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https://www.readbyqxmd.com/read/29771401/mir-133a-inhibits-fracture-healing-via-targeting-runx2-bmp2
#1
H Peng, S-L Lu, Y Bai, X Fang, H Huang, X-Q Zhuang
OBJECTIVE: To analyze the mechanism of miR-133a in inhibiting fracture healing through regulating runt-related transcription factor 2 (RUNX2) signaling pathway. PATIENTS AND METHODS: A total of 80 patients with fracture admitted to our hospital from January 2016 to January 2017 were divided into 2 groups according to nonunion fracture or healing fracture: nonunion fracture group (n = 40) and control group (n= 40). After admission, patients underwent the surgery, respectively, and the bone tissues were taken for stand-by application...
May 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29770583/angle-stable-interlocking-intramedullary-nails-for-tibial-plateau-fractures
#2
Peng Jia, Feng-Cheng Lu, Kifayat Ullah, Man Zhang, Yan-Sheng Dong, Chao Xiong, Zhi-Hui Zhao, Jin-Feng Wang, Ju-Wen Chen, Yong-Qing Wang
OBJECTIVE: Angle stable interlocking intramedullary nail (ASIN), a novel technique, has rarely been used for treatment of tibial plateau fractures (TPF). This retrospective study was designed to introduce this novel technique, ASIN, as well as to describe the initial experience and verify the effectiveness when ASIN was used for the management for TPF. METHODS: A cohort of 19 cases with closed TPF aged from 18-70 years with at least 23 months follow-up from November 2008 to September 2013 was analyzed retrospectively...
May 16, 2018: Orthopaedic Surgery
https://www.readbyqxmd.com/read/29762447/gastrocnemius-myocutaneous-flaps-for-knee-joint-coverage
#3
Alice Mayoly, Jean-Camille Mattei, Pierre Moullot, Charlotte Jaloux, Alexandre Rochwerger, Dominique Casanova, Baptiste Bertrand, Cécile Philandrianos
INTRODUCTION: The gastrocnemius muscular flap has already proven its efficiency for soft tissue coverage in cases of knee joint exposure. However, it may be too small to cover large defects and has not the same aesthetic and mechanical properties as normal skin. Perforator fasciocutaneous flaps have recently been described in knee joint coverage with good results as they replace skin by skin, but they can be hard to harvest. Gastrocnemius flaps can be easily harvested with a planned skin paddle designed over the chosen muscle...
May 14, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29762110/surgical-complications-associated-with-atypical-femur-fractures-attributed-to-bisphosphonate-use
#4
Douglas S Schultz, Henry M Gass, William R Barfield, Harry A Demos, Langdon A Hartsock
Complications of atypical femur fractures (AFFs) are common. AFFs often receive the same treatment as other femoral fractures; however, there appears to be a higher rate of adverse outcomes. Nine patients sustained a total of 13 AFFs, had documented bisphosphonate use before fracture, and had surgery between 2006 and 2012. Complications included continued pain, surgical revision, nonunion, malunion, deformity, or heterotopic ossification. The overall complication rate was 33.3%, with four of the 12 surgeries performed at this institution resulting in one nonunion and three minor complications...
2018: Journal of Surgical Orthopaedic Advances
https://www.readbyqxmd.com/read/29759927/incidence-of-nonunion-of-the-hallux-interphalangeal-joint-arthrodesis-a-systematic-review
#5
REVIEW
Eric So, Matthew D Wilson, Anson K Chu, Mark A Prissel
Hallux interphalangeal joint arthrodesis is an effective procedure to treat pain and provide stability and is often performed for intrinsic pain to the hallux interphalangeal joint. Additionally, this procedure is typically used in concert with the Jones tenosuspension. Although this as an accepted technique, the available data are scant, and questions remain regarding nonunion rates and contributory factors to poor healing. A systematic review of the reported data were undertaken to determine the rate of nonunion for hallux interphalangeal joint arthrodesis...
