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https://www.readbyqxmd.com/read/28351057/genome-wide-identification-and-analysis-of-the-type-b-authentic-response-regulator-gene-family-in-peach-prunus-persica
#1
Jingjue Zeng, Xudong Zhu, Muhammad S Haider, Xicheng Wang, Cheng Zhang, Chen Wang
The type-B authentic response regulator (ARR-B) family members serve as DNA-binding transcriptional regulators, whose activities are probably regulated by phosphorylation/dephosphorylation, resulting in the rapid induction of type-A ARR genes. Type-B ARRs are believed to be involved in many biological processes, including cytokinin signaling, plant growth, and stress responses through a chaperone or by isomerization of proline residues during protein folding. The public availability of complete peach genome sequences allows the identification of 23 ARR-B genes by HMMER and blast analysis...
March 29, 2017: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/28351055/comparison-of-the-induction-to-delivery-interval-in-terminations-of-pregnancy-with-or-without-dilapan-s%C3%A2
#2
Marie Vincienne, Olivia Anselem, Anne Gaelle Cordier, Camille Le Ray, Vassilis Tsatsaris, Alexandra Benachi, François Goffinet
OBJECTIVE: In France, terminations of pregnancy (TOP) for medical reasons beyond the second trimester use mifepristone and misoprostol. We sought to determine the effectiveness of Dilapan-S®, an osmotic cervical dilator, in shortening the induction-to-delivery interval (IDI). MATERIALS AND METHODS: This retrospective study of TOP in 2010-2012 compared the results from 2 hospitals with different TOP protocols starting at 16 weeks' gestation, one (164 women) with and one (106) without Dilapan-S®...
March 29, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28351007/catalytic-role-of-iron-in-the-formation-of-silver-nanoparticles-in-photo-irradiated-ag-dissolved-organic-matter-solution
#3
Yongguang Yin, Dan Han, Chao Tai, Zhiqiang Tan, Xiaoxia Zhou, Sujuan Yu, Jingfu Liu, Guibin Jiang
Photo-reduction of Ag(+) to silver nanoparticle (AgNPs) by dissolved organic matter (DOM) is a possible source of naturally occurring AgNPs. However, how this photo-reduction process is influenced by ubiquitous metal ions is still not well understood. In addition, in previous studies, the formation of AgNPs in DOM solution was usually monitored by UV-Vis spectroscopy, and there is still lack of quantitative analysis for the formed AgNPs. In the present study, the role of Fe(2+)/Fe(3+) at environmental concentration level on this photochemical process was investigated, and the enhanced formation of AgNPs by Fe(2+)/Fe(3+) was probed and quantified by using UV-Vis spectroscopy, transmission electron microscopy, and liquid chromatography-inductively coupled plasma mass spectrometry...
March 25, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28350804/syndecan-1-deficiency-promotes-tumor-growth-in-a-murine-model-of-colitis-induced-colon-carcinoma
#4
Adi Binder Gallimidi, Gabriel Nussbaum, Esther Hermano, Barak Weizman, Amichay Meirovitz, Israel Vlodavsky, Martin Götte, Michael Elkin
Syndecan-1 (Sdc1) is an important member of the cell surface heparan sulfate proteoglycan family, highly expressed by epithelial cells in adult organisms. Sdc1 is involved in the regulation of cell migration, cell-cell and cell-matrix interactions, growth-factor, chemokine and integrin activity, and implicated in inflammatory responses and tumorigenesis. Gastrointestinal tract represents an important anatomic site where loss of Sdc1 expression was reported both in inflammation and malignancy. However, the biological significance of Sdc1 in chronic colitis-associated tumorigenesis has not been elucidated...
2017: PloS One
https://www.readbyqxmd.com/read/28350760/involvement-of-hsp70-and-ho-1-in-the-protective-effects-of-raloxifene-on-multiple-organ-dysfunction-syndrome-by-endotoxemia-in-ovariectomized-rats
#5
Hsin-Hsueh Shen, Shieh-Yang Huang, Pao-Yun Cheng, Yen-Ju Chu, Shu-Ying Chen, Kwok-Keung Lam, Yen-Mei Lee
OBJECTIVE: Accumulating evidence demonstrates that raloxifene, a selective estrogen receptor modulator, possesses anti-inflammatory action. This study evaluates the preventive effects of long-term treatment of raloxifene on acute inflammation and multiple organ dysfunction syndrome (MODS) in ovariectomized (OVX) rats with endotoxemia and its underlying mechanism of action. METHODS: Adult female rats were OVX bilaterally to induce estrogen insufficiency. OVX rats were administered with raloxifene (1 mg/kg, gavage, once daily) for 8 weeks, beginning 1 week after surgery, followed by induction of sepsis via intravenous infusion of lipopolysaccharides (LPS; 30 mg/kg) for 4 hours...
