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https://www.readbyqxmd.com/read/28821197/regional-variability-in-percentage-of-breast-cancers-reported-as-positive-for-her2-in-california-implications-of-patient-demographics-on-laboratory-benchmarks
#1
Chieh-Yu Lin, Eugene E Carneal, Daphne Y Lichtensztajn, Scarlett L Gomez, Christina A Clarke, Kristin C Jensen, Allison W Kurian, Kimberly H Allison
Objectives: The expected regional variability in percent human epidermal growth factor receptor 2 (HER2)-positive breast cancers is not currently clear. Methods: Data from the 2006 to 2011 California Cancer Registry were examined by county and health service area. The influence of demographic and pathologic features was used in a multivariable logistic regression model to compare expected with observed HER2-positive percentages by region. Results: There was significant geographic variation by California counties (11...
September 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28820791/teleophthalmic-approach-for-detection-of-corneal-diseases-accuracy-and-reliability
#2
Maria A Woodward, David C Musch, Christopher T Hood, Jonathan B Greene, Leslie M Niziol, V Swetha E Jeganathan, Paul P Lee
PURPOSE: Corneal and anterior segment diseases cause most of the urgent visits to eye care professionals. We evaluated the diagnostic accuracy of detecting corneal diseases using external photographs from 2 portable cameras for telemedicine purposes. METHODS: This is a prospective study of adults with a clinical diagnosis of corneal pathology including corneal abrasions, ulcers, scars, and pterygia. A cornea specialist provided the gold standard diagnosis by slit-lamp examination...
August 17, 2017: Cornea
https://www.readbyqxmd.com/read/28817424/impact-of-simulator-based-training-in-focused-transesophageal-echocardiography-a-randomized-controlled-trial
#3
Andreas Bloch, Robert von Arx, Reto Etter, David Berger, Heiko Kaiser, Armando Lenz, Tobias M Merz
BACKGROUND: The aim of the study was to determine if training in transesophageal echocardiography (TEE) using a TEE simulator improves the ability of novice operators to perform and interpret a focused critical care TEE. METHODS: In this prospective, randomized, controlled study with blinded outcome assessment, 44 intensive care unit trainees were randomly assigned to a control group receiving 4 hours of lecture-based training only, or an intervention group which was additionally trained for 4 hours using a TEE simulator...
August 11, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28815337/fluorine-18-fluorodeoxyglucose-positron-emission-tomography-as-an-objective-substitute-for-ct-morphologic-response-criteria-in-patients-undergoing-chemotherapy-for-colorectal-liver-metastases
#4
Yujiro Nishioka, Ryuji Yoshioka, Wataru Gonoi, Toshitaka Sugawara, Shuntaro Yoshida, Masaji Hashimoto, Junichi Shindoh
PURPOSE: The computed tomography (CT) morphologic response of colorectal liver metastases (CLM) after chemotherapy is reportedly correlated with pathologic response and survival outcomes of patients undergoing surgery. However, they are rather subjective criteria and not evaluable without adequate quality of contrast-enhanced CT images. This study sought the potential use of fluorine-18-fluorodeoxyglucose (FDG) positron emission tomography (PET) as an objective substitute for predicting pathological viability of CLM after chemotherapy...
August 16, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28814181/full-mouth-intraoral-radiographic-survey-in-rabbits
#5
Adriana Regalado, Loïc Legendre
Dental pathologies are highly prevalent in pet rabbit populations, making oral radiography an essential tool in the evaluation of lagomorph dentitions. The unique anatomy of the rabbit's mouth limits the examination of the conscious animal to the rostral portion of it's mouth. In addition, the oral examination of an aradicular hypsodont tooth is restricted to the short coronal fraction of its crown. Erstwhile images obtained by the extraoral technique were once considered the most practical and informative tool in rabbit dentistry; however, limited visualization of the key structures of individual teeth became the major drawback of this technique...
