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https://www.readbyqxmd.com/read/29341834/improvement-in-overall-survival-with-carfilzomib-lenalidomide-and-dexamethasone-in-patients-with-relapsed-or-refractory-multiple-myeloma
#1
David S Siegel, Meletios A Dimopoulos, Heinz Ludwig, Thierry Facon, Hartmut Goldschmidt, Andrzej Jakubowiak, Jesus San-Miguel, Mihaela Obreja, Julie Blaedel, A Keith Stewart
Purpose In the ASPIRE study of carfilzomib, lenalidomide, and dexamethasone (KRd) versus lenalidomide plus dexamethasone (Rd) in patients with relapsed or refractory multiple myeloma, progression-free survival was significantly improved in the carfilzomib group (hazard ratio, 0.69; two-sided P < .001). This prespecified analysis reports final overall survival (OS) data and updated safety results. Patients and Methods Adults with relapsed multiple myeloma (one to three prior lines of therapy) were eligible and randomly assigned at a one-to-one ratio to receive KRd or Rd in 28-day cycles until withdrawal of consent, disease progression, or occurrence of unacceptable toxicity...
January 17, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29341157/minimizing-inequality-in-access-to-precision-medicine-in-breast-cancer-by-real-time-population-based-molecular-analysis-in-the-scan-b-initiative
#2
L Rydén, N Loman, C Larsson, C Hegardt, J Vallon-Christersson, M Malmberg, H Lindman, A Ehinger, L H Saal, Å Borg
BACKGROUND: Selection of systemic therapy for primary breast cancer is currently based on clinical biomarkers along with stage. Novel genomic tests are continuously being introduced as more precise tools for guidance of therapy, although they are often developed for specific patient subgroups. The Sweden Cancerome Analysis Network - Breast (SCAN-B) initiative aims to include all patients with breast cancer for tumour genomic analysis, and to deliver molecular subtype and mutational data back to the treating physician...
January 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29340884/-i-would-like-to-discuss-it-further-with-an-expert-a-focus-group-study-of-finnish-adults-perspectives-on-genetic-secondary-findings
#3
M Vornanen, K Aktan-Collan, N Hallowell, H Konttinen, H Kääriäinen, A Haukkala
Lowered costs of genomic sequencing facilitate analyzing large segments of genetic data. Ethical debate has focused on whether and what kind of incidental or secondary findings (SFs) to report, and how to obtain valid informed consent. However, people's support needs after receiving SFs have received less attention. We explored Finnish adults' perspectives on reporting genetic SFs. In this qualitative study which included four focus group discussions (N = 23) we used four vignette letters, each reporting a genetic SF predisposing to a different disease: familial hypercholesterolemia, long QT syndrome, Lynch syndrome, and Li-Fraumeni syndrome...
January 16, 2018: Journal of Community Genetics
https://www.readbyqxmd.com/read/29340574/effect-of-general-anesthesia-and-conscious-sedation-during-endovascular-therapy-on-infarct-growth-and-clinical-outcomes-in-acute-ischemic-stroke-a-randomized-clinical-trial
#4
Claus Z Simonsen, Albert J Yoo, Leif H Sørensen, Niels Juul, Søren P Johnsen, Grethe Andersen, Mads Rasmussen
Importance: Endovascular therapy (EVT) is the standard of care for select patients who had a stroke caused by a large vessel occlusion in the anterior circulation, but there is uncertainty regarding the optimal anesthetic approach during EVT. Observational studies suggest that general anesthesia (GA) is associated with worse outcomes compared with conscious sedation (CS). Objective: To examine the effect of type of anesthesia during EVT on infarct growth and clinical outcome...
