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https://www.readbyqxmd.com/read/29149761/crizotinib-achieves-long-lasting-disease-control-in-advanced-papillary-renal-cell-carcinoma-type-1-patients-with-met-mutations-or-amplification-eortc-90101-create-trial
#1
Patrick Schöffski, Agnieszka Wozniak, Bernard Escudier, Piotr Rutkowski, Alan Anthoney, Sebastian Bauer, Jozef Sufliarsky, Carla van Herpen, Lars H Lindner, Viktor Grünwald, Branko Zakotnik, Evelyne Lerut, Maria Debiec-Rychter, Sandrine Marréaud, Michela Lia, Tiana Raveloarivahy, Sandra Collette, Laurence Albiges
PURPOSE: Papillary renal-cell carcinoma type 1 (PRCC1) is associated with MET gene alterations. Our phase II trial prospectively assessed the efficacy and safety of crizotinib in patients with advanced/metastatic PRCC1 with or without MET mutations (MET+ and MET-). EXPERIMENTAL DESIGN: Eligible patients with reference pathology-confirmed PRCC1 received 250 mg oral crizotinib twice daily. Patients were attributed to MET+/MET- sub-cohorts by the sequencing of exons 16-19 of the MET gene in tumour tissue...
November 14, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29149652/estimation-of-stature-from-hand-and-handprint-measurements-in-iban-population-in-sarawak-malaysia-and-its-applications-in-forensic-investigation
#2
Nuranis-Raihan Zulkifly, Roswanira Abd Wahab, Elizabeth Layang, Dzulkiflee Ismail, Wan Nur Syuhaila Mat Desa, Salina Hisham, Naji A Mahat
Handprints and dismembered hands are commonly found during crime scene investigations and disaster victim identifications, respectively. It has been indicated that the accuracy of handprint and hand measurements for estimating stature maybe population specific. Since Iban is the largest ethnic population in Sarawak, Malaysia and because the application of anthropometry of hand and handprint within this population as well as other populations within the Southeast Asian countries remain unreported, this present study that investigated the reliability and accuracy of these two anthropometric aspects acquires forensic significance...
October 31, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29149396/a-survey-on-pediatric-brain-death-and-on-organ-transplantation-how-did-the-law-amendment-change-the-awareness-of-pediatric-healthcare-providers
#3
Takashi Araki, Hiroyuki Yokota, Koutaro Ichikawa
OBJECTIVES: In Japanese society taking a cautious attitude towards organ transplantation, we investigate how amendment of the Organ Transplant Law which legalized brain death (BD) determination criteria changed the awareness concerning BD and organ transplantation of pediatric healthcare providers. METHODS: The questionnaire survey adopted the bearer method and was sent to members of the Japanese Society of Emergency Pediatrics (JSEP). In both the surveys of 2008 and 2016, the same item "Questionnaire survey on BD and organ transplant" was disseminated...
October 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29149333/misleading-by-omission-rethinking-the-obligation-to-inform-research-subjects-about-funding-sources
#4
Neil C Manson
Informed consent requirements for medical research have expanded over the past half-century. The Declaration of Helsinki now includes an explicit positive obligation to inform subjects about funding sources. This is problematic in a number of ways and seems to oblige researchers to disclose information irrelevant to most consent decisions. It is argued here that such a problematic obligation involves an "informational fallacy." The aim in the second part of the paper is to provide a better approach to making sense of how a failure to inform about funding sources wrongs subjects: by making appeals to obligations to refrain from misleading by omission...
November 15, 2017: Journal of Medicine and Philosophy
https://www.readbyqxmd.com/read/29149267/taiwan-biobank-making-cross-database-convergence-possible-in-the-big-data-era
#5
Jui-Chu Lin, Chien-Te Fan, Chia-Cheng Liao, Yao-Sheng Chen
The Taiwan Biobank (TWB) is a biomedical research database of biopsy data from 200,000 participants. Access to this database has been granted to research communities taking part in the development of precision medicines; however, this has raised issues surrounding TWB's access to electronic medical records (EMR). The Personal Data Protection Act of Taiwan restricts access to EMR for purposes not covered by patients' original consent. This commentary explores possible legal solutions to help ensure that the access TWB has to EMR abides with legal obligations, and with governance frameworks associated with ethical, legal and social implications...
November 15, 2017: GigaScience
https://www.readbyqxmd.com/read/29149211/occupational-exposure-to-unburnt-tobacco-and-potential-risk-of-toxic-optic-neuropathy-a-cross-sectional-study-among-beedi-rollers-in-selected-rural-areas-of-coastal-karnataka-india
#6
Soujanya Kaup, Ansaba Naseer, Siddharudha Shivalli, Cynthia Arunachalam
BACKGROUND: Beedi also known as poor man's cigarette is manufactured in almost all major states of India. Beedi workers are exposed to various health risks. There is an increased risk of systemic absorption of tobacco through skin and mucous membrane. The optic nerve is susceptible to damage from several toxic substances including tobacco. This group of disorders is known as toxic optic neuropathy (TON). The association of TON with occupational exposure to unburnt tobacco in beedi rollers has not been explored...