September 2017: Journal of Veterinary Dentistry
https://www.readbyqxmd.com/read/28812968/jnk-pathway-in-osteoarthritis-pathological-and-therapeutic-aspects
#6
Hong-Xing Ge, Fu-Man Zou, Yan Li, An-Min Liu, Min Tu
CONTEXT: Osteoarthritis (OA) is a common chronic degenerative joint disease resulting in physical disability and reduced quality of life. Different biochemical signaling pathways are involved in the progression of OA, including the c-Jun NH2-terminal kinase (JNK) signal transduction pathway. OBJECTIVE: In this study, we have reviewed the recent updates on the association of JNK pathway with OA. METHODS: In this review, we have explored the databases like PubMed, Google Scholar, Medline, Scopus, etc...
October 2017: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/28810184/design-and-evaluation-of-a-parametric-model-for-cardiac-sounds
#7
Roilhi F Ibarra-Hernández, Miguel A Alonso-Arévalo, Alejandro Cruz-Gutiérrez, Ana L Licona-Chávez, Salvador Villarreal-Reyes
Heart sound analysis plays an important role in the auscultative diagnosis process to detect the presence of cardiovascular diseases. In this paper we propose a novel parametric heart sound model that accurately represents normal and pathological cardiac audio signals, also known as phonocardiograms (PCG). The proposed model considers that the PCG signal is formed by the sum of two parts: one of them is deterministic and the other one is stochastic. The first part contains most of the acoustic energy. This part is modeled by the Matching Pursuit (MP) algorithm, which performs an analysis-synthesis procedure to represent the PCG signal as a linear combination of elementary waveforms...
August 9, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28809847/genome-wide-expression-datasets-of-anti-vegf-and-dexamethasone-treatment-of-angiogenesis-in-the-rat-cornea
#8
Anthony Mukwaya, Pierfrancesco Mirabelli, Anton Lennikov, Maria Xeroudaki, Mira Schaupper, Beatrice Peebo, Neil Lagali
Therapeutics against pathologic new blood vessel growth, particularly those targeting vascular endothelial growth factor (VEGF) are of enormous clinical interest. In the eye, where anti-VEGF agents are in widespread clinical use for treating retinal and corneal blindness, only partial or transient efficacy and resistance to anti-VEGF agents are among the major drawbacks. Conversely, corticosteroids have long been used in ophthalmology for their potency in suppressing inflammation and angiogenesis, but their broad biological activity can give rise to side effects such as glaucoma and cataract...
August 15, 2017: Scientific Data
https://www.readbyqxmd.com/read/28809019/lentiviral-mediated-transgenesis-in-songbirds
#9
Wan-Chun Liu, Marian Hruska-Plochan, Atsushi Miyanohara
Transgenesis involves the insertion of an exogenous gene into an animal's genome, which allows the identification of the expressed phenotypes in brain function or behavior. Lentiviral-mediated transgenesis offers unique transduction potency making it possible to deliver and stably integrate transgenes into a wide variety of dividing and nondividing cells. The ability to establish long-term expression of such transgenes allows their use for transgenesis which is especially useful in organisms lacking quality pluripotent stem cell lines and which is otherwise difficult to produce via traditional pronuclear microinjection, such as songbirds...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28807742/a-cost-utility-analysis-of-dynesys-dynamic-stabilization-versus-instrumented-fusion-for-the-treatment-of-degenerative-lumbar-spine-diseases
#10
Kan Liu, Wei Sun, Qiang Lu, Jiying Chen, Jiaguang Tang
BACKGROUND: Symptomatic chronic low back and leg pain resulting from lumbar spine degenerative disorders is highly prevalent in China, and for some patients, surgery is the final option for improvement. Several techniques for spinal non-fusion have been introduced to reduce the side-effects of fusion methods and hasten postoperative recovery. In this study, the authors have evaluated the cost-effectiveness of Dynesys posterior dynamic stabilization system (DY) compared with lumbar fusion techniques in the treatment of single-level degenerative lumbar spinal conditions...
