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JOURNAL ARTICLE
Zayniddin K Muhidinov, Jamshed T Bobokalonov, Rahimjon S Kimatov, Erkin R Rahmonov, Gulnora I Komilova, Zamira U Sherova, LinShu Liu
INTRODUCTION: Intestinal infections are a significant health issue; antibiotics are essential in treating acute intestinal infections. However, evidence in the literature shows that the excessive use of antibiotics has created many threats to human health. This work aimed to study the impact of apple pectin in combination with antibiotics on treating patients with amebiasis and dysentery. METHODOLOGY: Patients suffering from acute intestinal diseases (amebiasis and dysentery) were treated with traditional antibiotic therapy and a new formula containing antibiotics with low and high methoxylated apple pectin in a randomized block design...
March 31, 2024: Journal of Infection in Developing Countries
#2
JOURNAL ARTICLE
Li Gao, Ai-Ping Zhang, Lei Fu, Qian-Wen Li, Xue-Mei Qin, Jing Zhao
BACKGROUND: The incidence of neuropathic pain is progressively increasing over time. The activation of M1-type microglia plays a crucial role in the initiation and progression of neuropathic pain. Huangqin Decoction (HQD) is traditionally used to alleviate dysentery and abdominal pain. However, it remains unclear whether HQD can effectively mitigate neuropathic pain and the underlying mechanisms. PURPOSE: The present study aims to investigate the impact of HQD on neuropathic pain induced by spared nerve injury (SNI) in mice, and to elucidate whether the analgesic effect of HQD is associated with microglia polarization...
April 7, 2024: Phytomedicine
#3
JOURNAL ARTICLE
Md Arju Hossain, Md Al Amin, Md Arif Khan, Md Rashedur Rahman Refat, Md Sohel, Md Habibur Rahman, Ariful Islam, M Nazmul Hoque
Shigella stands as a major contributor to bacterial dysentery worldwide scale , particularly in developing countries with inadequate sanitation and hygiene. The emergence of multidrug-resistant strains exacerbates the challenge of treating Shigella infections, particularly in regions where access to healthcare and alternative antibiotics is limited. Therefore, investigations on how bacteria evade antibiotics and eventually develop resistance could open new avenues for research to develop novel therapeutics...
2024: BioMed Research International
#4
JOURNAL ARTICLE
[Pathological profile of S.P. Botkin infectious hospital during the siege of Leningrad (1941-1944)].
P A Drozdovskaya, V A Zinserling, R V Deev
The results of autopsies performed in the pathological department of the Infectious Diseases Hospital named after. S.P. Botkin during the siege of Leningrad (from September 8, 1941 to January 27, 1944). The structure of diseases of the deceased varied during different periods of the siege of Leningrad. In the first period (September-December 1941), diphtheria, dysentery, measles, typhoid fever, and scarlet fever prevailed among the diseases. The most common causes of death in the second period (April-December 1942) were typhus, dysentery, tuberculosis, lobar pneumonia, and typhoid fever...
2024: Arkhiv Patologii
#5
JOURNAL ARTICLE
M V Mnikhovich, P A Akhsanova, T N Sotnikova
Ippolit Vasilyevich Davydovsky was born in 1887 in Danilov, Yaroslavl province, into the family of a clergyman. He received his primary education in a parochial church school. After I.V. Davydovsky's family moved to Yaroslavl, he continued his education in a men's gymnasium. Having successfully graduated from the gymnasium, I.V. Davydovsky in 1905 entered the medical faculty of Moscow State University, where he studied and was influenced by Acad. A.I. Abrikosov formed his first scientific interests. After graduating from the university in 1910, I...
2024: Arkhiv Patologii
#6
JOURNAL ARTICLE
Tesfaye Gobena, Dinaol Belina, Tine Hald, Sara M Pires
Acute childhood diarrhea is one of the leading causes of childhood morbidity and mortality in sub-Saharan African countries. Entamoeba histolytica and Giardia lamblia are the common cause of childhood diarrhea in the region. However, there are only few studies on protozoa causing diarrhea in sub-Saharan African countries. This study was conducted to investigate the relative prevalence and explore risk factors of E. histolytica and G. lamblia among diarrheic children of under 5 years in a public hospital of Ethiopia...
