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Acute decompensated heart failure

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https://www.readbyqxmd.com/read/28225875/decompensated-chagasic-heart-failure-versus-non-chagasic-heart-failure-at-a-tertiary-care-hospital-clinical-characteristics-and-outcomes
#1
Luiza Nauane Borges Azevedo Dos Santos, Mário de Seixas Rocha, Eloina Nunes de Oliveira, Carlos Antônio Gusmão de Moura, Ayslan Jorge Santos de Araujo, Ítalo Magalhães Gusmão, Gilson Soares Feitosa-Filho, Constança Margarida Sampaio Cruz
OBJECTIVE: To evaluate clinical and epidemiological characteristics and clinical outcomes in patients hospitalized with decompensated heart failure (DHF), with a comparison between Chagas and non-Chagas disease. METHOD: This is a retrospective cohort study involving 136 patients consecutively admitted with DHF between January 1 and December 31, 2011, with the following outcomes: acute renal failure, cardiogenic shock, rehospitalization, and hospital death. Individuals aged ≥ 18 years with DHF were included while those with more than 10% of missing data regarding outcomes were excluded...
January 1, 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28221314/which-dosing-of-furosemide-is-better-in-acute-decompensated-heart-failure
#2
Stephanie Jalaba, Jennifer Palermo, Adriane I Budavari
Continuous versus bolus dosing of furosemide has been a longstanding debate for clinicians treating patients with acute decompensated heart failure. This article discusses the efficacy and safety of both options, and reviews several meta-analyses examining this topic.
March 2017: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/28220240/effect-of-carperitide-on-in-hospital-mortality-of-patients-admitted-for-heart-failure-propensity-score-analyses
#3
Masataka Ogiso, Toshiaki Isogai, Yuta Okabe, Kansuke Ito, Masaki Tsuji, Hiroyuki Tanaka
Although a previous randomized study showed that the use of atrial natriuretic peptide (carperitide) improved the long-term prognosis of patients with heart failure, its effect on short-term prognosis remains unclear. We retrospectively identified patients who were admitted to our tertiary-care center with acute decompensated heart failure (ADHF) between April 2009 and December 2013.We divided the eligible patients into two groups: patients who started receiving carperitide on the day of admission (carperitide group) and those who did not receive carperitide during hospitalization (control group)...
February 20, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28215413/ratio-of-systolic-blood-pressure-to-right-atrial-pressure-a-novel-marker-to-predict-morbidity-and-mortality-in-acute-systolic-heart-failure
#4
Hesham R Omar, Richard Charnigo, Maya Guglin
Congestion is the main contributor to heart failure (HF) morbidity and mortality. We assessed the combined role of congestion and decreased forward flow in predicting morbidity and mortality in acute systolic HF. The Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness trial data set was used to determine if the ratio of simultaneously measured systolic blood pressure (SBP)/right atrial pressure (RAP) on admission predicted HF rehospitalization and 6-month mortality...
January 6, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28209176/infective-endocarditis-causing-mitral-valve-stenosis-a-rare-but-deadly-complication-a-case-report
#5
Michael A Hart, Gautam R Shroff
BACKGROUND: Infective endocarditis rarely causes mitral valve stenosis. When present, it has the potential to cause severe hemodynamic decompensation and death. There are only 15 reported cases in the literature of mitral prosthetic valve bacterial endocarditis causing stenosis by obstruction. This case is even more unusual due to the mechanism by which functional mitral stenosis occurred. CASE PRESENTATION: We report a case of a 23-year-old white woman with a history of intravenous drug abuse who presented with acute heart failure...
February 17, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28202885/tolvaptan-reduces-the-risk-of-worsening-renal-function-in-patients-with-acute-decompensated-heart-failure-and-preserved-left-ventricular-ejection-fraction%C3%A3-prospective-randomized-controlled-study
#6
Shunsuke Tamaki, Yoshihiro Sato, Takahisa Yamada, Takashi Morita, Yoshio Furukawa, Yusuke Iwasaki, Masato Kawasaki, Atsushi Kikuchi, Takumi Kondo, Tatsuhisa Ozaki, Masahiro Seo, Iyo Ikeda, Eiji Fukuhara, Makoto Abe, Jun Nakamura, Masatake Fukunami
BACKGROUND: Although the mainstay of treatment for acute decompensated heart failure (ADHF) is decongestion by diuretic therapy, it is often associated with worsening renal function (WRF). The effect of tolvaptan, a selective V2 receptor antagonist, on WRF in ADHF patients with preserved left ventricular ejection fraction (LVEF) is unknown.Methods and Results:We enrolled 50 consecutive ADHF patients whose LVEF on admission was ≥45%. Patients were randomly assigned to either tolvaptan add-on (n=26) or conventional diuretic therapy (n=24)...
