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https://www.readbyqxmd.com/read/28212557/using-high-sensitivity-sequencing-for-the-detection-of-mutations-in-btk-and-plc%C3%AE-2-genes-in-cellular-and-cell-free-dna-and-correlation-with-progression-in-patients-treated-with-btk-inhibitors
#1
Adam Albitar, Wanlong Ma, Ivan DeDios, Jeffrey Estella, Inhye Ahn, Mohammed Farooqui, Adrian Wiestner, Maher Albitar
Patients with chronic lymphocytic leukemia (CLL) that develop resistance to Bruton tyrosine kinase (BTK) inhibitors are typically positive for mutations in BTK or phospholipase c gamma 2 (PLCγ2). We developed a high sensitivity (HS) assay utilizing wild-type blocking polymerase chain reaction achieved via bridged and locked nucleic acids. We used this high sensitivity assay in combination with Sanger sequencing and next generation sequencing (NGS) and tested cellular DNA and cell-free DNA (cfDNA) from patients with CLL treated with the BTK inhibitor, ibrutinib...
February 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28212205/spontaneous-breathing-during-extracorporeal-membrane-oxygenation-in-acute-respiratory-failure
#2
Stefania Crotti, Nicola Bottino, Giulia Maria Ruggeri, Elena Spinelli, Daniela Tubiolo, Alfredo Lissoni, Alessandro Protti, Luciano Gattinoni
BACKGROUND: We evaluate the clinical feasibility of spontaneous breathing on extracorporeal membrane oxygenation and the interactions between artificial and native lungs in patients bridged to lung transplant or with acute exacerbation of chronic obstructive pulmonary disease (COPD) or acute respiratory distress syndrome. METHODS: The clinical course of a total of 48 patients was analyzed. Twenty-three of 48 patients were enrolled in the prospective study (nine bridged to lung transplant, six COPD, and eight acute respiratory distress syndrome)...
February 17, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28212082/semantic-highlight-retrieval-and-term-prediction
#3
Min Sun, Kuo-Hao Zeng, Yenchen Lin, Farhadi Ali
Due to the unprecedented growth of unedited videos, finding highlights relevant to a text query in a set of unedited videos has become increasingly important. We refer this task as semantic highlight retrieval and propose a query-dependent video representation for retrieving a variety of highlights. Our method consists of two parts: (1) "viralets", a mid-level representation bridging between semantic (Fig. 1(a)) and visual (Fig. 1(c)) spaces; (2) a novel Semantic-MODulation (SMOD) procedure to make viralets query-dependent (referred to as SMOD viralets)...
February 13, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28212036/development-of-ion-conductive-and-vapoluminescent-porous-coordination-polymers-composed-of-ruthenium-ii-metalloligand
#4
Ayako Watanabe, Atsushi Kobayashi, Erika Saitoh, Yuki Nagao, Shun Omagari, Takayuki Nakanishi, Yasuchika Hasegawa, W M C Sameera, Masaki Yoshida, Masako Kato
We synthesized two new porous coordination polymers (PCPs) {Ln7(OH)5[Ru(dcbpy)3]4·4nH2O} (Ln7-Ru4; Ln = Ce, Nd) composed of the luminescent ruthenium(II) metalloligand [Ru(4,4'-dcbpy)3](4-) ([4Ru]; 4,4'-dcbpy = 4,4'-dicarboxy-2,2'-bipyridine) and lanthanide ions Ln(3+) (Ln = Ce, Nd). These two PCPs Ln7-Ru4 are isomorphous with the previously reported PCP La7-Ru4, and the lattice constants (a, c, and unit cell volume V) changed systematically according to the lanthanide contraction. All three Ln7-Ru4 compounds have OH(-) anion containing porous structures and a large number of hydrate water molecules within the pores, resulting in moderate ion conductivities (10(-6)-10(-7) S cm(-1)) at 90% relative humidity (RH) and 298 K...