May 11, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29755239/type-iii-odontoid-fractures-a-subgroup-analysis-of-complex-high-energy-fractures-treated-with-external-immobilization
#6
Thomas E Niemeier, Adam R Dyas, Sakthivel R Manoharan, Steven M Theiss
Study Design: Retrospective cohort study. Objective: Type III odontoid fractures are classically treated nonoperatively, yet, the current literature on Type III odontoid fractures includes fractures of multiple etiologies and fracture morphologies. We hypothesize that a subgroup of complex, Type III fractures caused by high-energy mechanisms are more likely to fail nonoperative treatment. Materials and Methods: Acute Type III odontoid fractures were identified at a single institution from 2008 to 2015...
January 2018: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/29752219/immediate-weightbearing-after-first-metatarsophalangeal-joint-arthrodesis-with-screw-and-locking-plate-fixation-a-short-term-review
#7
Kyle W Abben, Matthew D Sorensen, Brett J Waverly
Historically, the postoperative protocol for patients undergoing first metatarsophalangeal joint arthrodesis has included 6 weeks of non-weightbearing, followed by protected weightbearing in a below-the-knee cast boot or postoperative shoe. This prolonged period of non-weightbearing predisposes the patient to disuse atrophy, osteopenia, deep vein thrombosis risk, and, overall, a prolonged time to recovery. The present study reports a retrospective review of a patient cohort that underwent first metatarsophalangeal joint fusion with immediate full weightbearing postoperatively...
May 8, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29740250/ilizarov-method-in-combination-with-autologous-mesenchymal-stem-cells-from-iliac-crest-shows-improved-outcome-in-tibial-non-union
#8
Hui Zhang, Feng Xue, Hai Jun Xiao
Autologous bone grafting and ilizarov technique are the preferred mode of treatment for bone nonunion, studies suggest that bone marrow derived mesenchymal stem cells can be effective in treatment of tibial non-union where there is length of bone defect. The current study investigates the beneficial clinical outcome of combining the ilizarov procedure with intraosseous injection of autologous mesenchymal stem cells. The open-label study enrolled 25 patients with infected tibial non-union at the Shanghai Fengxian District Central Hospital, Shanghai, China between April 2010 and July 2014...
May 2018: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29738401/locking-plate-fixation-in-a-series-of-bicondylar-tibial-plateau-fractures-raises-treatment-costs-without-clinical-benefit
#9
Matthew Cavallero, Richard Rosales, Jesse Caballero, Laurence B Kempton, Walter W Virkus, Greg E Gaski
OBJECTIVES: To compare outcomes and costs between locking and nonlocking constructs in the treatment of bicondylar tibial plateau (BTP) fractures. DESIGN: Retrospective cohort study. SETTING: Level 1 academic trauma center. PATIENTS: All patients that presented with complete articular, BTP fractures (AO/OTA 41-C and Schatzker 6) between 2013-2015 were screened (n=112). Patients treated with a mode of fixation other than plate-and-screw were excluded...
May 3, 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29736522/injectable-shear-thinning-hydrogels-for-delivering-osteogenic-and-angiogenic-cells-and-growth-factors
#10
Emine Alarçin, Tae Yong Lee, Sobha Karuthedom, Marzieh Mohammadi, Meadhbh A Brennan, Dong Hoon Lee, Alessandra Marrella, Jin Zhang, Denata Syla, Yu Shrike Zhang, Ali Khademhosseini, Hae Lin Jang
Bone nonunion may occur when the fracture is unstable, or blood supply is impeded. To provide an effective treatment for the healing of nonunion defects, we introduce an injectable osteogenic hydrogel that can deliver cells and vasculogenic growth factors. We used a silicate-based shear-thinning hydrogel (STH) to engineer an injectable scaffold and incorporated polycaprolactone (PCL) nanoparticles that entrap and release vasculogenic growth factors in a controlled manner. By adjusting the solid composition of gelatin and silicate nanoplatelets in the STH, we defined optimal conditions that enable injection of STHs, which can deliver cells and growth factors...
