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https://www.readbyqxmd.com/read/28944744/progress-in-the-formulation-and-delivery-of-somatostatin-analogs-for-acromegaly
#1
Sarinj Fattah, David J Brayden
A 14 amino acid cystin bridge containing neuropeptide was discovered in 1973 and designated as growth hormone-inhibiting hormone, in other words, somatostatin. Its discovery led to the synthesis of three analogs which were licensed for the treatment of acromegaly: octreotide, lanreotide and pasireotide. Somatostatin analogs are currently approved only as either subcutaneous or intramuscular long-acting injections. We examine the challenges that must be overcome to create oral formulations of somatostatin analogs and examine selected clinical trial data...
October 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28944668/a-ladder-type-heteroheptacene-12h-dithieno-2-3-4-5-thieno-3-2-b-2-3-h-fluorene-based-d-a-copolymer-with-strong-intermolecular-interactions-towards-efficient-polymer-solar-cells
#2
Mingyan Yang, Tsz-Ki Lau, Shengqiang Xiao, Jianhong Gao, Wei Wang, Xinhui Lu, Shoujie Zhang, Jiansheng Wu, Chun Zhan, Wei You
Ladder-type electron-donating units for D-A copolymers applied in polymer solar cells usually comprise multiple tetrahedral carbon bridges bonded with out-of-plane alkyl chains for desirable solubility for device processing. However, molecular packing of resultant copolymers in the solid state and charge transport within devices are also impeded in spite of with multiple fused aromatic backbones. To mitigate this issue, a structurally well-defined ladder-type electron donating heteroheptacene, 12H-dithieno[2',3':4,5]thieno[3,2-b:2',3'-h]fluorene (DTTF) with extended conjugated backbone and a single tetrahedral carbon bridge attached with two bulky alkyl chains, was designed and synthesized...
September 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28944667/self-supporting-hydrophobic-ionic-liquid-based-reference-electrodes-prepared-by-polymerization-induced-microphase-separation
#3
Sujay A Chopade, Evan L Anderson, Peter W Schmidt, Timothy P Lodge, Marc A Hillmyer, Philippe Bühlmann
Interfaces of ionic liquids and aqueous solutions exhibit stable electrical potentials over a wide range of aqueous electrolyte concentrations. This makes ionic liquids suitable as bridge materials that separate in electroanalytical measurements the reference electrode from samples with low and/or unknown ionic strengths. However, methods for the preparation of ionic liquid-based reference electrodes have not been explored widely. We have designed a convenient and reliable synthesis of ionic liquid-based reference electrodes by polymerization-induced microphase separation...
September 25, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28944560/a-zwitterionic-10-pi-aromatic-hemisphere
#4
Nema Hafezi, Wondimagegn T Shewa, James C Fettinger, Mark Mascal
A new concept in anionic 10 pi aromaticity is described by the embedding of a compensating charge within an aromatic cyclononatetraenide ring by the symmetric interposition of a methylammonium bridge. This is accomplished by the alkylation of azatriquinacene to give a quaternary ammonium salt, followed by oxidation to the tetraene and final deprotonation. The resulting zwitterion is a stable [9]annulene with strong aromaticity as shown by its degree of C-C bond equalization and a nucleus independent chemical shift value lower than that of benzene...
September 24, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28944511/cost-utility-analysis-of-direct-vad-versus-double-bridges-to-heart-transplantation-in-patients-with-refractory-heart-failure
#5
Hsiao-Huang Chang, Po-Lin Chen, I-Ming Chen, Tzu-Ting Kuo, Zen-Chung Weng, Pei-Jung Huang, Nai-Yuan Wu, Ching-Li Cheng
OBJECT: This study compared the cost-utility of direct ventricular assist device (VAD) versus double bridges, extracorporeal membrane oxygenation (ECMO) before VAD, to heart transplantation in patients with refractory heart failure. MATERIALS AND METHODS: From a health payer perspective, a Markov model was developed. The cycle length was one month and the time horizon was a lifetime. Probabilities and direct cost data were calculated from a nationwide claim database...
September 25, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28944252/anconeus-muscle-pedicle-bone-graft-with-periosteal-coverage-for-osteochondritis-dissecans-of-the-humeral-capitellum
#6
Kozo Shimada, Ko Temporin, Keiichiro Oura, Hiroyuki Tanaka, Ryosuke Noguchi
BACKGROUND: Treatment of advanced osteochondritis dissecans (OCD) of the capitellum is controversial, especially in moderate-sized lesions. PURPOSE: To establish a treatment algorithm for capitellum OCD, we tried to determine the utility of and problems associated with anconeus muscle-pedicle bone graft with periosteal coverage (ABGP) for the treatment of moderate-sized articular OCD defects of the capitellum. STUDY DESIGN: Case series; Level of evidence, 4...
