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Y-Q Zhu, H Xing, D Dai, D F Kallmes, R Kadirvel
BACKGROUND AND PURPOSE: Vetebrobasilar dolichoectasia is characterized by arterial elongation, dilation, and tortuosity and leads to high risks of ischemic stroke. Our aim was to investigate the differential susceptibility to elastase-induced vertebrobasilar dolichoectasia induction in 2 different mouse strains. MATERIALS AND METHODS: Elastase (25 mU) was injected into the cisterna magna in C57BL/6J (n = 36) and 129/SvEv (SV129) (n = 36) mice. Control animals were injected with heat-inactivated elastase (n = 12 for each strain)...
December 15, 2016: AJNR. American Journal of Neuroradiology
P Bhogal, M Aguilar Pérez, O Ganslandt, H Bäzner, H Henkes, S Fischer
BACKGROUND AND PURPOSE: Non-saccular aneurysms of the posterior fossa are an uncommon pathology with no clear treatment strategy. The use of flow-diverting stents (FDS) has had mixed results. We sought to evaluate our experience of FDS for the treatment of this pathology. METHODS: We retrospectively reviewed our database of prospectively collected information for all patients treated only with flow diversion for an unruptured non-saccular aneurysm of the posterior circulation between February 2009 and April 2016...
November 11, 2016: Journal of Neurointerventional Surgery
Gordon S Crabtree, David Gish, David Goldberg
A 47-year-old male presented with a 2-year history of hemifacial spasm. Magnetic resonance imaging performed showed his tortuous basilar artery with nerve compression, and the patient was treated conservatively with botulinum toxin injections with complete resolution of symptoms. This rare disease was caused by his long history of hypertension, which led to his major basilar artery dolichoectasia.
2016: Journal of Community Hospital Internal Medicine Perspectives
Kavin Vanikieti, Piyaphon Cheecharoen, Panitha Jindahra, Sirin Lueangaram, Tanyatuth Padungkiatsagul
Vertebrobasilar dolichoectasia (VBD) is a rare dilative arteriopathy defined as elongation or widening of the intracranial vertebral and/or basilar arteries. The prevalence ranges from 0.06% to 5.8%. The majority of VBDs are asymptomatic. Downbeat nystagmus has been reported as a component of an infrequent ocular movement disorder in VBD. Nevertheless, oculopalatal tremor (OPT), delayed sequelae of a brainstem lesion, has never been demonstrated in VBD cases. Synchronized rhythmic involuntary contractions of the soft palate with an ocular pendular nystagmus, predominantly vertical pendular nystagmus, are the hallmark presentation...
2016: International Medical Case Reports Journal
Vicente Vanaclocha, Juan Manuel Herrera, Deborah Martínez-Gómez, Marlon Rivera-Paz, Cristina Calabuig-Bayo, Leyre Vanaclocha
BACKGROUND: surgical treatment of trigeminal neuralgia (TN) associated with vertebro-basilar dolichoectasia (VBD) is challenging. AIM: to analyze the treatments for this disease discussing its advantages and drawbacks, presenting our own technique and series. METHODS: retrospective study January 2006-January 2016. On pre and postop MRI images VBD deviation from midline, BA and VA diameter, and BA apex distance above posterior clinoid process were measured...
August 29, 2016: World Neurosurgery
Kyeong Joon Kim, Jong-Min Kim, Yun Jung Bae, Hee Joon Bae, Beomseok Jeon, Jae Hyung Kim, Jeong Ho Han, Chang Wan Oh
BACKGROUND: Hemifacial spasm (HFS) is frequently caused by vascular compression of the facial nerve. Vertebrobasilar dolichoectasia (VBDE) may cause vascular crowding in the limited space of the posterior fossa, increasing the chance of vascular compression of the facial nerve. We investigated the prevalence of VBDE in HFS. METHODS: We analyzed the presence of VBDE on 3.0 T magnetic resonance images in patients with HFS and control subjects; age, sex and hypertension were matched...
August 20, 2016: Parkinsonism & related Disorders
Jose Gutierrez, Khaled Menshawy, James Goldman, Andrew J Dwork, Mitchell S V Elkind, Randolph S Marshall, Susan Morgello
BACKGROUND:  This study tests the hypothesis that increased elastolytic activity is associated differentially with dolichoectasia in individuals with and those without human immunodeficiency virus (HIV) infection. METHODS:  Large arteries from 84 autopsied brains from HIV-positive individuals and 78 autopsied brains from HIV-negative individuals were stained for metalloproteinase 2 (MMP-2), MMP-3, MMP-9, tissue inhibitor of metalloproteinases 1 (TIMP-1), TIMP-2, CD68, and caspase 3...
