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https://www.readbyqxmd.com/read/28651396/-interaction-between-family-history-of-diabetes-and-hyperlipidemia-on-risk-of-diabetes-in-population-with-normotension-in-harbin-a-cross-sectional-study
#1
C D Bao, B Sun, L Lan, H Qiao, D F Zhang, X Y Liu, J Wang, Y S Zhao
Objective: To explore the interaction between family history of diabetes and hyperlipidemia on the risk of diabetes in population with normotension. Methods: A multistage stratified probability random sampling was conducted to select a representative sample of urban residents aged 20-74 years in Harbin. A total of 376 diabetes patients with normotension and 3 692 residents with normal blood pressure, normal fasting glucose, and normal 2 hours glucose from OGTT were surveyed. The interaction was evaluated by using crossover analysis and additive model...
May 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28651337/preliminary-validation-of-a-method-combining-cultivation-and-cloning-based-approaches-to-monitor-airborne-bacteria
#2
Jenny Schäfer, Sarah Weiß, Udo Jäckel
It is already known that occupational exposure to bioaerosols or organic dust could be harmful for occupants, but mostly the correlation to occurring bacteria is missing. Especially, cultivation of bacteria from bioaerosols is important to get an insight on occurring and possibly infectious bacteria. These measures are highly time consuming and cost intensive. Therefore, to monitor bacterial diversity in bioaerosol samples and to avoid isolation procedures, an approach was applied using a combination of cultivation and cloning-based approach...
June 23, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/28651211/effect-of-insulin-degludec-versus-insulin-glargine-on-glycemic-control-and-daily-fasting-blood-glucose-variability-in-insulin-na%C3%A3-ve-japanese-patients-with-type-2-diabetes-i-d-got-trial
#3
Yoshimasa Aso, Kunihiro Suzuki, Yasuko Chiba, Minoru Sato, Nobuya Fujita, Yoshihisa Takada, Shunichi Murano, Hisamoto Kuroda
AIMS: Insulin degludec (IDeg) is an ultra-long-acting insulin that has a smooth time/action profile over more than 42h. The present study compared the effects of IDeg and insulin glargine (IGlar) on HbA1c reduction and on within-subject day-to-day variability of fasting blood glucose (FBG) in insulin-naïve patients with type 2 diabetes. SUBJECTS AND METHODS: Eligible patients were randomly allocated at a 3:1 ratio to receive once-daily IDeg (n=31) or IGlar (n=12)...
June 15, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28651192/efficient-photocatalytic-degradation-of-toxic-dyes-from-aqueous-environment-using-gelatin-zr-iv-phosphate-nanocomposite-and-its-antimicrobial-activity
#4
Manita Thakur, Gaurav Sharma, Tansir Ahamad, Ayman A Ghfar, Deepak Pathania, Mu Naushad
In the present study, gelatin-Zr(IV) phosphate nanocomposite (GT/ZPNC) was synthesized by sol-gel method by mixing the gelatin gel into the inorganic part Zr (IV) phosphate (ZP). The GT/ZPNC was characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis, scanning electron microscopy (SEM), transmission electron micron scope (TEM), X-ray powder diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). The photodegradation activity of GT/ZPNC was explored for the removal of methylene blue (MB) and fast green (FG) dyes from aqueous solution...
June 20, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28651174/label-free-chronopotentiometric-glycoprofiling-of-prostate-specific-antigen-using-sialic-acid-recognizing-lectins
#5
Stefan Belicky, Hana Černocká, Tomas Bertok, Alena Holazova, Kamila Réblová, Emil Paleček, Jan Tkac, Veronika Ostatná
In recent decades, it has become clear that most of human proteins are glycosylated and that protein glycosylation plays an important role in health and diseases. At present, simple, fast and inexpensive methods are sought for clinical applications and particularly for improved diagnostics of various diseases, including cancer. We propose a label- and reagent-free electrochemical method based on chronopotentiometric stripping (CPS) analysis and a hanging mercury drop electrode for the detection of interaction of sialylated protein biomarker a prostate specific antigen (PSA) with two important lectins: Sambucus nigra agglutinin (SNA) and Maackia amurensis agglutinin (MAA)...
