keyword
MENU ▼
Read by QxMD icon Read
search

Fast

keyword
https://www.readbyqxmd.com/read/29668111/efficient-in-planta-gene-targeting-in-tomato-using-geminiviral-replicons-and-the-crispr-cas9-system
#1
Tal Dahan-Meir, Shdema Filler-Hayut, Cathy Melamed-Bessudo, Samuel Bocobza, Henryk Czosnek, Asaph Aharoni, Avraham A Levy
Current breeding relies mostly on random mutagenesis and recombination to generate novel genetic variation. However, targeted genome editing is becoming an increasingly important tool for precise plant breeding. Using the CRISPR-Cas system combined with the bean yellow dwarf virus rolling circle replicon we optimized a method for targeted mutagenesis and gene replacement in tomato. The carotenoid isomerase (CRTISO) and phytoene synthase 1 (PSY1) genes from the carotenoid biosynthesis pathway were chosen as targets due to their easily detectable change of phenotype...
April 18, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29668001/aero-gel-assisted-synthesis-of-anatase-tio-2-nanoparticles-for-humidity-sensing-application
#2
Ekta Poonia, Prashant Kumar Mishra, Vijay Kiran, Jasbir Sangwan, Rakesh Kumar, Pramod Kumar Rai, Vijay K Tomer
Aero-gel based one-pot synthesis of anatase phase TiO2 nanoparticles having a high surface area of 125 m2 g-1 has been reported in this work. The humidity sensing perfomance of the obtained porous TiO2 nanoparticles exhibits a quick response (2 s) and fast recovery (1.5 s), negligible hysteresis (<1%) and good stability in the 11-98%RH range. The relationship between %RH and resistance was found to be linear while the sensitivity increases with increase in %RH.
April 18, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29667939/a-photochemical-approach-for-a-fast-and-self-limited-covalent-modification-of-surface-supported-graphene-with-photoactive-dyes
#3
Natalia Sergeeva, Alexander N Chaika, Brian Walls, Barry Murphy, Killian Walshe, David Martin, Billy D O Richards, Gin Jose, K Fleischer, Victor Aristov, Olga Molodtsova, Igor V Shvets, Sergey Krasnikov
Herein, we report a simple method for a covalent modification of surface-supported graphene with photoactive dyes. Graphene was fabricated on cubic-SiC/Si(001) wafers due to their low cost and suitability for mass-production of continuous graphene fit for electronic applications on millimetre scale. Functionalisation of the graphene surface was carried out in solution via white light-induced photochemical generation of phenazine radicals from phenazine diazonium salt. The resulting covalently bonded phenazine-graphene hybrid structure was characterised by scanning tunnelling microscopy (STM) and spectroscopy (STS), Raman spectroscopy and density functional theory (DFT) calculations...
April 18, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29667849/defensive-coping-facilitated-a-smaller-cortisol-to-estradiol-ratio-and-a-higher-hypertension-risk-the-sabpa-study
#4
Leoné Malan, Andrea de Kock, Mark Hamer, Marike Cockeran, Nicolaas Theodor Malan
OBJECTIVES: Taxing psychosocial stress and defensive coping have been associated with hypoactivity in cortisol, a vasoconstrictive agent. Estradiol has vasodilatory properties with cardio- and neuroprotective effects. It can however also induce α1 -adrenergic vasoconstrictive responsiveness. We aimed to determine whether the cortisol-to-estradiol ratio (Cort:E2) may augment α1 -adrenergic responsiveness and hypertension risk when habitually using defensive coping. METHODS: African (n = 168) and Caucasian (n = 207) men and women (46 ± 9 years) were included...
April 18, 2018: Blood Pressure
https://www.readbyqxmd.com/read/29667733/longitudinal-analysis-of-tibiofemoral-cartilage-contact-area-and-position-in-acl-reconstructed-patients
#5
Ellison Chen, Keiko Amano, Valentina Pedoia, Richard B Souza, C Benjamin Ma, Xiaojuan Li
Patients who have suffered ACL injury are more likely to develop early onset post-traumatic osteoarthritis despite reconstruction. The purpose of our study was to evaluate the longitudinal changes in the tibiofemoral cartilage contact area size and location after ACL injury and reconstruction. Thirty-one patients with isolated unilateral ACL injury were followed with T2 weighted Fast Spin Echo, T1ρ and T2 MRI at baseline prior to reconstruction, and 6 months, 1 year, and 2 years after surgery. Areas were delineated in FSE images with an in-house Matlab program using a spline-based semi-automated segmentation algorithm...