February 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28211682/exploring-the-influence-of-diamagnetic-ions-on-the-mechanism-of-magnetization-relaxation-in-co-iii-2ln-iii-2-ln-dy-tb-ho-butterfly-complexes
#5
Kuduva R Vignesh, Stuart K Langley, Keith S Murray, Gopalan Rajaraman
The synthesis and magnetic and theoretical studies of three isostructural heterometallic [Co(III)2Ln(III)2(μ3-OH)2(o-tol)4(mdea)2(NO3)2] (Ln = Dy (1), Tb (2), Ho (3)) "butterfly" complexes are reported (o-tol = o-toluate, (mdea)(2-) = doubly deprotonated N-methyldiethanolamine). The Co(III) ions are diamagnetic in these complexes. Analysis of the dc magnetic susceptibility measurements reveal antiferromagnetic exchange coupling between the two Ln(III) ions for all three complexes. ac magnetic susceptibility measurements reveal single-molecule magnet (SMM) behavior for complex 1, in the absence of an external magnetic field, with an anisotropy barrier Ueff of 81...
February 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28211519/palindromic-amplification-of-the-erbb2-oncogene-in-primary-her2-positive-breast-tumors
#6
Michael Marotta, Taku Onodera, Jeffrey Johnson, G Thomas Budd, Takaaki Watanabe, Xiaojiang Cui, Armando E Giuliano, Atsushi Niida, Hisashi Tanaka
Oncogene amplification confers a growth advantage to tumor cells for clonal expansion. There are several, recurrently amplified oncogenes throughout the human genome. However, it remains unclear whether this recurrent amplification is solely a manifestation of increased fitness resulting from random amplification mechanisms, or if a genomic locus-specific amplification mechanism plays a role. Here we show that the ERBB2 oncogene at 17q12 is susceptible to palindromic gene amplification, a mechanism characterized by the inverted (palindromic) duplication of genomic segments, in HER2-positive breast tumors...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28211516/high-efficient-oled-displays-prepared-with-the-air-gapped-bridges-on-quantum-dot-patterns-for-optical-recycling
#7
Hyo-Jun Kim, Min-Ho Shin, Joo-Suc Kim, Se-Eun Kim, Young-Joo Kim
An optically efficient structure was proposed and fabricated to realize high brightness organic light emitting diode (OLED) displays based on a white OLED prepared with the air-gapped bridges on the quantum dot (QD) patterns. Compared with a conventional white OLED display, in our experiments, the optical intensity of the proposed OLED display shows the enhancement of 58.2% in the red color and 16.8% in the green color after applying the air-gapped bridge structure on QD patterns of 20 wt% concentration. This enhancement comes from the two facts that the QD patterns downconvert unnecessary blue or blue/green light to the required green or red light and the air-gapped bridges increase the color conversion efficiency of QDs by optical recycling using total internal reflection (TIR) at the interface...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28211510/broadband-gradient-impedance-matching-using-an-acoustic-metamaterial-for-ultrasonic-transducers
#8
Zheng Li, Dan-Qing Yang, Shi-Lei Liu, Si-Yuan Yu, Ming-Hui Lu, Jie Zhu, Shan-Tao Zhang, Ming-Wei Zhu, Xia-Sheng Guo, Hao-Dong Wu, Xin-Long Wang, Yan-Feng Chen
High-quality broadband ultrasound transducers yield superior imaging performance in biomedical ultrasonography. However, proper design to perfectly bridge the energy between the active piezoelectric material and the target medium over the operating spectrum is still lacking. Here, we demonstrate a new anisotropic cone-structured acoustic metamaterial matching layer that acts as an inhomogeneous material with gradient acoustic impedance along the ultrasound propagation direction. When sandwiched between the piezoelectric material unit and the target medium, the acoustic metamaterial matching layer provides a broadband window to support extraordinary transmission of ultrasound over a wide frequency range...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28211453/mechanism-of-partial-agonism-in-ampa-type-glutamate-receptors
#9
Hector Salazar, Clarissa Eibl, Miriam Chebli, Andrew Plested
Neurotransmitters trigger synaptic currents by activating ligand-gated ion channel receptors. Whereas most neurotransmitters are efficacious agonists, molecules that activate receptors more weakly-partial agonists-also exist. Whether these partial agonists have weak activity because they stabilize less active forms, sustain active states for a lesser fraction of the time or both, remains an open question. Here we describe the crystal structure of an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor (AMPAR) ligand binding domain (LBD) tetramer in complex with the partial agonist 5-fluorowillardiine (FW)...