June 19, 2017: Bioelectrochemistry
https://www.readbyqxmd.com/read/28651167/error-prone-bypass-of-o-6-methylguanine-by-dna-polymerase-of-pseudomonas-aeruginosa-phage-pap1
#6
Shiling Gu, Jingyuan Xiong, Ying Shi, Jia You, Zhenyu Zou, Xiaoying Liu, Huidong Zhang
O(6)-Methylguanine (O(6)-MeG) is highly mutagenic and is commonly found in DNA exposed to methylating agents, generally leads to G:C to A:T mutagenesis. To study DNA replication encountering O(6)-MeG by the DNA polymerase (gp90) of P. aeruginosa phage PaP1, we analyzed steady-state and pre-steady-state kinetics of nucleotide incorporation opposite O(6)-MeG by gp90 exo(-). O(6)-MeG partially inhibited full-length extension by gp90 exo(-). O(6)-MeG greatly reduces dNTP incorporation efficiency, resulting in 67-fold preferential error-prone incorporation of dTTP than dCTP...
June 10, 2017: DNA Repair
https://www.readbyqxmd.com/read/28651154/new-comprehensive-studies-of-a-gold-iii-dithiocarbamate-complex-with-proven-anticancer-properties-aqueous-dissolution-with-cyclodextrins-pharmacokinetics-and-upstream-inhibition-of-the-ubiquitin-proteasome-pathway
#7
Marianna F Tomasello, Chiara Nardon, Valeria Lanza, Giuseppe Di Natale, Nicolò Pettenuzzo, Stefano Salmaso, Danilo Milardi, Paolo Caliceti, Giuseppe Pappalardo, Dolores Fregona
The gold(III)-dithiocarbamate complex AuL12 (dibromo [ethyl-N-(dithiocarboxy-kS,kS')-N-methylglycinate] gold(III)), is endowed with promising in vitro/in vivo antitumor activity and toxicological profile. Here, we report our recent strategies to improve its water solubility and stability under physiological conditions along with our efforts for unravelling its tangled mechanism of action. We used three types of α-cyclodextrins (CDs), namely β-CD, Me-β-CD and HP-β-CD to prepare aqueous solutions of AuL12...
June 19, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28651142/fast-pyrolysis-of-durian-durio-zibethinus-l-shell-in-a-drop-type-fixed-bed-reactor-pyrolysis-behavior-and-product-analyses
#8
Y L Tan, A Z Abdullah, B H Hameed
Durian shell (DS) was pyrolyzed in a drop-type fixed-bed reactor to study the physicochemical properties of the products. The experiment was carried out with different particle sizes (up to 5mm) and reaction temperatures (250-650°C). The highest bio-oil yield was obtained at 650°C (57.45wt%) with DS size of 1-2mm. The elemental composition and higher heating value of the feedstock, bio-oil (650°C), and bio-char (650°C) were determined and compared. The compositions of product gases were determined via gas chromatography with thermal conductivity detector...
June 23, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28651096/predicting-actions-from-subtle-preparatory-movements
#9
Maryam Vaziri-Pashkam, Sarah Cormiea, Ken Nakayama
To study how people anticipate others' actions, we designed a competitive reaching task. Subjects faced each other separated by a Plexiglas screen and their finger movements in 3D space were recorded with sensors. The first subject (Attacker) was instructed to touch one of two horizontally arranged targets on the screen. The other subject (Blocker) touched the same target as quickly as possible. Average finger reaction times (fRTs) were fast, much faster than reactions to a dot moving on the screen in the same manner as the Attacker's finger...
June 23, 2017: Cognition
https://www.readbyqxmd.com/read/28651008/production-and-purification-of-human-hsp90%C3%AE-in-escherichia-coli
#10
Martina Radli, Dmitry B Veprintsev, Stefan G D Rüdiger
The molecular chaperone Hsp90 is an essential member of the cellular proteostasis system. It plays an important role in the stabilisation and activation of a large number of client proteins and is involved in fatal disease processes, e.g. Alzheimer disease, cancer and cystic fibrosis. This makes Hsp90 a crucial protein to study. Mechanistic studies require large amounts of protein but the production and purification of recombinant human Hsp90 in Escherichia coli is challenging and laborious. Here we identified conditions that influence Hsp90 production, and optimised a fast and efficient purification protocol...