April 18, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29667682/modeling-the-free-radical-polymerization-of-hexanediol-diacrylate-hdda-a-molecular-dynamics-and-graph-theory-approach
#6
Ariana Torres-Knoop, Ivan Kryven, Verena Schamboeck, Piet D Iedema
In the printing, coating and ink industries, photocurable systems are becoming increasingly popular and multi-functional acrylates are one of the most commonly used monomers due to their high reactivity (fast curing). In this paper, we use molecular dynamics and graph theory tools to investigate the thermo-mechanical properties and topology of hexanediol diacrylate (HDDA) polymer networks. The gel point was determined as the point where a giant component was formed. For the conditions of our simulations, we found the gel point to be around 0...
April 18, 2018: Soft Matter
https://www.readbyqxmd.com/read/29667449/predicting-rapid-analgesic-onset-of-ibuprofen-salts-compared-with-ibuprofen-acid-t-lag-t-low-t-med-and-a-novel-parameter-t-cmaxref
#7
Lisa Miles, Jessica Hall, Bartosz Jenner, Richard Addis, Simon Hutchings
OBJECTIVE: This study evaluated the early absorption characteristics of ibuprofen salt formulations and standard ibuprofen acid (the reference). METHODS: In this open-label, crossover, single-center study (NCT02452450) in 32 healthy, fasted adults receiving single oral doses (400 mg ibuprofen) of ibuprofen lysine, ibuprofen liquid capsule, ibuprofen sodium, ibuprofen acid, and paracetamol, intensive blood sampling was conducted for up to 6 hours. Time between dosing and the start of absorption (Tlag ); a novel parameter, time at which the test formulations (ibuprofen salts) reached the observed maximum plasma concentration (Cmax ) of the reference (standard ibuprofen acid) (TCmaxRef ); and time to achieve therapeutic plasma concentration were measured...
April 18, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29667421/associations-between-variants-of-bone-morphogenetic-protein-7-gene-and-growth-traits-in-chickens
#8
Yan Wang, Fuyou Guo, Hao Qu, Chenglong Luo, Jie Wang, Dingming Shu
1. Enhancing bone strength to solve leg disorders in poultry has become an important goal in broiler production. 2. Bone morphogenetic protein 7 (BMP7), a member of the BMP family, represents an attractive therapeutic target for bone regeneration in humans and plays critical roles in skeletal development. 3. The objective of this study was to investigate the relationship between BMP7 gene expression, single nucleotide polymorphisms (SNPs) and growth traits in chickens. Here, a SNP (c.1995T>C) in the chicken (Gallus gallus) BMP7 gene was identified, that was associated with growth and carcass traits...
April 18, 2018: British Poultry Science
https://www.readbyqxmd.com/read/29667377/the-usefulness-of-determination-of-the-procalcitonin-pct-concentration-in-gbs-piositive-pregnant-womens-blood-serum-for-anticipations-of-infections-in-newborns
#9
Wojciech Cnota, Dominika Mucha, Jan Mucha
Group-B streptococci (GBS) are commensal bacteria of the human body. They may, however, pose a serious life hazard to pregnant women. During labour, newborns of GBS-positive mothers run the risk of infections that may eventually lead to severe complications, sepsis or even death. For this reason, it is very important to find new diagnostic markers that will enable fast and effective diagnostics and control of the disease process. The level of procalcitonin emerges as a promising diagnostic parameter. AIM. Analysis of the impact of the procalcitonin (PCT) level in GBS-positive pregnant women on the possibility of complications and infections in mothers and newborns MATERIAL AND METHODS...
2018: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/29667371/biases-from-different-dna-extraction-methods-in-intestine-microbiome-research-based-on-16s-rdna-sequencing-a-case-in-the-koi-carp-cyprinus-carpio-var-koi
#10
Zhuoran Han, Jingfeng Sun, Aijun Lv, Anli Wang
This study examined the technical bias associated with different DNA extraction methods used in microbiome research. Three methods were used to extract genomic DNA from the same intestinal microbiota sample that was taken from the koi carp Cyprinus carpio var. koi, after which their microbial diversity and community structure were investigated on the basis of a 16S rDNA high-throughput sequencing analysis. Biased results were observed in relation to the number of reads, alpha diversity indexes and taxonomic composition among the three DNA extraction protocols...