February 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/28211257/renal-replacement-therapy-in-critically-ill-liver-cirrhotic-patients-outcome-and-clinical-implications
#10
Katharina Staufer, Kevin Roedl, Danijel Kivaranovic, Andreas Drolz, Thomas Horvatits, Susanne Rasoul-Rockenschaub, Christian Zauner, Michael Trauner, Valentin Fuhrmann
BACKGROUND & AIMS: Current guidelines discourage renal replacement therapy (RRT) in critically ill cirrhotics in the lack of liver transplant (LT) options. This study aimed to identify patients who benefit from RRT in the short and long-term. METHODS: Critically ill cirrhotics were included over a time period of 6 years (y) and followed for at least 1y. CLIF-C ACLF, CLIF-SOFA, SOFA and MELD scores on admission, 24h prior to RRT, 24h and 48h after start of RRT were analyzed for their predictive value of ICU-mortality...
February 16, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28211208/one-pot-assembly-of-amino-acid-bridged-hybrid-macromulticyclic-cages-through-multiple-multicomponent-macrocyclizations
#11
Ludger A Wessjohann, Oliver Kreye, Daniel G Rivera
An important development in the field of macrocyclization strategies towards molecular cages is described. The approach comprises the utilization of a double Ugi four-component macrocyclization for the assembly of macromulticycles with up to four different tethers, that is, hybrid cages. The innovation of this method rests on setting up the macromulticycle connectivities not through the tethers but through the bridgeheads, which in this case involve N-substituted amino acids. Both dilution and metal-template-driven macrocyclization conditions were implemented with success, enabling the one-pot formation of cryptands and cages including steroidal, polyether, heterocyclic, peptidic, and aryl tethers...
February 17, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28210880/can-fe-3-and-al-3-ions-serve-as-cationic-bridges-to-facilitate-the-adsorption-of-anionic-as-v-species-on-humic-acids-a-density-functional-theory-study
#12
Leonid Gorb, Manoj K Shukla
A computational chemistry investigation was undertaken to shed light on the facilitatory role played by Fe(3+) and Al(3+) cations in the adsorption of anionic As(V) species by humic acids through the formation of so-called cationic bridges. Geometric and energetic parameters were obtained using density functional theory at the B3LYP/6-31G(d,p) level in conjunction with the polarizable continuum model (to account for the influence of bulk water). We found that, despite their similar molecular geometries, the adsorption energies of the As(V) species AsO4(3-) and H2AsO(4-) differ when Fe(3+), FeOH(2+), Al(3+), and AlOH(2+) participate in the bridge...
March 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28210872/responsiveness-and-minimum-important-change-of-the-oswestry-disability-index-in-italian-subjects-with-symptomatic-lumbar-spondylolisthesis
#13
Carla Vanti, Silvano Ferrari, Jorge Hugo Villafañe, Pedro Berjano, Marco Monticone
BACKGROUND: This study aims to investigate the responsiveness and the minimum important change of the Italian version of the Oswestry Disability Index (ODI-I) in subjects with symptomatic specific low back pain associated with lumbar spondylolisthesis (SPL). MATERIALS AND METHODS: One hundred and fifty-one patients with symptomatic SPL completed the ODI-I, a 0-100 numerical rating scale (NRS), and performed the prone and supine bridge tests. The global perception of effectiveness was measured with a 7-point Likert scale...
February 16, 2017: Journal of Orthopaedics and Traumatology: Official Journal of the Italian Society of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/28210739/retinal-oxidative-stress-at-the-onset-of-diabetes-determined-by-synchrotron-ftir-widefield-imaging-towards-diabetes-pathogenesis
#14
Ebrahim Aboualizadeh, Mahsa Ranji, Christine M Sorenson, Reyhaneh Sepehr, Nader Sheibani, Carol J Hirschmugl
Diabetic retinopathy is a microvascular complication of diabetes that can lead to blindness. In the present study, we aimed to determine the nature of diabetes-induced, highly localized biochemical changes in the neuroretina at the onset of diabetes. High-resolution synchrotron Fourier transform infrared (s-FTIR) wide field microscopy coupled with multivariate analysis (PCA-LDA) was employed to identify biomarkers of diabetic retinopathy with spatial resolution at the cellular level. We compared the retinal tissue prepared from 6-week-old Ins2(Akita/+) heterozygous (Akita/+, N = 6; a model of diabetes) male mice with the wild-type (control, N = 6) mice...