2024: Inquiry: a Journal of Medical Care Organization, Provision and Financing
#7
JOURNAL ARTICLE
Yingjian Liu, Qian Zhu, Gongjie Guo, Zhipeng Xie, Senlin Li, Chengyang Lai, Yonglin Wu, Liansheng Wang, Shilong Zhong
BACKGROUND: Inflammation serves as a key pathologic mediator in the progression of infections and various diseases, involving significant alterations in the gut microbiome and metabolism. This study aims to probe into the potential causal relationships between gut microbial taxa and human blood metabolites with various serum inflammatory markers (CRP, SAA1, IL-6, TNF-α, WBC, and GlycA) and the risks of seven common infections (gastrointestinal infections, dysentery, pneumonia, bacterial pneumonia, bronchopneumonia and lung abscess, pneumococcal pneumonia, and urinary tract infections)...
2024: Frontiers in Microbiology
#8
JOURNAL ARTICLE
Shuling Zhang, Yanwu Li, Gang Chen, Xu Wang, Bin Wu
ETHNOPHARMACOLOGICAL RELEVANCE: Sarcandra glabra is officially named Zhong Jie Feng as a traditional medicine. In the nationality of Yao and Zhuang, it has been used to treat digestive diseases like stomachache and dysentery. Similarly, in Dai nationality, it has been used to treat intestinal diseases like gastric ulcers. However, the effect and mechanism of S. glabra on experimental ulcerative colitis (UC) are known. AIM OF STUDY: The main objective of this study was to investigate the effect and mechanism of S...
March 31, 2024: Journal of Ethnopharmacology
#9
REVIEW
Yufei Wang, Dan Yu, Shaojie Zhu, Xiaowei Du, Xijun Wang
ETHNOPHARMACOLOGICAL RELEVANCE: The genus Dioscorea, a member of the Dioscoreaceae family, comprises approximately 600 species and is widely distributed across temperate and tropical regions such as Asia, South Africa, and North America. The traditional medicinal uses of Dioscorea have been documented in Asian and African pharmacological systems. In Asia, this genus is traditionally used to treat respiratory illnesses, rheumatism, diabetes, diarrhea, dysentery, and other conditions. In Africa, this genus has been used to treat human immunodeficiency virus and ring worms...
March 27, 2024: Journal of Ethnopharmacology
#10
JOURNAL ARTICLE
Feifei Zhu, Yunyun Zhi, Yonghui Li, Haiyan Niu, Shouzhong Ren
BACKGROUND: Polygonum hydropiper L (PH) was widely used to treat dysentery, gastroenteritis, diarrhea and other diseases. Coptis chinensis (CC) had the effects of clearing dampness-heat, purging fire, and detoxifying. Study confirmed that flavonoids in PH and alkaloids in CC alleviated inflammation to inhibit the development of intestinal inflammation. However, how PH-CC affects UC was unclear. Therefore, the aim of this study is to analyze the mechanism of PH-CC on ulcerative colitis (UC) through network pharmacology and in vivo experiments...
March 8, 2024: Frontiers in Bioscience (Landmark Edition)
#11
JOURNAL ARTICLE
Hannah E Atlas, Bakary Conteh, Md Taufiqul Islam, Khuzwayo C Jere, Richard Omore, Doh Sanogo, Francesca Schiaffino, Mohammad Tahir Yousafzai, Naveed Ahmed, Alex O Awuor, Henry Badji, Jennifer Cornick, Erika Feutz, Sean R Galagan, Fadima C Haidara, Bri'Anna Horne, Md Ismail Hossen, Aneeta Hotwani, Eric R Houpt, Abdoulie F Jallow, Mehrab Karim, Adama Mamby Keita, Youssouf Keita, Farhana Khanam, Jie Liu, Thandizo Malemia, Alhagie Manneh, Christine J McGrath, Dilruba Nasrin, Maureen Ndalama, John Benjamin Ochieng, Billy Ogwel, Maribel Paredes Olortegui, Loyda Fiorella Zegarra Paredes, Tackeshy Pinedo Vasquez, James A Platts-Mills, Syed Qudrat-E-Khuda, Sonia Qureshi, Md Nazmul Hasan Rajib, Elizabeth T Rogawski McQuade, Shazia Sultana, Sharon M Tennant, Kirkby D Tickell, Desiree Witte, Pablo Peñataro Yori, Nigel A Cunliffe, M Jahangir Hossain, Margaret N Kosek, Karen L Kotloff, Firdausi Qadri, Farah Naz Qamar, Milagritos D Tapia, Patricia B Pavlinac
BACKGROUND: Shigella is a leading cause of acute watery diarrhea, dysentery, and diarrhea-attributed linear growth faltering, a precursor to stunting and lifelong morbidity. Several promising Shigella vaccines are in development and field efficacy trials will require a consortium of potential vaccine trial sites with up-to-date Shigella diarrhea incidence data. METHODS: The Enterics for Global Health (EFGH) Shigella surveillance study will employ facility-based enrollment of diarrhea cases aged 6-35 months with 3 months of follow-up to establish incidence rates and document clinical, anthropometric, and financial consequences of Shigella diarrhea at 7 country sites (Mali, Kenya, The Gambia, Malawi, Bangladesh, Pakistan, and Peru)...