February 16, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28192257/anti-thrombotic-and-pro-fibrinolytic-effects-of-levosimendan-in-human-endothelial-cells-in-vitro
#7
Konstantin A Krychtiuk, Christoph Kaun, Philipp J Hohensinner, Stefan Stojkovic, Jacqueline Seigner, Stefan P Kastl, Andreas Zuckermann, Wolfgang Eppel, Sabine Rauscher, Rainer de Martin, Gerald Maurer, Kurt Huber, Johann Wojta, Walter S Speidl
AIMS: Levosimendan is an inodilator for the treatment of acute decompensated heart failure (HF). Data from clinical studies suggest that levosimendan is particularly effective in HF due to myocardial infarction. After acute revascularization, no reflow-phenomenon is a common complication that may lead to pump failure and cardiogenic shock. Our aim was to examine whether levosimendan interferes with the pro-thrombotic phenotype of activated endothelial cells in vitro. METHODS: Human heart microvascular endothelial cells (HHMEC) and human umbilical vein endothelial cells (HUVEC) were treated with interleukin-1β (IL-1β) (200U/mL) or thrombin (5U/mL) and co-treated with or without levosimendan (0...
February 10, 2017: Vascular Pharmacology
https://www.readbyqxmd.com/read/28187908/relationship-among-body-mass-index-nt-probnp-and-mortality-in%C3%A2-decompensated-chronic-heart-failure
#8
Domenico Scrutinio, Andrea Passantino, Pietro Guida, Enrico Ammirati, Fabrizio Oliva, Simona Sarzi Braga, Maria Teresa La Rovere, Rocco Lagioia, Maria Frigerio, Salvatore Di Somma
BACKGROUND: Obesity has been suggested to confer a survival benefit in acute heart failure. The concentrations of NT-proBNP may be reduced in patients with high body mass index (BMI). OBJECTIVES: To investigate the relationship among BMI, NT-proBNP, and mortality risk in decompensated chronic heart failure (DCHF). METHODS: This was a retrospective study. We studied 1001 patients with DCHF. Hazard ratios (HR) were calculated with Cox regression analysis...
February 7, 2017: Heart & Lung: the Journal of Critical Care
https://www.readbyqxmd.com/read/28185703/bnp-and-obesity-in-acute-decompensated-heart-failure-with-preserved-vs-reduced-ejection-fraction-the-atherosclerosis-risk-in-communities-surveillance-study
#9
Umair Khalid, Lisa Miller Wruck, Pedro Miguel Quibrera, Biykem Bozkurt, Vijay Nambi, Salim S Virani, Hani Jneid, Sunil Agarwal, Patricia P Chang, Laura Loehr, Sukhdeep Singh Basra, Wayne Rosamond, Christie M Ballantyne, Anita Deswal
BACKGROUND: Levels of B-type natriuretic peptide (BNP), a prognostic marker in patients with heart failure (HF), are lower among HF patients with obesity or preserved Left Ventricular Ejection Fraction (LVEF). We examined the distribution and prognostic value of BNP across BMI categories in acute decompensated heart failure (ADHF) patients with preserved vs. reduced LVEF. METHODS: We analyzed data from the Atherosclerosis Risk in Communities (ARIC) HF surveillance study which sampled and adjudicated ADHF hospitalizations in patients aged ≥55years from 4 US communities (2005-2009)...
January 31, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28179967/the-change-in-body-weight-during-hospitalization-predicts-mortality-in-patients-with-acute-decompensated-heart-failure
#10
Tomo Komaki, Shin-Ichiro Miura, Tadaaki Arimura, Yuhei Shiga, Joji Morii, Takashi Kuwano, Satoshi Imaizumi, Ken Kitajima, Atsushi Iwata, Natsumi Morito, Eiji Yahiro, Kanta Fujimi, Akira Matsunaga, Keijiro Saku
BACKGROUND: In our experience, the change in body weight (BW) during hospitalization varies greatly in patients with acute decompensated heart failure (HF). Since the clinical significance of a change in BW is not clear, we investigated whether a change in BW could predict mortality. METHODS: We retrospectively enrolled 130 patients (72 males; aged 68 ± 10 years) who were hospitalized due to acute decompensated HF and followed for 2 years after discharge. The change in the BW index during hospitalization (ΔBWI) was calculated as (BW at hospital admission minus BW at hospital discharge)/body surface area at hospital discharge...