January 16, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29340448/-uses-of-madness-towards-the-recognition-of-new-interpretations-of-human-suffering
#5
Miguel Salas Soneira
This article addresses the controversy associated with the construct schizophrenia/psychosis/madness, indicating the need to acknowledge the multiplicity of experiences and interpretations which arise through the use of the construct. The plurality and complexity intrinsic to the phenomenon, the discrepancies in its possible meanings and the value of first-hand experience are indicated as aspects whose recognition is indispensable to both understanding suffering and confronting it socio-educationally. Using interviews carried out in September 2013 and May 2014 with six people diagnosed at least with schizophrenia, who gave their informed consent to participate, these dimensions are explored...
October 2017: Salud Colectiva
https://www.readbyqxmd.com/read/29340299/prospective-study-of-the-feasibility-of-point-of-care-testing-strategy-for-carbapenem-resistant-organism-detection
#6
Rahul Pannala, Bruce Baldwin, Vijay Aluru, Thomas E Grys, Jordan Holmes, Laurence J Miller, M Edwyn Harrison, Cuong C Nguyen, Fred C Tenover, David Persing, Douglas O Faigel
Background/aims:  In an investigator-initiated, prospective study, we evaluated the feasibility of a five-gene sequence point-of-care (POC) testing strategy (Xpert CARBA-R Assay, Cepheid Inc., Sunnyvale, CA, USA), compared to reference laboratory PCR (48 - 72 hours turnaround time, two gene sequences), in patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) and in a hospital outbreak investigation. Methods:  After informed consent, patients undergoing ERCP (September 2015 - April 2016, n = 191) at Mayo Clinic and potential hospital contacts (n = 9) of an index carbapenem-resistant organism (CRO)-positive inpatient were included...
January 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29338487/acupuncture-treatments-for-infantile-colic-a-systematic-review-and-individual-patient-data-meta-analysis-of-blinding-test-validated-randomised-controlled-trials
#7
Holgeir Skjeie, Trygve Skonnord, Mette Brekke, Atle Klovning, Arne Fetveit, Kajsa Landgren, Inger Kristensson Hallström, Kjetil Gundro Brurberg
OBJECTIVE: Needle acupuncture in small children has gained some acceptance in Western medicine. It is controversial, as infants and toddlers are unable to consent to treatment. We aimed to assess its efficacy for treating infantile colic. DESIGN: A systematic review and a blinding-test validation based on individual patient data from randomised controlled trials. Primary end-points were crying time at mid-treatment, at the end of treatment and at a 1-month follow-up...
January 17, 2018: Scandinavian Journal of Primary Health Care
https://www.readbyqxmd.com/read/29337801/informed-or-misinformed-consent
#8
Geert Meyfroidt
No abstract text is available yet for this article.
February 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29337775/comparisons-of-rigid-proctoscopy-flexible-colonoscopy-and-digital-rectal-examination-for-determining-the-localization-of-rectal-cancers
#9
Akira Tanaka, Sotaro Sadahiro, Toshiyuki Suzuki, Kazutake Okada, Gota Saito
BACKGROUND: Rigid proctoscopy is considered essential for rectal tumor localization, although the current gold standard for detection of colorectal cancers is colonoscopy. The European Society for Medical Oncology Guidelines indicate that rigid and flexible endoscopies afford essentially identical results, although little evidence is yet available to support this. OBJECTIVE: The purpose of this study was to determine the accuracy of colonoscopy in identifying the location of rectal cancer and to compare the results with those of rigid proctoscopy and digital rectal examination...
February 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29336903/one-year-experience-of-a-regional-service-model-of-teleconsultation-for-planning-and-treatment-of-complex-thoracoabdominal-aortic-disease
#10
Emiliano Chisci, Gianmarco de Donato, Aaron Fargion, Giorgio Ventoruzzo, Gianbattista Parlani, Carlo Setacci, Leonardo Ercolini, Stefano Michelagnoli
OBJECTIVE: The objective of this study was to report the methodology and 1-year experience of a regional service model of teleconsultation for planning and treatment of complex thoracoabdominal aortic disease (TAAD). METHODS: Complex TAADs without a feasible conventional surgical repair were prospectively evaluated by vascular surgeons of the same public health service (National Health System) located in a huge area of 22,994 km2 with 3.7 million inhabitants and 11 tertiary hospitals...
