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https://www.readbyqxmd.com/read/28092663/neural-regulation-of-immunity-molecular-mechanisms-and-clinical-translation
#1
REVIEW
Valentin A Pavlov, Kevin J Tracey
Studies bridging neuroscience and immunology have identified neural pathways that regulate immunity and inflammation. Recent research using methodological advances in molecular genetics has improved our understanding of the neural control of immunity. Here we outline mechanistic insights, focusing on translational relevance and conceptual developments. We also summarize findings from recent clinical studies of bioelectronic neuromodulation in inflammatory and autoimmune diseases.
January 16, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28092477/long-term-oncological-outcomes-of-endoscopic-stenting-as-a-bridge-to-surgery-versus-emergency-surgery-for-malignant-colorectal-obstruction-a-comparative-study
#2
Fei-Hu Yan, Zheng Lou, Xiao-Shuang Liu, Zhen Wang, Xiao-Dong Xu, Yong-Jun-Yi Gao, Jian He, Hao Wang, Chuan-Gang Fu, Wei Zhang, Hai-Yan He, Bei-Li Cai, En-da Yu
AIM: With consideration of the theoretical link between the stent insertion and the increased risk of tumor cells spillaged, which may lead to distant metastases, there is a concern about long-term clinical outcomes after the usage of self-expanding metallic stents (SEMS) as a "bridge to surgery" in the malignant colorectal obstruction (MCO) treatment. This cohort study aimed to compare the long-term oncological outcomes of SEMS as a bridge to surgery (SEMS group) with those of emergency surgery (ES group) for MCO...
January 16, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28092471/genomics-pipelines-and-data-integration-challenges-and-opportunities-in-the-research-setting
#3
Jeremy Davis-Turak, Sean M Courtney, E Starr Hazard, W Bailey Glen, Willian da Silveira, Timothy Wesselman, Larry P Harbin, Bethany J Wolf, Dongjun Chung, Gary Hardiman
The emergence and mass utilization of high-throughput (HT) technologies, including sequencing technologies (genomics) and mass spectrometry (proteomics, metabolomics, lipids), has allowed geneticists, biologists, and biostatisticians to bridge the gap between genotype and phenotype on a massive scale. These new technologies have brought rapid advances in our understanding of cell biology, evolutionary history, microbial environments, and are increasingly providing new insights and applications towards clinical care and personalized medicine...
January 16, 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28092182/an-estrogen-receptor-%C3%AE-selective-agonist-inhibits-non-alcoholic-steatohepatitis-in-preclinical-models-by-regulating-bile-acid-and-xenobiotic-receptors
#4
Suriyan Ponnusamy, Quynh T Tran, Thirumagal Thiyagarajan, Duane D Miller, Dave Bridges, Ramesh Narayanan
Non-alcoholic steatohepatitis (NASH) affects 8-10 million people in the US and up to 75% of obese individuals. Despite this, there are no approved oral therapeutics to treat NASH and therefore the need for novel approaches exists. The estrogen receptor β (ER-β)-selective agonist, β-LGND2, inhibits body weight and white adipose tissue, and increases metabolism, resulting in higher energy expenditure and thermogenesis. Due to favorable effects of β-LGND2 on obesity, we hypothesized that β-LGND2 will prevent NASH directly by reducing lipid accumulation in the liver or indirectly by favorably changing body composition...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28092133/why-are-dithienylethene-linked-biscobaltocenes-so-hard-to-photoswitch
#5
Jürgen Heck, Alejandra Escribano, Torben Steenbock, Carmen Herrmann, Conrad Stork
Attaching an organometallic unit to a dithienylethene (DTE) molecular switch can allow to vary its switching and spectroscopic properties, and to create switchable magnetic properties. In this work, two different dithienylethene molecular switches were used as a bridge between two cobalt sandwich units. The only difference between the switching cores was in the size of the cycloalkene ring connecting both thiophene rings. The complexes present different oxidation states for the cobalt atoms, which were demonstrated to determine the switching reaction...