March 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28176004/impact-of-decreased-serum-albumin-levels-on-acute-kidney-injury-in-patients-with-acute-decompensated-heart-failure-a-potential-association-of-atrial-natriuretic-peptide
#11
Yoichi Takaya, Fumiki Yoshihara, Hiroyuki Yokoyama, Hideaki Kanzaki, Masafumi Kitakaze, Yoichi Goto, Toshihisa Anzai, Satoshi Yasuda, Hisao Ogawa, Yuhei Kawano, Kenji Kangawa
Although hypoalbuminemia at admission is a risk for acute kidney injury (AKI) and mortality in patients with acute decompensated heart failure (ADHF), the clinical significance of decreased serum albumin levels (DAL) during ADHF therapy has not been elucidated. This study aimed to evaluate whether DAL was associated with AKI, and whether intravenous atrial natriuretic peptide (ANP) administration, which provides an effective treatment for ADHF but promotes albumin extravasation, was associated with DAL and AKI...
February 7, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28164253/heart-failure-in-the-elderly-ten-peculiar-management-considerations
#12
Feras Bader, Bassam Atallah, Lisa F Brennan, Rola H Rimawi, Mohammed E Khalil
Chronic heart failure (HF) is a disease with significantly higher prevalence in the elderly or patients older than 65 years old. Typically, older patients have more risk factors for HF, more comorbidities, and are more likely to have recurrent admissions for acute decompensations. With HF burden on health care systems primarily related to hospital and nursing home costs, it is critical that elderly patients are approached with a clear understanding of certain unique clinical, laboratory, imaging, and pharmacokinetic differences that can alter their management and outcomes...
February 6, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28154601/cardiac-resynchronization-therapy-device-implantation-in-a-patient-with-cardiogenic-shock-under-percutaneous-mechanical-circulatory-support
#13
Kyunghee Lim, Jin-Oh Choi, Jeong Hoon Yang, Seung-Jung Park, Sun Hwa Kim, Jiseok Kang, Hyun Sung Joh, Sun Hye Shin
65-year-old woman was admitted to our hospital with acute decompensated heart failure with reduced left ventricular ejection fraction and severe mitral regurgitation. Electrocardiography revealed a typical left bundle branch block and atrial fibrillation. Her condition deteriorated despite administering high-doses of inotropes and vasopressors. Pending a decision to therapy, venoarterial extracorporeal membrane oxygenation (ECMO) was performed when the patient underwent a cardiogenic shock. Although the hemodynamic status stabilized with ECMO support, weaning the patient from ECMO was not possible...
January 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/28153551/current-and-future-percutaneous-strategies-for-the-treatment-of-acute-and-chronic-heart-failure
#14
Ignacio J Amat-Santos, Luis H Varela-Falcón, William T Abraham
The prevalence of heart failure (HF) has risen in parallel with improved survival in patients after a myocardial infarction and an aging population worldwide. In recent years, new percutaneous therapies have been developed to complement current established treatments for acute/decompensated and chronic HF and minimize risks. In acute presentations, the failure of medical treatment is no longer the end of the road in refractory circulatory shock; the use of mechanical circulatory support devices may be the next milestone in well-resourced health settings...
January 30, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28132779/acute-infusion-of-levosimendan-enhances-atrial-fibrillation-in-an-experimental-whole-heart-model
#15
Gerrit Frommeyer, Anja Kohnke, Christian Ellermann, Dirk G Dechering, Simon Kochhäuser, Florian Reinke, Michael Fehr, Lars Eckardt
BACKGROUND: The calcium sensitizer levosimendan is clinically employed in decompensated heart failure. The aim of the present study was to assess effects of levosimendan on atrial electrophysiology in an experimental whole-heart model. METHODS AND RESULTS: 13 rabbit hearts were isolated and Langendorff-perfused. Thereafter, hearts were paced at cycle lengths of 350ms, 250ms and 200ms in the atrium. A standardized protocol employing atrial burst pacing induced atrial fibrillation (AF) in 4 of 13 hearts under baseline conditions (mean: 3...
