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https://www.readbyqxmd.com/read/28350804/syndecan-1-deficiency-promotes-tumor-growth-in-a-murine-model-of-colitis-induced-colon-carcinoma
#1
Adi Binder Gallimidi, Gabriel Nussbaum, Esther Hermano, Barak Weizman, Amichay Meirovitz, Israel Vlodavsky, Martin Götte, Michael Elkin
Syndecan-1 (Sdc1) is an important member of the cell surface heparan sulfate proteoglycan family, highly expressed by epithelial cells in adult organisms. Sdc1 is involved in the regulation of cell migration, cell-cell and cell-matrix interactions, growth-factor, chemokine and integrin activity, and implicated in inflammatory responses and tumorigenesis. Gastrointestinal tract represents an important anatomic site where loss of Sdc1 expression was reported both in inflammation and malignancy. However, the biological significance of Sdc1 in chronic colitis-associated tumorigenesis has not been elucidated...
2017: PloS One
https://www.readbyqxmd.com/read/28345571/laser-capsulotomy-following-cataract-surgery-comparing-time-to-capsulotomy-with-implantation-of-two-broadly-used-intraocular-lenses
#2
Yael Sharon, Eitan Livny, Michael Mimouni, Dov Weinberger, Irit Bahar
PURPOSE: The aim of this study is to compare the length of time from uneventful cataract surgery using one of two common posterior chamber intraocular lenses (IOLs) (hydrophilic versus hydrophobic acrylic) to laser capsulotomy. MATERIALS AND METHODS: Retrospective analysis of all patients who underwent neodymium: yttrium-aluminum-garnet laser capsulotomy between 2011 and 2014 following uneventful phacoemulsification surgery at a tertiary university-affiliated medical center...
February 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28344768/an-end-to-lifetime-blood-donation-ban-in-israel-for-msm-would-be-a-major-step-toward-a-science-based-policy-that-reduces-stigma
#3
EDITORIAL
Sean Cahill, Timothy Wang
In recent years, countries around the world have revised their blood donation policies regarding gay and bisexual men, and other men who have sex with men (MSM). The United States lifted the lifetime ban on MSM from donating blood in 2015, replacing it with a 1 year deferral policy allowing MSM to donate if they abstain from sex for 12 months. Other countries followed suit, while Italy and Spain have implemented deferral policies based on individual risk assessments regardless of sexual orientation. If Israel were to adopt a one year deferral policy for MSM, as recommended by Drs...
2017: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/28344758/no-evidence-of-early-head-circumference-enlargements-in-children-later-diagnosed-with-autism-in-israel
#4
Ilan Dinstein, Shlomi Haar, Shir Atsmon, Hen Schtaerman
BACKGROUND: Large controversy exists regarding the potential existence and clinical significance of larger brain volumes in toddlers who later develop autism. Assessing this relationship is important for determining the clinical utility of early head circumference (HC) measures and for assessing the validity of the early overgrowth hypothesis of autism, which suggests that early accelerated brain development may be a hallmark of the disorder. METHODS: We performed a retrospective comparison of HC, height, and weight measurements between 66 toddlers who were later diagnosed with autism and 66 matched controls...
2017: Molecular Autism
https://www.readbyqxmd.com/read/28344144/a-patient-specific-tailored-intervention-improves-inr-time-in-therapeutic-range-and-inr-variability-in-heart-failure-patients
#5
Israel Gotsman, Orly Ezra, Bruria Hirsh-Rokach, Dan Admon, Chaim Lotan, Freda DeKeyser Ganz
BACKGROUND: Many patients with heart failure need anticoagulants including Warfarin. Good control is particularly challenging in heart failure patients, with less than 60% of International Normalized Ratio (INR) measurements in the therapeutic range, thereby increasing the risk of complications. OBJECTIVE: To evaluate the effect of a patient-specific tailored intervention on anticoagulation control in patients with heart failure. METHODS: Patients with heart failure on Warfarin therapy (N=145) were randomized to either standard care or a one-time intervention assessing potential risk factors for lability of INR, where they received patient-specific instructions...