March 2024: Open Forum Infectious Diseases
#12
JOURNAL ARTICLE
Katia Manzanares Villanueva, Tackeshy Pinedo Vasquez, Pablo Peñataro Yori, Lucero Romaina Cacique, Paul F Garcia Bardales, Wagner V Shapiama Lopez, Fiorella Zegarra Paredes, Karin F Perez, Silvia Rengifo Pinedo, Hermann Silva Delgado, Thomas Flynn, Francesca Schiaffino, Josh M Colston, Maribel Paredes Paredes Olortegui, Margaret N Kosek
BACKGROUND: The Enterics for Global Health (EFGH) Peru site will enroll subjects in a periurban area of the low Amazon rainforest. The political department of Loreto lags behind most of Peru in access to improved sources of water and sanitation, per capita income, children born <2.5 kg, and infant and child mortality. Chronic undernutrition as manifested by linear growth shortfalls is common, but wasting and acute malnutrition are not. METHODS: The recruitment of children seeking care for acute diarrheal disease takes place at a geographic cluster of government-based primary care centers in an area where most residents are beneficiaries of free primary healthcare...
March 2024: Open Forum Infectious Diseases
#13
JOURNAL ARTICLE
Bri'Anna Horne, Henry Badji, Md Taufiqur Rahman Bhuiyan, Lucero Romaina Cachique, Jennifer Cornick, Aneeta Hotwani, Jane Juma, John Benjamin Ochieng, Mahamadou Abdou, Evans Apondi, Hannah E Atlas, Alex O Awuor, Kate S Baker, Bubacarr E Ceesay, Mary Charles, Nigel A Cunliffe, Erika Feutz, Sean R Galagan, Ibrehima Guindo, M Jahangir Hossain, Junaid Iqbal, Fatima Jallow, Noumou Yakhouba Keita, Farhana Khanam, Karen L Kotloff, Victor Maiden, Katia Manzanares Villanueva, Oscar Mito, Md Parvej Mosharraf, Joseph Nkeze, Usman N Ikumapayi, Maribel Paredes Olortegui, Patricia B Pavlinac, Tackeshy Pinedo Vasquez, Firdausi Qadri, Farah Naz Qamar, Sonia Qureshi, Nazia Rahman, Aminata Sangare, Sunil Sen, Pablo Peñataro Yori, Mohammad Tahir Yousafzai, Dilruba Ahmed, Khuzwayo C Jere, Margaret N Kosek, Richard Omore, Jasnehta Permala-Booth, Ousman Secka, Sharon M Tennant
BACKGROUND: Shigella is a major cause of diarrhea in young children worldwide. Multiple vaccines targeting Shigella are in development, and phase 3 clinical trials are imminent to determine efficacy against shigellosis. METHODS: The Enterics for Global Health (EFGH) Shigella surveillance study is designed to determine the incidence of medically attended shigellosis in 6- to 35-month-old children in 7 resource-limited settings. Here, we describe the microbiological methods used to isolate and identify Shigella ...
March 2024: Open Forum Infectious Diseases
#14
JOURNAL ARTICLE
Kaijun Wang, Jie Yin, Jiayi Chen, Jie Ma, Hongbin Si, Diqi Xia
BACKGROUND: Traditional Chinese Medicine (TCM), renowned for its holistic approach with a 2000-year history of utilizing natural remedies, offers unique advantages in disease prevention and treatment. Berberine, found in various Chinese herbs, has been employed for many years, primarily for addressing conditions such as diarrhea and dysentery. Berberine has recently become a research focus owing to its pharmacological activities and benefits to human bodies. However, little is known about the anti-inflammatory mechanism of berberine...
