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Fibroadenoma breast

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https://www.readbyqxmd.com/read/29156385/interaction-with-the-gdf8-11-pathway-reveals-treatment-options-for-adenocarcinoma-of-the-breast
#1
Christoph Wallner, Marius Drysch, Mustafa Becerikli, Henriette Jaurich, Johannes Maximilian Wagner, Stephanie Dittfeld, Julia Nagler, Kamran Harati, Mehran Dadras, Stathis Philippou, Marcus Lehnhardt, Björn Behr
Breast adenocarcinoma continues to be the most frequently diagnosed tumor entity. Despite established therapy options, mortality for breast cancer remains to be as high as 40,000 patients in the US annually. Thus, a need to develop a patient-oriented, targeted therapy exists. In this study, we investigated the interaction of breast adenocarcinoma with the ubiquitously present protein Follistatin and subsequently the GDF8/11 pathway. We analyzed primary histological samples from adenocarcinoma patients for expression of Follistatin and GDF8/11...
November 17, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29137236/the-nucleocytoplasmic-translocation-and-up-regulation-of-ing5-protein-in-breast-cancer-a-potential-target-for-gene-therapy
#2
Xiao-Qing Ding, Shuang Zhao, Lei Yang, Xin Zhao, Gui-Feng Zhao, Shu-Peng Zhao, Zhi-Jie Li, Hua-Chuan Zheng
Here, we found that ING5 overexpression resulted in a lower proliferation, reduced glucose metabolism, S arrest, decreased migration and invasion, apoptotic induction, fat accumulation, autophagy, senescence and mesenchymal-epithelial-transition of breast cancer cells. It also suppressed the tumor growth of breast cancer cells by inhibiting proliferation, inducing apoptosis and autophagy. ING5-mediated chemoresistance was positively linked to Akt and NF-κB activation, MRP1 and GST-π overexpression, and FBXW7 hypoexpression...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29128819/the-saw-tooth-operation-for-giant-fibroadenomas
#3
Vijay Naraynsingh, Lemuel Pran, Shariful Islam, Shamir Cawich
Fibroadenomas are the most common benign breast lesions affecting adolescents and young women. Cosmesis is an important factor when considering surgical management for these masses. Giant fibroadenomas (>5cm), because of their size, may require larger incisions resulting in significant scarring and scar complications in these young women. Several approaches have been employed, usually involving large incisions, when performing a lumpectomy for giant fibroadenomas. In this report, we highlight a new technique for removal of these masses, which allows the removal of large fibroadenomas through a relatively small, cosmetically acceptable, circumareolar incision...
November 8, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29108303/anesthetic-dreaming-anesthesia-awareness-and-patient-satisfaction-after-deep-sedation-with-propofol-target-controlled-infusion-a-prospective-cohort-study-of-patients-undergoing-day-case-breast-surgery
#4
Marco Cascella, Roberta Fusco, Domenico Caliendo, Vincenza Granata, Domenico Carbone, Maria Rosaria Muzio, Giuseppe Laurelli, Stefano Greggi, Francesca Falcone, Cira Antonietta Forte, Arturo Cuomo
Background: Anesthetic dreaming and anesthesia awareness are well distinct phenomena. Although the incidence of intraoperative awareness is more common among patients who reported a dream after surgery, the exact correlation between the two phenomena remains an unsolved rebus. The main purpose of this study was to investigate anesthetic dreaming, anesthesia awareness and psychological consequences eventually occurred under deep sedation. Intraoperative dreaming experiences were correlated with dream features in natural sleep...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29082377/sub-classification-of-breast-masses-by-fine-needle-aspiration-cytology
#5
C I Madubogwu, C O Ukah, Snc Anyanwu, G U Chianakwana, I V Onyiaorah, Dcd Anyiam
OBJECTIVE: The aim of this study is to evaluate the accuracy of sub-classification of breast diseases using Fine Needle Aspiration cytology (FNAC). MATERIALS AND METHODS: A one-year prospective study of 180 consecutive patients with palpable breast lesions who underwent FNAC and subsequently open surgical biopsy for histological confirmation. FNAC was used to sub-classify breast lesions and then correlated with histological diagnosis. RESULTS: A total of 180 patients were enrolled into the study but only 110 patients with histology report were used for test validity...
