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https://www.readbyqxmd.com/read/28742794/the-cost-effectiveness-of-screening-for-ovarian-cancer-results-from-the-uk-collaborative-trial-of-ovarian-cancer-screening-ukctocs
#1
Usha Menon, Alistair J McGuire, Maria Raikou, Andy Ryan, Susan K Davies, Matthew Burnell, Aleksandra Gentry-Maharaj, Jatinderpal K Kalsi, Naveena Singh, Nazar N Amso, Derek Cruickshank, Stephen Dobbs, Keith Godfrey, Jonathan Herod, Simon Leeson, Tim Mould, John Murdoch, David Oram, Ian Scott, Mourad W Seif, Karin Williamson, Robert Woolas, Lesley Fallowfield, Stuart Campbell, Steven J Skates, Mahesh Parmar, Ian J Jacobs
BACKGROUND: To assess the within-trial cost-effectiveness of an NHS ovarian cancer screening (OCS) programme using data from UKCTOCS and extrapolate results based on average life expectancy. METHODS: Within-trial economic evaluation of no screening (C) vs either (1) an annual OCS programme using transvaginal ultrasound (USS) or (2) an annual ovarian cancer multimodal screening programme with serum CA125 interpreted using a risk algorithm (ROCA) and transvaginal ultrasound as a second-line test (MMS), plus comparison of lifetime extrapolation of the no screening arm and the MMS programme using both a predictive and a Markov model...
July 25, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28735119/a-case-series-of-pediatric-seymour-fractures-related-to-hoverboards-increasing-trend-with-changing-lifestyle
#2
A E Kattan, F AlShomer, A K Alhujayri, M Alfowzan, K A Murrad, H Alsajjan
BACKGROUND: Several recreational activities such as roller skating, skateboarding, and scooter riding create the risk for hand injuries, which are the fourth most commonly injured body part in relation to their use. Seymour first identified a specific pattern of digit injury as an open fracture affecting the distal phalangeal physis associated with nail avulsion from the eponychial fold. In this article, we report a series of Seymour fractures associated with misuse of the newly emerging recreational/transportation vehicle, the hoverboard...
July 10, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28725216/survey-of-antibiotic-producing-bacteria-associated-with-the-epidermal-mucus-layers-of-rays-and-skates
#3
Kim B Ritchie, Melbert Schwarz, Joseph Mueller, Valeri A Lapacek, Daniel Merselis, Catherine J Walsh, Carl A Luer
Elasmobranchs represent a distinct group of cartilaginous fishes that harbor a remarkable ability to heal wounds rapidly and without infection. To date very little work has addressed this phenomenon although it is suggested that antibiotic capabilities associated with epidermal surfaces may be a factor. The study of benefits derived from mutualistic interactions between unicellular and multicellular organisms is a rapidly growing area of research. Here we survey and identify bacterial associates of three ray and one skate species in order to assess the potential for antibiotic production from elasmobranch associated bacteria as a novel source for new antibiotics...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28696930/dramatic-improvement-of-tardive-dyskinesia-movements-by-inline-skating
#4
Sara Carvalho Barbosa Casagrande, Rubens Gisbert Cury, Andrea Cristina de Lima-Pardini, Daniel Boari Coelho, Carolina de Oliveira Souza, Maria Gabriela Dos Santos Ghilardi, Laura Silveira-Moriyama, Luis Augusto Teixeira, Egberto Reis Barbosa, Erich Talamoni Fonoff
No abstract text is available yet for this article.
July 11, 2017: Neurology
https://www.readbyqxmd.com/read/28662163/association-between-laboratory-capacities-and-world-cup-performance-in-nordic-combined
#5
Vegard Rasdal, Ronny Fudel, Jan Kocbach, Frode Moen, Gertjan Ettema, Øyvind Sandbakk
BACKGROUND: Nordic combined (NC) is an Olympic winter-sport performed as a ski jumping (SJ) event followed by a cross-country (XC) pursuit race employing the skating style. PURPOSE: To elucidate the associations between sport-specific laboratory capacities and SJ, XC skiing, and overall NC performance in a world-cup NC event. METHODS: Twelve international world-cup NC athletes from 8 nations performed laboratory testing one day prior to participating in a world-cup NC event...
