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Fibroadenoma breast

Shu-Ya Tsai, Chih-Yi Hsu, Yi-Hong Chou, Yi-Chen Lai, Yung-Hui Lin, Hsin-Kai Wang, Hong-Jen Chiou, Jane Wang, Chui-Mei Tiu
Solitary fibrous tumor (SFT) is an uncommon neoplasm of mesenchymal origin, which can be benign or malignant. Most SFTs develop from the pleura, but they can also be found in other sites. There are only few reports of SFT occurring in the breast. We herein report such a rare case. Sonography demonstrated an ovoid lesion mimicking a fibroadenoma, whereas color Doppler imaging showed marked internal vascularity. A brief literature review on imaging features of SFTs is added. © 2016 Wiley Periodicals, Inc. J Clin Ultrasound, 2016...
October 18, 2016: Journal of Clinical Ultrasound: JCU
Charlotte Schillebeeckx, Guy Verbeeck, Geert Daenen, Dirk Servaes, Marc Bronckaers
Phyllodes tumors of the breast are rare, accounting for less than 1% of the breast tumors. They are mostly seen in women between 45 and 49 years old. These are fast growing tumors with a large spectrum of behavior (from benign to metastatic) and can resemble fibroadenomas. Correct diagnosis mostly through core needle biopsy is important to decide whether a surgical excision has to be done. Here we report a case of a 57-year-old woman with a fast growing, ulcerated tumor in the left breast. Core needle biopsy suggested a malignant phyllodes tumor with heterologous liposarcomatous differentiation...
September 5, 2016: Rare Tumors
Sang Yu Nam, Eun Young Ko, Boo-Kyung Han, Jung Hee Shin, Eun Sook Ko, Soo Yeon Hahn
PURPOSE: This study assessed the incidence and cancer rate of probably benign lesions detected on bilateral whole-breast screening ultrasound (US), which corresponded to US Breast Imaging Reporting and Data System (BI-RADS) category 3, and evaluated the proper management of those lesions. METHODS: This study was approved by the Institutional Review Board in our institution, which waived informed patient consent. We retrospectively reviewed US images of 1,666 patients who underwent bilateral whole-breast screening US as a supplemental screening test to negative screening mammography or screening US only...
September 2016: Journal of Breast Cancer
Eleftherios Agorogiannis, Lamprini Vlara, Betania Mahler-Araujo, George Metaxas
No abstract text is available yet for this article.
September 26, 2016: Breast Journal
Ishrat Ferdousee, S M Yasir Arafat, Zuhayer Ahmed
Though fibroadenoma is the most common benign tumor of the breast and is more common under the age of 30, giant fibroadenoma is rare representing less than 4% of all fibroadenomas. A 12 years old girl presented with rapidly enlarging well-circumscribed firm, non-tender mass in right breast for 2 months which was painless and with no history of trauma, nipple discharge, fever, anorexia, weight loss or axillary lymphadenopathy. There was no family history of neoplasms. Clinically, the lump was about 12 × 12 cm and not fixed to skin or underlying structures with the absence of nipple retraction or discharge...
September 1, 2016: Polski Przeglad Chirurgiczny
Kishori Moni Panda, Reena Naik
INTRODUCTION: Benign Phyllodes Tumours (PTs) are rare fibroepithelial neoplasms that resemble fibroadenoma. But unlike fibroadenoma, benign PT can recur and both stromal & epithelial components can progress to malignancy. Contrary to earlier belief that benign PT is a stromal neoplasm and possibly arises from fibroadenoma, more recent molecular studies have suggested that both stroma and epithelium can become neoplastic. Sometimes, benign PT can occur synchronously with fibroadenoma. Here histomorphologic analysis of eleven cases of benign PT are presented including some unusual features...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
Lucas Delmonico, Maryah Bravo, Rafaele Tavares Silvestre, Maria Helena Faria Ornellas, Carolina Maria De Azevedo, Gilda Alves
The present study evaluated the proteomic profile of saliva and plasma from women with impalpable breast lesions using nano-liquid chromatography-quadrupole-time-of-flight (nLC-Q-TOF) technology. Plasma and saliva from patients with fibroadenoma (n=10), infiltrating ductal carcinoma (n=10) and healthy control groups (n=8) were assessed by combinations of inter/intra-group analyses, revealing significant quantitative and qualitative differences. The major differentially-expressed proteins in the saliva of patients compared with the controls were α2-macroglobulin and ceruloplasmin, but the proteins that met the minimum fold-change and P-value cut-offs were leukocyte elastase inhibitor and α-enolase, and deleted in malignant brain tumors 1...