August 11, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28806936/enhancement-of-hepatitis-virus-immunoassay-outcome-predictions-in-imbalanced-routine-pathology-data-by-data-balancing-and-feature-selection-before-the-application-of-support-vector-machines
#11
Alice M Richardson, Brett A Lidbury
BACKGROUND: Data mining techniques such as support vector machines (SVMs) have been successfully used to predict outcomes for complex problems, including for human health. Much health data is imbalanced, with many more controls than positive cases. METHODS: The impact of three balancing methods and one feature selection method is explored, to assess the ability of SVMs to classify imbalanced diagnostic pathology data associated with the laboratory diagnosis of hepatitis B (HBV) and hepatitis C (HCV) infections...
August 14, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28806721/the-effect-of-visual-perturbation-upon-femoral-acceleration-during-the-single-and-bilateral-squat
#12
R Barry Dale, Ravi P Gollapalli, Taylor Price, Katie Megahee, Morgan Duncan, Nick Tolstick, Luke Ford
OBJECTIVES: Record femoral accelerations using a smartphone accelerometer attached to the distal thigh during single-legged (SLS) and bilateral squats, and each squat condition occurred under two visual conditions: 1) normal vision and 2) visual perturbation with stroboscopic glasses. DESIGN: Repeated-measures cross-over with counter-balanced order for four total conditions. SETTING: Laboratory. PARTICIPANTS: 22 females and 16 males without lower extremity pathologies...
June 20, 2017: Physical Therapy in Sport
https://www.readbyqxmd.com/read/28805588/weight-in-parkinson-s-disease-phenotypical-significance
#13
Jagdish C Sharma, Anna Lewis
Body weight in Parkinson's disease (PD) is a significant nonmotor feature. Weight homeostasis is a complex physiological process and gets deranged in PD patients leading to changes in weight. While both the low and high body weight have been reported as risk factors for PD, the majority of PD patients have a lower weight and a subset of patients lose weight during the course of the disease, while a small proportion gain weight. A number of clinical parameters such as older age, impaired cognition, severity of disease, and an imbalance of food intake determined by satiety and hunger hormones have been reported to be associated with but not the cause of weight change...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28805141/inhibited-attachment-disordered-behavior-in-institutionalized-preschool-children-links-with-early-and-current-relational-experiences
#14
Raquel Corval, Jay Belsky, Joana Baptista, Paula Oliveira, Ana Mesquita, Isabel Soares
Inhibited attachment disordered behavior (IADB) is characterized by difficulty in establishing an attachment relationship with a primary caregiver; is associated with persistent social and emotional problems; and is observed most frequently in contexts of pathological care such as institutional rearing. Here, we seek to enhance understanding of the conditions that give rise to IADB among institutionalized children by examining prior family experiences of neglect and deprivation and concurrent relational experiences at the institution...
August 14, 2017: Attachment & Human Development
https://www.readbyqxmd.com/read/28803385/-real-life-experience-recurrence-rate-at-3%C3%A2-years-with-hexvix-%C3%A2-photodynamic-diagnosis-assisted-turbt-compared-with-good-quality-white-light-turbt-in-new-nmibc-a-prospective-controlled-study
#15
Kevin M Gallagher, Kayleigh Gray, Claire H Anderson, Hannah Lee, Sarah Stewart, Roland Donat, Paramananthan Mariappan
PURPOSE: To compare the recurrence rate at 3 years (RR-3y) for non-muscle invasive bladder cancer (NMIBC) between good quality (GQ) PDD-TURBT and GQWL-TURBT where PDD is used in routine practice for all new tumours. METHODS: All new, consecutive, NMIBC that received "good quality" criteria first TURBT across a university hospital service were prospectively recruited to this study over a 4-year period. Data were prospectively collected on all WL-TURBTs performed in 2007/8 and compared with PDD-TURBT from 2009/10...