March 23, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28343693/utility-of-radiation-therapy-for-early-stage-uterine-papillary-serous-carcinoma
#6
Stephanie Cham, Yongmei Huang, Ana I Tergas, June Y Hou, William M Burke, Israel Deutsch, Cande V Ananth, Alfred I Neugut, Dawn L Hershman, Jason D Wright
OBJECTIVE: Early-stage uterine papillary serous carcinoma (UPSC) has a poor prognosis and high recurrence rate. While adjuvant chemotherapy is generally recommended, the role of radiation is uncertain. We examined the association between vaginal brachytherapy and whole pelvic radiation and survival in women treated with and without adjuvant chemotherapy. METHODS: The National Cancer Data Base was used to identify women with stage I-II UPSC treated between 1998 and 2012...
March 23, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28343099/source-apportionments-of-ambient-fine-particulate-matter-in-israeli-jordanian-and-palestinian-cities
#7
Jongbae Heo, Bo Wu, Ziad Abdeen, Radwan Qasrawi, Jeremy A Sarnat, Geula Sharf, Kobby Shpund, James J Schauer
This manuscript evaluates spatial and temporal variations of source contributions to ambient fine particulate matter (PM2.5) in Israeli, Jordanian, and Palestinian cities. Twenty-four hour integrated PM2.5 samples were collected every six days over a 1-year period (January to December 2007) in four cities in Israel (West Jerusalem, Eilat, Tel Aviv, and Haifa), four cities in Jordan (Amman, Aqaba, Rahma, and Zarka), and three cities in Palestine (Nablus, East Jerusalem, and Hebron). The PM2.5 samples were analyzed for major chemical components, including organic carbon and elemental carbon, ions, and metals, and the results were used in a positive matrix factorization (PMF) model to estimate source contributions to PM2...
March 23, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28343093/influence-of-genetic-variants-of-cyp2d6-cyp2c9-cyp2c19-and-cyp3a4-on-antiepileptic-drug-metabolism-in-pediatric-patients-with-refractory-epilepsy
#8
Miguel A López-García, Iris A Feria-Romero, Héctor Serrano, Darío Rayo-Mares, Pietro Fagiolino, Marta Vázquez, Consuelo Escamilla-Núñez, Israel Grijalva, David Escalante-Santiago, Sandra Orozco-Suarez
BACKGROUND: Identified the polymorphisms of CYP2D6, CYP2C9, CYP2C19 and CYP3A4, within a rigorously selected population of pediatric patients with drug-resistant epilepsy. METHOD: The genomic DNA of 23 drug-resistant epilepsy patients and 7 patients with good responses were analyzed. Ten exons in these four genes were genotyped, and the drug concentrations in saliva and plasma were determined. RESULTS: The relevant SNPs with pharmacogenomics relations were CYP2D6*2 (rs16947) decreased your activity and CYP2D6*4 (rs1065852), CYP2C19*2 (rs4244285) and CYP3A4*1B (rs2740574) by association with poor metabolizer...
January 19, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28342668/the-herd-effects-of-infant-pcv7-pcv13-sequential-implementation-on-adult-invasive-pneumococcal-disease-six-years-post-implementation-a-nationwide-study-in-israel
#9
Gili Regev-Yochay, Michal Katzir, Jacob Strahilevitz, Galia Rahav, Talya Finn, Dan Miron, Yasmin Maor, Bibiana Chazan, Yehudith Schindler, Ron Dagan
BACKGROUND: Introduction of pneumococcal conjugate vaccine (PCV) has nearly eliminated vaccine-type (VT) invasive pneumococcal disease (IPD) in children, yet the reported resulting reduction of adult IPD is variable. We present the indirect impact of sequential PCV7/PCV13 implementation in Israel on adult IPD. METHODS: An ongoing nationwide active surveillance was initiated on July 2009 when PCV7 was implemented (with Catch-up). PCV7 was gradually replaced by PCV13 since November 2010...
March 22, 2017: Vaccine
https://www.readbyqxmd.com/read/28342635/-nature-knows-no-boundaries-the-role-of-nature-conservation-in-peacebuilding
#10
Alexandre Roulin, Mansour Abu Rashid, Baruch Spiegel, Motti Charter, Amélie N Dreiss, Yossi Leshem
Humanity is facing a biodiversity crisis. To solve environmental problems, we bring people from Israel, Jordan, and the Palestinian Authority to the same table. Conservation efforts are beneficial for all communities and facilitate constructive dialog across divides in conflict zones. This pleads for the integration of nature conservation into peacebuilding interventions.
