bilal Farhan, Nobel Nguyen, Lishi Zhang, Rebecca Do, Danh V Nguyen, Gamal Ghoniem
INTRODUCTION: Overactive bladder (OAB) syndrome is defined as urinary urgency, usually accompanied by frequency and nocturia, with or without urgency urinary incontinence, in the absence of urinary tract infection (UTI) or other obvious pathology. Electronic questionnaires (eQs) have been used in few specialties with hopes of improving treatment outcomes and patient satisfaction. However, they have not been widely utilized in the urological field. In treating OAB the main outcome is to improve patient's quality of life...
March 29, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29604409/hippocampal-gene-expression-profiling-in-a-rat-model-of-functional-constipation-reveals-abnormal-expression-genes-associated-with-cognitive-function
#14
Ying Li, Lei Shi, Ling Yue, Rui Gao, Zheng Qiang Yu, Xiao Hang Yang, Li Liu, Hui Zheng
Disease progress and pathological proceeding of functional gastrointestinal disorder (FGID) are considered to be closely related to disordered brain-gut interaction, but only a few researches reported the relationship of functional constipation (FC) and disordered brain-gut interaction. It has been found that FC has a great correlation with emotional problems in clinical patients, but its related mechanisms have not been clearly clarified. In order to explore the molecular pathogenesis of FC related to emotional problem, BGI-500 sequencing technology was used for the first time to study the transcriptomics changes of hippocampus in a rat model...
March 28, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29602926/health-of-ophthalmologists-as-a-prerequisite-of-quality-medical-services
#15
Stanislav G Saksonov, Tetiana S Gruzeva, Oksana P Vitovska
OBJECTIVE: Introduction: The effectiveness and efficiency of the medical sector workforce directly depend on health of medical professionals. Scientific literature pays considerable attention to the health of surgeons, physicians, obstetricians, gynecologists, infectionists and dentists paying very little, if any, attention to health problems of ophthalmologists. This study is intended to bridge this gap. The aim at revealing the current situation and characteristics of health status of ophthalmologists using the results of sociological research and identifying health problems of the respondents in order to determine reliable preventive measures...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29602654/an-evaluation-of-the-reliability-of-wrist-arthroscopy-in-the-assessment-of-tears-of-the-triangular-fibrocartilage-complex
#16
Andrew Park, Kevin Lutsky, Jonas Matzon, Charlie Leinberry, Talia Chapman, Pedro K Beredjiklian
PURPOSE: Wrist arthroscopy is generally considered the reference standard in the diagnosis of triangular fibrocartilage complex (TFCC) injuries. There is a paucity of data examining the reliability of wrist arthroscopy as a diagnostic modality for TFCC injuries. The goal of this study was to evaluate the interobserver and intraobserver reliability of the diagnosis of TFCC pathology during wrist arthroscopy. METHODS: Twenty-five intraoperative digital videos were captured by the senior author during diagnostic and surgical arthroscopy of the wrist joint for known or suspected articular pathology...
March 28, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29602451/-autologous-serum-tears-long-term-treatment-in-dry-eye-syndrome
#17
M Beylerian, M Lazaro, J Magalon, J Veran, A Darque, F Grimaud, N Stolowy, H Beylerian, F Sabatier, L Hoffart
INTRODUCTION: Dry eye disease is a multifactorial pathology of the ocular surface. The high incidence of this pathology, as well as its significant impact on quality of life and vision and its financial cost, makes it a real public health problem. While the treatment of mild cases is generally simple and effective, treatment of severe forms is often disappointing. The use of autologous serum tears (AST) represents a therapeutic alternative for the most severe cases. The purpose of our study is to evaluate the efficacy of long-term AST treatment in patients with severe dry eye disease refractory to conventional treatment or secondary to systemic diseases such as Sjögren's syndrome or Graft versus Host disease (GVH), or ocular pathologies such as neurotrophic keratitis, chemical burns and ocular cicatricial pemphigoid...
March 27, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29601152/combat-zone-exposure-and-respiratory-tract-disease
#18
REVIEW
Sean M Parsel, Charles A Riley, Edward D McCoul
BACKGROUND: The impact of deployment to combat zones on the respiratory and sinonasal health of U.S. soldiers is an emerging public health concern. Retrospective studies have shown a correlation between deployment and development of post-deployment pathology, particularly of the aerodigestive system. Respiratory disease, including sinusitis, allergic rhinitis, and asthma, are commonly reported in soldiers deployed to the Middle East and Southwest Asia. METHODS: Current literature pertaining to combat zone exposure and development of respiratory disease was retrieved using PubMed, Embase, Web of Science, and Google Scholar...
March 30, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29599396/diagnostic-concordance-of-reporting-lymphovascular-invasion-in-breast-cancer
#19
Emad A Rakha, Areeg Abbas, Pablo Pinto Ahumada, Maysa E ElSayed, Derek Colman, Sarah E Pinder, Ian O Ellis
AIMS: This study aims to assess the diagnostic agreement of lymphovascular invasion (LVI) in invasive breast cancer (BC). METHODS: Data on LVI were collected from the UK National Health Service Breast Screening Programme pathology external quality assurance scheme database. 101 BCs assessed over a 10-year period (2004-2014) were included. Cases were scored by an average of 600 pathologists. Three H&E stained slides from each case were reviewed by three pathologists and additional variables were evaluated...
March 29, 2018: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29595652/determinants-of-lymph-node-count-and-positivity-in-patients-undergoing-surgery-for-colon-cancer
#20
Ross D Dolan, Stephen T McSorley, Paul G Horgan, Donald C McMillan
Prognosis in colon cancer is based on pathological criteria including TNM staging. However, there are deficiencies in this approach, and the lymph node ratio (LNR) has been proposed to improve the prediction of outcomes. LNR is dependent on optimal retrieval of lymph nodes-lymph node count (LNC). Recent studies have suggested that an elevated preoperative systemic inflammatory response (SIR) was associated with a lower LNC and a higher LNR. However, there are a number of potential confounding factors. The aim of the present study was to examine, in detail, these relationships in a large cohort of patients...
March 2018: Medicine (Baltimore)
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