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https://www.readbyqxmd.com/read/28445901/comparative-pharmacokinetics-of-cholecalciferol-in-dogs-from-2-different-oral-formulations-using-corrective-measures-to-overcome-interference-from-endogenous-cholecalciferol
#1
Harilal Patel, Prakash Patel, Chandrakant Bhatt, Ashok Ghoghari, Urvesh Patel, Mukesh Ukawalal, Shafiq Sheikh, Vikram Ramanathan, Nuggehally R Srinivas
The aim of the preclinical investigation was to obtain single dose pharmacokinetics in dogs from 2 different oral cholecalciferol formulations using corrective measures to overcome the interference of endogenous cholecalciferol. 6 dogs were fasted overnight and the following day received 60 000 IU dose cholecalciferol [reference, Eris(®), vs. test, Sunbless(®)] by oral dosing. Blood samples were collected on day 0 (baseline establishment) and after dosing on day 1 up to 28 days. The serum samples were extracted using protein precipitation/solid phase extraction and analysed to determine cholecalciferol by LC-MS/MS assay with calibrators prepared from cholecalciferol free serum...
April 26, 2017: Drug Research
https://www.readbyqxmd.com/read/28445850/simultaneous-quantification-of-busulfan-clofarabine-and-f-ara-a-using-isotope-labelled-standards-and-standard-addition-in-plasma-by-lc-ms-ms-for-exposure-monitoring-in-hematopoietic-cell-transplantation-conditioning
#2
Arjen M Punt, Jurgen B Langenhorst, Annelies C Egas, Jaap Jan Boelens, Charlotte van Kesteren, Erik M van Maarseveen
In allogeneic hematopoietic cell transplantation (HCT) it has been shown that over- or underexposure to conditioning agents have an impact on patient outcomes. Conditioning regimens combining busulfan (Bu) and fludarabine (Flu) with or without clofarabine (Clo) are gaining interest worldwide in HCT. To evaluate and possibly adjust full conditioning exposure a simultaneous analysis of Bu, F-ARA-A (active metabolite of Flu) and Clo in one analytical run would be of great interest. However, this is a chromatographical challenge due to the large structural differences of Bu compared to F-ARA-A and Clo...
April 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28445768/polymer-free-electrospun-nanofibers-from-sulfobutyl-ether7-beta-cyclodextrin-sbe7-%C3%AE-cd-inclusion-complex-with-sulfisoxazole-fast-dissolving-and-enhanced-water-solubility-of-sulfisoxazole
#3
Zehra Irem Yildiz, Asli Celebioglu, Tamer Uyar
In this study, our aim was to develop solid drug-cyclodextrin inclusion complex system having nanofibrous morphology in order to have fast-dissolving property and enhanced water-solubility of poorly water-soluble drug. Here, we prepared a highly concentrated aqueous solution of inclusion complex between sulfisoxazole and sulfobutyl ether7-beta-cyclodextrin (SBE7-β-CD, Captisol(®)), and then, without using any polymeric matrix, the electrospinning of sulfisoxazole/SBE7-β-CD-IC nanofibers was performed in order to obtain free-standing and handy nanofibrous web...
April 23, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28445637/control-of-charge-carriers-trapping-and-relaxation-in-hematite-by-oxygen-vacancy-charge-ab-initio-non-adiabatic-molecular-dynamics
#4
Zhaohui Zhou, Jin Liu, Run Long, Linqiu Li, Liejin Guo, Oleg V Prezhdo
Ultrafast charge recombination in hematite (α-Fe2O3) severely limits its applications in solar energy conversion and utilization, for instance, in photo-electrochemical water splitting. We report the first time-domain ab initio study of charge relaxation dynamics in α-Fe2O3 with and without the oxygen vacancy (Ov) defect, using non-adiabatic molecular dynamics implemented within time-dependent density functional theory. The simulations show that the hole trapping is the rate-limiting step in the electron-hole recombination process for both neutral and ionized Ov systems...