September 2016: Oncology Letters
Joško Bezic, Ivana Karaman, Nenad Kunac
We herein report a case of the breast fibroadenoma with foci of so-called immature variant of the conventional ductal hyperplasia. This type of usual ductal hyperplasia is histologically characterised by encircling intraductal proliferation of large cells with pale to amphophilic cytoplasm and large nuclei which vary in shape and in staining quality of the chromatin. We showed here, using the cytokeratin immunohistochemistry, that the proliferating cells were not of immature but rather mature immunohistochemical phenotype...
August 30, 2016: Breast Disease
Almir G V Bitencourt, Eduardo N P Lima, Bruna R C Macedo, Jorge L F A Conrado, Elvira F Marques, Rubens Chojniak
OBJECTIVE: To evaluate the diagnostic accuracy of positron emission mammography (PEM) for identifying malignant lesions in patients with suspicious microcalcifications detected on mammography. METHODS: A prospective, single-centre study that evaluated 40 patients with suspicious calcifications at mammography and indication for percutaneous or surgical biopsy, with mean age of 56.4 years (range: 28-81 years). Patients who agreed to participate in the study underwent PEM with 18F-fluorodeoxyglucose before the final histological evaluation...
September 2, 2016: European Radiology
Zeina Chakhtoura, Fatima Laki, Marie Bernadet, Ibtissem Cherifi, Aurélie Chiche, Natascha Pigat, Sophie Bernichtein, Carine Courtillot, Florence Boutillon, Ivan Bièche, Sophie Vacher, Marie-Laure Tanguy, Anne Bissery, Virginie Grouthier, Philippe Camparo, Marc Foretz, Marcio Do Cruzeiro, Rémi Pierre, Fabienne Rakotozafy, Jean Tichet, Isabelle Tejedor, Jacques-Emmanuel Guidotti, Brigitte Sigal-Zafrani, Vincent Goffin, Philippe Touraine
CONTEXT: in a cohort of 95 women with multiple breast fibroadenomas (MFA), we recently identified patients harboring germline heterozygous variants of the prolactin receptor (PRLR) exhibiting constitutive activity (PRLRI146L and PRLRI176V). OBJECTIVE: to better delineate the potential role of PRLR gain-of-function variants in benign and malignant mammary tumorigenesis Design: observational study and transgenic mouse model analysis Setting: Department of Endocrinology, Reproductive Disorders and Rare Gynecologic Diseases, Pitié Salpêtrière, Paris, and Inserm Unit 1151, Paris Patients or Other Participants: we generated a second MFA cohort (n=71) as well as a group of control subjects (n=496) and a cohort of women with breast cancer (BC, n=119)...
August 30, 2016: Journal of Clinical Endocrinology and Metabolism
Francisco Felipe Laitano, Francisco Laitano Neto, Felipe Pereira Zerwes
Fibroadenoma is the most common benign tumor of the breast but giant juvenile fibroadenoma represent only 0.5% of all fibroadenomas and when bilateral are much more rare. We describe the case of a 25 years old girl that presented with bilateral giant juvenile fibroadenomas and was treated by bilateral skin reducing mastectomy using the inferior dermal flap, implant, and free nipple graft.
August 2016: Gland Surgery
A O Daramola, O A Oguntunde, N A Awolola
BACKGROUND AND OBJECTIVES: Fibroepithelial lesions are the most common lesions of the breast seen in our laboratory consisting of fibroadenomas (FAs) and phyllodes tumors (PT). The aim of the study was to audit all fibroepithelial lesions and to reclassify all confirmed cases of PTs seen in the study period according to standard criteria. METHODOLOGY: Records and slides of fibroepithelial lesions of the breast received at the department between January 2008 and December 2013 were retrieved and reviewed by the authors...
September 2016: Nigerian Journal of Clinical Practice
Puneet Agarwal, Gaurav Kohli
Truth or myth is seldom encountered in the practice of surgery, especially in cases of breast diseases. Yet, even after thousands of years of treating breast disease by surgeons/healers, fibroadenoma in the male breast seems to be a myth, due to the absence of fibro-glandular tissue. We wish to break this myth by our own experience as well as other studies by others all over the world, and unveil the truth that fibroadenoma in the male breast is a definitive entity and has a prevalence among the vast spectrum of breast diseases...
2016: Ulusal Cerrahi Dergisi
Yihong Wang, Murray B Resnick, Shaolei Lu, Yiang Hui, Alexander S Brodsky, Dongfang Yang, Evgeny Yakirevich, Lijuan Wang
Phyllodes tumors of the breast constitute an uncommon group of fibroepithelial neoplasms that are classified into benign, borderline and malignant categories based on a constellation of histological characteristics including cytologic atypia, mitotic count, degree of stromal cellularity, stromal overgrowth, and microscopic margins. Accurately and reproducibly differentiating these tumors is a long-standing diagnostic challenge. In addition, the distinction between benign phyllodes tumor (PT) from cellular fibroadenoma (FA) is especially difficult due to overlapping microscopic features...
