keyword
MENU ▼
Read by QxMD icon Read
search

Ionotrope

keyword
https://www.readbyqxmd.com/read/29034089/more-than-meets-the-ir-the-expanding-roles-of-variant-ionotropic-glutamate-receptors-in-sensing-odor-taste-temperature-and-moisture
#1
REVIEW
Lena van Giesen, Paul A Garrity
The ionotropic receptors (IRs) are a branch of the ionotropic glutamate receptor family and serve as important mediators of sensory transduction in invertebrates. Recent work shows that, though initially studied as olfactory receptors, the IRs also mediate the detection of taste, temperature, and humidity. Here, we summarize recent insights into IR evolution and its potential ecological significance as well as recent advances in our understanding of how IRs contribute to diverse sensory modalities.
2017: F1000Research
https://www.readbyqxmd.com/read/29030596/mesenchymal-stem-cells-from-tumor-microenvironment-favour-breast-cancer-stem-cell-proliferation-cancerogenic-and-metastatic-potential-via-ionotropic-purinergic-signalling
#2
A Maffey, C Storini, C Diceglie, C Martelli, L Sironi, C Calzarossa, N Tonna, R Lovchik, E Delamarche, L Ottobrini, F Bianco
Interaction between tumor cells and the microenvironment is key in initiation, progression, and invasiveness of cancer. In particular, mesenchymal stem cells (MSCs) are recruited to the sites of developing tumors, thus promoting metastasis formation. Although it is well known that MSCs migrate and integrate in the tumor microenvironment (TME), their fate and function inside the tumor is still not clear. In this study, we analyzed the role played by MSCs in breast cancer oncogenesis. Data indicate that interaction of breast cancer cells with MSCs results in an increased proliferation and metabolic activity of breast cancer cells, partially due to MSC-derived microvesicles that are shed in the TME...
October 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29028183/non-synaptic-signaling-from-cerebellar-climbing-fibers-modulates-golgi-cell-activity
#3
Angela K Nietz, Jada H Vaden, Luke T Coddington, Linda Overstreet-Wadiche, Jacques I Wadiche
Golgi cells are the principal inhibitory neurons at the input stage of the cerebellum, providing feedforward and feedback inhibition through mossy fiber and parallel fiber synapses. In vivo studies have shown that Golgi cell activity is regulated by climbing fiber stimulation, yet there is little functional or anatomical evidence for synapses between climbing fibers and Golgi cells. Here, we show that glutamate released from climbing fibers activates ionotropic and metabotropic receptors on Golgi cells through spillover-mediated transmission...
October 13, 2017: ELife
https://www.readbyqxmd.com/read/29026097/chemosensing-of-honeybee-parasite-varroa-destructor-transcriptomic-analysis
#4
Nurit Eliash, Nitin K Singh, Starlin Thangarajan, Noa Sela, Dena Leshkowitz, Yosi Kamer, Ilia Zaidman, Ada Rafaeli, Victoria Soroker
Chemosensing is a primary sense in nature, however little is known about its mechanism in Chelicerata. As a model organism we used the mite Varroa destructor, a key parasite of honeybees. Here we describe a transcriptomic analysis of two physiological stages for the Varroa foreleg, the site of primary olfactory organ. The transcriptomic analysis revealed transcripts of chemosensory related genes belonging to several groups. These include Niemann-Pick disease protein, type C2 (NPC2), gustatory receptors (GRs), ionotropic receptors (IRs), sensory neuron membrane proteins (SNMPs) and odorant binding proteins (OBP)...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29024451/activation-of%C3%A2-group-ii-metabotropic-glutamate-receptors-increases-proliferation-but-does-not-influence-neuronal-differentiation-of-a-human-neural-stem-cell-line
#5
Anne Dindler, Morten Blaabjerg, Morad Kamand, Helle Bogetofte, Morten Meyer
The multiple functions of glutamate include regulation of neural development and stem cells. While the importance of the ionotropic glutamate receptors is well established, less is known about the role of metabotropic glutamate receptors (mGluRs). In this study, we examined the effects of pharmacological activation and inhibition of mGluR2/3 on proliferation, differentiation and viability of a human neural stem cell line. Immunofluorescence staining revealed the presence of mGluR2/3 receptors on both proliferating and differentiating stem cells, including cells differentiated into β-tubulin III-positive immature neurons and glial fibrillary acidic protein-positive astrocytes...