January 11, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29336878/healing-of-periapical-lesions-after-endodontic-treatment-with-the-gentlewave-procedure-a-prospective-multicenter-clinical-study
#11
Asgeir Sigurdsson, Randy W Garland, Khang T Le, Shahriar A Rassoulian
INTRODUCTION: This report includes outcomes for a group of patients with significant periapical lesions who were treated and evaluated in two single-arm, multicenter, prospective, nonsignificant risk clinical studies. METHODS: Forty-five teeth were from 45 patients who met the inclusion criteria and consented for the clinical studies and were diagnosed with periapical lesions with periapical index score ≥3. Patients were treated with a standardized treatment protocol including instrumentation to an apical diameter of #20 without orifice enlargement, the GentleWave Procedure, and warm vertical obturation...
January 12, 2018: Journal of Endodontics
https://www.readbyqxmd.com/read/29336765/robotic-inguinal-hernia-repair
#12
David S Edelman
Laparoscopic inguinal hernia repair has certain advantages over open repair including less pain and earlier return to normal activity. Concurrent robotic inguinal hernia repair at the time of prostatectomy has been shown to have a lower recurrence rate than open repair. Robotic surgery adds high definition visualization and articulating instruments which enhances dexterity that makes laparoscopic hernia repair more refined. A series of robotic, laparoscopic, inguinal hernia repairs by a single surgeon with an extensive laparoscopic hernia experience at a single institution was undertaken to determine the role of robotic laparoscopic inguinal hernia repair in minimally invasive surgery...
December 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/29336687/reasons-why-undergraduate-women-comply-with-unwanted-non-coercive-sexual-advances-a-serial-indirect-effect-model-integrating-sexual-script-theory-and-sexual-self-control-perspectives
#13
Christopher Quinn-Nilas, Deborah J Kennett
This study explored the predictors of young women's compliance with unwanted sexual activities integrating the social with the cognitive and behavioural correlates of sexual compliance. In total, 222 young heterosexual women completed measures examining the Sexual Self-Control model including reasons for consenting, sexual resourcefulness, and compliance with unwanted sex, as well as gender role measures pertaining to sexual script theory including the sexual double standard, gender role stress, and virginity scripts...
January 16, 2018: Journal of Social Psychology
https://www.readbyqxmd.com/read/29336506/influence-of-culture-change-on-the-perception-of-fear-and-anxiety-pathways-in-endodontics-a-pilot-proof-of-concept-study
#14
Ava Elizabeth Carter, Emad AlShwaimi, Mark Boschen, Geoffery Carter, Roy George
This study assessed the influence of cultural changes (known as acculturation) on pathways of fear and anxiety in Endodontics. A purposive sampling technique identified patients of Saudi Arabian descent living in Australia and Saudi Arabia. Only patients with root canal fillings (or treatment planned for endodontic treatment) were included. Patients with intellectual disabilities, surgical root therapy, and aged under 20 were excluded. Consenting patients attending the dental clinics of University of Griffith University, Australia and University of Dammam, Saudi Arabia completed the "My Endodontic Fear Questionnaire...
January 16, 2018: Australian Endodontic Journal: the Journal of the Australian Society of Endodontology Inc
https://www.readbyqxmd.com/read/29336323/nivolumab-for-recurrent-cutaneous-squamous-cell-carcinoma-three-cases
#15
Veronika Blum, Beat Müller, Silvia Hofer, Esther Pardo, Kristin Zeidler, Joachim Diebold, Klaus Strobel, Christoph Brand, Stefan Aebi, Oliver Gautschi
Programmed cell death ligand 1 (PD-L1) is frequently expressed in cutaneous squamous cell cancer (CSCC) and preliminary data from an ongoing clinical trial suggest that programmed death receptor 1 (PD-1) checkpoint inhibitors may be useful to treat patients with metastatic non-melanoma skin cancer. To report a series of three patients with advanced CSCC treated with nivolumab, showing that commercially available PD-1 checkpoint inhibitors may be useful in non-melanoma skin cancer patients without access to a clinical trial...