2017: PloS One
https://www.readbyqxmd.com/read/28651003/iron-elevation-and-adipose-tissue-remodeling-in-the-epididymal-depot-of-a-mouse-model-of-polygenic-obesity
#11
Xiaoya Ma, Vinh T Pham, Hiroyuki Mori, Ormond A MacDougald, Yatrik M Shah, Peter F Bodary
BACKGROUND: Iron dysregulation is a potential contributor to the pathology of obesity-related metabolic complications. KK/HIJ (KK) mice, a polygenic obese mouse model, have elevated serum iron levels. A subset of KK male mice display a bronzing of epididymal adipose tissue (eAT) associated with >100-fold (p<0.001) higher iron concentration. METHODS: To further phenotype and characterize the adipose tissue iron overload, 27 male KK mice were evaluated. 14 had bronzing eAT and 13 had normal appearing eAT...
2017: PloS One
https://www.readbyqxmd.com/read/28650993/a-novel-potential-biomarker-for-metabolic-syndrome-in-chinese-adults-circulating-protein-disulfide-isomerase-family-a-member-4
#12
Chu-Yen Chien, Yi-Jen Hung, Yi-Shing Shieh, Chang-Hsun Hsieh, Chieh-Hua Lu, Fu-Huang Lin, Sheng-Chiang Su, Chien-Hsing Lee
BACKGROUND/OBJECTIVES: Protein disulfide isomerase (PDI) family members are specific endoplasmic reticulum proteins that are involved in the pathogenesis of numerous diseases including neurodegenerative diseases, cancer and obesity. However, the metabolic effects of PDIA4 remain unclear in humans. The aims of this study were to investigate the associations of serum PDIA4 with the metabolic syndrome (MetS) and its components in Chinese adults. SUBJECTS/METHODS: A total of 669 adults (399 men and 270 women) were recruited...
2017: PloS One
https://www.readbyqxmd.com/read/28650986/evolutionary-history-and-phylogeographic-relationships-of-shrews-from-sorex-araneus-group
#13
Paweł Mackiewicz, Magdalena Moska, Heliodor Wierzbicki, Przemysław Gagat, Dorota Mackiewicz
Shrews of the Sorex genus are an evolutionarily successful group that includes more than 77 species widely distributed in Eurasia and North America. The genus is one of the rare cases where karyotypic changes reflect well the evolutionary relationships among its species. The taxa showing the greatest variation in karyotype are usually classified into the Sorex araneus group. Its evolution was associated with chromosomal rearrangements, which could have promoted fast diversification of this group into many chromosomal races and species...
2017: PloS One
https://www.readbyqxmd.com/read/28650901/application-of-quality-by-design-approach-to-bioanalysis-development-of-a-method-for-elvitegravir-quantification-in-human-plasma
#14
Sara Baldelli, Giorgio Marrubini, Dario Cattaneo, Emilio Clementi, Matteo Cerea
BACKGROUND: The application of Quality by Design (QbD) principles in clinical laboratories can help to develop an analytical method through a systematic approach, providing a significant advance over the traditional heuristic and empirical methodology. In the present work, we applied for the first time the QbD concept in the development of a method for drug quantification in human plasma using elvitegravir as the test molecule. METHODS: The goal of the study was to develop a fast and inexpensive quantification method, with precision and accuracy as requested by the EMA guidelines on bioanalytical method validation...
June 22, 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/28650900/a-high-throughput-hplc-ms-ms-assay-for-the-detection-quantification-and-simultaneous-structural-confirmation-of-136-drugs-and-metabolites-in-human-urine
#15
Jacek Klepacki, Baharak Davari, Marion Boulet, Ryan Lizarraga, Uwe Christians
BACKGROUND: Due to its superior sensitivity and specificity, multi-analyte high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS) has become the gold standard in clinical toxicology. Although several qualitative and quantitative LC-MS/MS assays on various mass spectrometry platforms have been described in the literature, the majority of these methods either analyze only a limited number of compounds, and/or require tedious and time-consuming sample preparation...
