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Quality use of pathology

Douglas J Demetrick
Context Specimen misidentification is the most significant error in laboratory medicine, potentially accounting for hundreds of millions of dollars in extra health care expenses and significant morbidity in patient populations in the United States alone. New technology allows the unequivocal documentation of specimen misidentification or contamination; however, the value of this technology currently depends on suspicion of the specimen integrity by a pathologist or other health care worker. Objective To test the hypothesis that there is a detectable incidence of unsuspected tissue specimen misidentification among cases submitted for routine surgical pathology examination...
June 18, 2018: Archives of Pathology & Laboratory Medicine
Henrik Helin, Teemu Tolonen, Onni Ylinen, Petteri Tolonen, Juha Näpänkangas, Jorma Isola
Background: Whole slide images (WSIs, digitized histopathology glass slides) are large data files whose long-term storage remains a significant cost for pathology departments. Currently used WSI formats are based on lossy image compression alogrithms, either using JPEG or its more efficient successor JPEG 2000. While the advantages of the JPEG 2000 algorithm (JP2) are commonly recognized, its compression parameters have not been fully optimized for pathology WSIs. Methods: We defined an optimized parametrization for JPEG 2000 image compression, designated JP2-WSI, to be used specifically with histopathological WSIs...
2018: Journal of Pathology Informatics
Anil Reddy Konduru, Balasaheb R Yelikar, K V Sathyashree, Ankur Kumar
Background: Open source technologies and mobile innovations have radically changed the way people interact with technology. These innovations and advancements have been used across various disciplines and already have a significant impact. Microscopy, with focus on visually appealing contrasting colors for better appreciation of morphology, forms the core of the disciplines such as Pathology, microbiology, and anatomy. Here, learning happens with the aid of multi-head microscopes and digital camera systems for teaching larger groups and in organizing interactive sessions for students or faculty of other departments...
2018: Journal of Pathology Informatics
Sheng-Min Guo, Jian-Xiong Wang, Jin Li, Fang-Yuan Xu, Quan Wei, Hai-Ming Wang, Hou-Qiang Huang, Si-Lin Zheng, Yu-Jie Xie, Chi Zhang
Osteoarthritis (OA) significantly influences the quality life of people around the world. It is urgent to find an effective way to understand the genetic etiology of OA. We used weighted gene coexpression network analysis (WGCNA) to explore the key genes involved in the subchondral bone pathological process of OA. Fifty gene expression profiles of GSE51588 were downloaded from the Gene Expression Omnibus database. The OA-associated genes and gene ontologies were acquired from JuniorDoc. Weighted gene coexpression network analysis was used to find disease-related networks based on 21756 gene expression correlation coefficients, hub-genes with the highest connectivity in each module were selected, and the correlation between module eigengene and clinical traits was calculated...
June 15, 2018: Journal of Cellular Biochemistry
Fabiana Terra Cunha Belache, Cíntia Pereira de Souza, Jessica Fernandez, Julia Castro, Paula Dos Santos Ferreira, Elizana Rodrigues de Sousa Rosa, Nathalia Cristina Gimenez de Araújo, Felipe José Jandre Reis, Renato Santos de Almeida, Leandro Alberto Calazans Nogueira, Luís Cláudio Lemos Correia, Ney Meziat-Filho
INTRODUCTION: Chronic low back pain is a public health problem, and there is strong evidence that it is associated with a complex interaction of biopsychosocial factors. Cognitive functional therapy is an intervention that deals with potentially modifiable multidimensional aspects of pain (eg, provocative cognitive, movement and lifestyle behaviours). There is evidence (from a single randomised, controlled trial) that cognitive functional therapy is better than combined manual therapy and motor control exercise...
June 11, 2018: Journal of Physiotherapy
Anne S Chin, Martin J Willemink, Aya Kino, Virginia Hinostroza, Anna M Sailer, Michael P Fischbein, R Scott Mitchell, Gerald J Berry, D Craig Miller, Dominik Fleischmann
BACKGROUND: Limited intimal tears (LITs) of the aorta (Class 3 dissection variant) are the least common form of aortic pathology in patients presenting with acute aortic syndrome (AAS). LITs are difficult to detect on imaging and may be underappreciated. OBJECTIVES: This study sought to describe the frequency, pathology, treatment, and outcome of LITs compared with other AAS, and to demonstrate that LITs can be detected pre-operatively by contemporary imaging. METHODS: The authors retrospectively reviewed 497 patients admitted for 513 AAS events at a single academic aortic center between 2003 and 2012...