March 27, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28350665/moderate-intensity-intermittent-external-volume-expansion-optimizes-the-soft-tissue-response-in-a-murine-model
#6
Giorgio Giatsidis, Liying Cheng, Federico Facchin, Anthony Haddad, Jorge Lujan-Hernandez, Luca Lancerotto, Christoph Gunther Nabzdyk, Hajime Matsumine, Dennis P Orgill
BACKGROUND: Intermittent external volume expansion using suction enhances the vascular network of soft tissues, possibly increasing fat graft survival. However, the optimal kinetics of application have not been determined. Based on their previous experience, the authors hypothesized that moderate-intensity intermittent external volume expansion application may further enhance both the angiogenic and adipogenic potential. METHODS: Fifty 12-week-old wild-type mice were assigned to five experimental groups (n = 10 per group) and underwent five different intermittent applications of external volume expansion (i...
April 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28350580/alemtuzumab-induction-therapy-in-hiv-positive-renal-transplant-recipients
#7
Florence E Mclean, Esther Gathogo, Dawn Goodall, Rachael Jones, Sabine Kinlcoh, Frank A Post
No abstract text is available yet for this article.
April 24, 2017: AIDS
https://www.readbyqxmd.com/read/28350549/loss-of-e-cadherin-as-part-of-a-migratory-phenotype-in-melanoma-is-associated-with-ulceration
#8
Marie L Bønnelykke-Behrndtz, Torben Steiniche, Peter Nørgaard, Allan V Danielsen, Tine E Damsgaard, Ib J Christensen, Lars Bastholt, Holger J Møller, Henrik Schmidt
It has been suggested that embryogenic properties of migratory cells are reactivated during wound healing and metastasis in adults. This might explain the association between wound-induced inflammation and poor survival in patients with ulcerated melanoma. Linking inflammation with a migratory phenotype, we characterize the infiltration of innate inflammatory cells, loss of cell-to-cell adhesion (E-cadherin), factors associated with extracellular matrix degradation [matrix metalloproteinase-9 (MMP-9), and neutrophil elastase (NE)], and spindle-shaped cell morphology, between ulcerated (n = 179) and nonulcerated (n = 206) melanoma...
March 18, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28350529/risk-of-caesarean-delivery-after-induction-of-labour-stratified-by-foetal-sex
#9
Eran Hadar, Liran Hiersch, Eran Ashwal, Amir Aviram, Arnon Wiznitzer, Rinat Gabbay-Benziv
This study describes a retrospective analysis of all women admitted for induction of labour (IoL), carrying a viable singleton foetus, after 34 + 0 weeks of gestation. We aimed to evaluate if foetal sex has an impact on the rate of caesarean delivery following labour induction. Our results demonstrate that among the 1062 women who met the inclusion criteria, 49% (521/1062) were carrying a male foetus. Other than a lower rate of Oxytocin use for the female sex pregnancies, there were no significant differences in pre-labour and labour characteristics between male or female sex pregnancies...
March 28, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28350465/3-5-diarylimidazo-1-2-a-pyridines-as-highly-color-tunable-fluorophores
#10
Ju Young Lee, Jae Yul Shim, Hong Ki Kim, Donguk Ko, Mu-Hyun Baik, Eun Jeong Yoo
A new protocol for the synthesis of color-tunable fluorescent 3,5-diarylimidazo[1,2-a]pyridines has been achieved via palladium-catalyzed C-H amination of pyridinium zwitterions. Based on experimental results and computational analysis, we extracted a high correlation of photophysical properties with the theoretical concept and predicted emission wavelengths of 3,5-diarylimidazo[1,2-a]pyridines. The emission wavelengths of imidazo[1,2-a]pyridines increases as a function of the electron-withdrawing nature of the substituent on the C5-aryl group of imidazo[1,2-a]pyridine, as a result of inductive effects on the LUMO levels...
March 28, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28350441/chemical-probes-unravel-an-antimicrobial-defense-response-triggered-by-binding-of-the-human-opioid-dynorphin-to-a-bacterial-sensor-kinase
#11
Megan Holly Wright, Christian Fetzer, Stephan A Sieber
Host-microbe communication via small molecule signals is important for both symbiotic and pathogenic relationships, but is often poorly understood at the molecular level. Under conditions of host stress, levels of the human opioid peptide dynorphin are elevated, triggering virulence in the opportunistic pathogenic bacterium Pseudomonas aeruginosa via an unknown pathway. Here we apply a multilayered chemical biology strategy to unravel the mode of action of this putative interkingdom signal. We designed and applied dynorphin-inspired photoaffinity probes to reveal the protein targets of the peptide in live bacteria via chemical proteomics...