October 11, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29022871/a-postmortem-analysis-of-nmda-ionotropic-and-group-1-metabotropic-glutamate-receptors-in-the-nucleus-accumbens-in-schizophrenia
#6
Jeremy S Lum, Samuel J Millard, Xu-Feng Huang, Lezanne Ooi, Kelly A Newell
BACKGROUND: The nucleus accumbens (NAcc) has been implicated in the pathology and treatment of schizophrenia. Recent postmortem evidence suggests a hyperglutamatergic state in the NAcc. With the present study we aimed to explore possible glutamatergic alterations in the NAcc of a large schizophrenia cohort. METHODS: We performed immunoblots on postmortem NAcc samples from 30 individuals who had schizophrenia and 30 matched controls. We examined the protein expression of primary glutamatergic receptors, including the N-methyl-D-aspartate (NMDA) receptor (NR1, NR2A and NR2B subunits) and the group 1 metabotropic glutamate receptor (mGluR1 and mGluR5; dimeric and monomeric forms)...
October 6, 2017: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29020917/deciphering-the-olfactory-repertoire-of-the-tiger-mosquito-aedes-albopictus
#7
Fabrizio Lombardo, Marco Salvemini, Carmine Fiorillo, Tony Nolan, Laurence J Zwiebel, José M Ribeiro, Bruno Arcà
BACKGROUND: The Asian tiger mosquito Aedes albopictus is a highly invasive species and competent vector of several arboviruses (e.g. dengue, chikungunya, Zika) and parasites (e.g. dirofilaria) of public health importance. Compared to other mosquito species, Ae. albopictus females exhibit a generalist host seeking as well as a very aggressive biting behaviour that are responsible for its high degree of nuisance. Several complex mosquito behaviours such as host seeking, feeding, mating or oviposition rely on olfactory stimuli that target a range of sensory neurons localized mainly on specialized head appendages such as antennae, maxillary palps and the mouthparts...
October 11, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29016847/a-point-mutation-in-the-ion-conduction-pore-of-ampa-receptor-gria3-causes-dramatically-perturbed-sleep-patterns-as-well-as-intellectual-disability
#8
Benjamin Davies, Laurence A Brown, Ondrej Cais, Jake Watson, Amber J Clayton, Veronica T Chang, Daniel Biggs, Christopher Preece, Polinka Hernandez-Pliego, Jon Krohn, Amarjit Bhomra, Stephen R F Twigg, Andrew Rimmer, Alexander Kanapin, Arjune Sen, Zenobia Zaiwalla, Gil McVean, Russell Foster, Peter Donnelly, Jenny C Taylor, Edward Blair, David Nutt, A Radu Aricescu, Ingo H Greger, Stuart N Peirson, Jonathan Flint, Hilary C Martin
The discovery of genetic variants influencing sleep patterns can shed light on the physiological processes underlying sleep. As part of a large clinical sequencing project, WGS500, we sequenced a family in which the two male children had severe developmental delay and a dramatically disturbed sleep-wake cycle, with very long wake and sleep durations, reaching up to 106-h awake and 48-h asleep. The most likely causal variant identified was a novel missense variant in the X-linked GRIA3 gene, which has been implicated in intellectual disability...
October 15, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28990294/genetic-and-molecular-risk-factors-within-the-newly-identified-primate-specific-exon-of-the-sap97-dlg1-gene-in-the-3q29-schizophrenia-associated-locus
#9
Akihito Uezato, Naoki Yamamoto, Daisuke Jitoku, Emiko Haramo, Eri Hiraaki, Yoshimi Iwayama, Tomoko Toyota, Masakazu Umino, Asami Umino, Yasuhide Iwata, Katsuaki Suzuki, Mitsuru Kikuchi, Tasuku Hashimoto, Nobuhisa Kanahara, Akeo Kurumaji, Takeo Yoshikawa, Toru Nishikawa
The synapse-associated protein 97/discs, large homolog 1 of Drosophila (DLG1) gene encodes synaptic scaffold PDZ proteins interacting with ionotropic glutamate receptors including the N-methyl-D-aspartate type glutamate receptor (NMDAR) that is presumed to be hypoactive in brains of patients with schizophrenia. The DLG1 gene resides in the chromosomal position 3q29, the microdeletion of which confers a 40-fold increase in the risk for schizophrenia. In the present study, we performed genetic association analyses for DLG1 gene using a Japanese cohort with 1808 schizophrenia patients and 2170 controls...