April 17, 2018: MicrobiologyOpen
https://www.readbyqxmd.com/read/29667364/heritability-of-body-size-in-the-polar-bears-of-western-hudson-bay
#11
René M Malenfant, Corey S Davis, Evan S Richardson, Nicholas J Lunn, David W Coltman
Among polar bears (Ursus maritimus), fitness is dependent on body size through males' abilities to win mates, females' abilities to provide for their young, and all bears' abilities to survive increasingly longer fasting periods caused by climate change. In the Western Hudson Bay subpopulation (near Churchill, Manitoba, Canada), polar bears have declined in body size and condition, but nothing is known about the genetic underpinnings of body size variation, which may be subject to natural selection. Here, we combine a 4449-individual pedigree and an array of 5433 single-nucleotide polymorphisms (SNPs) to provide the first quantitative genetics study of polar bears...
April 18, 2018: Molecular Ecology Resources
https://www.readbyqxmd.com/read/29667325/a-host-configured-lithium-sulfur-cell-built-on-3d-nickel-photonic-crystal-with-superior-electrochemical-performances
#12
Shengxuan Lin, Yang Yan, Zihe Cai, Lin Liu, Xiaobin Hu
The insulator of the sulfur cathode and the easy dendrites growth of the lithium anode are the main barriers for lithium-sulfur cells in commercial application. Here, a 3D NPC@S/3D NPC@Li full cell is reported based on 3D hierarchical and continuously porous nickel photonic crystal (NPC) to solve the problems of sulfur cathode and lithium anode at the same time. In this case, the 3D NPC@S cathode can not only offer a fast transfer of electron and lithium ion, but also effectively prevent the dissolution of polysulfides and the tremendous volume change during cycling, and the 3D NPC@Li anode can efficiently inhibit the growth of lithium dendrites and volume expansion, too...
April 18, 2018: Small
https://www.readbyqxmd.com/read/29667109/ideal-cardiovascular-health-among-ghanaian-populations-in-three-european-countries-and-rural-and-urban-ghana-the-rodam-study
#13
Benjamin van Nieuwenhuizen, Mohammad Hadi Zafarmand, Erik Beune, Karlijn Meeks, Ama de-Graft Aikins, Juliet Addo, Ellis Owusu-Dabo, Frank P Mockenhaupt, Silver Bahendeka, Matthias B Schulze, Ina Danquah, Joachim Spranger, Kerstin Klipstein-Grobusch, Lambert Tetteh Appiah, Liam Smeeth, Karien Stronks, Charles Agyemang
Cardiovascular health (CVH) is a construct defined by the American Heart Association (AHA) as part of its 2020 Impact Goal definition. CVH has, until now, not been evaluated in Sub-Saharan African populations. The aim of this study was to investigate differences in the prevalence of ideal CVH and its constituent metrics among Ghanaians living in rural and urban Ghana and Ghanaian migrants living in three European countries. The AHA definition of CVH is based on 7 metrics: smoking, body mass index, diet, physical activity, blood pressure, total cholesterol, and fasting plasma glucose...
April 17, 2018: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/29667039/perception-of-time-to-contact-of-slow-and-fast-moving-objects-using-monocular-and-binocular-motion-information
#14
Aaron J Fath, Mats Lind, Geoffrey P Bingham
The role of the monocular-flow-based optical variable τ in the perception of the time to contact of approaching objects has been well-studied. There are additional contributions from binocular sources of information, such as changes in disparity over time (CDOT), but these are less understood. We conducted an experiment to determine whether an object's velocity affects which source is most effective for perceiving time to contact. We presented participants with stimuli that simulated two approaching squares...
April 17, 2018: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/29666986/impaired-fasting-glucose-is-associated-with-unfavorable-outcome-in-ischemic-stroke-patients-treated-with-intravenous-alteplase
#15
E Osei, S Fonville, A A M Zandbergen, P J Koudstaal, D W J Dippel, H M den Hertog
OBJECTIVES: Hyperglycemia on admission and diabetes mellitus type II are associated with unfavorable outcome in stroke patients. We studied whether impaired fasting glucose (IFG) is associated with unfavorable outcome in ischemic stroke patients treated with intravenous alteplase as well and if IFG is a stronger prognostic factor than hyperglycemia on admission. METHODS: We studied 220 consecutive patients with ischemic stroke treated with intravenous alteplase...
