keyword
MENU ▼
Read by QxMD icon Read
search

Brain tumor recurrence

keyword
https://www.readbyqxmd.com/read/27913480/thrombosis-in-the-setting-of-cancer
#1
Michael B Streiff
Venous thromboembolism (VTE) is a common cause of adverse outcomes in patients with cancer. The risk of VTE varies with cancer type, stage and grade, cancer therapy, and supportive care, as well as patient characteristics including age, ethnicity, and inherited and acquired comorbid conditions. VTE prophylaxis should be provided to all hospitalized cancer patients and high-risk outpatients. Low-molecular-weight heparin (LMWH) remains the first-line therapy for VTE in patients with active cancer. Anticoagulation should be continued as long as there is evidence of active disease or patients are receiving cancer treatment...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27903179/gamma-knife-radiosurgery-for-brain-metastases-from-pulmonary-large-cell-neuroendocrine-carcinoma-a-japanese-multi-institutional-cooperative-study-jlgk1401
#2
Takuya Kawabe, Masaaki Yamamoto, Yasunori Sato, Shoji Yomo, Takeshi Kondoh, Osamu Nagano, Toru Serizawa, Takahiko Tsugawa, Hisayo Okamoto, Atsuya Akabane, Kazuyasu Aita, Manabu Sato, Hidefumi Jokura, Jun Kawagishi, Takashi Shuto, Hideya Kawai, Akihito Moriki, Hiroyuki Kenai, Yoshiyasu Iwai, Masazumi Gondo, Toshinori Hasegawa, Soichiro Yasuda, Yasuhiro Kikuchi, Yasushi Nagatomo, Shinya Watanabe, Naoya Hashimoto
OBJECTIVE In 1999, the World Health Organization categorized large cell neuroendocrine carcinoma (LCNEC) of the lung as a variant of large cell carcinoma, and LCNEC now accounts for 3% of all lung cancers. Although LCNEC is categorized among the non-small cell lung cancers, its biological behavior has recently been suggested to be very similar to that of a small cell pulmonary malignancy. The clinical outcome for patients with LCNEC is generally poor, and the optimal treatment for this malignancy has not yet been established...
December 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27903177/follow-up-results-of-brain-metastasis-patients-undergoing-repeat-gamma-knife-radiosurgery
#3
Takao Koiso, Masaaki Yamamoto, Takuya Kawabe, Shinya Watanabe, Yasunori Sato, Yoshinori Higuchi, Tetsuya Yamamoto, Akira Matsumura, Hidetoshi Kasuya
OBJECTIVE Stereotactic radiosurgery (SRS) without upfront whole-brain radiotherapy (WBRT) has influenced recent treatment recommendations for brain metastasis patients. However, in brain metastasis patients who undergo SRS alone, new brain metastases inevitably appear with relatively high incidences during post-SRS follow-up. However, little is known about the second SRS results. The treatment results of second SRS were retrospectively reviewed, mainly for newly developed or, uncommonly, for recurrent brain metastases in order to reappraise the efficacy of this treatment strategy with a special focus on the maintenance of neurological status and safety...
December 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27900644/elevated-levels-of-p-mnk1-p-eif4e-and-p-p70s6k-proteins-are-associated-with-tumor-recurrence-and-poor-prognosis-in-astrocytomas
#4
Weibing Fan, Weiyuan Wang, Xinfa Mao, Shuzhou Chu, Juan Feng, Desheng Xiao, Jianhua Zhou, Songqing Fan
Malignant astrocytomas are able to invade neighboring and distant areas of the normal brain. Signaling pathway alterations play important role in the development of astrocytomas. Deregulation of eukaryotic translation initiation factor 4E (eIF4E) by MAP kinase-interacting kinases (Mnk) on Ser-209 directly or PI3K/mTOR/S6K pathway indirectly has a critical effect on promoting cellular proliferation, malignant transformation and metastasis. We examined and analyzed the correlation between expression of p-Mnk1, p-eIF4E and p-p70S6K proteins and clinicopathological features in 103 astrocytomas and 54 non-tumorous brain tissues...