September 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28944035/polyandry-enhances-offspring-viability-with-survival-costs-to-mothers-only-when-mating-exclusively-with-virgin-males-in-drosophila-melanogaster
#7
Sergio Castrezana, Brant C Faircloth, William C Bridges, Patricia Adair Gowaty
A prominent hypothesis for polyandry says that male-male competitive drivers induce males to coerce already-mated females to copulate, suggesting that females are more likely to be harassed in the presence of multiple males. This early sociobiological idea of male competitive drive seemed to explain why sperm-storing females mate multiply. Here, we describe an experiment eliminating all opportunities for male-male behavioral competition, while varying females' opportunities to mate or not with the same male many times, or with many other males only one time each...
September 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28943722/from-faces-to-prosocial-behavior-cues-tools-and-mechanisms
#8
Ralph Adolphs, Anita Tusche
In this review we ask how looking at people's faces can influence prosocial behaviors towards them. Components of this process have often been studied by disparate literatures: one focused on perception and judgment of faces, using both psychological and neuroscience approaches; and a second focused on actual social behaviors, as studied in behavioral economics and decision science. Bridging these disciplines requires a more mechanistic account of how processing of particular face attributes or features influences social judgments and behaviors...
June 1, 2017: Current Directions in Psychological Science
https://www.readbyqxmd.com/read/28943688/bayesian-group-bridge-for-bi-level-variable-selection
#9
Himel Mallick, Nengjun Yi
A Bayesian bi-level variable selection method (BAGB: Bayesian Analysis of Group Bridge) is developed for regularized regression and classification. This new development is motivated by grouped data, where generic variables can be divided into multiple groups, with variables in the same group being mechanistically related or statistically correlated. As an alternative to frequentist group variable selection methods, BAGB incorporates structural information among predictors through a group-wise shrinkage prior...
June 2017: Computational Statistics & Data Analysis
https://www.readbyqxmd.com/read/28943527/crossing-bridges-between-extra-and-intra-cellular-events-in-thoracic-aortic-aneurysms
#10
Yoshito Yamashiro, Hiromi Yanagisawa
Thoracic aortic aneurysms (TAAs) are common, life-threatening diseases and are a major cause of mortality and morbidity. Over the past decade, genetic approaches have revealed that 1) activation of the transforming growth factor beta (TGF-β) signaling, 2) alterations in the contractile apparatus of vascular smooth muscle cells (SMCs), and 3) defects in the extracellular matrix (ECM) were responsible for development of TAAs. Most recently, a fourth mechanism has been proposed in that dysfunction of mechanosensing in the aortic wall in response to hemodynamic stress may be a key driver of TAAs...
September 22, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28943416/top-100-most-cited-articles-on-spontaneous-intracerebral-hemorrhage-a-bibliometric-analysis
#11
REVIEW
Syed Ali Raza Nasir, Jaleed Ahmed Gilani, Kaneez Fatima, Urooba Faheem, Omar Kazmi, Javed Siddiqi, Faisal Khosa
BACKGROUND: A bibliometric uses the citation count of an article to determine its impact on the clinical world. There is a paucity of literature concerning top article citations on spontaneous intracerebral hemorrhage (ICH). The main objective of this investigation was to bridge this gap and to provide understanding of the trends on the most influential articles written on this subject. METHODS: Scopus Library database was searched to determine the citations of all published spontaneous ICH articles...
September 21, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28943402/effect-of-modified-bridge-exercise-on-trunk-muscle-activity-in-healthy-adults-a-cross-sectional-study
#12
Jeong-Oh Yoon, Min-Hyeok Kang, Jun-Seok Kim, Jae-Seop Oh
DESIGN: This is a cross-sectional study. SETTING: University research laboratory. PARTICIPANTS: Fifteen healthy adults (mean age: 27.47 years) volunteered for this study. INTERVENTION: The individuals performed standard bridge exercise and modified bridge exercises with right leg-lift (single-leg-lift bridge exercise, single-leg-lift bridge exercise on an unstable surface, and single-leg-lift hip abduction bridge exercise)...
September 9, 2017: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/28942783/japanese-registry-for-mechanically-assisted-circulatory-support-first-report
#13
Takeshi Nakatani, Kazuhiro Sase, Hiroaki Oshiyama, Masatoshi Akiyama, Masao Horie, Kan Nawata, Tomohiro Nishinaka, Yoshihisa Tanoue, Koichi Toda, Masao Tozawa, Shunichi Yamazaki, Masanobu Yanase, Hiroshi Ohtsu, Michiko Ishida, Ayaka Hiramatsu, Kensuke Ishii, Soichiro Kitamura
BACKGROUND: In Japan, ventricular assist devices (VADs) have been used for patients with severe heart failure as a bridge to transplantation (BTT) since 1992. However, it was not until 1997, when the Organ Transplant Law was enacted, that medical devices received approval by the national health insurance system for that use. To encourage research and development of innovative medical devices, the Pharmaceuticals and Medical Devices Agency has established a public-private partnership in collaboration with academic societies, hospitals and manufacturers...