October 9, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/28988113/effects-of-dexamethasone-on-purinergic-signaling-in-murine-mast-cells-selective-suppression-of-p2x7-receptor-expression
#10
Kazuki Yoshida, Masaaki Ito, Yui Hoshino, Isao Matsuoka
Mast cells express many different purinergic receptors, including ionotropic P2X4 and P2X7, which recognize the accumulation of extracellular ATP released from activated and/or damaged cells. This results in the stimulation of mast cell functions. In this study, we investigated the effects of dexamethasone (Dex), an anti-inflammatory glucocorticoid widely used for the treatment of allergic disease, on purinergic receptor expression in mouse bone marrow-derived mast cells (BMMCs). Treatment of BMMCs with Dex decreased P2X7 receptor mRNA levels in a time- and concentration-dependent manner without affecting the expression of other purinergic receptor subtypes...
October 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28986875/gene-targeted-mice-with-conditional-knock-in-out-of-nmdar-mutations
#11
Rolf Sprengel, Ahmed Eltokhi, Frank N Single
For the genetic alterations of NMDA receptor (NMDAR) properties like Ca(2+)-permeability or voltage-dependent gating in mice and for the experimental analysis of nonsense or missense mutations that were identified in human patients, single nucleotide mutations have to be introduced into the germ line of mice (Burnashev and Szepetowski, Curr Opin Pharmacol 20:73-82, 2015; Endele et al., Nat Genet 42:1021-1026, 2010). This can be done with very high precision by the well-established method of gene replacement, which makes use of homologous recombination in pluripotent embryonic stem (ES) cells of mice...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28986871/selective-cell-surface-expression-of-triheteromeric-nmda-receptors
#12
Feng Yi, Stephen F Traynelis, Kasper B Hansen
The NMDA-type ionotropic glutamate receptors play pivotal roles in many brain functions, but are also involved in numerous brain disorders. Seven NMDA receptor subunits exist (GluN1, GluN2A-D, and GluN3A-B) that assemble into a diverse array of tetrameric receptor subtypes with distinct functional properties and physiological roles. Most NMDA receptors are composed of two GluN1 and two GluN2 subunits, which can assemble into four diheteromeric receptor subtypes composed of GluN1 and one type of GluN2 subunit (e...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28986867/genetic-and-functional-analysis-of-grin2a-in-tumor-samples
#13
Todd D Prickett, Jared J Gartner, Yardena Samuels
Ionotropic glutamate receptors (iGluRs) are large integral membrane multi-protein complexes that create ion channels in plasma membranes. Upon binding of receptor specific ligands (e.g., glutamate), increased efflux or influx of mono- or divalent cations (e.g., Ca(2+)) promotes synaptic transmission, cellular migration, and survival. Three classes of iGluRs were originally defined after their respective agonists: AMPA, kainate, and NMDA receptors (NMDARs). Recently, we examined iGluR families at the genetic level using Next-Generation Sequencing (NGS) (whole-exome sequencing (WES)) and discovered a high prevalence of somatic mutations within the gene for one of the NMDAR subunits, GRIN2A, specifically in malignant melanoma...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28965520/the-multifaceted-role-of-inhibitory-interneurons-in-the-dorsal-lateral-geniculate-nucleus
#14
Charles L Cox, Joseph A Beatty
Intrinsic interneurons within the dorsal lateral geniculate nucleus (dLGN) provide a feed-forward inhibitory pathway for afferent visual information originating from the retina. These interneurons are unique because in addition to traditional axodendritic output onto thalamocortical neurons, these interneurons have presynaptic dendrites that form dendrodendritic synapses onto thalamocortical neurons as well. These presynaptic dendrites, termed F2 terminals, are tightly coupled to the retinogeniculate afferents that synapse onto thalamocortical relay neurons...
January 2017: Visual Neuroscience
https://www.readbyqxmd.com/read/28965497/purinergic-modulation-of-frog-electroretinographic-responses-the-role-of-the-ionotropic-receptor-p2x7
#15
Petia Kupenova, Elka Popova, Liliya Vitanova
The contribution of the purinergic receptors P2X7 (P2X7Rs) to the electroretinographic (ERG) responses was studied by testing the effects of the selective P2X7R antagonist A438079 and the selective P2X7R agonist Bz-ATP on the electroretinograms obtained in perfused frog (Rana ridibunda) eyecup preparations under a variety of stimulation conditions. The P2X7R blockade by 200 µM A438079 diminished the amplitude of the photoreceptor components: the a-wave and the pharmacologically isolated mass receptor potential...