June 19, 2018: Journal of the American College of Cardiology
Karen Barlow, Michael M J Esser, Myra Veidt, Roslyn Boyd
Traumatic brain injury is common and yet effective treatments of the secondary brain injury are scarce. Melatonin is a potent, non-selective neuroprotective and anti-inflammatory agent that is showing promising results in neonatal brain injury. The aim of this study was to systematically evaluate the pre-clinical and clinical literature for the effectiveness of Melatonin to improve outcome after TBI. Using the systematic review protocol for animal intervention studies (SYRCLE) and Cochrane methodology for clinical studies, a search of English articles was performed...
June 14, 2018: Journal of Neurotrauma
Yu G Alyaev, L M Rapoport, A Z Vinarov, N I Sorokin, A M Dymov, D A Kislyakov, E V Afanasyevskaya, V Yu Lekarev
Currently, transurethral resection of a bladder tumor (TUR) is the gold standart treatment for non-muscle invasive bladder cancer (NMIBC). Standard TUR for a bladder wall tumor has a high recurrence rate, which is caused mainly by malignant cell implantation during the surgery. Besides, specimens obtained with conventional TUR are insufficient for accurate pathological staging. The non-conformity of the standard TUR with the established oncological principle of dissecting through normal tissue prompted a search for the optimal surgical modality...
May 2018: Urologii︠a︡
Nhu-Nguyen Do, Sebastian Willenborg, Beate Eckes, Christian Jüngst, Gerhard Sengle, Frank Zaucke, Sabine A Eming
Myeloid cells can be beneficial as well as harmful in tissue regenerative responses. The molecular mechanisms by which myeloid cells control this critical decision of the immune system are not well understood. Using two different models of physiological acute or pathological chronic skin damage, in this study we identified myeloid cell-restricted STAT3 signaling as important and an injury context-dependent regulator of skin fibrosis. Targeted disruption of STAT3 signaling in myeloid cells significantly accelerated development of pathological skin fibrosis in a model of chronic bleomycin-induced tissue injury, whereas the impact on wound closure dynamics and quality of healing after acute excision skin injury was minor...
June 13, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
Michael E Osadebey, Marius Pedersen, Douglas L Arnold, Katrina E Wendel-Mitoraj
BACKGROUND: Rician noise, bias fields and blur are the common distortions that degrade MRI images during acquisition. Blur is unique in comparison to Rician noise and bias fields because it can be introduced into an image beyond the acquisition stage such as postacquisition processing and the manifestation of pathological conditions. Most current blur assessment algorithms are designed and validated on consumer electronics such as television, video and mobile appliances. The few algorithms dedicated to medical images either requires a reference image or incorporate manual approach...
June 13, 2018: Biomedical Engineering Online
Andrew J Hotchen, Charis Demetriou, Dennis Edwards, Joel T K Melton
The presentation and clinical course of mucoid degeneration of the anterior cruciate ligament (MD-ACL) are poorly documented within the literature. Subsequently, it is under-diagnosed and the optimal management strategy remains ill-defined. Here, we characterize the syndrome associated with MD-ACL and compare the natural clinical course with the outcomes of arthroscopic management. Thirty-one patients with radiological features of MD-ACL over a 2-year period had their clinical notes retrospectively reviewed...
June 13, 2018: Journal of Knee Surgery
Ruchika Goel, Eshan U Patel, Melissa M Cushing, Steven M Frank, Paul M Ness, Clifford M Takemoto, Ljiljana V Vasovic, Sujit Sheth, Marianne E Nellis, Beth Shaz, Aaron A R Tobian
Importance: Increasing evidence supports the role of red blood cells (RBCs) in physiological hemostasis and pathologic thrombosis. Red blood cells are commonly transfused in the perioperative period; however, their association with postoperative thrombotic events remains unclear. Objective: To examine the association between perioperative RBC transfusions and postoperative venous thromboembolism (VTE) within 30 days of surgery. Design, Setting, and Participants: This analysis used prospectively collected registry data from the American College of Surgery National Surgical Quality Improvement Program (ACS-NSQIP) database, a validated registry of 525 teaching and nonteaching hospitals in North America...
June 13, 2018: JAMA Surgery
Daniel H Moreno, Daniel G Cacione, Jose Cc Baptista-Silva
BACKGROUND: An abdominal aortic aneurysm (AAA) is the pathological enlargement of the aorta and can develop in both men and women. Progressive aneurysm enlargement can lead to rupture. The rupture of an AAA is frequently fatal and accounts for the death from haemorrhagic shock of at least 45 people per 100,000 population. The outcome of people with ruptured AAA varies among countries and healthcare systems, with mortality ranging from 53% to 90%. Definitive treatment for ruptured AAA includes open surgery or endovascular repair...