January 18, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28130379/impact-of-ultrafiltration-on-serum-sodium-homeostasis-and-its-clinical-implication-in-patients-with-acute-heart-failure-congestion-and-worsening-renal-function
#16
Takeshi Kitai, Justin L Grodin, Yong-Hyun Kim, W H Wilson Tang
BACKGROUND: The relationship between changes in serum sodium with clinical events in acute heart failure patients using different decongestive events has not been investigated. This study aimed to describe changes in serum sodium levels during decongestion therapy in patients receiving stepped pharmacological therapy versus ultrafiltration. METHODS AND RESULTS: We studied 188 patients who were enrolled in the CARRESS-HF trial (Cardiorenal Rescue Study in Acute Decompensated Heart Failure)...
February 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28125958/long-term-mortality-in-older-patients-discharged-after-acute-decompensated-heart-failure-a-prospective-cohort-study
#17
Pierre-André Natella, Philippe Le Corvoisier, Elena Paillaud, Bertrand Renaud, Isabelle Mahé, Jean-François Bergmann, Hervé Perchet, Dominique Mottier, Olivier Montagne, Sylvie Bastuji-Garin
BACKGROUND: Data are available on short- and intermediate-term mortality rates after discharge for acutely decompensated heart failure (ADHF). However, few studies specifically addressed ADHF outcomes in patients aged 75 years or over, who contribute more than half of all ADHF admissions. Our objectives here were to estimate the long-term mortality of patients aged 75 years or over who were discharged after admission for ADHF and to identify factors, especially geriatric findings, independently associated with 2-year mortality...
January 26, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28116486/inferior-vena-cava-diameter-in-acute-decompensated-heart-failure-as-predictor-of-all-cause-mortality
#18
Alexander Jobs, Kerstin Brünjes, Alexander Katalinic, Valentin Babaev, Steffen Desch, Michael Reppel, Holger Thiele
Inferior vena cava (IVC) diameter can be used to approximate right atrial pressure in patients admitted for acute decompensated heart failure (ADHF). Recent studies linked IVC dilation to an increased risk of early re-admission and short-term mortality. Moreover, renal insufficiency (RI) is an established risk factor for mortality in ADHF and is associated with congestion. We hypothesized that the IVC diameter is a marker of all-cause mortality but its prognostic impact may be influenced by kidney function...
January 23, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28115811/deficiency-of-endothelial-progenitor-cells-associates-with-graft-thrombosis-in-patients-undergoing-endovascular-therapy-of-dysfunctional-dialysis-grafts
#19
Tsung-Yan Chen, Lin Lin, Mu-Yang Hsieh, Jui-Cheng Kuo, Chia-Ling Wang, Ren-Huei Wang, Chao-Lun Lai, Po-Hsun Huang, Chih-Cheng Wu
BACKGROUND: The deficiency of endothelial progenitor cells has been demonstrated to be associated with cardiovascular events in patients undergoing dialysis. However, their correlation with dialysis graft outcomes remains unknown. The objective of this study was to investigate the relationship between circulating endothelial progenitor cells and dialysis graft outcomes. METHODS: After excluding 14 patients with acute coronary syndrome, decompensated heart failure or graft thrombosis in the prior three months, a total of 120 patients undergoing dialysis who underwent endovascular therapy of dysfunctional dialysis grafts were prospectively enrolled...
January 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/28109578/liver-fibrogenesis-marker-7s-domain-of-collagen-type-iv-in-patients-with-acutely-decompensated-heart-failure-correlates-prognostic-value-and-time-course
#20
Kazuya Nagao, Akinori Tamura, Takeshi Morimoto, Kiyotaka Shimamura, Hiroshi Yukawa, Haruyasu Ito, Fujio Hayashi, Toshinori Makita, Genzou Takemura, Yukihito Sato, Tsukasa Inada, Takeshi Kimura, Masaru Tanaka
BACKGROUND: Congestion in heart failure (HF) induces multiple organ injury, which may cause remodeling of extracellular matrix. We hypothesized that liver fibrogenesis marker, 7S domain of collagen type IV (P4NP 7S) was correlated with congestion and liver injury in HF. METHODS AND RESULTS: We measured serum P4NP 7S in two cohorts. Cohort 1 included 70 patients undergoing catheterization. P4NP 7S was correlated with pulmonary capillary wedge pressure, right ventricular and atrial pressure (r=0...
January 15, 2017: International Journal of Cardiology
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