2017: PloS One
https://www.readbyqxmd.com/read/28637689/elevation-of-tp53-autoantibody-prior-to-ca125-in-preclinical-invasive-epithelial-ovarian-cancer
#6
Wei-Lei Yang, Aleksandra Gentry-Maharaj, Archana R Simmons, Andy Ryan, Evangelia O Fourkala, Zhen Lu, Keith A Baggerly, Yang Zhao, Karen Lu, David D L Bowtell, Ian Jacobs, Steven J Skates, Wei-Wu He, Usha Menon, Robert C Bast
Purpose: The TP53 tumor suppressor gene is mutated in >95% of high grade serous ovarian cancers. Detecting an autologous antibody response to TP53 might improve early detection. <p>Experimental design: An immunoassay was developed to measure TP53 autoantibody in sera from 378 cases of invasive epithelial ovarian cancer and in 944 age-matched healthy controls from the United States, Australia and the United Kingdom. Serial preclinical samples from cases and controls were also assayed from the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)...
June 21, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28632052/motor-unit-firing-frequency-of-lower-limb-muscles-during-an-incremental-slide-board-skating-test
#7
Tatiane Piucco, Rodrigo Bini, Masanori Sakaguchi, Fernando Diefenthaeler, Darren Stefanyshyn
This study investigated how the combination of workload and fatigue affected the frequency components of muscle activation and possible recruitment priority of motor units during skating to exhaustion. Ten male competitive speed skaters performed an incremental maximal test on a slide board. Activation of six muscles from the right leg was recorded throughout the test. A time-frequency analysis was performed to compute overall, high, and low frequency bands from the whole signal at 10, 40, 70, and 90% of total test time...
February 28, 2017: Sports Biomechanics
https://www.readbyqxmd.com/read/28630823/teaching-on-task-rollerblading-and-ice-skating-to-a-child-with-autism
#8
Stacey Bord, Tina M Sidener, Kenneth F Reeve, David W Sidener
The present study used a multi-component intervention package to teach on-task rollerblading and ice-skating to a boy with autism. Intervention consisted of response prompts, stimulus prompts, multiple-exemplar training, and a conditioned reinforcement system. The participant learned to remain on-task while rollerblading in a circular route marked by cones for up to 26 min. Both stimulus and response generalization of skating were demonstrated in a variety of non-training settings, including ice-skating at a rink...
June 2017: Behavior Analysis in Practice
https://www.readbyqxmd.com/read/28617322/chondroitin-sulfate-rich-extract-of-skate-cartilage-attenuates-lipopolysaccharide-induced-liver-damage-in-mice
#9
Yeong Ok Song, Mijeong Kim, Minji Woo, Jang-Mi Baek, Keon-Hee Kang, Sang-Ho Kim, Seong-Soo Roh, Chan Hum Park, Kap-Seop Jeong, Jeong-Sook Noh
The protective effects of a chondroitin sulfate-rich extract (CSE) from skate cartilage against lipopolysaccharide (LPS)-induced hepatic damage were investigated, and its mechanism of action was compared with that of chondroitin sulfate (CS) from shark cartilage. ICR mice were orally administrated 200 mg/kg body weight (BW) of CS or 400 mg/kg BW of CSE for 3 consecutive days, followed by a one-time intraperitoneal injection of LPS (20 mg/kg BW). The experimental groups were vehicle treatment without LPS injection (NC group), vehicle treatment with LPS injection (LPS group), CS pretreatment with LPS injection (CS group), and CSE pretreatment with LPS injection (CSE group)...