August 12, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28803114/the-inferomedial-femoral-neck-is-compromised-by-age-but-not-disease-fracture-toughness-and-the-multifactorial-mechanisms-comprising-reference-point-microindentation
#16
T Jenkins, O L Katsamenis, O G Andriotis, L V Coutts, B Carter, D G Dunlop, R O C Oreffo, C Cooper, N C Harvey, P J Thurner, The OStEO Group
The influence of ageing on the fracture mechanics of cortical bone tissue is well documented, though little is known about if and how related material properties are further affected in two of the most prominent musculoskeletal diseases, osteoporosis and osteoarthritis (OA). The femoral neck, in close proximity to the most pertinent osteoporotic fracture site and near the hip joint affected by osteoarthritis, is a site of particular interest for investigation. We have recently shown that Reference Point micro-Indentation (RPI) detects differences between cortical bone from the femoral neck of healthy, osteoporotic fractured and osteoarthritic hip replacement patients...
June 30, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28803049/modeling-aging-in-hiv-infection-in-nonhuman-primates-to-address-an-emerging-challenge-of-the-post-art-era
#17
REVIEW
Tianyu He, Elizabeth Falwell, Egidio Brocca-Cofano, Ivona Pandrea
The advent of antiretroviral therapy (ART) has dramatically improved both quality and length of life for subjects infected with human immunodeficiency virus (HIV), delaying or preventing progression to acquired immunodeficiency syndrome (AIDS). However, the virus induces aging-related changes to the immune system which confound treatment. Additionally, the normal physiologic events that occur during aging lead to deficiencies in immunity which not only exacerbate HIV pathogenesis but also trigger a variety of comorbidities...
August 9, 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/28802225/the-value-of-ultrasound-guided-surgery-for-breast-cancer
#18
REVIEW
Darja Arko, Nina Čas Sikošek, Nejc Kozar, Monika Sobočan, Iztok Takač
OBJECTIVE: An increasing number of breast-conserving surgeries (BCS) has lead clinicians to the dilemma how to provide patients with the best pathological, short-term and long-term outcomes, while at the same time improving the cosmetic outcome and the patients' quality of life. A proposed solution is the use of intraoperative ultrasound (IOUS) for lesion resection in palpable as well as non-palpable breast cancer. METHODS: This review identifies and compares evidence on palpation-guided/wire-guided vs...
August 2, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28801763/a-situational-analysis-of-breast-cancer-early-detection-services-in-trinidad-and-tobago
#19
Kimberly Badal, Fidel Rampersad, Wayne A Warner, Adetunji T Toriola, Hamish Mohammed, Harold-Alexis Scheffel, Rehanna Ali, Murrie Moosoodeen, Siva Konduru, Adaila Russel, Rajini Haraksingh
PURPOSE: A situational analysis of breast cancer (BC) early detection services was carried out to investigate whether Trinidad and Tobago (T&T) has the framework for successful organized national screening. METHODS: An online survey was designed to assess the availability, accessibility, quality control and assurance (QC&A), and monitoring and evaluation (M&E) mechanisms for public and private BC early detection. A focus group with local radiologists (n = 3) was held to identify unaddressed challenges and make recommendations for improvement...
August 11, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28801211/parkin-clearance-of-dysfunctional-mitochondria-regulates-ros-levels-and-increases-survival-of-human-chondrocytes
#20
M Y Ansari, N M Khan, I Ahmad, T M Haqqi
OBJECTIVE: Mitochondrial dysfunction, oxidative stress and chondrocyte death are important contributors to the development and pathogenesis of osteoarthritis (OA). In this study, we determined the expression and role of Parkin in the clearance of damaged/dysfunctional mitochondria, regulation of reactive oxygen species (ROS) levels and chondrocyte survival under pathological conditions. METHODS: Human chondrocytes were from the unaffected area of knee OA cartilage (n = 12) and were stimulated with IL-1β to mimic pathological conditions...
August 8, 2017: Osteoarthritis and Cartilage
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