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https://www.readbyqxmd.com/read/27661422/resuscitation-and-treatment-of-shock
#1
Michael J Beltran, Tyson E Becker, Richard K Hurley, Jennifer M Gurney, Roman A Hayda
Hemorrhage continues to be the most common cause of death among service members wounded in combat. Injuries that were previously nonsurvivable in previous wars are now routinely seen by combat surgeons in forward surgical units, the result of improvements in body armor, the universal use of field tourniquets to control extremity hemorrhage at the point of injury, and rapid air evacuation strategies. Combat orthopaedic surgeons remain a vital aspect of the forward surgical unit, tasked with assisting general surgical colleagues in the resuscitation of patients in hemorrhagic shock while also addressing traumatic amputations, open and closed long bone fractures, and mechanically unstable pelvic trauma...
October 2016: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/27383587/chronic-cognitive-dysfunction-after-traumatic-brain-injury-is-improved-with-a-phosphodiesterase-4b-inhibitor
#2
David J Titus, Nicole M Wilson, Julie E Freund, Melissa M Carballosa, Kevin E Sikah, Concepcion Furones, W Dalton Dietrich, Mark E Gurney, Coleen M Atkins
UNLABELLED: Learning and memory impairments are common in traumatic brain injury (TBI) survivors. However, there are no effective treatments to improve TBI-induced learning and memory impairments. TBI results in decreased cAMP signaling and reduced cAMP-response-element binding protein (CREB) activation, a critical pathway involved in learning and memory. TBI also acutely upregulates phosphodiesterase 4B2 (PDE4B2), which terminates cAMP signaling by hydrolyzing cAMP. We hypothesized that a subtype-selective PDE4B inhibitor could reverse the learning deficits induced by TBI...
July 6, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27348349/current-concepts-in-midface-fracture-management
#3
Alf L Nastri, Ben Gurney
PURPOSE OF REVIEW: Management of midface trauma is complex and challenging and requires a clear understanding of the facial buttress system, subunit anatomy and inter-relationships. Too often clinicians attempt surgical repair without adequate knowledge of the common complications associated with poor reduction and improper sequencing of fracture repair. This review outlines a working approach to the identification and management of such injuries, and the definitive management of common injury patterns...
August 2016: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/27257717/metabolism-and-toxicological-analysis-of-synthetic-cannabinoids-in-biological-fluids-and-tissues
#4
REVIEW
B C Presley, S M R Gurney, K S Scott, S L Kacinko, B K Logan
Synthetic cannabinoids, which began proliferating in the United States in 2009, have gone through numerous iterations of modification to their chemical structures. More recent generations of compounds have been associated with significant adverse outcomes following use, including cognitive and psychomotor impairment, seizures, psychosis, tissue injury and death. These effects increase the urgency for forensic and public health laboratories to develop methods for the detection and identification of novel substances, and apply these to the determination of their metabolism and disposition in biological samples...
July 2016: Forensic Science Review
https://www.readbyqxmd.com/read/25384506/knee-chondrolysis-by-infusion-of-bupivacaine-with-epinephrine-through-an-intra-articular-pain-pump-catheter-after-arthroscopic-acl-reconstruction
#5
Jordan Z Buchko, Tanner Gurney-Dunlop, Jason J Shin
BACKGROUND: Postoperative knee chondrolysis caused by continuous intra-articular pain pumps infusing bupivacaine with epinephrine is a rare but serious complication. PURPOSE: To determine the association between postoperative intra-articular infusion of bupivacaine with epinephrine and the development of knee chondrolysis in patients who have undergone arthroscopic anterior cruciate ligament reconstruction (ACLR). The authors hypothesized that the development of knee chondrolysis after ACLR is associated with postoperative high-dose intra-articular bupivacaine with epinephrine infusion...
February 2015: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/24630360/occupant-accelerations-and-injury-potential-during-an-ambulance-to-curb-impact
#6
Ellen L Lee, Wilson C Hayes
This paper presents real world acceleration data for an ambulance driving up and over a curb. A full scale reenactment was performed for a litigated case in which a patient on a gurney in an ambulance claimed a variety of bodily injuries after the ambulance struck a curb. A height and weight matched surrogate rode on the gurney during the tests. Results demonstrated that peak vehicle and occupant accelerations never exceeded 1.1g's. To address the claimed injuries, the accelerations likely sustained by the patient were compared to those experienced during daily life...