2017: PloS One
https://www.readbyqxmd.com/read/29148954/our-life-depends-on-this-drug-competence-inequity-and-voluntary-consent-in-clinical-trials-on-supervised-injectable-opioid-assisted-treatment
#7
Daniel Steel, Kirsten Marchand, Eugenia Oviedo-Joekes
Supervised injectable opioid assisted treament (siOAT) prescribes injectable opioids to individuals for whom other forms of addiction treatment have been ineffective. In this article, we examine arguments that opioid-dependent people should be assumed incompetent to voluntarily consent to clinical research on siOAT unless proven otherwise. We agree that concerns about competence and voluntary consent deserve careful attention in this context. But we oppose framing the issue solely as a matter of the competence of opioid-dependent people and emphasize that it should be considered in the context of inequities in access to siOAT as a medical treatment...
December 2017: American Journal of Bioethics: AJOB
https://www.readbyqxmd.com/read/29148953/a-matter-of-heart-beyond-informed-consent
#8
Haavi Morreim
No abstract text is available yet for this article.
December 2017: American Journal of Bioethics: AJOB
https://www.readbyqxmd.com/read/29148951/reframing-consent-for-clinical-research-a-function-based-approach
#9
Neal W Dickert, Nir Eyal, Sara F Goldkind, Christine Grady, Steven Joffe, Bernard Lo, Franklin G Miller, Rebecca D Pentz, Robert Silbergleit, Kevin P Weinfurt, David Wendler, Scott Y H Kim
Although informed consent is important in clinical research, questions persist regarding when it is necessary, what it requires, and how it should be obtained. The standard view in research ethics is that the function of informed consent is to respect individual autonomy. However, consent processes are multidimensional and serve other ethical functions as well. These functions deserve particular attention when barriers to consent exist. We argue that consent serves seven ethically important and conceptually distinct functions...
December 2017: American Journal of Bioethics: AJOB
https://www.readbyqxmd.com/read/29148950/considering-consent-to-research-for-patients-in-chronic-pain-and-with-mental-illnesses
#10
Caroline J Huang, David Wasserman
No abstract text is available yet for this article.
December 2017: American Journal of Bioethics: AJOB
https://www.readbyqxmd.com/read/29148949/does-consent-form-follow-function
#11
Cory E Goldstein, Jamie Brehaut, Charles Weijer
No abstract text is available yet for this article.
December 2017: American Journal of Bioethics: AJOB
https://www.readbyqxmd.com/read/29148947/germline-genome-editing-and-the-functions-of-consent
#12
Robert Ranisch
No abstract text is available yet for this article.
December 2017: American Journal of Bioethics: AJOB
https://www.readbyqxmd.com/read/29148942/attending-to-the-interrelatedness-of-the-functions-of-consent
#13
Benjamin S Wilfond, Stephanie A Kraft
No abstract text is available yet for this article.
December 2017: American Journal of Bioethics: AJOB
https://www.readbyqxmd.com/read/29148940/a-functional-approach-to-assessing-consent-for-biospecimen-research
#14
Holly Fernandez Lynch
No abstract text is available yet for this article.
December 2017: American Journal of Bioethics: AJOB
https://www.readbyqxmd.com/read/29148938/applicability-of-a-function-based-approach-to-informed-consent-in-international-settings
#15
Henry J Silverman, Shahd Osman
No abstract text is available yet for this article.
December 2017: American Journal of Bioethics: AJOB
https://www.readbyqxmd.com/read/29148936/on-the-wrongness-of-exploitation-and-the-voluntariness-of-consent-in-clinical-research-on-opioid-assisted-treatment
#16
Susanne Uusitalo
No abstract text is available yet for this article.
December 2017: American Journal of Bioethics: AJOB
https://www.readbyqxmd.com/read/29148935/the-idea-of-a-standard-view-of-informed-consent
#17
Tom L Beauchamp
No abstract text is available yet for this article.
December 2017: American Journal of Bioethics: AJOB
https://www.readbyqxmd.com/read/29148934/reconciling-competence-and-consent-in-opioid-dependence-research-the-value-of-vulnerability-rhetoric
#18
Michael O S Afolabi, Stephen O Sodeke
No abstract text is available yet for this article.
December 2017: American Journal of Bioethics: AJOB
https://www.readbyqxmd.com/read/29148277/care-ful-definition-of-consent
#19
Emese Ilyes
This proposal is an attempt to intervene in psychology's violent past and troubling present by calling for notions of "care-ful" practice, compelling us to recognize and celebrate the permeable, porous, and flexible boundaries between bodies and selves. With this heuristic of care, this article hopes to trouble the separation between rigor and relational responsibility, to trouble objectivism, to oust the illusion of cool rationality, and to offer an affective understanding of consent that refuses to deny sexuality in bodies oppressed with the label of intellectually disabled...
November 1, 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/29147964/diabetes-care-in-qatar-a-survey-of-pharmacists-activities-attitudes-and-knowledge
#20
Maguy Saffouh El Hajj, Safae E Abu Yousef, Meena Ali Basri
Background Diabetes mellitus is recognized as a major public health issue and is one of the top ten causes of death in Qatar. Objective To describe the activities, and attitudes of Qatar pharmacists toward diabetes, to measure their diabetes knowledge and to assess their perceived barriers for diabetes care. Setting Community and ambulatory pharmacies in Qatar. Method Study objectives were addressed in a cross sectional survey of community and ambulatory pharmacists in Qatar. A phone call explaining the study was made to all community and ambulatory pharmacists in Qatar...
November 17, 2017: International Journal of Clinical Pharmacy
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