May 8, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29735376/operative-versus-nonoperative-treatment-of-proximal-humeral-fractures-a-systematic-review-meta-analysis-and-comparison-of-observational-studies-and-randomized-controlled-trials
#11
REVIEW
Reinier B Beks, Yassine Ochen, Herman Frima, Diederik P J Smeeing, Olivier van der Meijden, Tim K Timmers, Detlef van der Velde, Mark van Heijl, Luke P H Leenen, Rolf H H Groenwold, R Marijn Houwert
BACKGROUND: There is no consensus on the choice of treatment for displaced proximal humeral fractures in older patients (aged > 65 years). The aims of this systematic review and meta-analysis were (1) to compare operative with nonoperative management of displaced proximal humeral fractures and (2) to compare effect estimates obtained from randomized controlled trials (RCTs) and observational studies. METHODS: The databases of MEDLINE, Embase, CENTRAL (Cochrane Central Register of Controlled Trials), and CINAHL (Cumulative Index to Nursing and Allied Health Literature) were searched on September 5, 2017, for studies comparing operative versus nonoperative treatment of proximal humeral fractures; both RCTs and observational studies were included...
May 4, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29734895/insufficiency-fracture-of-the-radial-diaphysis-following-a-sauve-kapandji-procedure-for-osteoarthritis-of-the-distal-radioulnar-joint-a-case-report
#12
Takuma Wakasugi, Ritsuro Shirasaka, Koji Fujita
The Sauve-Kapandji (SK) procedure for distal radioulnar joint osteoarthritis have complications including pain over the proximal ulnar stump, nonunion of the fused distal radioulnar joint, and less frequently, insufficiency fracture of the distal radius. We report a case of insufficiency fracture of the radial diaphysis as a rare complication of the SK procedure.
June 2018: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/29734844/the-effect-of-patient-fracture-and-surgery-on-outcomes-of-high-energy-neck-of-femur-fractures-in-patients-aged-15-50
#13
Wayne Hoskins, Johnny Rayner, Rohan Sheehy, Harry Claireaux, Roger Bingham, Roselyn Santos, Andrew Bucknill, Xavier L Griffin
INTRODUCTION: High-energy femoral neck fractures in young patients can be devastating, with the risk of osteonecrosis, nonunion, malunion and lifelong morbidity. The aim of this study is to define the effects of patient, fracture and surgical factors on the outcome of high-energy femoral neck fractures in patients aged from 15 to 50 years. METHODS: A retrospective review was conducted of high-energy femoral neck fractures in patients aged 15-50 managed surgically at a Level 1 Trauma Centre, using a prospectively recorded trauma database...
May 1, 2018: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29730840/technical-and-clinical-feasibility-of-contrast-enhanced-ultrasound-evaluation-of-long-bone-non-infected-nonunion-healing
#14
Simona Pozza, Armanda De Marchi, Chiara Albertin, Domenico Albano, Ginevra Biino, Domenico Aloj, Luca Maria Sconfienza
PURPOSE: To assess the technical feasibility of contrast-enhanced ultrasound (CEUS) in the monitoring of non-infected long bone nonunion healing. METHODS: Twenty-five patients (16 males; mean age: 40.4 ± 11.7) with long bone nonunion were treated using surgery and mesenchymal stem cells and platelet-rich plasma. They performed CEUS up to 15 days before, 7 days, 4 and 8 weeks after treatment. To categorize the angiogenesis around the fracture site, the microvascular blood flow from CEUS was classified into four categories, depending on the portion of the investigated area that was involved in the neovascularization process: grade 0 = 0%; grade 1 = 0-30%; grade 2 = 30-70%; grade 3 = 70-100%...
May 5, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29729819/one-year-after-proximal-or-distal-periprosthetic-fracture-of-the-femur-two-conditions-with-divergent-outcomes
#15
D Eschbach, B Buecking, H Kivioja, M Fischer, T Wiesmann, R Zettl, L Oberkircher, J Barthel, R Aigner, S Ruchholtz, C Bliemel
INTRODUCTION: Arthroplasty of the hip and knee is 1 of the 20 most frequent operations in Germany. Periprosthetic fracture is one of the most feared complications following primary or revision arthroplasty. Present publication aims to analyse differences between patients with periprosthetic fracture around total knee arthroplasty (PFTKA) and patients with periprosthetic fracture around total hip arthroplasty (PFTHA) concerning demographics, clinical course, complications and return to pre-fracture mobility...