November 29, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27900341/subventricular-zone-associated-glioblastoma-a-call-for-translational-research-to-guide-clinical-decision-making
#5
Andrew W Smith, Bhupesh Parashar, A Gabriella Wernicke
Glioblastoma (GBM) is both the most common and the most devastating primary cancer of the central nervous system, with an expected overall survival in most patients of about 14 months. Despite extensive research, outcomes for GBM have been largely unchanged since the introduction of temozolomide in 2005. We believe that in order to achieve a breakthrough in therapeutic management, we must begin to identify subtypes of GBM, and tailor treatment to best target a particular tumor's vulnerabilities. Our group has recently produced an examination of the clinical outcomes of radiation therapy directed at tumors that contact the subventricular zone (SVZ), the 3-5 mm lateral border of the lateral ventricles that contains the largest collection of neural stem cells in the adult brain...
2016: Neurogenesis (Austin, Tex.)
https://www.readbyqxmd.com/read/27899882/tumor-metabolism-the-ketogenic-diet-and-%C3%AE-hydroxybutyrate-novel-approaches-to-adjuvant-brain-tumor-therapy
#6
REVIEW
Eric C Woolf, Nelofer Syed, Adrienne C Scheck
Malignant brain tumors are devastating despite aggressive treatments such as surgical resection, chemotherapy and radiation therapy. The average life expectancy of patients with newly diagnosed glioblastoma is approximately ~18 months. It is clear that increased survival of brain tumor patients requires the design of new therapeutic modalities, especially those that enhance currently available treatments and/or limit tumor growth. One novel therapeutic arena is the metabolic dysregulation that results in an increased need for glucose in tumor cells...
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/27895770/classical-intracranial-chondrosarcoma-a-case-report
#7
Jingyang Chi, Mingchao Zhang, Jianmin Kang
Intracranial chondrosarcoma is a rare malignant cartilage-forming tumor, with only a small number of cases in the posterior cranial fossa reported previously. The present study reports the case of a 40-year-old male patient who was admitted to Tianjin Huanhu Hospital with a progressive headache and dizziness that had lasted for 2 years. Physical and neurological examinations were normal. Radiography of the skull identified an opaque lesion in the left frontal region of the brain. Cranial computed tomography and magnetic resonance imaging revealed a lesion with calcification and homogenous contrast enhancement in the left frontal region...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27894339/the-identification-of-human-pituitary-adenoma-initiating-cells
#8
Branavan Manoranjan, Sujeivan Mahendram, Saleh A Almenawer, Chitra Venugopal, Nicole McFarlane, Robin Hallett, Thusyanth Vijayakumar, Almunder Algird, Naresh K Murty, Doron D Sommer, John P Provias, Kesava Reddy, Sheila K Singh
Classified as benign central nervous system (CNS) tumors, pituitary adenomas account for 10% of diagnosed intracranial neoplasms. Although surgery is often curative, patients with invasive macroadenomas continue to experience significant morbidity and are prone to tumor recurrence. Given the identification of human brain tumor-initiating cells (TICs) that initiate and maintain tumor growth while promoting disease progression and relapse in multiple CNS tumors, we investigated whether TICs also drive the growth of human pituitary adenomas...
November 28, 2016: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/27885954/novel-biomarker-identification-using-metabolomic-profiling-to-differentiate-radiation-necrosis-and-recurrent-tumor-following-gamma-knife-radiosurgery
#9
Alex Y Lu, Jack L Turban, Eyiyemisi C Damisah, Jie Li, Ahmed K Alomari, Tore Eid, Alexander O Vortmeyer, Veronica L Chiang
OBJECTIVE Following an initial response of brain metastases to Gamma Knife radiosurgery, regrowth of the enhancing lesion as detected on MRI may represent either radiation necrosis (a treatment-related inflammatory change) or recurrent tumor. Differentiation of radiation necrosis from tumor is vital for management decision making but remains difficult by imaging alone. In this study, gas chromatography with time-of-flight mass spectrometry (GC-TOF) was used to identify differential metabolite profiles of the 2 tissue types obtained by surgical biopsy to find potential targets for noninvasive imaging...
November 25, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27885545/optimization-of-scan-initiation-timing-after-11-c-methionine-administration-for-the-diagnosis-of-suspected-recurrent-brain-tumors
#10
Reiko Nakajima, Koichiro Abe, Mitsuru Momose, Kenji Fukushima, Yuka Matsuo, Ken Kimura, Chisato Kondo, Shuji Sakai
OBJECTIVE: (11)C-Methionine (MET) positron emission tomography (PET) imaging is a valuable technique for the evaluation of primary and recurrent brain tumors. Many studies have used MET-PET for data acquisition starting at 20 min after the tracer injection, while others have used scan initiation times at 5-15 min postinjection. No previous studies have identified the best acquisition timing during MET-PET imaging for suspected recurrent brain tumors. Here we sought to determine the optimal scan initiating timing after MET administration for the detection of recurrent brain tumors...