March 28, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28346903/the-oceanus-statue-of-the-fontana-di-trevi-rome-the-analysis-of-black-crust-as-a-tool-to-investigate-the-urban-air-pollution-and-its-impact-on-the-stone-degradation
#12
Mauro F La Russa, Paola Fermo, Valeria Comite, Cristina M Belfiore, Donatella Barca, Annamaria Cerioni, Marina De Santis, Lorena Francesca Barbagallo, Michela Ricca, Silvestro A Ruffolo
This paper deals with the analysis of black crust coming from the statue of Oceanus belonging to the Fontana di Trevi (Rome). This monument is undoubtedly one of the main touristic attractions of Rome. During the restoration held between 2014 and 2015, some diagnostic analyses had been carried out. It has been highlighted that the sheltered surfaces suffer the formation of black crust, especially on the marble statues. The possibility to sample those degradation products, together with the unaltered substrate, represented an excellent opportunity to characterize the marble itself, to assess the impact of the urban air pollution on the stone material, and to detect the pollutant on a precise timescale...
March 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28346860/comparison-of-short-term-effects-of-diquafosol-and-rebamipide-on-mucin-5ac-level-on-the-rabbit-ocular-surface
#13
Yuichi Hori, Tomofumi Kageyama, Asuka Sakamoto, Tomoaki Shiba, Masatsugu Nakamura, Takatoshi Maeno
PURPOSE: To investigate the short-term effects of 2 new secretagogue eye drops for dry eye, 3% diquafosol tetrasodium ophthalmic solution (diquafosol) and 2% rebamipide ophthalmic suspension (rebamipide), on the concentration of mucin 5AC (MUC5AC) in rabbit tear fluid and conjunctival goblet cells. METHODS: One dose of artificial tears, diquafosol or rebamipide, was instilled into 8 eyes of Japanese white rabbits. MUC5AC concentration in the tear fluid was examined using the enzyme-linked immunosorbent assay 15 min after instillation and compared with 8 untreated controls...
March 27, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28346810/an-automated-multiplexed-hepatotoxicity-and-cyp-induction-assay-using-heparg-cells-in-2d-and-3d
#14
Lindsey M Ott, Karthik Ramachandran, Lisa Stehno-Bittel
Drug-induced liver injury (DILI) and drug-drug interactions (DDIs) are concerns when developing safe and efficacious compounds. We have developed an automated multiplex assay to detect hepatotoxicity (i.e., ATP depletion) and metabolism (i.e., cytochrome P450 1A [CYP1A] and cytochrome P450 3A4 [CYP3A4] enzyme activity) in two-dimensional (2D) and three-dimensional (3D) cell cultures. HepaRG cells were cultured in our proprietary micromold plates and produced spheroids. HepaRG cells, in 2D or 3D, expressed liver-specific proteins throughout the culture period, although 3D cultures consistently exhibited higher albumin secretion and CYP1A/CYP3A4 enzyme activity than 2D cultures...
March 1, 2017: SLAS Discov
https://www.readbyqxmd.com/read/28346709/synthetic-%C3%AE-nitrostyrene-derivative-cyt-rx20-as-inhibitor-of-oral-cancer-cell-proliferation-and-tumor-growth-through-glutathione-suppression-and-reactive-oxygen-species-induction
#15
Yen-Yun Wang, Yuk-Kwan Chen, Ya-Ling Hsu, Wen-Chin Chiu, Chun-Hao Tsai, Stephen Chu-Sung Hu, Pei-Wen Hsieh, Shyng-Shiou F Yuan
BACKGROUND: The β-nitrostyrene family possesses anticancer properties. In this study, β-nitrostyrene derivative CYT-Rx20 (3'-hydroxy-4'-methoxy-β-methyl-β-nitrostyrene) was synthesized and investigated its anticancer activity in oral cancer. METHODS: Anticancer activity of CYT-Rx20 and the underlying mechanisms were analyzed using cell viability assay, reactive oxygen species (ROS) generation assay, fluorescence-activated cell sorter analysis, annexin V staining, comet assay, glutathione (GSH)/glutathione disulfide (GSSG) ratio, immunoblotting, soft agar assay, nude mice xenograft study, and immunohistochemistry...