October 2017: Eur J Breast Health
https://www.readbyqxmd.com/read/29080125/clinical-breast-concerns-in-low-risk-pediatric-patients-practice-review-with-proposed-recommendations
#6
Linda M Sanders, Pinky Sharma, Miriam El Madany, Alexander B King, Koren S Goodman, Alison Esteva Sanders
BACKGROUND: Fibroadenoma is overwhelmingly the most common pediatric breast lesion. Breast malignancy is quite uncommon in children, most frequently metastatic or hematological malignancy. Core biopsy has largely replaced excision for diagnosis of breast masses in adults. OBJECTIVE: The purpose of this study is two-fold: (1) compare utilization at our institution of interventional procedures vs. surgery for breast mass diagnosis in patients ≤18 years and (2) propose guidelines for breast imaging and biopsy in this population...
October 27, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/29070987/results-of-short-term-follow-up-in-bi-rads-3-and-4a-breast-lesions-with-a-histological-diagnosis-of-fibroadenoma-at-percutaneous-needle-biopsy
#7
Paola Clauser, Massimo Bazzocchi, Magda Marcon, Viviana Londero, Chiara Zuiani
OBJECTIVE: To evaluate the usefulness of short-term (6 months) follow-up in patients with Breast Imaging Report and Data System (BI-RADS) 3 and 4a lesions, after a diagnosis of fibroadenoma at an image-guided biopsy. PATIENTS AND METHODS: The data of 318 women with 349 biopsy-proven fibroadenomas, a 6-month follow-up, and a follow-up of ≥ 24 months were retrospectively reviewed. Information on clinical history, lesion characteristics on ultrasound (US), mammography, and magnetic resonance imaging (MRI), BI-RADS classification, and follow-up was collected...
September 2017: Breast Care
https://www.readbyqxmd.com/read/29043292/phyllodes-tumors-with-and-without-fibroadenoma-like-areas-display-distinct-genomic-features-and-may-evolve-through-distinct-pathways
#8
Fresia Pareja, Felipe C Geyer, Rahul Kumar, Pier Selenica, Salvatore Piscuoglio, Charlotte K Y Ng, Kathleen A Burke, Marcia Edelweiss, Melissa P Murray, Edi Brogi, Britta Weigelt, Jorge S Reis-Filho
Breast fibroepithelial lesions (fibroadenomas and phyllodes tumors) are underpinned by recurrent MED12 exon 2 mutations, which are more common in fibroadenomas and benign phyllodes tumors. TERT promoter hotspot mutations have been documented in phyllodes tumors, and found to be more frequent in borderline and malignant lesions. Several lines of evidence suggest that a subset of phyllodes tumors might arise from fibroadenomas. Here we sought to investigate the genetic differences between phyllodes tumors with fibroadenoma-like areas vs...
2017: NPJ Breast Cancer
https://www.readbyqxmd.com/read/29033391/breast-diseases-in-children-the-spectrum-of-radiologic-findings-in-a-cohort-study
#9
Emel Durmaz, Murat Alp Öztek, Hatice Arıöz Habibi, Uğur Kesimal, Hakkı Timur Sindel
PURPOSE: We aimed to investigate the spectrum of radiologic findings and referral reasons for breast diseases in children considering age-appropriate presentation. METHODS: Our retrospective cohort study included 348 consecutive pediatric patients aged <19 years (median, 13 years) referred to radiology with a clinical presentation between 2005 and 2016. Radiologic findings were reviewed in four age ranges (0-2 years, 2-8 years, 8-15 years, >15 years). RESULTS: Of 348 patients, 257 had a referral reason...
November 2017: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/29024205/the-intact-%C3%A2-breast-lesion-excision-system-as-a-therapeutic-device-for-selected-benign-breast-lesions
#10
Miri Sklair-Levy, Shlomi Rayman, Ady Yosepovich, Andrew Zbar, David Goitein, Douglas Zippel
The aim of this paper is to evaluate our Unit's initial experience using the Intact breast lesion excision system as a therapeutic excision option for benign or borderline breast lesions, which otherwise would entail open operative excision. The study includes the first 111 patients who underwent therapeutic excision with the intact radiofrequency system between December 2012 and May 2016 performed at the Meirav Center for Breast Health, at the Chaim Sheba Medical Center, Ramat Gan Israel. The indications for the procedure included those patients who have benign, or atypical high risk lesions following a previous core needle biospy (CNB) who would have normally undergone conventional excision biopsy...