April 2014: Forensic Science International
https://www.readbyqxmd.com/read/23121294/haemophagocytic-lymphohistiocytosis-in-a-patient-with-severe-burns
#7
J R S Porter, J Handy, H Yarranton, S Gurney
Recently, increasing attention has been drawn to haemophagocytic lymphohistiocytosis as a potentially under-diagnosed condition in critically ill patients with severe sepsis. It is thought to be caused by a highly stimulated, but ineffective, immune system. We report the case of a patient suffering from major burns who, despite extensive investigations showing the absence of concurrent sepsis or infection, developed haemophagocytic lymphohistiocytosis refractory to treatment. We believe that this is the first report suggestive of haemophagocytic lymphohistiocytosis triggered by a burns injury...
April 2013: Anaesthesia
https://www.readbyqxmd.com/read/22183615/adiponectin-protects-against-hyperoxic-lung-injury-and-vascular-leak
#8
Sean M Sliman, Rishi B Patel, Jason P Cruff, Sainath R Kotha, Christie A Newland, Carrie A Schrader, Shariq I Sherwani, Travis O Gurney, Ulysses J Magalang, Narasimham L Parinandi
Adiponectin (Ad), an adipokine exclusively secreted by the adipose tissue, has emerged as a paracrine metabolic regulator as well as a protectant against oxidative stress. Pharmacological approaches of protecting against clinical hyperoxic lung injury during oxygen therapy/treatment are limited. We have previously reported that Ad inhibits the NADPH oxidase-catalyzed formation of superoxide from molecular oxygen in human neutrophils. Based on this premise, we conducted studies to determine whether (i) exogenous Ad would protect against the hyperoxia-induced barrier dysfunction in the lung endothelial cells (ECs) in vitro, and (ii) endogenously synthesized Ad would protect against hyperoxic lung injury in wild-type (WT) and Ad-overexpressing transgenic (AdTg) mice in vivo...
November 2013: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/21085945/low-renal-oximetry-correlates-with-acute-kidney-injury-after-infant-cardiac-surgery
#9
Gabe E Owens, Karen King, James G Gurney, John R Charpie
Acute kidney injury (AKI) is a frequent complication after cardiopulmonary bypass surgery during infancy. Standard methods for evaluating renal function are not particularly sensitive nor are proximate indicators of renal dysfunction that allow intervention in real time. Near-infrared spectroscopy (NIRS) is a newer noninvasive technology that continuously evaluates regional oximetry and may correlate with renal injury and adverse outcomes after cardiac surgery in infants. This prospective observational study enrolled 40 infants (age, <12 months) undergoing biventricular repair...
February 2011: Pediatric Cardiology
https://www.readbyqxmd.com/read/19794327/vasoactive-inotropic-score-as-a-predictor-of-morbidity-and-mortality-in-infants-after-cardiopulmonary-bypass
#10
Michael G Gaies, James G Gurney, Alberta H Yen, Michelle L Napoli, Robert J Gajarski, Richard G Ohye, John R Charpie, Jennifer C Hirsch
OBJECTIVE: Inotrope score has been proposed as a marker of illness severity after pediatric cardiac surgery despite a lack of data to support its use as such. The goal of this study was to determine the association between inotropic/vasoactive support and clinical outcome in infants after cardiac surgery. DESIGN: Retrospective chart review. SETTING: Dedicated pediatric cardiothoracic intensive care unit at an academic, tertiary care medical center...
March 2010: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/19753826/arrow-trauma-to-cervical-spine
#11
Gregory Geissinger, Gail A Magid, Robert C McMahon
A 50-year-old man was the victim of an accidental arrow shooting while hunting. The arrow entered his posterolateral neck and came to rest in the space between the C1/C2 vertebrae in his cervical spine. He was able to maintain his own cervical immobilization. His hunting partners drove him to meet emergency medical technicians, who stabilized the arrow shaft, transferred him to a backboard and gurney, and continued manual cervical immobilization en route to a local hospital. Cervical spine X-ray results compelled an air ambulance transfer to a trauma center where he underwent surgical intervention to remove the arrow...