March 27, 2017: Head & Neck
https://www.readbyqxmd.com/read/28346448/a-footprint-of-desiccation-tolerance-in-the-genome-of-xerophyta-viscosa
#16
Maria-Cecília D Costa, Mariana A S Artur, Julio Maia, Eef Jonkheer, Martijn F L Derks, Harm Nijveen, Brett Williams, Sagadevan G Mundree, José M Jiménez-Gómez, Thamara Hesselink, Elio G W M Schijlen, Wilco Ligterink, Melvin J Oliver, Jill M Farrant, Henk W M Hilhorst
Desiccation tolerance is common in seeds and various other organisms, but only a few angiosperm species possess vegetative desiccation tolerance. These 'resurrection species' may serve as ideal models for the ultimate design of crops with enhanced drought tolerance. To understand the molecular and genetic mechanisms enabling vegetative desiccation tolerance, we produced a high-quality whole-genome sequence for the resurrection plant Xerophyta viscosa and assessed transcriptome changes during its dehydration...
March 27, 2017: Nature Plants
https://www.readbyqxmd.com/read/28346420/hepatic-cyclooxygenase-2-overexpression-induced-spontaneous-hepatocellular-carcinoma-formation-in-mice
#17
H Chen, W Cai, E S H Chu, J Tang, C-C Wong, S H Wong, W Sun, Q Liang, J Fang, Z Sun, J Yu
Cyclooxygenase (COX)-2 is upregulated in hepatocellular carcinoma (HCC). However, the direct causative effect of COX-2 in spontaneous HCC formation remains unknown. We thus investigate the role and molecular pathogenesis of COX-2 in HCC by using liver-specific COX-2 transgenic (TG) mice. We found spontaneous HCC formation with elevated inflammatory infiltrates and neovessels in male TG mice (3/21, 14.3%), but not in any of male WT mice (0/19). Reduced representation bisulfite sequencing (RRBS) and gene expression microarrays were performed in the HCC tumor and non-HCC liver tissues to investigate the molecular mechanisms of COX-2-driven HCC...
March 27, 2017: Oncogene
https://www.readbyqxmd.com/read/28346399/endothelial-cell-specific-activation-of-transforming-growth-factor-%C3%AE-signaling-in-mice-induces-cutaneous-visceral-and-microvascular-fibrosis
#18
Peter J Wermuth, Kellan R Carney, Fabian A Mendoza, Sonsoles Piera-Velazquez, Sergio A Jimenez
In this study, we tested the hypothesis that constitutive endothelial cell-specific activation of TGF-β signaling induces tissue fibrosis and vasculopathy resembling the characteristic fibrotic and vascular alterations of systemic sclerosis. Transgenic mice with inducible expression of a constitutively active TGF-β receptor I specifically in endothelial cells were generated by intercrossing mice harboring a constitutively active TGF-β receptor I with a mouse strain containing the endothelial cell-specific Cdh5 gene promoter directing the tamoxifen-inducible expression of the Cre-ER(T2) cassette...
March 27, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28346212/stability-of-extemporaneously-prepared-hydroxycarbamide-oral-suspensions
#19
Djamila Kabiche, Issa-Bella Balde, Elyes Majoul, Sofiane Kabiche, Elodie Bourguignon, Jean-Eudes Fontan, Salvatore Cisternino, Jöel Schlatter
Hydroxycarbamide, available as tablets, is a pharmacological agent for fetal hemoglobin induction such as sickle cell anemia. The need for alternative dosage form options for patients unable to take tablets led hospital pharmacies to prepare solutions and suspensions. The objective of this study was to determine the stability of hydroxycarbamide in Ora-Plus in combination with either Ora-Sweet or Ora-Sweet SF, Ora-Blend, or Ora-Blend SF suspending agents. The studied samples were compounded into 100-mg/mL suspensions and stored in 60-mL amber glass bottles at room (22°C to 25°C) or refrigerated (4°C to 8°C) temperature...
March 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28346102/phage-display-derived-ligand-for-mucosal-transcytotic-receptor-gp-2-promotes-antigen-delivery-to-m-cells-and-induces-antigen-specific-immune-response
#20
Inam Ullah Khan, Jiansheng Huang, Rui Liu, Jingbo Wang, Jun Xie, Naishuo Zhu
Successful oral immunization depends on efficient delivery of antigens (Ags) to the mucosal immune induction site. Glycoprotein-2 (GP-2) is an integral membrane protein that is expressed specifically on M cells within follicle-associated epithelium (FAE) and serves as transcytotic receptor for luminal Ags. In this study, we selected peptide ligands against recombinant human GP-2 by screening a phage display library and evaluated their interaction with GP-2 in vitro and ex vivo. Selected peptides were conjugated to the C-terminal of enhanced green fluorescence protein (EGFP) and evaluated for their ability to induce an immune response in mice...
February 1, 2017: SLAS Discov
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