January 11, 2024: Phytomedicine
#15
REVIEW
Qianwen Wu, Xing Liu, Jingyu Wang, Sijia Xu, Fanliang Zeng, Ling Chen, Guihong Zhang, Heng Wang
Viral diarrhea is the predominant digestive tract sickness in piglings, resulting in substantial profit losses in the porcine industry. Porcine rotavirus A (PoRVA) and porcine epidemic diarrhea virus (PEDV) are the main causes of grave gastroenteritis and massive dysentery, especially in piglets. PoRVA and PEDV have high transmissibility, exhibit similar clinical symptoms, and frequently co-occur. Therefore, to avoid financial losses, a quick, highly efficient, objective diagnostic test for the prevention and detection of these diseases is required...
March 20, 2024: Virology
#16
JOURNAL ARTICLE
Tian Ren, Jiang Yuyan, Lu Huan, Pei Yingxin, Tan Dongmei, Deng Qiumei, Yanxu Zhong
OBJECTIVE: To provide a scientific basis for identifying the causes of an outbreak and providing preventive and control measures to prevent the recurrence of similar outbreaks. STUDY DESIGN: A case-control study. METHODS: We defined a suspected case as residents living in the affected town presented with inexplicable diarrhea (≥3 times/24 h) and at least with fever (above 37.5) or abdominal pain or vomiting from June 20 to July 14, 2016...
December 2023: Dialogues Health
#17
REVIEW
Mehak Thakur, Rachna Verma, Dinesh Kumar, Priyanku Pradip Das, Rajni Dhalaria, Ajay Kumar, Kamil Kuca, Shavkatjon Azizov, Deepak Kumar
Solanum viarum, a perennial shrub, belongs to the family Solanaceae known for its therapeutic value worldwide. As a beneficial remedial plant, it is used for treating several disorders like dysentery, diabetes, inflammation, and respiratory disorders. Phytochemistry studies of this plant have shown the presence of steroidal glycoside alkaloids, including solasonine, solasodine, and solamargine. It also has flavonoids, saponins, minerals, and other substances. S. viarum extracts and compounds possess a variety of pharmacological effects, including antipyretic, antioxidant, antibacterial, insecticidal, analgesic, and anticancer activity...
March 18, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
#18
JOURNAL ARTICLE
Ankul Singh S, Chitra Vellapandian
The loofah/sponge gourd Luffa cylindrica (L.), a member of the Cucurbitaceae family, is one of the neglected medicinal plants. Traditionally, Luffa cylindrica is prescribed for inducing labor. It has a long history of use in China for the treatment of fever, diabetes, dyspnea, and dysentery. This study investigated the toxicity profile of the alkaloid-rich fraction of Luffa cylindrica (ARF-LC) for the first time in Sprague Dawley rats. A total of 80 rats (40 male and 40 female rats) aged 13 weeks old and weighing 200-220 g were selected for this study...
June 2024: Toxicology Reports
#19
REVIEW
Meyada Khaled, Rachid Ouache, Patrick Pale, Hassina Harkat
The relatively small Frankeniaceae family is represented by halophyte plants, growing in arid and semi-arid climates in saline, alkaline or calcareous soils. Due to their living conditions, they usually produce a large diversity of compounds, which often exhibit bioactivities. Some species of this genus have long been used as traditional herbal medicines to treat dysentery, diarrhea, gonorrhea, vaginal leucorrhea, respiratory diseases and wounds. To date, several studies on either phytochemical or pharmacological aspects, or both, have revealed that this genus is a rich source of diverse and novel bioactive chemicals, including phenolics, flavonoids, alkaloids and fatty acids...
February 23, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
#20
REVIEW
Nahla S El-Gazzar
Tamarindus indica L., the sole species in the genus Tamarind , which is a member of the subfamily Caesalpiniaceae in the family Leguminosae (Fabaceae), is extensively dispersed in many tropical and subtropical regions. This plant's Arabic name, Tamr Al-Hindi, is the basis for its English name, Tamarind. In traditional medicine, this genus has played a major role since the time of the ancient Egyptians. Folkloric medicine has traditionally used Tamarind to treat a variety of conditions, including diabetes mellitus, fever, malaria, ulcers, diarrhoea, dysentery and wounds...
March 7, 2024: Natural Product Research
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