April 17, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29666972/initial-experience-with-a-sipm-based-pet-ct-scanner-influence-of-acquisition-time-on-image-quality
#16
Ida Sonni, Lucia Baratto, Sonya Park, Negin Hatami, Shyam Srinivas, Guido Davidzon, Sanjiv Sam Gambhir, Andrei Iagaru
BACKGROUND: A newly introduced PET/CT scanner (Discovery Meaningful Insights-DMI, GE Healthcare) includes the silicon photomultiplier (SiPM) with time-of-flight (TOF) technology first used in the GE SIGNA PET/MRI. In this study, we investigated the impact of various acquisition times on image quality using this SiPM-based PET/CT. METHODS: We reviewed data from 58 participants with cancer who were scanned using the DMI PET/CT scanner. The administered dosages ranged 295...
April 18, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/29666869/a-unique-tetranuclear-ag-i-complex-emitting-efficient-thermally-activated-delayed-fluorescence-with-a-remarkably-short-decay-time
#17
Xue-Min Gan, Rongmin Yu, Xu-Lin Chen, MingXue Yang, Ling Lin, Xiao-Yuan Wu, Can-Zhong Lu
A novel tetranuclear Ag(i) complex, [Ag4(μ-DMPTP)2(POP)3][BF4]2 (Ag4N2P3), has been designed to achieve highly efficient thermally activated delayed fluorescence (TADF). Photophysical investigations show that the compound exhibits highly efficient TADF (Φ = 76%) and has a very short ambient-temperature TADF decay time of only 0.65 μs, corresponding to a radiative decay rate of k = Φ/τ = 1.2 × 106 s-1, a value belonging to the fast radiative rates in TADF materials.
April 18, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29666858/polytyrosine-nanoparticles-enable-ultra-high-loading-of-doxorubicin-and-rapid-enzyme-responsive-drug-release
#18
Xiaolei Gu, Min Qiu, Huanli Sun, Jian Zhang, Liang Cheng, Chao Deng, Zhiyuan Zhong
Despite the great significance of clinically viable nanovehicles, very few of them exhibit stability and high anticancer drug loading with fast intracellular drug release. Herein, we report that polytyrosine nanoparticles (PTNs) self-assembled from poly(ethylene glycol)-b-poly(l-tyrosine) block copolymer enable the ultra-high loading and rapid enzyme-responsive release of doxorubicin (DOX). Notably, PTNs achieve a remarkably high DOX loading of 63.1 wt% likely due to the existence of strong π-π stacking between polytyrosine and DOX, as shown by UV-vis analysis...
April 18, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29666715/identification-of-hollow-viscus-injury-with-fast-examination-in-kurdistan-iraq
#19
Ruj Al-Sindy, Heleen Alaqrawy, Mahmood Sh Hafdullah, Christine Butts
Point-of-care ultrasound has become indispensable in the evaluation of trauma, particularly in low resource areas, where it may be the only rapidly available imaging modality. The FAST (Focused Assessment with Sonography in Trauma) in particular can be lifesaving, by rapidly detecting signs of intra-abdominal hemorrhage. However, the FAST is primarily designed to identify free fluid associated with solid organ injury and is thought to have less sensitivity and power in identifying evidence of hollow viscus injury...
2018: Case Reports in Emergency Medicine
https://www.readbyqxmd.com/read/29666593/interaction-in-spoken-word-recognition-models-feedback-helps
#20
James S Magnuson, Daniel Mirman, Sahil Luthra, Ted Strauss, Harlan D Harris
Human perception, cognition, and action requires fast integration of bottom-up signals with top-down knowledge and context. A key theoretical perspective in cognitive science is the interactive activation hypothesis: forward and backward flow in bidirectionally connected neural networks allows humans and other biological systems to approximate optimal integration of bottom-up and top-down information under real-world constraints. An alternative view is that online feedback is neither necessary nor helpful; purely feed forward alternatives can be constructed for any feedback system, and online feedback could not improve processing and would preclude veridical perception...
2018: Frontiers in Psychology
keyword
keyword
23640
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"