July 2009: WMJ: Official Publication of the State Medical Society of Wisconsin
https://www.readbyqxmd.com/read/19585543/parents-safety-beliefs-and-childhood-agricultural-injury
#12
Muree Larson-Bright, Susan G Gerberich, Ann S Masten, Bruce H Alexander, James G Gurney, Timothy R Church, Andrew D Ryan, Colleen M Renier
BACKGROUND: This study examined potential associations between parental safety beliefs and children's chore assignments or risk of agricultural injury. METHODS: Analyses were based on nested case-control data collected by the 1999 and 2001 Regional Rural Injury Study-II (RRIS-II) surveillance efforts. Cases (n = 425, reporting injuries) and controls (n = 1,886, no injuries; selected using incidence density sampling) were persons younger than 20 years of age from Midwestern agricultural households...
September 2009: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/18448879/the-effect-of-skin-thickness-and-time-in-the-absorption-of-dexamethasone-in-human-tendons-using-iontophoresis
#13
COMPARATIVE STUDY
Burke Gurney, Daniel Wascher, Leslie Eaton, Errin Benesh, Joseph Lucak
STUDY DESIGN: Experimental laboratory study. OBJECTIVES: To measure the transmission of dexamethasone sodium phosphate (DEX-P) using iontophoresis as a function of skinfold tissue thickness and time elapsed between treatment and tissue extraction. BACKGROUND: Iontophoresis is a modality used in physical therapy with the intent to drive medications through the skin to underlying tissues using a direct electrical current. DEX-P is the most commonly used medication with iontophoresis and is used to treat a variety of connective tissue conditions...
May 2008: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/18056319/work-practices-and-childhood-agricultural-injury
#14
MULTICENTER STUDY
Muree Larson-Bright, Susan Goodwin Gerberich, Bruce H Alexander, James G Gurney, Ann S Masten, Timothy R Church, Andrew D Ryan, Colleen M Renier
OBJECTIVE: To evaluate whether children's agricultural work practices were associated with agricultural injury and to identify injury and work practice predictors. DESIGN: Analyses were based on nested case-control data collected by the Regional Rural Injury Study-II (RRIS-II) surveillance study in 1999 and 2001 by computer-assisted telephone interviews. SUBJECTS: Cases (n=425) and controls (n=1886) were persons younger than 20 years of age from Midwestern agricultural households...
December 2007: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/17693087/between-day-reliability-of-repeated-plantar-pressure-distribution-measurements-in-a-normal-population
#15
Jason K Gurney, Uwe G Kersting, Dieter Rosenbaum
The objective of this study was to determine the reliability of repeated plantar pressure distribution measurements during normal gait across multiple testing sessions. Testing sessions were conducted on 5 separate days at approximately the same time of day. Nine subjects (five males, four females, age 26+/-8.4 years) who were free of any musculoskeletal injury were recruited. A capacitive pressure distribution platform (EMED AT, Novel GmbH, Munich, Germany), sampling at 50Hz was used to collect plantar pressure patterns during barefoot walking at a self-selected speed...
May 2008: Gait & Posture
https://www.readbyqxmd.com/read/17088517/the-association-between-parents-past-agricultural-injuries-and-their-children-s-risk-of-injury-analyses-from-the-regional-rural-injury-study-ii
#16
Kathleen Ferguson Carlson, Deborah Langner, Bruce H Alexander, James G Gurney, Susan G Gerberich, Andrew D Ryan, Colleen M Renier, Steven J Mongin
OBJECTIVE: To examine associations between parents' and children's agricultural injuries in a cohort of farming and ranching households. DESIGN: Analyses from a population-based, nested case-control study. SETTING: The 1999 Regional Rural Injury Study-II, involving a cohort of 3765 agricultural households. Demographic, injury, and exposure data were collected for household members for 1 year. PARTICIPANTS: A total of 203 injured children (cases) and 755 randomly selected control children were identified for the study...