June 13, 2018: Cochrane Database of Systematic Reviews
Pavel Seredin, Dmitry Goloshchapov, Yuri Ippolitov, Pimm Vongsvivut
Background: Improving the quality of life is part of the global agenda. The focus is predominantly on prevention of socially significant diseases. Combating dental caries-related diseases is a top priority as it has a huge impact on people's social lives. Therefore, the purpose of the work was to study the changes in the molecular composition of saliva from subjects with multiple caries lesions using spectroscopic methods of analysis to identify potential tissue markers of caries development for predictive, preventive and personalised medical services...
June 2018: EPMA Journal
Katharine Boyle, Ryan Felling, Alvin Yiu, Wejdan Battarjee, Jamie McElrath Schwartz, Cynthia Salorio, Melania M Bembea
OBJECTIVES: The goal of this systematic review of the literature was to summarize neurologic outcomes following neonatal and pediatric extracorporeal membrane oxygenation. DATA SOURCES: We conducted electronic searches of PubMed, Scopus, Web of Science, CINAHL, Cochrane, and EMBASE. STUDY SELECTION: Inclusion criteria included publication dates 2000-2016, patient ages 0-18 years, and use of standardized measures to evaluate outcomes after extracorporeal membrane oxygenation...
June 11, 2018: Pediatric Critical Care Medicine
Xiang-Ke Niu, Xue-Hui Chen, Zhi-Fan Chen, Lin Chen, Jun Li, Tao Peng
OBJECTIVE: The purpose of this study was to perform a systematic review and meta-analysis to estimate the diagnostic performance of biparametric MRI (bpMRI) for detection of prostate cancer (PCa). MATERIALS AND METHODS: Two independent reviewers performed a systematic review of the literature published from January 2000 to July 2017 by using predefined search terms. The standard of pathologic reference was established at prostatectomy or prostate biopsy. The numbers of true- and false-positive and true- and false-negative results were extracted...
June 12, 2018: AJR. American Journal of Roentgenology
Alan Campion, Kenneth J Smith, Alexey V Fedulov, David Gregory, Yuwei Fan, John J Godleski
The precise identification of foreign particles in tissue for patient care and research has been studied using polarized light microscopy, electron microscopy with X-ray analysis, and electron diffraction. The goal of this study was to unambiguously identify particles in tissues using a combina-tion of polarized light microscopy and Raman microscopy, which provides chemical composition and microstructural characterization of complex materials with submicron spatial resolution. We designed a model system of stained and unstained cells that contained birefringent talc particles, and systematically investigated the influence of slide and coverslip materials, laser wavelengths, and mounting media on the Raman spectra ob-tained...
June 12, 2018: Analytical Chemistry
Alexi Baidoshvili, Nikolas Stathonikos, Gerard Freling, Jos Bart, Nils 't Hart, Jeroen van der Laak, Jan Doff, Bert van der Vegt, Philip Kluin, Paul J van Diest
BACKGROUND: Most validation studies on digital pathology diagnostics have been performed in single institutes. Since rapid consultation of extramural experts is one of the most important use cases for digital pathology laboratory networks, the aim of this study was to validate a whole slide image-based teleconsultation network between three independent laboratories. METHODS: Each laboratory contributed 30 biopsies and / or excisions, adding up to 90 specimens (776 slides) of varying difficulty and covering a wide variety of organs and subspecialties...
June 12, 2018: Histopathology
Jenna L Mueller, Christopher T Lam, Denali Dahl, Mercy Nyamewaa Asiedu, Marlee S Krieger, Yenny Bellido-Fuentes, Mark Kellish, Jenna Peters, Alaattin Erkanli, Ernesto J Ortiz, Lisa C Muasher, Peyton T Taylor, John W Schmitt, Gino Venegas, Nirmala Ramanujam
OBJECTIVE: Our goal is to develop a tele-colposcopy platform for primary care clinics to improve screening sensitivity and access. Specifically, we developed a low-cost, portable Pocket colposcope and evaluated its performance in a tertiary healthcare center in Perú. DESIGN AND SETTING: Images of the cervix were captured with a standard-of-care and Pocket colposcope at la Liga Contra el Cáncer in Lima, Perú. POPULATION: 200 Peruvian women with abnormal cytology and/or HPV positivity were enrolled...
June 12, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
D Indrawan, G Tacken, H Hogeveen
In Indonesia, market channels play an important role in food security in poultry meats. This review explains Indonesian consumers' choice of market channels to purchase poultry, and consumer concern of food scares and food safety in their consumption due to highly pathology avian influenza (HPAI) outbreak. The survey was conducted for the traditional and the modern channels and involves a sample of 1096 respondents in the Greater Jakarta Area. The logistic regression analysis reports the model proved that the substantial findings in the choice for the modern poultry market channel are the price/quality relationship, the safety feature, and the level of consumer trust...
June 8, 2018: Poultry Science
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