April 26, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28445595/ventricular-fibrillation-cardiac-arrest-produces-a-chronic-striatal-hyperdopaminergic-state-that-is-worsened-by-methylphenidate-treatment
#5
Gerald J Nora, Rashed Harun, David F Fine, Daniel Hutchison, Adam C Grobart, Jason P Stezoski, Miranda Munoz, Patrick M Kochanek, Rehana K Leak, Tomas Drabek, Amy K Wagner
Cardiac arrest survival rates have improved with modern resuscitation techniques, but many survivors experience impairments associated with hypoxic-ischemic brain injury. Currently, little is understood about chronic changes in striatal dopamine (DA) systems after hypoxic-ischemic brain injury. Given the common empiric clinical use of DA enhancing agents in neurorehabilitation, investigation evaluating dopaminergic alterations after cardiac arrest (CA) is necessary to optimize rehabilitation approaches. We hypothesized that striatal DA neurotransmission would be altered chronically after ventricular fibrillation cardiac arrest (VF-CA)...
April 26, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28445520/serum-irisin-levels-correlated-to-peritoneal-dialysis-adequacy-in-nondiabetic-peritoneal-dialysis-patients
#6
Zhijun Tan, Zengchun Ye, Jun Zhang, Yanru Chen, Cailian Cheng, Cheng Wang, Xun Liu, Tanqi Lou, Hui Peng
BACKGROUND: Irisin is a recently discovered myokine thought to be involved in multiple metabolism abnormalities in most dialysis patients. However, the myokine has not been thoroughly studied in peritoneal dialysis. This study aimed to evaluate serum irisin levels and establish their relation to dialysis adequacy, insulin resistance, and bone metabolism status in patients on peritoneal dialysis. METHODS: A total of 59 nondiabetic prevalent peritoneal dialysis patients and 52 age- and sex-matched healthy controls were enrolled in this cross-sectional study...
2017: PloS One
https://www.readbyqxmd.com/read/28445507/various-mutations-compensate-for-a-deleterious-lacz%C3%AE-insert-in-the-replication-enhancer-of-m13-bacteriophage
#7
Emily M Zygiel, Karen A Noren, Marta A Adamkiewicz, Richard J Aprile, Heather K Bowditch, Christine L Carroll, Maria Abigail S Cerezo, Adelle M Dagher, Courtney R Hebert, Lauren E Hebert, Gloria M Mahame, Stephanie C Milne, Kelly M Silvestri, Sara E Sutherland, Alexandria M Sylvia, Caitlyn N Taveira, David J VanValkenburgh, Christopher J Noren, Marilena Fitzsimons Hall
M13 and other members of the Ff class of filamentous bacteriophages have been extensively employed in myriad applications. The Ph.D. series of phage-displayed peptide libraries were constructed from the M13-based vector M13KE. As a direct descendent of M13mp19, M13KE contains the lacZα insert in the intergenic region between genes IV and II, where it interrupts the replication enhancer of the (+) strand origin. Phage carrying this 816-nucleotide insert are viable, but propagate in E. coli at a reduced rate compared to wild-type M13 phage, presumably due to a replication defect caused by the insert...
2017: PloS One
https://www.readbyqxmd.com/read/28445503/therapeutic-efficacy-of-artemether-lumefantrine-against-uncomplicated-plasmodium-falciparum-malaria-in-a-high-transmission-area-in-northwest-ethiopia
#8
Michael Teklemariam, Ashenafi Assefa, Moges Kassa, Hussien Mohammed, Hassen Mamo
Malaria, particularly due to Plasmodium falciparum, remains a major public health threat in Ethiopia. Artemether-lumefantine (AL) has been the first-line antimalarial drug against uncomplicated P. falciparum malaria in the country since 2004. Regular monitoring of antimalarial drugs is recommended by the World Health Organization (WHO) to help early detection of drug resistant strains of the parasite and contain their rapid spread. The objective of this study was to assess the therapeutic efficacy of AL in a high-transmission setting in Ethiopia...
2017: PloS One
https://www.readbyqxmd.com/read/28445352/consensus-review-of-optimal-perioperative-care-in-breast-reconstruction-enhanced-recovery-after-surgery-eras-society-recommendations
#9
Claire Temple-Oberle, Melissa A Shea-Budgell, Mark Tan, John L Semple, Christiaan Schrag, Marcio Barreto, Phillip Blondeel, Jeremy Hamming, Joseph Dayan, Olle Ljungqvist
BACKGROUND: Enhanced recovery following surgery can be achieved through the introduction of evidence-based perioperative maneuvers. This review aims to present a consensus for optimal perioperative management of patients undergoing breast reconstructive surgery and to provide evidence-based recommendations for an enhanced perioperative protocol. METHODS: A systematic review of meta-analyses, randomized controlled trials, and large prospective cohorts was conducted for each protocol element...