June 15, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28610121/a-new-species-of-velvet-skate-i-notoraja-i-i-sereti-i-n-sp-rajiformes-arhynchobatidae-from-papua-new-guinea
#10
William T White, Peter R Last, Ralph R Mana
A new arhynchobatin skate, Notoraja sereti n. sp., is described based on three specimens collected from off Madang (Papua New Guinea) at depths of 800-980 m. This medium-size Notoraja skate shares with other velcro skates from the Western Pacific, N. alisae, N. fijiensis, N. inusitata and N. longiventralis, a ventral surface covering of fine denticles giving the skin a velvety feel. Notoraja sereti differs from all of these species in having a shorter snout (preorbital length 10.1-11.1 vs. 11.5-14.5% TL, prenasal length 8...
March 19, 2017: Zootaxa
https://www.readbyqxmd.com/read/28593636/biosynthesis-of-1%C3%AE-hydroxycorticosterone-in-the-winter-skate-leucoraja-ocellata-evidence-to-suggest-a-novel-steroidogenic-route
#11
J Wiens, R Ho, A K Brassinga, C A Deck, P J Walsh, R N Ben, K Mcclymont, T Charlton, A N Evans, W G Anderson
The present study explores the ability of intracellular bacteria within the renal-inter-renal tissue of the winter skate Leucoraja ocellata to metabolize steroids and contribute to the synthesis of the novel elasmobranch corticosteroid, 1α-hydroxycorticosterone (1α-OH-B). Despite the rarity of C1 hydroxylation noted in the original identification of 1α-OH-B, literature provides evidence for steroid C1 hydroxylation by micro-organisms. Eight ureolytic bacterial isolates were identified in the renal-inter-renal tissue of L...
June 7, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/28591215/application-of-environmental-dna-to-detect-an-endangered-marine-skate-species-in-the-wild
#12
Kay Weltz, Jeremy M Lyle, Jennifer Ovenden, Jessica A T Morgan, David A Moreno, Jayson M Semmens
Environmental DNA (eDNA) techniques have only recently been applied in the marine environment to detect the presence of marine species. Species-specific primers and probes were designed to detect the eDNA of the endangered Maugean skate (Zearaja maugeana) from as little as 1 L of water collected at depth (10-15 m) in Macquarie Harbour (MH), Tasmania. The identity of the eDNA was confirmed as Z. maugeana by sequencing the qPCR products and aligning these with the target sequence for a 100% match. This result has validated the use of this eDNA technique for detecting a rare species, Z...
2017: PloS One
https://www.readbyqxmd.com/read/28557852/analysis-of-high-intensity-skating-in-top-class-ice-hockey-match-play-in-relation-to-training-status-and-muscle-damage
#13
Erik Lignell, Dan Fransson, Peter Krustrup, Magni Mohr
We examined high-intensity activities in a top-class ice-hockey game and the effect of training status. Male ice-hockey players (n=36) from the NHL participated. Match-analysis was performed during a game and physical capacity was assessed by a submaximal Yo-Yo Intermittent Recovery Ice-hockey test, level 1 (YYIR1-IHSUB). Venous blood samples were collected 24-h post-game to determine markers of muscle damage. Players performed 119±8 and 31±3 m·min of high-intensity and sprint-skating, respectively, during a game...
May 23, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28542231/ten-simple-rules-for-surviving-an-interdisciplinary-phd
#14
EDITORIAL
Samuel Demharter, Nicholas Pearce, Kylie Beattie, Isabel Frost, Jinwoo Leem, Alistair Martin, Robert Oppenheimer, Cristian Regep, Tammo Rukat, Alexander Skates, Nicola Trendel, David J Gavaghan, Charlotte M Deane, Bernhard Knapp
No abstract text is available yet for this article.
May 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28536017/do-chondroitin-sulfates-with-different-structures-have-different-activities-on-chondrocytes-and-macrophages
#15
André L da Cunha, Jair A K Aguiar, Flavio S Correa da Silva, Yara M Michelacci
The aim of the present study was to investigate the activities of natural chondroitin sulfates (CS) with different structures on cultured chondrocytes and macrophages. CS were isolated from cartilages of bovine trachea (BT), porcine trachea (PT), chicken sternum (Ch) and skate (Sk). The preparations were 90-98% pure, with ∼1% proteins, nucleic acids and keratan sulfate contaminants. Structural analysis of these CS and of commercial chondroitin 4- and 6-sulfate (C4S, C6S) have shown that most of their disaccharides are monosulfated, with varying proportions of 4- and 6-sulfation, and 2-7% non-sulfated disaccharides...