January 16, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28091947/characteristics-of-the-energetic-micro-initiator-through-integrating-al-ni-nano-multilayers-with-cu-film-bridge
#6
Yuxin Zhang, Hongchuan Jiang, Xiaohui Zhao, Yichao Yan, Wanli Zhang, Yanrong Li
An energetic micro-initiator through integrating Al/Ni nano-multilayers with Cu film bridge was investigated in this study. The Cu film bridge was initially fabricated with wet etching, and Al/Ni nano-multilayers were alternately deposited on the surface of Cu film bridge by magnetron sputtering. The periodic layer structure of Al/Ni nano-multilayers was verified by scanning electron microscopy. The exothermic reaction in Al/Ni nano-multilayers can be initiated with onset reaction temperature as low as 503 K, and the total reaction heat is about 774...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28091663/markedly-enhanced-up-conversion-luminescence-by-combining-ir-808-dye-sensitization-and-core-shell-shell-structures
#7
Jiating Xu, Mingdi Sun, Ye Kuang, Huiting Bi, Bin Liu, Dan Yang, Ruichan Lv, Shili Gai, Fei He, Piaoping Yang
Rare-earth-doped up-conversion nanoparticles (UCNPs), which are capable of converting infrared light to shorter-wavelength photons, have attracted worldwide attention due to their unique characteristics. However, the emission brightness of UCNPs is greatly limited by the unsatisfactory absorptivity of lanthanide ions. Herein, we adopted a novel strategy to enhance the up-conversion intensity using NIR dye IR-808 as an antenna to sensitize the core-shell-shell structured NaGdF4:Yb,Er@NaGdF4:Yb@NaNdF4:Yb UCNPs...
January 16, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28091655/probing-the-magnetic-relaxation-and-magnetic-moment-arrangement-in-a-series-of-dy4-squares
#8
Jianfeng Wu, Shuang-Yan Lin, Si Shen, Xiao-Lei Li, Lang Zhao, Li Zhang, Jinkui Tang
Three μ4-O bridged Dy4 squares, {[Dy4(μ4-O)(HL(1))4(H2O)4]2(NO3)3(OH)}·2H2O·2CH3OH (1), [Dy4(μ4-O)(HL(2))4(SCN)2]·2H2O·4CH3OH (2) and [Dy4(μ4-O)(H2L(3))2(SCN)2]·6H2O (3) were assembled by using a Schiff base ligand and its dimerized and reduced congener, respectively. These complexes share a similar μ4-O bridged Dy4 core, while, both the coordination geometry and metal-ligand interactions are slightly changed upon the modulation of the ligands, resulting in distinct single-molecular magnetic (SMM) and single-molecular toroic (SMT) properties...
January 16, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28091652/a-novel-3-d-photoluminescent-cuprous-chloride-polymer-based-on-bifunctional-imidazolate-tetrazolate-bridges
#9
Qiuling Tang, Jian Zhou, Filipe A Almeida Paz, Lianshe Fu, Hong Xiao, Qi Zhou, Ju Li
A novel 3-D cuprous chloride polymer [CuCl(μ5-L)]n (1, HL = 1-tetrazole-4-imidazole-benzene) has been hydrothermally synthesized and structurally characterized. 1 displays a 3-D network with a bimodal fsc-3,5-Cmce-2 topological type constructed by the linkages of rare [CuCl](+) cations and L(-) ligands. The photoluminescence properties and density functional theory calculations of 1 have also been studied.
January 16, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28091649/optical-properties-of-trinuclear-metal-chalcogenolate-complexes-room-temperature-nir-fluorescence-in-cu2ti-sph-6-pph3-2
#10
Michael Kühn, Sergei Lebedkin, Florian Weigend, Andreas Eichhöfer
The optical properties of four isostructural trinuclear chalcogenolato bridged metal complexes [Cu2Sn(SPh)6(PPh3)2], [Cu2Sn(SePh)6(PPh3)2], [Ag2Sn(SPh)6(PPh3)2] and [Cu2Ti(SPh)6(PPh3)2] have been investigated by absorption and photoluminescence spectroscopy and time-dependent density functional theory (TDDFT) calculations. All copper-tin compounds demonstrate near-infrared (NIR) phosphorescence at ∼900-1100 nm in the solid state at low temperature, which is nearly absent at ambient temperature. Stokes shifts of these emissions are found to be unusually large with values of about 1...