November 24, 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27879538/efficacy-of-ifosfamide-cisplatin-etoposide-ice-chemotherapy-for-a-cns-germinoma-in-a-child-with-down-syndrome
#11
Seishiro Nodomi, Katsutsugu Umeda, Hiroo Ueno, Satoshi Saida, Hidefumi Hiramatsu, Takeshi Funaki, Yoshiki Arakawa, Takashi Mizowaki, Souichi Adachi, Toshio Heike
Intracranial germ cell tumor is sometimes associated with Down syndrome; however, no optimal treatment has been developed due to the high risk of recurrence and treatment-related mortality. Here, we report on a patient with an intracranial germinoma in the bilateral basal ganglia. The patient received 3 courses of ifosfamide-cisplatin-etoposide in combination with whole-brain irradiation (24 Gy), with no serious complications. The patient is alive and disease free 16 months after the initial diagnosis. This regimen is a feasible treatment for intracranial germ cell tumor associated with Down syndrome, although careful attention must be paid to the increased risk for severe infection...
November 22, 2016: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/27877908/an-immuno-wall-microdevice-exhibits-rapid-and-sensitive-detection-of-idh1-r132h-mutation-specific-to-grade-ii-and-iii-gliomas
#12
Akane Yamamichi, Toshihiro Kasama, Fumiharu Ohka, Hiromichi Suzuki, Akira Kato, Kazuya Motomura, Masaki Hirano, Melissa Ranjit, Lushun Chalise, Michihiro Kurimoto, Goro Kondo, Kosuke Aoki, Noritada Kaji, Manabu Tokeshi, Toshio Matsubara, Takeshi Senga, Mika K Kaneko, Hidenori Suzuki, Masahito Hara, Toshihiko Wakabayashi, Yoshinobu Baba, Yukinari Kato, Atsushi Natsume
World Health Organization grade II and III gliomas most frequently occur in the central nervous system (CNS) in adults. Gliomas are not circumscribed; tumor edges are irregular and consist of tumor cells, normal brain tissue, and hyperplastic reactive glial cells. Therefore, the tumors are not fully resectable, resulting in recurrence, malignant progression, and eventual death. Approximately 69-80% of grade II and III gliomas harbor mutations in the isocitrate dehydrogenase 1 gene (IDH1), of which 83-90% are found to be the IDH1-R132H mutation...
2016: Science and Technology of Advanced Materials
https://www.readbyqxmd.com/read/27876660/total-resection-of-brainstem-extension-of-tentorial-schwannoma-using-an-occipital-trans-tentorial-approach-a-case-report
#13
Liu Xinrui, Yuichi Sato, Mitsuru Dan, Hiroki Kuroda, Toshihiro Kumabe
BACKGROUND: Approximately 60 cases of schwannoma unrelated to the cranial nerve have been reported, and only 12 arose from the tentorium. We present a case of tentorial schwannoma extending into the pons and midbrain without cranial nerve involvement, which was almost totally resected through an occipital trans-tentorial approach. CASE DESCRIPTION: A 37-year-old man was admitted to our institution with memory disturbance beginning 2 years ago and gait disturbance from one year ago...
November 19, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27872484/co-occurrence-of-local-anisotropic-gradient-orientations-collage-a-new-radiomics-descriptor
#14
Prateek Prasanna, Pallavi Tiwari, Anant Madabhushi
In this paper, we introduce a new radiomic descriptor, Co-occurrence of Local Anisotropic Gradient Orientations (CoLlAGe) for capturing subtle differences between benign and pathologic phenotypes which may be visually indistinguishable on routine anatomic imaging. CoLlAGe seeks to capture and exploit local anisotropic differences in voxel-level gradient orientations to distinguish similar appearing phenotypes. CoLlAGe involves assigning every image voxel an entropy value associated with the co-occurrence matrix of gradient orientations computed around every voxel...
November 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27871894/optimizing-gdna-extraction-from-fresh-frozen-meningioma-tissue-for-downstream-genetic-analysis
#15
D T Proctor, E H Yoo, Z Vujadinovic, S Lama, G van Marle, G R Sutherland
OBJECTIVE: Meningioma is the most common brain tumor. Genetic mutations in meningioma that include deletion of the neurofibromatosis type 2 gene, (NF2), offer diagnostic information on tumor behavior, recurrence and potential response to treatment. Obtaining high-grade genetic material is critical for accurate, sensitive and robust molecular testing. Currently, no standardized procedure exists for extracting gDNA from meningioma, and this problem was addressed in this report. METHOD: This study compared the yield and quality of extracted gDNA from patient meningioma specimens using an optimized phenol chloroform method and two commercial silica column-based extractions kits and tested respective performances as template in qPCR tests and multiplex ligation-dependent probe amplification (MLPA) NF2 screening...