August 3, 2016: Human Pathology
Tunc Eren, Adem Aslan, Ibrahim A Ozemir, Hakan Baysal, Julide Sagiroglu, Ozgur Ekinci, Orhan Alimoglu
BACKGROUND: Breast pain is one of the leading complaints that ends up with referral to breast surgery clinics. The purpose of the present study was to investigate the factors that cause mastalgia, and its relation with benign or malignant breast disease. METHODS: The study was performed in 700 patients. Data obtained from surveys, and imaging findings were prospectively recorded, and analyzed. RESULTS: The mean age was 45.20 ± 10.78 years...
June 2016: Breast Care
Vandana Puri, Manjula Jain, Gunjan Mahajan, Mukta Pujani
BACKGROUND: Fibroepithelial lesions of the breast are classified into fibroadenoma and phyllodes tumor (PT). Although WHO has established a well-defined grading system for PT, dilemma of discriminating borderline from malignant PT still exists. Stromal CD10 is a known poor prognostic factor in invasive breast cancer, its expression in fibroepithelial lesions of the breast is not well-documented. Till date, only one study has correlated the CD10 staining score with tumor grade in PT. OBJECTIVE: To evaluate whether the differences in expression patterns of CD10 and staining intensity correlate with the degree of malignancy in fibroepithelial tumors of the breast...
April 2016: Journal of Cancer Research and Therapeutics
Anna-Lena Volckmar, Jonas Leichsenring, Christa Flechtenmacher, Nicole Pfarr, Udo Siebolts, Martina Kirchner, Jan Budczies, Michael Bockmayr, Kathrin Ridinger, Katja Lorenz, Esther Herpel, Aurelia Noske, Wilko Weichert, Frederick Klauschen, Peter Schirmacher, Roland Penzel, Volker Endris, Albrecht Stenzinger
Adenomas of the breast are rare benign tumors although single cases with malignant behavior have been reported. However, the genetic basis of these tumors is unknown. Employing targeted next generation sequencing of 50 cancer-related genes as well as Sanger sequencing, we profiled a cohort of 18 mammary adenomas comprising 9 ductal, 6 tubular, and 3 lactating adenoma. Missense mutations were detected in 8 of the 18 cases (44%). Specifically, five (56%) ductal adenomas and three (50%) tubular adenomas harbored mutated genes...
July 20, 2016: Genes, Chromosomes & Cancer
Haishan Zhao, Zhaojin Yu, Lin Zhao, Miao He, Jie Ren, Huizhe Wu, Qiuchen Chen, Weifan Yao, Minjie Wei
OBJECTIVE: Previous studies have revealed the association of multidrug resistance with histone deacetylases inhibitors treatment in cancer cells. But little data were available for the correlation of histone deacetylases and drug-resistant-related proteins in breast cancer tissue. This study aimed to exploring the association of histone deacetylases expression with clinicopathological features, drug-resistant-related proteins, prognosis and therapeutic responses in breast cancer patients...
July 18, 2016: Japanese Journal of Clinical Oncology
Seema Thakur, Rajesh K Grover, Sanjay Gupta, Ajay K Yadav, Bhudev C Das
Of several subtypes of breast cancer, triple negative breast cancer (TNBC) is a highly aggressive tumor that lacks expression of hormone receptors for estrogen, progesterone and human epidermal growth factor receptor 2 and shows a worst prognosis. The small noncoding RNAs (miRNAs) considered as master regulator of gene expression play a key role in cancer initiation, progression and drug resistance and have emerged as attractive molecular biomarkers for diagnosis, prognosis and treatment targets in cancer. We have done expression profiling of selected miRNAs in paired serum and tissue samples of TNBC patients and corresponding cell lines and compared with that of other subtypes, in order to identify novel serum miRNA biomarkers for early detection and progression of TNBC...
2016: PloS One
Sana Parsian, Nadia V Giannakopoulos, Habib Rahbar, Mara H Rendi, Xiaoyu Chai, Savannah C Partridge
OBJECTIVE: To determine the underlying histopathologic features influencing apparent diffusion coefficient (ADC) values of breast fibroadenomas. MATERIALS AND METHODS: Biopsy-proven fibroadenomas (n=26) initially identified as suspicious on breast magnetic resonance imaging (MRI) were retrospectively evaluated. Histopathologic assessments of lesion cellularity and stromal type were compared with ADC measures on diffusion-weighted MRI. RESULTS: Presence of epithelial hyperplasia (increased cellularity) and dense collagenous stroma were both significantly associated with lower lesion ADC values (P=...
September 2016: Clinical Imaging
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