November 1, 2016: Journal of Infectious Diseases
Ignacio Arrese, Rosario Sarabia
INTRODUCTION: Vertebrobasilar dolichoectasia is a condition in which there is elongation and dilatation of the vertebral and basilar arteries. Few studies have been reported that focus on cases of trigeminal neuralgia (TN) secondary to vertebrobasilar dolichoectasia (VD) and treated by microvascular decompression (MD). PATIENTS AND METHODS: A case is presented of trigeminal neuralgia caused by vertebral artery compression. An analysis of the microsurgical technique, as well as a systematic review of the literature about this uncommon nerve compression is performed, in order to investigate, by pooled case analysis, if MD is a good option for this type of patient...
July 18, 2016: Neurocirugía
Arseny A Sokolov, Shakir Husain, Roman Sztajzel, Alexandre Croquelois, Johannes A Lobrinus, David Thaler, Claudio Städler, Hansjörg Hungerbühler, Valeria Caso, Gabriel J Rinkel, Patrik Michel
Vertebrobasilar dolichoectasia (VBD) is a chronic disorder with various cerebrovascular and compressive manifestations, involving subarachnoid hemorrhage (SAH). Occurrence of SAH shortly after worsening of clinical VBD symptoms has occasionally been reported. The goal of the study was to examine this association, in particular its pathophysiology, clinical precursor signs, time course, and outcome.To this end, in a retrospective multicenter study, we analyzed 20 patients with VBD and SAH in regard to preceding clinical symptoms, presence of vertebrobasilar thrombosis and ischemia, outcome and neuropathological correlates...
July 2016: Medicine (Baltimore)
Yue-Qi Zhu, Da-Ying Dai, Hai-Xia Xing, Yong-Hong Ding, Ramanathan Kadirvel, David F Kallmes
OBJECTIVE: To assess the feasibility of using MicroFil polymer perfusion to detect concomitant saccular aneurysms in an intracranial arterial dolichoectasia (IADE) model in mice, and to report detailed histomorphometric features of these aneurysms. MATERIALS AND METHODS: IADE models were created in C57/BL6 mice via microsurgical injection of 25 mU elastase into the cisterna magna. The cerebral vasculature was perfused with MicroFil polymer and harvested at 1, 3, and 7 days, and 2 and 4 weeks (n=8 for each group)...
July 5, 2016: Journal of Neurointerventional Surgery
Mohammad Samim, Alan Goldstein, Joseph Schindler, Michele H Johnson
Vertebrobasilar dolichoectasia (VBD) is characterized by ectasia, elongation, and tortuosity of the vertebrobasilar arteries, with a high degree of variability in clinical presentation. The disease origin is believed to involve degeneration of the internal elastic lamina, thinning of the media secondary to reticular fiber deficiency, and smooth muscle atrophy. The prevalence of VBD is variable, ranging from 0.05% to 18%. Most patients with VBD are asymptomatic and their VBD is detected incidentally; however, it is important to recognize that the presence of symptoms, which can lead to clinically significant morbidity and sometimes mortality, may influence clinical management...
July 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
Xi Wu, Yanjun Li, Qinghai Huang, Jianmin Liu
BACKGROUND Vertebrobasilar dolichoectasia (VBD) is characterized by abnormal dilation, distortion, and extension of the vertebral artery (VA) and basilar artery (BA). This study investigated whether BA and VA morphological characteristics were factors predicting VBD. MATERIAL AND METHODS Individuals aged ≥18 years undergoing contrast-enhanced magnetic resonance angiography (CE-MRA) of the head/neck were enrolled in 2012 at Changhai Hospital, Shanghai. Data concerning cardiovascular risk factors were recorded...
May 21, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Mohammad Reza Najafi, Nafiseh Toghianifar, Morteza Abdar Esfahani, Mohammad Amin Najafi, Mohammad Javad Mollakouchakian
BACKGROUND: Vertebrobasilar dolichoectasia (VBD) is a rare vasculopathy. The etiology of this disease is unknown. Transient ischemic attacks (TIAs) of vertebrobasilar system refer to a transient (< 24 hours) lowering of blood flow in the posterior circulation of the brain. We present a case of dolichoectasia in the vertebrobasilar artery that presented with TIAs. CASE REPORT: A hypertensive 54-year-old man with true vertigo, nausea, imbalance, dysarthria, dysmetria, horizontal nystagmus, and gait ataxia was referred to Alzahra Hospital, Isfahan, Iran...