May 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28445311/an-observational-study-on-the-relationship-between-serum-uric-acid-and-hypertension-in-a-northern-chinese-population-aged-45-to-59-years
#10
Feng-Na Yu, Yun-Xia Shi, Hai-Ying Cheng, Xun-Lan Huang, Shan-Shan Liu
Little is known about the relationship serum uric acid (SUA) and hypertension in Chinese population. Therefore, the aim of this study was to determine the association between SUA and hypertension in a northern Chinese population. The participants were a group of 1730 Chinese adults aged 45 to 59 years in Shandong Province, who were recruited from the Linyi Nutrition and Health Survey (2015-2016). Hypertension was defined as systolic blood pressure ≥140 mm Hg and/or diastolic blood pressure ≥90 mm Hg...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28445310/diagnostic-accuracy-of-serum-alanine-aminotransferase-as-biomarker-for-nonalcoholic-fatty-liver-disease-and-insulin-resistance-in-healthy-subjects-using-3t-mr-spectroscopy
#11
Jose Luis Martin-Rodriguez, Jorge Gonzalez-Cantero, Alvaro Gonzalez-Cantero, Juan Pedro Arrebola, Jorge Luis Gonzalez-Calvin
Recognition of the close relationship of nonalcoholic fatty liver disease (NAFLD) with diabetes mellitus 2, obesity, metabolic syndrome, and cardiovascular disease has stimulated growing interest in NAFLD as a public health problem. Serum alanine aminotransferase (ALT) has been proposed as a marker of NAFLD, but levels are within the range currently considered "normal" in a large proportion of NAFLD subjects.The aim of the study was to determine the diagnostic accuracy of serum ALT for identifying individuals with NAFLD, using 3-Tesla (T) magnetic resonance spectroscopy (H-MRS)...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28445254/the-clinical-features-treatment-and-prognosis-of-primary-mediastinal-malignant-melanoma-a-case-report
#12
ZiHai Li, Hui Jia, Baijiang Zhang, Yongming Zhang, Hui Li, Pingping Song
RATIONALE: Primary malignant melanoma (MM) of the mediastinum is exceedingly rare; a review of the English-language literature reveals only a small number of case reports. In this paper, we discuss a case of primary mediastinal MM and present a review of the relevant literature on its clinical features and treatment. PATIENT CONCERNS: A 52-year-old male presenting with back pain was admitted to our hospital for treatment. Imaging examination revealed an anterior mediastinal mass and no evidence of other metastatic or primary lesions...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28445169/continuous-size-and-shape-control-synthesis-of-hollow-silica-nanoparticles-enabled-by-a-microreactor-assisted-rapid-mixing-process
#13
Yujuan He, Ki-Joong Kim, Chih-Hung Alex Chang
Hollow silica nanoparticles (HSNPs) were synthesized using a microreactor-assisted system with a hydrodynamic focusing micromixer (HFM). Due to the fast mixing of each precursor in the system, the PAA thermodynamic-locked (TML) conformations were protected from their random aggregations by the immediately initiated growth of silica shells. When altering the mixing time through varying flow rates and flow rate ratios, the different degrees of the aggregation of PAA TML conformations were observed. The globular and necklace-like TML conformations were successfully captured by modifying the PAA concentration at the optimized mixing condition...
April 26, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28445059/iron-catalyzed-dehydrogenative-sp-3-sp-2-coupling-via-direct-oxidative-c-h-activation-of-acetonitrile
#14
Huimin Su, Luyao Wang, Honghua Rao, Hao Xu
An iron-catalyzed dehydrogenative sp(3)-sp(2) coupling of acetonitrile and 2-arylimidazo[1,2-a]pyridine has been realized, which can serve as a novel approach toward heteroarylacetonitriles. The merit of this strategy is illustrated by the breadth of functional groups tolerated in the transformation and the fast access to pharmaceuticals (such as zolpidem) directly from the heteroarylacetonitriles.