March 22, 2017: Trends in Ecology & Evolution
https://www.readbyqxmd.com/read/28342389/pilot-randomised-controlled-trial-comparing-the-risk-of-neonatal-respiratory-distress-in-elective-caesarean-section-at-38-weeks-gestation-following-a-course-of-corticosteroids-versus-caesarean-at-39-weeks
#11
Nicolas Sananès, Antoine Koch, Benoît Escande, Germain Aissi, Gabrielle Fritz, Emmanuel Roth, Michèle Weil, Ahmad Bakri, Chantal Bolender, Nicolas Meyer, Christophe Vayssiere, Adrien Gaudineau, Israël Nisand, Romain Favre, Pierre Kuhn, Bruno Langer
INTRODUCTION: The objective of this study was to compare neonatal respiratory morbidity and rate of emergency caesarean section between elective caesarean sections at 38 gestational weeks following a course of corticosteroids and planned caesarean sections at 39 gestational weeks. MATERIAL AND METHODS: This was a multicentre randomised controlled trial. The study was conducted between 2007 and 2013 in level 2 and 3 maternity units in France. A total of 208 women with an indication for elective caesarean section were enrolled and 200 analysed in per-protocol analysis...
March 10, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28340982/corrigendum-to-untangling-the-relatedness-among-correlations-part-i-nonparametric-approaches-to-inter-subject-correlation-analysis-at-the-group-level-neuroimage-in-press
#12
Gang Chen, Yong Wook Shin, Paul A Taylor, Daniel R Glen, Richard C Reynolds, Robert B Israel, Robert W Cox
No abstract text is available yet for this article.
January 15, 2017: NeuroImage
https://www.readbyqxmd.com/read/28340909/investigation-of-bias-related-to-differences-between-case-and-control-interview-dates-in-five-interphone-countries
#13
Michelle C Turner, Siegal Sadetzki, Chelsea E Langer, Rodrigo Villegas PhD, Jordi Figuerola, Bruce K Armstrong, Angela Chetrit, Graham G Giles, Daniel Krewski, Martine Hours, Mary L McBride, Marie-Elise Parent, Lesley Richardson, Jack Siemiatycki, Alistair Woodward, Elisabeth Cardis
PURPOSE: Associations between cellular telephone use and glioma risk have been examined in several epidemiological studies including the 13-country INTERPHONE study. Although results showed no positive association between cellular telephone use and glioma risk overall, no increased risk for long-term users, and no exposure-response relationship, there was an elevated risk for those in the highest decile of cumulative call time. However, results may be biased as data were collected during a period of rapidly increasing cellular telephone use, and as controls were usually interviewed later in time than cases...
December 2016: Annals of Epidemiology
https://www.readbyqxmd.com/read/28340462/assessment-of-arsenic-and-fluorine-in-surface-soil-to-determine-environmental-and-health-risk-factors-in-the-comarca-lagunera-mexico
#14
Yareli A Sariñana-Ruiz, Jorge Vazquez-Arenas, Fabiola S Sosa-Rodríguez, Israel Labastida, Ma Aurora Armienta, Antonio Aragón-Piña, Miguel A Escobedo-Bretado, Laura S González-Valdez, Patricia Ponce-Peña, Hugo Ramírez-Aldaba, René H Lara
Total, bioaccessible and mobile concentrations of arsenic and fluorine are determined in polluted surface soil within the Comarca Lagunera region using standardized protocols to obtain a full description of the environmental behavior for these elements. The composition of mineral phases associated with them is evaluated with microscopic and spectroscopic techniques. Mineralogical characterizations indicate that ultra-fine particles (<1-5 μm) including mimetite-vanadite (Pb5(AsO4)3Cl, Pb5(AsO4, VO4)3Cl)-like, lead arseniate (Pb3(AsO4)2)-like and complex arsenic-bearing compounds are main arsenic-bearing phases, while fluorite (CaF2) is the only fluorine-bearing phase...