February 17, 2017: Analyst
https://www.readbyqxmd.com/read/28209802/doublet-stimulation-increases-ca-2-binding-to-troponin-c-to-ensure-rapid-force-development-in-skeletal-muscle
#15
Anthony J Bakker, Tanya R Cully, Catherine D Wingate, Christopher J Barclay, Bradley S Launikonis
Fast-twitch skeletal muscle fibers are often exposed to motor neuron double discharges (≥200 Hz), which markedly increase both the rate of contraction and the magnitude of the resulting force responses. However, the mechanism responsible for these effects is poorly understood, likely because of technical limitations in previous studies. In this study, we measured cytosolic Ca(2+) during doublet activation using the low-affinity indicator Mag-Fluo-4 at high temporal resolution and modeled the effects of doublet stimulation on sarcoplasmic reticulum (SR) Ca(2+) release, binding of Ca(2+) to cytosolic buffers, and force enhancement in fast-twitch fibers...
February 16, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28209410/bridge-over-troubled-water
#16
EDITORIAL
Ingmar Skoog
No abstract text is available yet for this article.
January 19, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28209199/making-life-difficult-for-clostridium-difficile-augmenting-the-pathogen-s-metabolic-model-with-transcriptomic-and-codon-usage-data-for-better-therapeutic-target-characterization
#17
Sara Saheb Kashaf, Claudio Angione, Pietro Lió
BACKGROUND: Clostridium difficile is a bacterium which can infect various animal species, including humans. Infection with this bacterium is a leading healthcare-associated illness. A better understanding of this organism and the relationship between its genotype and phenotype is essential to the search for an effective treatment. Genome-scale metabolic models contain all known biochemical reactions of a microorganism and can be used to investigate this relationship. RESULTS: We present icdf834, an updated metabolic network of C...
February 16, 2017: BMC Systems Biology
https://www.readbyqxmd.com/read/28209185/health-literacy-in-a-community-with-low-levels-of-education-findings-from-chakaria-a-rural-area-of-bangladesh
#18
Susmita Das, Mohammad Nahid Mia, Syed Manzoor Ahmed Hanifi, Shahidul Hoque, Abbas Bhuiya
BACKGROUND: Health literacy (HL) helps individuals to make effective use of available health services. In low-income countries such as Bangladesh, the less than optimum use of services could be due to low levels of HL. Bangladesh's health service delivery is pluralistic with a mix of public, private and informally trained healthcare providers. Emphasis on HL has been inadequate. Thus, it is important to assess the levels of HL and service utilization patterns. The findings from this study aim to bridge the knowledge gap...
February 16, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28209134/first-clinical-experience-in-14-patients-treated-with-advos-a-study-on-feasibility-safety-and-efficacy-of-a-new-type-of-albumin-dialysis
#19
Wolfgang Huber, Benedikt Henschel, Roland Schmid, Ahmed Al-Chalabi
BACKGROUND: Liver failure (LF) is associated with prolonged hospital stay, increased cost and substantial mortality. Due to the limited number of donor organs, extracorporeal liver support is suggested as an appealing concept to "bridge to transplant" or to avoid transplant in case of recovery. ADVanced Organ Support (ADVOS) is a new type of albumin dialysis, that provides rapid regeneration of toxin-binding albumin by two purification circuits altering the binding capacities of albumin by biochemical (changing of pH) and physical (changing of temperature) modulation of the dialysate...
February 16, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28208956/a-comprehensive-study-of-internal-distraction-plating-an-alternative-method-for-distal-radius-fractures
#20
Mohit J Jain, Kinjal J Mavani
INTRODUCTION: The management of highly comminuted distal radius fractures still remains a major treatment challenge. Articular comminution and compromised bone quality are the culprits. One novel approach is the technique of Internal Distraction Plating which involves "bridging" the fracture with the use of a standard 3.5mm plate applied dorsally in distraction from the radius, proximal to the fracture, to the long finger metacarpal distally, bypassing the comminuted segment. The plate is removed once fracture union has been achieved...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
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