April 26, 2017: Organic Letters
https://www.readbyqxmd.com/read/28445027/structurally-linked-dynamics-in-lactate-dehydrogenases-of-evolutionarily-distinct-species
#15
Matthew J Varga, Michael W Dzierlenga, Steven D Schwartz
We present new findings on how primary and secondary structure affects the role of fast protein motions in the reaction coordinates of enzymatic reactions. Using transition path sam- pling (TPS) and committor distribution analysis, we examined the difference in the role of these fast protein motions in the reaction coordinate of lactate dehydrogenases (LDH) of Api- complexa organisms Plasmodium falciparum and Cryptosporidium parvum. Having evolved separately from a common malate dehydrogenase ancestor, there are several important struc- tural differences between the two enzymes, notably a five amino acid insertion into the active site loop of P...
April 26, 2017: Biochemistry
https://www.readbyqxmd.com/read/28444863/the-prevalence-of-type-2-diabetes-in-urban-bo-sierra-leone-and-in-the-16-countries-of-the-west-africa-region
#16
Abu James Sundufu, Cecil N Bockarie, Kathryn H Jacobsen
BACKGROUND: The goal of this study was to measure the prevalence of diabetes among adults in urban Bo, Sierra Leone, and to compare the new result to the diabetes prevalence rates reported from studies across West Africa. METHODS: A total of 694 outpatients ages 18 and older at Bo Government Hospital were tested for diabetes between January 2012 and December 2014. Diabetes was defined as a fasting blood sugar level of ≥126 mg/dl (≥7.0 mmol/l). RESULTS: The overall prevalence of diabetes was 6...
April 26, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28444842/microwave-assisted-preparation-of-poly-ionic-liquid-modified-polystyrene-magnetic-nanospheres-for-phthalate-esters-extraction-from-beverages
#17
Gehui Liu, Ping Su, Lian Zhou, Yi Yang
The fabrication of novel poly(ionic liquid)-modified polystyrene magnetic nanospheres by a one-pot mini-emulsion copolymerization reaction was achieved through an efficient microwave-assisted synthesis method. The morphology, structure, and magnetic behavior of the as-prepared magnetic materials were characterized by using transmission electron microscopy, vibrating sample magnetometry, etc. The magnetic materials were utilized as sorbents for the extraction of phthalate esters from beverage samples followed by ultra-fast liquid chromatography analysis...
April 26, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28444834/direct-and-indirect-effects-of-attention-and-visual-function-on-gait-impairment-in-parkinson-s-disease-influence-of-task-and-turning
#18
Samuel Stuart, Brook Galna, Louise S Delicato, Sue Lord, Lynn Rochester
Gait impairment is a core feature of Parkinson's disease (PD) which has been linked to cognitive and visual deficits, but interactions between these features are poorly understood. Monitoring saccades allows investigation of real-time cognitive and visual processes and their impact on gait when walking. This study explored; 1) saccade frequency when walking under different attentional manipulations of turning and dual-task; and 2) direct and indirect relationships between saccades, gait impairment, vision and attention...
April 26, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28444808/fast-and-simple-discriminative-analysis-of-anthocyanins-containing-berries-using-lc-ms-spectral-data
#19
Heejung Yang, Hyun Woo Kim, Yong Soo Kwon, Ho Kyong Kim, Sang Hyun Sung
INTRODUCTION: Anthocyanins are potent antioxidant agents that protect against many degenerative diseases; however, they are unstable because they are vulnerable to external stimuli including temperature, pH and light. This vulnerability hinders the quality control of anthocyanin-containing berries using classical high-performance liquid chromatography (HPLC) analytical methodologies based on UV or MS chromatograms. OBJECTIVE: To develop an alternative approach for the quality assessment and discrimination of anthocyanin-containing berries, we used MS spectral data acquired in a short analytical time rather than UV or MS chromatograms...
April 25, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28444805/2d-multi-spectral-imaging-for-fast-mri-near-metal
#20
Brian A Hargreaves, Valentina Taviani, Daniel V Litwiller, Daehyun Yoon
PURPOSE: To develop a fast 2D method for MRI near metal with reduced B0 in-plane and through-slice artifacts. METHODS: Multi-spectral imaging (MSI) approaches reduce artifacts in MR images near metal, but require 3D imaging of multiple excited volumes regardless of imaging geometry or artifact severity. The proposed 2D MSI method rapidly excites a limited slice and spectral region using gradient reversal between excitation and refocusing pulses, then uses standard 2D imaging, with the process repeating to cover multiple spectral offsets that are combined as in other MSI techniques...
April 25, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
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