November 19, 2016: Clinical Biochemistry
https://www.readbyqxmd.com/read/27867926/a-case-of-solitary-brain-metastasis-from-uterine-mullerian-adenosarcoma-with-sarcomatous-overgrowth
#16
Suk Bo Hong, Min Jung Kim, Ji Yeon Kwon, Seok Jin Choi, Eun Young Kim, Joohan Lim
Uterine adenosarcoma (AS) are rare tumors and have more favorable outcomes than the aggressive uterine carcinosarcomas. Uterine adenosarcoma with sarcomatous overgrowth (ASSO) is a variant form of AS and exhibits aggressive growth of tumor and the prognosis is relatively poor compared with typical AS. Usually patterns of metastasis have been known to behave like endometrial carcinoma and spread through the lymphatics. Brain metastasis from uterine AS is extremely rare. Herein, we report a case of successfully surgically removed solitary brain metastasis without any extracranial recurrence from uterine ASSO after 4 years of primary treatment...
October 2016: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/27867924/metastatic-intracranial-hemangiopericytoma-to-the-spinal-column-a-case-report
#17
Myung Sung Joo, Young Joon Rho, Sang Woo Song, Young-Cho Koh, Hong Gee Roh, So-Dug Lim
Intracranial hemangiopericytoma (HPC) is a rare brain tumor with aggressive biologic behavior associated with high recurrence rate and often with extracranial metastasis. The most common sites of extracranial metastasis of the intracranial HPC are the long bones, lung, liver and abdominal cavity in the order of frequencies. Extracranial metastases usually occur long after the initial diagnosis of the primary tumor. Metastatic intracranial HPC to the vertebra has been rarely reported. We present a case of intracranial HPC metastasized to the L2 vertebral body 13 years after multiple surgical resections and radiotherapy of the primary intracranial HPC...
October 2016: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/27867922/palliative-resection-of-metastatic-brain-tumors-previously-treated-by-stereotactic-radiosurgery
#18
Yoo Sung Jeon, Young-Cho Koh, Sang Woo Song, Joon Cho, So Dug Lim
BACKGROUND: Therapeutic approaches to brain metastases include surgery, whole-brain radiotherapy, stereotactic radiosurgery (SRS), and combination therapy. Recently, postoperative or preoperative SRS draws more attention to reduce postoperative recurrence in brain metastases. The goal of this study is to review surgical outcome of patients who had been treated by SRS, and to discuss the effectiveness of preoperative SRS. METHODS: From 2009 to 2015, 174 patients were treated by SRS for brain metastases, and among these 50 patients underwent surgery...
October 2016: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/27867918/clinical-and-radiological-characteristics-of-angiomatous-meningiomas
#19
Juyoung Hwang, Doo-Sik Kong, Ho Jun Seol, Do-Hyun Nam, Jung-Il Lee, Jung Won Choi
BACKGROUND: Angiomatous meningioma is a rare histological subtype of meningioma. Therefore, this specific medical condition is rarely reviewed in the literature. In the present work, we report the clinical and radiological features with postoperative outcomes of angiomatous meningioma. METHODS: This retrospective study included the patients who were pathologically diagnosed with angiomatous meningioma after surgical resection between February 2010 and September 2015 in our institute...
October 2016: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/27864705/the-clinical-and-financial-impact-of-a-pediatric-surgical-neuro-oncology-clinical-trial
#20
Eric M Thompson, Sridharan Gururangan, Gerald Grant, Duane Mitchell, John H Sampson
Pediatric surgical trials are rare and the impact of such trials on the institutions in which they are conducted is unknown. The purpose of this study was to analyze the clinical and financial impact of The Re-MATCH trial, a Phase I clinical trial requiring the biopsy or resection of recurrent medulloblastoma or PNET for enrollment. Inpatient financial and clinical volume information was collected during the 3 years of trial enrollment and the years preceding and following it. The primary endpoints were the difference in direct contribution margin (DCM), or net gain, of study and non-study patients and the difference in surgical volume during the study and non-study periods...
November 18, 2016: Journal of Neuro-oncology
keyword
keyword
23630
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"