November 2006: Archives of Pediatrics & Adolescent Medicine
https://www.readbyqxmd.com/read/16540964/bovine-polymerized-hemoglobin-hemoglobin-based-oxygen-carrier-201-resuscitation-in-three-swine-models-of-hemorrhagic-shock-with-militarily-relevant-delayed-evacuation-effects-on-histopathology-and-organ-function
#17
COMPARATIVE STUDY
Todd Johnson, Francoise Arnaud, Feng Dong, Nora Philbin, Jennifer Rice, Ludmila Asher, Martin Arrisueno, Matthew Warndorf, Jennifer Gurney, Gerald McGwin, Lewis Kaplan, W Shannon Flournoy, Fred S Apple, L B Pearce, Stephen Ahlers, Richard McCarron, Daniel Freilich
OBJECTIVE: To test our hypothesis that hemoglobin-based oxygen carrier (HBOC)-201 resuscitation in hemorrhagic shock (HS) will not lead to increased organ injury and dysfunction. DESIGN: Three swine HS models simulating military-relevant delayed evacuation: a) moderate controlled HS, b) severe controlled HS, and c) severe uncontrolled HS. SETTING: Military research laboratory. SUBJECTS: Swine. INTERVENTIONS: Swine were anesthetized/intubated and instrumented...
May 2006: Critical Care Medicine
https://www.readbyqxmd.com/read/16369186/immune-effects-of-resuscitation-with-hboc-201-a-hemoglobin-based-oxygen-carrier-in-swine-with-moderately-severe-hemorrhagic-shock-from-controlled-hemorrhage
#18
COMPARATIVE STUDY
Feng Dong, Carrie H Hall, Suzanne A Golech, Nora B Philbin, Jennifer P Rice, Jennifer Gurney, Francoise G Arnaud, Michael Hammett, Xia Ma, W Shannon Flournoy, Jiang Hong, Lewis J Kaplan, L Bruce Pearce, Gerald McGwin, Stephen Ahlers, Richard McCarron, Daniel Freilich
HBOC-201, a hemoglobin-based oxygen carrier, improved physiologic parameters and survival in hemorrhagic shock (HS) animal models. However, resuscitation from HS and the properties of different fluids influence immune responses. The aim of this study was to determine if HBOC-201 significantly alters immune function in traumatic HS. Anesthetized pigs underwent soft tissue injury, controlled hemorrhage of 40% of blood volume, and resuscitation with HBOC-201 or Hextend, or no resuscitation. Sequential whole-blood samples were collected for analyses of leukocyte differential (hematology analyzer), T-lymphocyte subsets (CD3, CD4, and CD8) (FACS), lymphocyte adhesion marker CD49d (alpha4-integrin) expression (FACS), plasma cytokines-tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-10-(ELISA), and lymphocyte apoptosis (annexin-V/propidium iodide staining) (FACS)...
January 2006: Shock
https://www.readbyqxmd.com/read/16081200/a-hemoglobin-based-oxygen-carrier-bovine-polymerized-hemoglobin-hboc-201-versus-hetastarch-hex-in-a-moderate-severity-hemorrhagic-shock-swine-model-with-delayed-evacuation
#19
COMPARATIVE STUDY
Nora Philbin, Jennifer Rice, Jennifer Gurney, Gerald McGwin, Fran├žoise Arnaud, Feng Dong, Todd Johnson, W Shannon Flournoy, Stephen Ahlers, L Bruce Pearce, Richard McCarron, Daniel Freilich
OBJECTIVE: To evaluate the efficacy of HBOC-201 for resuscitation of hemorrhagic shock in a swine model incorporating soft tissue injury and delayed evacuation. METHODS: A muscle crush injury and 40% estimated blood volume controlled hemorrhage was completed in 24 Yucatan mini-pigs. Pigs were untreated or resuscitated with HBOC-201 or 6% hetastarch (HEX) at 20 min. Invasive hemodynamics and clinical variables were monitored for 4 h (pre-hospital phase) and subsequent fluid infusions were administered for severe hypotension or tachycardia...
September 2005: Resuscitation
https://www.readbyqxmd.com/read/15834396/a-61-year-old-man-with-a-self-diagnosed-back-injury-and-difficulty-walking-be-suspicious-ask-the-question
#20
Diane Gurney
No abstract text is available yet for this article.
April 2005: Journal of Emergency Nursing: JEN: Official Publication of the Emergency Department Nurses Association
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