January 2016: ARYA Atherosclerosis
G Serebrinsky, M Calvo, S Fernandez, S Saito, K Ohno, E Wallace, D Warnock, H Sakuraba, J Politei
BACKGROUND: Screening for Fabry disease (FD) in high risk populations yields a significant number of individuals with novel, ultra rare genetic variants in the GLA gene, largely without classic manifestations of FD. These variants often have significant residual α-galactosidase A activity. The establishment of the pathogenic character of previously unknown or rare variants is challenging but necessary to guide therapeutic decisions. OBJECTIVES: To present 2 cases of non-classical presentations of FD with renal involvement as well as to discuss the importance of high risk population screenings for FD...
September 2015: Molecular Genetics and Metabolism Reports
Vikram Huded, Vikram Bohra, Jignesh Prajapati, Romnesh DeSouza, Ritesh Ramankutty
IMPORTANCE: In almost a third of stroke in young cases, etiology remains unclear. We report a radiological entity which might give a clue toward detection of late onset Pompe's disease in some cases. OBSERVATION: Here we report two cases of stroke in young in which evaluation led to diagnosis of late onset Pompe's disease. Both patients presented with recurrent stroke. On evaluation, one of them was found to have slowly progressive predominantly proximal quadriparesis...
April 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Federica Montagnese, Francesca Granata, Olimpia Musumeci, Carmelo Rodolico, Stefania Mondello, Emanuele Barca, Maria Cucinotta, Anna Ciranni, Marcello Longo, Antonio Toscano
BACKGROUND AND OBJECTIVES: Pompe disease is a rare metabolic disorder due to lysosomal alpha-glucosidase (GAA) deficiency. It is considered as a multi-systemic disease since, although glycogen accumulation is largely prominent in heart, skeletal and respiratory muscles, other organs can also be affected. As regards the vascular system, few reports have documented cerebrovascular malformations in Pompe patients. The aim of this study was to define the presence and type of intracranial arterial abnormalities in a cohort of late onset Pompe disease (LOPD) patients...
May 2016: Journal of Inherited Metabolic Disease
Jose Gutierrez, Khaled Menshawy, Marco Gonzalez, James Goldman, Mitchell S V Elkind, Randolph Marshall, Susan Morgello
OBJECTIVE: To test the hypothesis that brain arteries from HIV+ cases have a greater degree of inflammation than brain arteries from HIV- cases, and that inflammation is associated with brain arterial remodeling. DESIGN: Case-control study, cross-sectional. METHODS: Brain arteries from 162 autopsy cases (84 with HIV) were systematically analyzed for thickness of the intima, media, and adventitia, and atherosclerosis and dolichoectasia. Inflammation was assessed with CD68 immunohistochemistry, and measured with a semiquantitative score reflecting the number and location (i...
January 28, 2016: AIDS
Hidetoshi Matsukawa, Masaki Shinoda, Motoharu Fujii, Akihiro Uemura, Osamu Takahashi, Yasunari Niimi
OBJECT: Basilar dolichoectasia (BD) is an atherosclerotic, a distinct arteriopathy or a chronic-phase dissection characterized by elongation and dilation of the basilar artery. Spontaneous intradural vertebral artery dissection (siVAD) is an important cause of stroke in young and middle-aged people. It is hypothesized that the BD and the siVAD might partially share aetiologies and this study aimed to examine the relationship. METHODS: This study compared clinical and radiological characteristics in 93 patients with siVAD with 93 controls...
2016: Brain Injury: [BI]
Mustafa AbdelHamid, Kuruvilla John, Tanvir Rizvi, Nicholas Huff
Hemifacial spasm (HFS) happens because of vascular compression of the facial nerve at the root exit zone. Vertebrobasilar dolichoectasia (VBD) is a very rare cause of HFS. VBD is diagnosed by computed tomography angiography and magnetic resonance imaging. Here, we report a case of 65-year-old female patient with HFS due to VBD. We discuss the complications and the treatment options for the case.
December 2015: Radiology case reports
Jose Gutierrez, James Goldman, Andrew J Dwork, Mitchell S V Elkind, Randolph S Marshall, Susan Morgello
BACKGROUND: Cerebrovascular disease is a cause of morbidity in HIV-infected populations. The relationship among HIV infection, brain arterial remodeling, and stroke is unclear. METHODS: Large brain arteries (n = 1,878 segments) from 284 brain donors with and without HIV were analyzed to obtain media and wall thickness and lumen-to-wall ratio, and to determine the presence of atherosclerosis and dolichoectasia (arterial remodeling extremes). Neuropathologic assessment was used to characterize brain infarcts...
September 29, 2015: Neurology
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