April 24, 2018: Injury
https://www.readbyqxmd.com/read/29729795/is-the-rotational-deformity-important-in-our-decision-making-process-for-correction-of-hallux-valgus-deformity
#16
REVIEW
Pablo Wagner, Emilio Wagner
Rotational deformity in hallux valgus is a recognized component and a demonstrated recurrence factor in patients who have undergone surgery. More than 20 years ago, publications started reporting metatarsal pronation as part of the hallux valgus pathology. Identifying metatarsal pronation should be part of the preoperative angular measurements. The proximal metatarsal rotational osteotomy and Lapidus fusion are some of the few techniques that reliably correct metatarsal pronation. They have good results, with more nonunions reported for the Lapidus...
June 2018: Foot and Ankle Clinics
https://www.readbyqxmd.com/read/29709422/arthroscopic-subtalar-arthrodesis-does-the-type-of-fixation-modify-outcomes
#17
Jesús Vilá-Rico, Beatriz Bravo-Giménez, Verónica Jimenez-Díaz, Maria Angeles Mellado-Romero, Cristina Ojeda-Thies
The goal of the present study was to analyze a modified American Orthopaedic Foot and Ankle Society (AOFAS) ankle-hindfoot scale score, time to union, and the incidence of fusion after isolated arthroscopic posterior subtalar arthrodesis using either 1 or 2 screws of different diameters. We reviewed a consecutive series of 65 patients, mean age 50.0 ± 15.6 years, including 38 males (58.5%) and 27 females (41.5%), who had undergone arthrodesis from May 2004 to February 2011. The mean follow-up duration was 57...
April 27, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29703460/comparison-and-use-of-allograft-bone-morphogenetic-protein-versus-other-materials-in-ankle-and-hindfoot-fusions
#18
J George DeVries, Brandon Scharer
Bone grafting is a common procedure in foot and ankle surgery. Because autogenous graft use results in comorbidity to the patient, the search has been ongoing for the ideal substitute. A novel processing technique for allograft using bone marrow, which retains many of the growth factors, has shown promise in the spinal data and early reports of foot and ankle surgery. We performed a retrospective, comparative study of patients undergoing hindfoot and ankle arthrodesis, with a total of 68 patients included. Of the 68 patients, 29 (42...
April 24, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29701102/the-indications-and-donor-site-morbidity-of-tibial-cortical-strut-autografts-in-the-management-of-defects-in-long-bones
#19
O Lauthe, M Soubeyrand, A Babinet, V Dumaine, P Anract, D J Biau
Aims The primary aim of this study was to determine the morbidity of a tibial strut autograft and characterize the rate of bony union following its use. Patients and Methods We retrospectively assessed a series of 104 patients from a single centre who were treated with a tibial strut autograft of > 5 cm in length. A total of 30 had a segmental reconstruction with continuity of bone, 27 had a segmental reconstruction without continuity of bone, 29 had an arthrodesis and 18 had a nonunion. Donor-site morbidity was defined as any event that required a modification of the postoperative management...
May 1, 2018: Bone & Joint Journal
https://www.readbyqxmd.com/read/29701097/-rail-and-nail-bifocal-management-of-atrophic-femoral-nonunion
#20
K Davda, N Heidari, P Calder, D Goodier
Aims The management of a significant bony defect following excision of a diaphyseal atrophic femoral nonunion remains a challenge. We present the outcomes using a combined technique of acute femoral shortening, stabilized with a long retrograde intramedullary nail, accompanied by bifocal osteotomy compression and distraction osteogenesis with a temporary monolateral fixator. Patients and Methods Eight men and two women underwent the 'rail and nail' technique between 2008 and 2016. Proximal locking of the nail and removal of the external fixator was undertaken once the length of the femur had been restored and prior to full consolidation of the regenerate...
May 1, 2018: Bone & Joint Journal
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