January 2017: Visual Neuroscience
https://www.readbyqxmd.com/read/28965411/next-generation-proteomic-pipeline-for-chromosome-based-proteomic-research-using-nextprot-and-gencode-databases
#16
Heeyoun Hwang, Gun Wook Park, Ji Yeong Park, Hyun Kyoung Lee, Ju Yeon Lee, Ji Eun Jeong, Sung-Kyu Robin Park, John R Yates, Kyung-Hoon Kwon, Young Mok Park, Hyoung-Joo Lee, Young-Ki Paik, Jin Young Kim, Jong Shin Yoo
Human Proteome Project aims to map all human proteins including missing proteins as well as proteoforms with post translational modifications, alternative splicing variants (ASVs), and single amino acid variants (SAAVs). neXtProt and Ensemble databases are usually used to provide curated information of human coding genes. However, in order to find these proteoforms, we (Chr #11 team) first introduce a streamlined pipeline using customized and concatenated neXtProt and GENCODE originated from Ensemble, with controlled false discovery rate (FDR)...
October 1, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28963530/super-resolution-microscopy-reveals-functional-organization-of-dopamine-transporters-into-cholesterol-and-neuronal-activity-dependent-nanodomains
#17
Troels Rahbek-Clemmensen, Matthew D Lycas, Simon Erlendsson, Jacob Eriksen, Mia Apuschkin, Frederik Vilhardt, Trine N Jørgensen, Freja H Hansen, Ulrik Gether
Dopamine regulates reward, cognition, and locomotor functions. By mediating rapid reuptake of extracellular dopamine, the dopamine transporter is critical for spatiotemporal control of dopaminergic neurotransmission. Here, we use super-resolution imaging to show that the dopamine transporter is dynamically sequestrated into cholesterol-dependent nanodomains in the plasma membrane of presynaptic varicosities and neuronal projections of dopaminergic neurons. Stochastic optical reconstruction microscopy reveals irregular dopamine transporter nanodomains (∼70 nm mean diameter) that were highly sensitive to cholesterol depletion...
September 29, 2017: Nature Communications
https://www.readbyqxmd.com/read/28959208/olfactory-plasticity-variation-in-the-expression-of-chemosensory-receptors-in-bactrocera-dorsalis-in-different-physiological-states
#18
Sha Jin, Xiaofan Zhou, Feng Gu, Guohua Zhong, Xin Yi
Changes in physiological conditions could influence the perception of external odors, which is important for the reproduction and survival of insect. With the alteration of physiological conditions, such as, age, feeding state, circadian rhythm, and mating status, insect can modulate their olfactory systems accordingly. Ionotropic, gustatory, and odorant receptors (IR, GR, and ORs) are important elements of the insect chemosensory system, which enable insects to detect various external stimuli. In this study, we investigated the changes in these receptors at the mRNA level in Bactrocera dorsalis in different physiological states...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28957809/geniposide-attenuates-post-ischaemic-neurovascular-damage-via-glun2a-akt-erk-dependent-mechanism
#19
Baosheng Huang, Panhong Chen, Lei Huang, Shuai Li, Ronglan Zhu, Tao Sheng, Wan Yu, Zheng Chen, Tianlu Wang
BACKGROUND/AIMS: Calcium-permeable ionotropic NMDAR-mediated hyperactivity is regarded as the critical factor in modulating the development of ischaemic stroke. Recently, there has been increasing interest in preventing post-stroke neuronal death by focusing on intervening in the function of subpopulations of NMDARs and their downstream signalling. Geniposide, an iridoid glycoside, has been found to have cytoprotective functions in various conditions. However, it is still unclear whether and how geniposide affects neuronal insult under experimental stroke...
September 22, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28956947/effects-of-intra-accumbal-administration-of-dopamine-and-ionotropic-glutamate-receptor-drugs-on-delay-discounting-performance-in-rats
#20
Justin R Yates, Michael T Bardo
Nucleus accumbens core (NAcc) has been implicated in impulsive choice, as measured in delay discounting. The role of dopamine (DA) in impulsive choice has received considerable attention, whereas glutamate (Glu) has recently been shown to be an important mediator of discounting. However, research has not examined how DA or Glu receptors in NAcc mediate different aspects of delay discounting performance, that is, (a) sensitivity to reinforcer magnitude and (b) sensitivity to delayed reinforcement. Adult male Sprague-Dawley rats were first trained in a delay discounting task, in which the delay to a large magnitude food reinforcer increased across blocks of trials...
October 2017: Behavioral Neuroscience
keyword
keyword
23668
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"