January 16, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28091640/the-binuclear-dual-emitter-br-co-3re-pn-np-re-co-3br-pn-3-chloro-6-4-diphenylphosphinyl-butoxypyridazine-a-new-bridging-p-n-bidentate-ligand-resulting-from-the-ring-opening-of-tetrahydrofuran
#11
Marianela Saldías, Jorge Manzur, Rodrigo E Palacios, María L Gómez, Julio De La Fuente, Germán Günther, Nancy Pizarro, Andrés Vega
Lithium diphenylphosphide unexpectedly provokes the ring-opening of tetrahydrofuran (THF) and by reaction with 3,6-dichloropyridazine leads to the formation of the ligand 3-chloro-6-(4-diphenylphosphinyl)butoxypyridazine (P⋯N), which was isolated. The reaction of this ligand with the (Re(CO)3(THF)Br)2 dimer yields the novel complex [Br(CO)3Re(μ-3-chloro-6-(4-diphenylphosphinyl)butoxypyridazine)2Re(CO)3Br] (BrRe(P⋯N)(N⋯P)ReBr), which was crystallized in the form of a chloroform solvate, (C46H40Br2Cl2N4O8P2Re2)·(CHCl3)...
January 16, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28091523/origin-of-anti-tumor-activity-of-the-cysteine-containing-go-peptides-and-further-optimization-of-their-cytotoxic-properties
#12
Irina I Tyuryaeva, Olga G Lyublinskaya, Ivan S Podkorytov, Nikolai R Skrynnikov
Antitumor GO peptides have been designed as dimerization inhibitors of prominent oncoprotein mucin 1. In this study we demonstrate that activity of GO peptides is independent of the level of cellular expression of mucin 1. Furthermore, these peptides prove to be broadly cytotoxic, causing cell death also in normal cells such as dermal fibroblasts and endometrial mesenchymal stem cells. To explore molecular mechanism of their cytotoxicity, we have designed and tested a number of new peptide sequences containing the key CxC or CxxC motifs...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28090816/tacit-knowledge-and-risk-perceptions-tullow-oil-and-lay-publics-in-ghana-s-offshore-oil-region
#13
Sylvester Senyo Ofori-Parku
This study examines how local residents make sense of offshore oil production risks in Ghana's nascent petroleum industry. From a naturalistic-interpretive perspective, it is primarily based on in-depth interviews with community residents: 8 opinion leaders, 15 residents, and 1 journalist. Residents associate Tullow's oil activities with health concerns (e.g. conjunctivitis), environmental challenges (e.g. the emergence of decomposed seaweeds along the shore), and socio-economic concerns (e.g. loss of livelihoods, decline in fish harvest, and increased rent and cost of living)...
January 1, 2017: Public Understanding of Science
https://www.readbyqxmd.com/read/28090644/evaluation-of-a-telehealth-training-package-to-remotely-train-staff-to-conduct-a-preference-assessment
#14
William J Higgins, Kevin C Luczynski, Regina A Carroll, Wayne W Fisher, Oliver C Mudford
Recent advancements in telecommunication technologies make it possible to conduct a variety of healthcare services remotely (e.g., behavioral-analytic intervention services), thereby bridging the gap between qualified providers and consumers in isolated locations. In this study, web-based telehealth technologies were used to remotely train direct-care staff to conduct a multiple-stimulus-without-replacement preference assessment. The training package included three components: (a) a multimedia presentation; (b) descriptive feedback from previously recorded baseline sessions; and (c) scripted role-play with immediate feedback...