January 16, 2018: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29336240/treatment-of-anemia-in-patients-with-solid-tumors-receiving-chemotherapy-in-palliative-setting-usual-practice-versus-guidelines
#16
Robin de Putter, Karen Geboes, Marc De Man, Simon Van Belle
Background Anemia is frequent in patients with cancer and is often multifactorial. Treatment depends on etiology and can consist of transfusions, intravenous iron (IV Fe), and/or erythropoiesis-stimulating agents (ESA). Several studies have shown that cancer-related anemia is undertreated. The aim of this study is to compare usual practice in a university hospital with the international guidelines. Methods Using the hospital and pharmacy informatics all adults (≥18 years), who received a treatment for anemia (transfusion, IV Fe, ESA) from February to August 2016 during palliative chemotherapy, were identified...
January 16, 2018: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29336195/is-aspiration-and-sclerotherapy-treatment-for-hydroceles-in-the-aging-male-an-evidence-based-treatment
#17
W St J Taylor, J Cobley, W Mahmalji
Symptomatic hydroceles are commonly treated with surgical repair. They are associated with sexual dysfunction in the aging male. Patients who are not fit for surgery often undergo aspiration and sclerotherapy of the hydrocele. There is a range of sclerosing agents used in the literature. I performed a literature search to assess whether one sclerosant was better than the others. STDS is the sclerosing agent with the best cure rate after a single injection and low side effect rates. The cure rates of sodium tetradecyl sulphate (STDS) after a single aspiration and injection were 76%...
January 16, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29336125/association-of-chronic-subjective-tinnitus-with-neuro-cognitive-performance
#18
Sunita Gudwani, Sanjay K Munjal, Naresh K Panda, Adarsh Kohli
INTRODUCTION: Chronic subjective tinnitus is associated with cognitive disruptions affecting perception, thinking, language, reasoning, problem solving, memory, visual tasks (reading) and attention. OBJECTIVE: To evaluate existence of any association between tinnitus parameters and neuropsychological performance to explain cognitive processing. MATERIALS AND METHODS: Study design was prospective, consisting 25 patients with idiopathic chronic subjective tinnitus and gave informed consent before planning their treatment...
December 1, 2017: International Tinnitus Journal
https://www.readbyqxmd.com/read/29335745/-health-privacy-in-the-age-of-digital-networks
#19
REVIEW
Thilo Weichert
Digitization in the health sector embodies opportunities and risks. These consist of patient and data confidentiality. Vulnerability of data concerning integrity and availability can lead to financial losses and to damage of the health of data subjects. Those risks must be tackled by privacy or data protection law. For this purpose we have the European Data Protection Regulation as a comprehensive legal framework and a harmonizing bracket.This framework contains regulations on consent, purpose binding and data transfer, on rights of the data subject, technical and organizational measures and procedural arrangements...
January 15, 2018: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/29335103/new-objective-lens-density-quantification-method-using-swept-source-optical-coherence-tomography-technology-comparison-with-existing-methods
#20
Christophe Panthier, Justine Burgos, Helene Rouger, Alain Saad, Damien Gatinel
PURPOSE: To assess a new objective cataract grading method based on lens densitometry on swept-source optical coherence tomography (SS-OCT) scans provided by the IOLMaster 700. SETTINGS: Rothschild Foundation, Paris, France. DESIGN: Prospective case series. METHODS: All patients consulting for cataract evaluation who provided their consent to participate in the study were included. A history of eye surgery, corneal or retinal disorders, and ocular dryness were exclusion criteria...
December 2017: Journal of Cataract and Refractive Surgery
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