May 20, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28534433/skating-start-propulsion-three-dimensional-kinematic-analysis-of-elite-male-and-female-ice-hockey-players
#16
Jaymee R Shell, Shawn M K Robbins, Philippe C Dixon, Philippe J Renaud, René A Turcotte, Tom Wu, David J Pearsall
The forward skating start is a fundamental skill for male and female ice hockey players. However, performance differences by athlete's sex cannot be fully explained by physiological variables; hence, other factors such as skating technique warrant examination. Therefore, the purpose of this study was to evaluate the body movement kinematics of ice hockey skating starts between elite male and female ice hockey participants. Male (n = 9) and female (n = 10) elite ice hockey players performed five forward skating start accelerations...
May 23, 2017: Sports Biomechanics
https://www.readbyqxmd.com/read/28530528/objectifying-tactics-athlete-and-race-variability-in-elite-short-track-speed-skating
#17
Marco J Konings, Florentina J Hettinga
PURPOSE: To objectively capture and understand tactical considerations in a race, we explored whether race-to-race variation of an athlete and the variation of competitors within a race could provide insight into how and when athletes modify their pacing decisions in response to other competitors. METHODS: Lap times of elite 500, 1000 and 1500 m short-track speed skating competitions between 2011-2016 (n=6965 races) were collected. Log-transformed lap and finishing times were analyzed with mixed linear models...
May 22, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28523488/morphological-and-molecular-evidence-for-a-new-species-of-pseudanisakis-layman-borovkova-1926-nematoda-ascaridida-parasitizing-rajiformes-in-southern-southwest-atlantic-waters
#18
Manuel M Irigoitia, Paola E Braicovich, Marisa D Farber, Juan T Timi
Pseudanisakis argentinensis n. sp. is proposed to accommodate parasitic nematodes found in six skate species (Rajidae and Arhynchobatidae) examined from southern Southwest Atlantic waters. The new species differs from its congeners by the following combination of characters: a cupola on each lip, males with 8-12 pairs of precloacal genital papillae, a larger size for both males and females, a greater length-to-breadth ratio of the ventriculus and the presence of a small knob on the tip of the tail. Allometric growth was observed for several morphometric features; however, the slopes of the allometric relationships across host species exhibited non-significant differences and were considered as a strong evidence for conspecificity...
July 2017: Parasitology Research
https://www.readbyqxmd.com/read/28516726/clasper-morphology-of-skates-of-the-tribe-riorajini-chondrichthyes-rajiformes-arhynchobatidae-and-its-systematic-significance
#19
Renan A Moreira, Ulisses L Gomes, Marcelo R de Carvalho
Claspers of adult specimens of the skate tribe Riorajini, family Arhynchobatidae, comprising Atlantoraja and Rioraja, are described, compared, and systematically reinterpreted based on material collected off southeastern and southern Brazil. For the first time the external components and musculature of the clasper of members of this tribe are described and related to internal (skeletal) structures. The component pecten is present in all species of Atlantoraja but absent in Rioraja. The new external component grip, an autapomorphy of A...
May 17, 2017: Journal of Morphology
https://www.readbyqxmd.com/read/28513541/promoting-healthy-lifestyle-and-well-being-in-adolescents-through-outdoor-physical-activity
#20
Karel Fromel, Michal Kudlacek, Dorota Groffik, Zbynek Svozil, Adam Simunek, Wieslaw Garbaciak
Health-enhancing physical activities (PA) performed outdoors could markedly contribute to the adoption of a healthy lifestyle in adolescence. The differences between PA preferences and actual opportunities for these PA are an issue that has received frequent attention. To date, the extent to which these differences are reflected in adolescents meeting PA recommendations and their well-being has not been explored. In total, 10,086 respondents took part in an on-line research project regarding PA preferences...
May 17, 2017: International Journal of Environmental Research and Public Health
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