October 11, 2017: Breast Journal
https://www.readbyqxmd.com/read/29023075/evaluation-of-mir-21-and-mir-10b-expression-of-human-breast-cancer-in-west-sumatera
#11
Yanwirasti, Wirsma A Harahap, Dessy Arisanty
BACKGROUND: Abnormal expression of several microRNAs (miRNAs) has been demonstrated in many types of cancer tumor tissue. The miR-10b and miR-21 are an oncogenic miRNAs which play role in proliferation and invasion of Breast Cancer (BC) tumorigenesis. The aim of this study was to evaluate the miR-21 and miR-10b expression in BC in West Sumatran women, Indonesia. MATERIALS AND METHODS: A total of 40 samples, consisting of 30 samples of breast cancer tissues (BC) and 10 samples of fibroadenoma tissues (FATs) as control and non-cancerous were analyzed...
2017: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/29016373/cancer-yield-of-incidental-breast-lesions-detected-on-chest-computed-tomography
#12
Terrance T Healey, Saurabh Agarwal, Ronak Patel, Lisa Ratanaprasatporn, Linda Ratanaprasatporn, Ana P Lourenco
OBJECTIVE: This study aimed to determine the cancer yield for abnormal breast findings initially identified on chest computed tomography (CT). MATERIALS AND METHODS: This institutional review board-approved, Health Insurance Portability and Accountability Act-compliant study retrospectively reviewed reports of 41,217 consecutive chest CT examinations done from January 1, 2006, to December 31, 2011, to identify those with breast findings noted in the impression of the report...
October 7, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28974914/a-case-report-of-juvenile-giant-fibroadenoma-of-the-breast-how-common
#13
C A Mohd Firdaus, A J Norjazliney, Nor Faezan Abdul Rashid
Breast lesions are rare prepubescents. The majority of breast lesions in this age group are benign. The most common of these rare lesions is juvenile fibroadenoma, which accounts for only 0.5% of all fibroadenomas. It is uncommon to have a palpable lesion in juveniles as very small lesions show obvious asymmetry. Fibroadenomas can grow to a large size, and surgical intervention is cosmetically challenging, especially in achieving symmetry in a developing breast. A 12-year-old girl presented with right breast swelling associated with tenderness...
July 2017: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
https://www.readbyqxmd.com/read/28964575/dip2c-expression-in-breast-cancer-and-its-clinical-significance
#14
Jing Li, Jin Liang Ping, Bo Ma, Ying Rong Chen, Li Qin Li
INTRODUCTION: The aim of this study was to investigate DIP2C expression in different subtypes of breast cancer tissues and cell lines and its correlation with clinicopathologic and histopathological features, in an effort to elucidate the DIP2C expression profile in breast cancer and its clinical significance. METHODS: Hereby, we investigated the DIP2C expression in breast cancer tissues using TMA-IHC method and the DIP2C expression in breast cell lines using quantitative RT-PCR...
September 12, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28941757/contrast-enhanced-spectral-mammography-as-work-up-tool-in-patients-recalled-from-breast-cancer-screening-has-low-risks-and-might-hold-clinical-benefits
#15
I P L Houben, P Van de Voorde, C R L P N Jeukens, J E Wildberger, L F Kooreman, M L Smidt, M B I Lobbes
OBJECTIVE: Contrast-enhanced spectral mammography (CESM) is a reliable problem solving tool in the work-up of women recalled from breast cancer screening. We evaluated additional findings caused by CESM alone and outweighed them against the disadvantages of this technique. METHODS: From December 2012 to December 2015, all women recalled from screening who underwent CESM were considered for this study. Radiation exposure and number of adverse contrast reactions were analysed...