January 16, 2017: Journal of Applied Behavior Analysis
https://www.readbyqxmd.com/read/28090514/pancreatic-cancer-from-bench-to-bedside
#15
REVIEW
Yaokai Ma, Qing Wu, Xin Li, Xiaoqiang Gu, Jiahua Xu, Jinzu Yang
Pancreatic cancer is recognized as the king of carcinoma, and the gap between basic research and clinical practice is difficult to improve the treatment effect. Translational medicine builds an important bridge between pancreatic cancer basic research and clinical practice from the pathogenesis, early diagnosis of pancreatic carcinoma, drug screening, treatment strategies and metastasis prediction. This article will carry on the concrete elaboration to the above several aspects.
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28090309/bridging-the-science-into-practice
#16
Ioana R Preston
No abstract text is available yet for this article.
December 2016: Pulmonary Circulation
https://www.readbyqxmd.com/read/28089930/scaffolds-containing-chitosan-gelatin-and-graphene-oxide-for-bone-tissue-regeneration-in-vitro-and-in-vivo
#17
S Saravanan, Anjali C, M Vairamani, T P Sastry, K S Subramanian, N Selvamurugan
Critical-sized bone defects are augmented with cell free and cell loaded constructs to bridge bone defects. Improving the properties of three-dimensional scaffolds with multiple polymers and others is of growing interest in recent decades. Chitosan (CS), a natural biopolymer has limitations for its use in bone regeneration, and its properties can be enhanced with other materials. In the present study, the composite scaffolds containing CS, gelatin (Gn) and graphene oxide (GO) were fabricated through freeze-drying...
January 12, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28089686/simulations-of-cytochrome-p450-3a4-mediated-drug-drug-interactions-by-simple-two-compartment-model-assisted-static-method
#18
Katsumi Iga, Akiko Kiriyama
In order to predict cytochrome P450 3A4 (CYP3A4)-mediated drug-drug interactions (DDIs), a simple two-compartment model assisted, overall inhibition-activity (Ai, overall) method was derived based upon two concepts. One concept was that the increase in blood victim-level and fold increase in the area under the blood victim-level curve (AUCR) produced by DDI are determined entirely by Ai, overall, the hepatic availability of the victim and fraction of urinary excreted unchanged victim, where Ai, overall is determined by the perpetrator-specific CYP isoform inhibition activities (Ai,CYPs, DDI predictor-1) and victim-specific fractional CYP isoform contributions (fm,CYPs, predictor-2)...
January 12, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28089652/hippocampal-prefrontal-connectivity-as-a-translational-phenotype-for-schizophrenia
#19
REVIEW
Florian Bähner, Andreas Meyer-Lindenberg
Finding novel biological targets in psychiatry has been difficult, partly because current diagnostic categories are not defined by pathophysiology and difficult to model in animals. The study of species-conserved systems-level mechanisms implicated in psychiatric disease could be a promising strategy to address some of these difficulties. Altered hippocampal-prefrontal (HC-PFC) connectivity during working memory (WM) processing is a candidate for such a translational phenotype as it has been repeatedly associated with impaired cognition in schizophrenia patients and animal models for psychiatric risk factors...
January 12, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28089198/point-of-care-detection-devices-for-food-safety-monitoring-proactive-disease-prevention
#20
REVIEW
Marie Yung-Chen Wu, Min-Yen Hsu, Shih-Jen Chen, De-Kuang Hwang, Tzung-Hai Yen, Chao-Min Cheng
Food safety has become an increasingly significant public concern in both developed and under-developed nations around the world; it increases morbidity, mortality, human suffering, and economic burden. This Opinion focuses on (i) examining the influence of pathogens and chemicals (e.g., food additives and pesticide residue) on food-borne illnesses, (ii) summarizing food hazards that are present in Asia, and (iii) summarizing the array of current point-of-care (POC) detection devices that have potential applications in food safety monitoring...
January 11, 2017: Trends in Biotechnology
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