March 10, 2017: Chemosphere
https://www.readbyqxmd.com/read/28338797/an-estimation-of-the-exposure-of-the-population-of-israel-to-natural-sources-of-ionizing-radiation
#15
L Epstein, J Koch, T Riemer, G Haquin, I Orion
The radiation dose to the population of Israel due to exposure to natural sources of ionizing radiation was assessed. The main contributor to the dose is radon that accounts for 60% of the exposure to natural sources. The dose due to radon inhalation was assessed by combining the results of a radon survey in single-family houses with the results of a survey in apartments in multi-storey buildings. The average annual dose due to radon inhalation was found to be 1.2 mSv. The dose rate due to exposure to cosmic radiation was assessed using a code that calculates the dose rate at different heights above sea level, taking into account the solar cycle...
February 18, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/28338430/trends-of-second-primary-malignancy-in-patients-with-thyroid-cancer-a-population-based-cohort-study-in-israel
#16
Elena Izkhakov, Micha Barchana, Irena Liphshiz, Barbara Silverman, Naftali Stern, Lital Keinan-Boker
BACKGROUND: Thyroid cancer (TC) is the most common endocrine malignancy. TC patients have a good prognosis and a low disease-related mortality rate. Since the patients are often young, they may be at a higher risk for a second primary malignancy (SPM). We sought to determine the incidence, risk and types of SPM between 1980-2011, and to assess SPM trends over time among Israeli TC patients. METHODS: Data were derived from the Israel National Cancer Registry. Primary TC patients diagnosed during 1980-2009 were followed-up for SPM incidence until December 31, 2011...
March 24, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28338243/influence-of-the-transition-metal-fragment-on-the-reactivity-of-metallaanthracenes
#17
Yago García-Rodeja, Israel Fernandez
The influence of the nature of the transition-metal fragment on the Diels-Alder reactivity of metallaanthracenes has been explored computationally within the Density Functional Theory framework. It is found that the cycloaddition reactions with maleic anhydride become kinetically less favored for those processes involving metallaanthracenes as compared to the analogous reaction involving the parent anthracene. The origins of this reduction in the Diels-Alder reactivity have been quantitatively analyzed in detail using the activation strain model of reactivity in combination with the energy decomposition analysis method...
March 24, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28337517/a-column-switching-ultrahigh-performance-liquid-chromatography-tandem-mass-spectrometry-method-to-determine-anandamide-and-2-arachidonoylglycerol-in-plasma-samples
#18
Camila Marchioni, Israel Donizeti de Souza, Caroline Fernandes Grecco, José Alexandre Crippa, Vitor Tumas, Maria Eugênia Costa Queiroz
This study reports a fast, sensitive, and selective column switching ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method to determine the endocannabinoids (eCBs), anandamide (AEA), and 2-arachidonoylglycerol (2-AG) in plasma samples. This bidimensional system used a restricted access media column (RP-8 ADS, 25 mm × 4 mm × 25 μM) in the first dimension and a core-shell Kinetex C18 (100 mm × 2, 1.7 mm × 1 μM) column in the second dimension, followed by detection in a mass spectrometer triple quadrupole (multiple reactions monitoring mode) operating in the positive mode...
March 23, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28336589/first-complete-genome-sequence-of-cucumber-green-mottle-mosaic-virus-isolated-from-australia
#19
Monica A Kehoe, Roger A C Jones, Brenda A Coutts
We present here the first complete genome sequence of the tobamovirus Cucumber green mottle mosaic virus (CGMMV) from Australia, obtained from an infected cucumber plant. Compared with other CGMMV genomes, its closest nucleotide identities were 99.6% to KP772568, 99.3% to KF155229, and 99.1% to DQ767631 from Canada, Israel, and India, respectively.
March 23, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28334503/the-fetal-safety-of-clomiphene-citrate-a-population-based-retrospective-cohort-study
#20
Asher Weller, Sharon Daniel, Gideon Koren, Eitan Lunenfeld, Amalia Levy
OBJECTIVE: To evaluate whether exposure to CC for ovulation induction is associated with either overall major malformations or specific fetal anomalies. DESIGN: We conducted a population-based retrospective cohort. Exposure was defined as CC dispension from two months before conception through the first month of pregnancy. SETTINGS: Four databases were combined: medication, birth, hospitalization and pregnancy terminations. POPULATION: The study included all women in southern Israel who gave birth or underwent pregnancy termination at Soroka Medical Center from 1998 to 2009...
March 23, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
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