October 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28942685/arthroscopic-single-row-versus-double-row-suture-bridge-technique-for-rotator-cuff-tears-in-patients-younger-than-55-years-a-prospective-comparative-study
#14
Michael E Hantes, Yohei Ono, Vasilios A Raoulis, Nikolaos Doxariotis, Aaron Venouziou, Aristidis Zibis, Marianna Vlychou
BACKGROUND: When arthroscopic rotator cuff repair is performed on a young patient, long-lasting structural and functional tendon integrity is desired. A fixation technique that potentially provides superior tendon healing should be considered for the younger population to achieve long-term clinical success. Hypothesis/Purpose: The purpose was to compare the radiological and clinical midterm results between single-row and double-row (ie, suture bridge) fixation techniques for arthroscopic rotator cuff repair in patients younger than 55 years...
September 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28942426/rapid-dna-synthesis-during-early-drosophila%C3%A2-embryogenesis-is-sensitive-to-maternal-humpty-dumpty-protein-function
#15
Shera Lesly, Jennifer L Bandura, Brian R Calvi
Problems with DNA replication cause cancer and developmental malformations. It is not fully understood how DNA replication is coordinated with development and perturbed in disease. We had previously identified the Drosophila gene humpty dumpty (hd) and showed that null alleles cause incomplete DNA replication, tissue undergrowth, and lethality. Animals homozygous for the missense allele, hd(272-9) , were viable, but adult females had impaired amplification of eggshell protein genes in the ovary, resulting in the maternal effects of thin eggshells and embryonic lethality...
September 23, 2017: Genetics
https://www.readbyqxmd.com/read/28942358/claspin-functions-in-cell-homeostasis-a-link-to-cancer
#16
REVIEW
Diana Azenha, Maria Celeste Lopes, Teresa C Martins
Cancer remains one of the leading causes of mortality worldwide. Most cancers present high degrees of genomic instability. DNA damage and replication checkpoints function as barriers to halt cell cycle progression until damage is resolved, preventing the perpetuation of errors. Activation of these checkpoints is critically dependent on Claspin, an adaptor protein that mediates the phosphorylation of the effector kinase Chk1 by ATR. However, Claspin also performs other roles related to the protection and maintenance of cell and genome integrity...
September 8, 2017: DNA Repair
https://www.readbyqxmd.com/read/28942230/investigation-of-zeolitic-imidazolate-frameworks-using-13-c-and-15-n-solid-state-nmr-spectroscopy
#17
Scott Sneddon, Jürgen Kahr, Angelica F Orsi, David J Price, Daniel M Dawson, Paul A Wright, Sharon E Ashbrook
Zeolitic imidazolate frameworks (ZIFs) are a subclass of metal-organic frameworks (MOFs) with extended three-dimensional networks of transition metal nodes (bridged by rigid imidazolate linkers), with potential applications in gas storage and separation, sensing and controlled delivery of drug molecules. Here, we investigate the use of (13)C and (15)N solid-state NMR spectroscopy to characterise the local structure and disorder in a variety of single- and dual-linker ZIFs. In most cases, a combination of a basic knowledge of chemical shifts typically observed in solution-state NMR spectroscopy and the use of dipolar dephasing NMR experiments to reveal information about quaternary carbon species are combined to enable spectral assignment...
September 9, 2017: Solid State Nuclear Magnetic Resonance
https://www.readbyqxmd.com/read/28942213/efficient-label-free-chemiluminescent-immunosensor-based-on-dual-functional-cupric-oxide-nanorods-as-peroxidase-mimics
#18
Juan Li, Yue Cao, Samuel S Hinman, Kristy S McKeating, Yiwen Guan, Xiaoya Hu, Quan Cheng, Zhanjun Yang
Dual-functional cupric oxide nanorods (CuONRs) as peroxidase mimics are proposed for the development of a flow-through, label-free chemiluminescent (CL) immunosensor. Forming the basis of this cost-efficient, label-free immunoassay, CuONRs, synthesized using a simple hydrothermal method, were deposited onto epoxy-activated standard glass slides, followed by immobilization of biotinylated capture antibodies through a streptavidin bridge. The CuONRs possess excellent catalytic activity, along with high stability as a solid support...
September 9, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28941991/conservation-in-gene-encoding-mycobacterium-tuberculosis-antigen-rv2660-and-a-high-predicted-population-coverage-of-h56-multistage-vaccine-in-south-africa
#19
Angy P Perez-Martinez, Edison Ong, Lixin Zhang, Carl F Marrs, Yongqun He, Zhenhua Yang
H56/AERAS-456+IC31 (H56), composed of two early secretion proteins, Ag85B and ESAT-6, and a latency associated protein, Rv2660, and the IC31 Intercell adjuvant, is a new fusion subunit vaccine candidate designed to induce immunity against both new infection and reactivation of latent tuberculosis infection. Efficacy of subunit vaccines may be affected by the diversity of vaccine antigens among clinical strains and the extent of recognition by the diverse HLA molecules in the recipient population. Although a previous study showed the conservative nature of Ag85B- and ESAT-6-encoding genes, genetic diversity of Rv2660c that encodes RV2660 is largely unknown...
September 20, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28941483/transitioning-youth-with-hiv-to-adult-hiv-care-bridging-the-gap-with-adult-care-clinics-for-the-life-span
#20
EDITORIAL
Patricia A Garvie
No abstract text is available yet for this article.
October 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
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