June 22, 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/28650899/evaluation-of-a-digital-behavioral-counseling-program-for-reducing-risk-factors-for-chronic-disease-in-a-workforce
#16
Mark G Wilson, Cynthia M Castro Sweet, Michael D Edge, Erica N Madero, Megan McGuire, Megan Pilsmaker, Dan Carpenter, Scott Kirschner
OBJECTIVE: To evaluate a digitally delivered, intensive behavioral counseling program for a workforce at risk for obesity-related chronic disease. METHODS: Employees were offered a digital health program modeled after the diabetes prevention program (DPP). Annual workforce health assessments were used to examine changes in chronic disease risk factors between participants (n = 634) relative to a matched comparison group (n = 1268). RESULTS: Overall, employees were gaining an average of 3...
June 23, 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28650845/sealing-free-fast-response-paraffin-nanoporous-gold-hybrid-actuator
#17
Xinglong Ye, Haijun Jin
Paraffin-based actuators can deliver large actuation strokes and high actuation stress, but often suffer from low response rate and leaking problems. Here we report a new paraffin/metal hybrid actuator, which is formed by infiltrating nanoporous gold with paraffin. It exhibits fast actuation rate owing to high thermal conductivity of the inter-connected metal phase, and requires no external sealing because paraffin could be well confined in nanoscale channels due to the capillary force. We found that in this hybrid actuator, the stress generated by actuation is negligibly small when the characteristic size of the nanoporous gold (L) is above ~ 70 nm, and increases dramatically with decreasing size when L < ~ 70 nm...
June 26, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28650834/angle-2dpca-a-new-formulation-for-2dpca
#18
Quanxue Gao, Lan Ma, Yang Liu, Xinbo Gao, Feiping Nie
2-D principal component analysis (2DPCA), which employs squared F-norm as the distance metric, has been widely used in dimensionality reduction for data representation and classification. It, however, is commonly known that squared F-norm is very sensitivity to outliers. To handle this problem, we present a novel formulation for 2DPCA, namely Angle-2DPCA. It employs F-norm as the distance metric and takes into consideration the relationship between reconstruction error and variance in the objective function...
June 22, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28650702/a-case-report-of-methadone-associated-hypoglycemia-in-an-11-month-old-male
#19
Michael S Toce, Margaret A Stefater, David T Breault, Michele M Burns
BACKGROUND: Methadone is a synthetic μ-opioid receptor agonist that is used in the management of pain, neonatal abstinence withdrawal syndrome, and opioid dependence. Overdose can cause miosis, respiratory depression, and central nervous system depression. Rarely, hypoglycemia has been reported. We present the case of an 11-month-old male who developed hypoketotic, hyperinsulinemic, hypoglycemia after an acute, unintentional methadone exposure. CASE DETAILS: The patient was a previously healthy 11-month-old male who presented in respiratory failure...
June 26, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28650621/novel-cdta-based-bifunctional-chelators-for-stable-and-inert-mn-ii-complexation-synthesis-and-physicochemical-characterization
#20
Christian Vanasschen, Enikő Molnár, Gyula Tircsó, Ferenc K Kálmán, Éva Tóth, Marie Brandt, Heinz H Coenen, Bernd Neumaier
In the search for Mn(II) MR and PET/MR imaging agents with optimal balance between thermodynamic stability, kinetic inertness, and relaxivity, two novel bifunctional Mn(II) chelators (BFMnCs) based on CDTA (trans-1,2-diaminocyclohexane-N,N,N',N'-tetraacetic acid) were synthesized. A six-step synthesis, involving the buildup of a functionalized trans-1,2-diaminocyclohexane core, provided CuAAC-reactive 6a and 6b bearing an alkyne or azide substituent on the cyclohexane ring, respectively (CuAAC = Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition)...
June 26, 2017: Inorganic Chemistry
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