September 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28930603/centchroman-a-safe-reversible-postcoital-contraceptive-with-curative-and-prophylactic-activity-in-many-disorders
#16
Ved P Kamboj, Suprabhat Ray, Nitya Anand
Centchroman (INN: Ormeloxifene), a reversible post-coital/weekly oral contraceptive (half-life of about 168 hours), designed and developed at CDRI, Lucknow is the only non-steroidal oral contraceptive in clinical use in the world today. Synthesized in 1967 and completing pre-clinical and clinical studies in 1989, this drug was approved for marketing in 1991, social marketing in 1995 and NFPW in April 2016. It acts by preventing implantation of blastocyst in endometrium. It is the only contraceptive which neither suppresses ovulation nor interferes with the hypothalamic-pituitary-ovarian axis...
January 1, 2018: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/28911335/mammary-phyllodes-tumor-with-six-episodes-of-a-relapse-a-case-report
#17
Nozomi Iimori, Shinichiro Kashiwagi, Tetsuro Ishikawa, Hidemi Kawajiri, Tsutomu Takashima, Masahiko Ohsawa, Kosei Hirakawa, Masaichi Ohira
BACKGROUND: Phyllodes tumor is a rare breast mass. Most phyllodes tumors are benign, but occasionally some show malignancy. Even if the tumors are benign, they can easily show recurrence. CASE PRESENTATION: We report a case of a 48-year-old Asian woman, who had previously undergone a tumorectomy of her left breast 12 years before, with a pathological diagnosis of fibroadenoma. Five years after the initial tumorectomy, the patient presented with an abnormally enlarged left breast...
September 15, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28894856/intraparenchymal-leiomyoma-of-the-breast-a-rare-location-for-an-infrequent-tumor
#18
Mehmet Tolga Kafadar, Metin Yalçın, Mehmet Ali Gök, Ayşegül Aktaş, Tacittin Semih Yürekli, Ayşegül İsal Arslan
Intraparenchymal leiomyoma of the breast are among benign non-epithelial tumors with the lowest incidence. Although it displays a benign histology, it may be confused with malignant lesions and create diagnostic confusion. In this paper, we report a 44-year-old woman with a painless mass with a diameter of 1.5 cm in the upper medial quadrant of her right breast. The lesion was removed surgically. The lesion's histologic examination and immunohistochemical analysis revealed a smooth muscle tumor of the breast...
July 2017: Eur J Breast Health
https://www.readbyqxmd.com/read/28872974/the-postoperative-immunosuppressive-phenotypes-of-peripheral-t-helper-cells-are-associated-with-poor-prognosis-of-breast-cancer-patients
#19
Ganglan Fu, Liping Miao, Meng Wang, MingYan Guo, Chengli Wang, Fengtao Ji, Minghui Cao
PURPOSE: T helper cells play essential roles in anti-tumor immune response. However, the postoperative changes of peripheral T cell subsets and their clinical significance in breast cancer patients remain largely unknown. METHODS: We evaluated the perioperative changes of T lymphocyte subsets in invasive breast cancer (IBC) patients and breast fibroadenoma (BF) patients preoperatively (preop) and 6, 24, 72 hours postoperatively (POH6, POH24, and POH72). Proportions of CD3, CD4, CD8, T helper (Th) 1, Th2, Th17 cells, regulatory T cells (Treg), and CD4(+)/CD8(+), Th1/Th2 ratio were detected by flow cytometry...
October 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28870060/sonographic-features-that-can-be-used-to-differentiate-between-small-triple-negative-breast-cancer-and-fibroadenoma
#20
Ga Young Yoon, Joo Hee Cha, Hak Hee Kim, Hee Jung Shin, Eun Young Chae, Woo Jung Choi
Purpose: Our study investigated whether any sonographic findings could be useful for differentiating between small triple-negative breast cancer (TNBC) and fibroadenoma. Methods: This retrospective study was approved by our Institutional Review Board, which waived the requirement for patient consent. From January 2009 to December 2010, the sonographic features of 181 pathologically proven TNBC tumors and 172 fibroadenomas measuring less than or equal to 2 cm in the longest dimension were reviewed and analyzed according to the fifth edition of the Breast Imaging Reporting and Data System (BI-RADS) lexicon...
August 4, 2017: Ultrasonography
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