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https://www.readbyqxmd.com/read/28628005/emergence-of-visually-evoked-reward-expectation-signals-in-dopamine-neurons-via-the-superior-colliculus-in-v1-lesioned-monkeys
#1
Norihiro Takakuwa, Rikako Kato, Peter Redgrave, Tadashi Isa
Responses of midbrain dopamine (DA) neurons reflecting expected reward from sensory cues are critical for reward-based associative learning. However, critical pathways by which reward-related visual information is relayed to DA neurons remain unclear. To address this question, we investigated Pavlovian conditioning in macaque monkeys with unilateral primary visual cortex (V1) lesions (an animal model of 'blindsight'). Anticipatory licking responses to obtain juice drops were elicited in response to visual conditioned stimuli (CS) in the affected visual field...
June 19, 2017: ELife
https://www.readbyqxmd.com/read/28627906/evidence-of-a-goal-directed-process-in-human-pavlovian-instrumental-transfer
#2
Tina Seabrooke, Mike E Le Pelley, Lee Hogarth, Chris J Mitchell
Cues that signal rewards can motivate reward-seeking behaviors, even for outcomes that are not currently desired. Three experiments examined this phenomenon, using an outcome-selective Pavlovian-instrumental transfer (PIT) design and an outcome devaluation procedure. In Experiment 1, participants learned to perform one response to earn crisps points and another response to earn popcorn points. One outcome was then devalued by adulterating it to make it taste unpleasant. On test, overall response choice was biased toward the outcome that had not been devalued, indicating goal-directed control...
June 19, 2017: Journal of Experimental Psychology. Animal Learning and Cognition
https://www.readbyqxmd.com/read/28617449/assessment-of-social-transmission-of-threats-in-humans-using-observational-fear-conditioning
#3
Jan Haaker, Armita Golkar, Ida Selbing, Andreas Olsson
Across the human life span, fear is often acquired indirectly by observation of the emotional expressions of others. The observational fear conditioning protocol was previously developed as a laboratory model for investigating socially acquired threat responses. This protocol serves as a suitable alternative to the widely used Pavlovian fear conditioning, in which threat responses are acquired through direct experiences. In the observational fear conditioning protocol, the participant (observer) watches a demonstrator being presented with a conditioned stimulus (CS) paired with an aversive unconditioned stimulus (US)...
July 2017: Nature Protocols
https://www.readbyqxmd.com/read/28612645/associative-mechanisms-involved-in-specific-pavlovian-to-instrumental-transfer-pit-in-human-learning-tasks
#4
Daniel E Alarcón, Charlotte Bonardi, Andrew R Delamater
Four experiments compared the effect of forward and backward conditioning procedures on the ability of conditioned stimuli (CSs) to elevate instrumental responding in a Pavlovian-to-instrumental transfer (PIT) task. Two responses were each trained with one distinct outcome (R1->O1, R2->O2), either concurrently (Experiment 1) or separately (Experiments 2, 3 and 4). Then, in Experiments 1 and 2, four CSs were either followed or preceded by one outcome (A-->O1, B->O2,O1->C, O2->D). In Experiment 3 each CS was preceded and followed by an outcome: for one group of participants both outcomes were identical (e...
June 14, 2017: Quarterly Journal of Experimental Psychology: QJEP
https://www.readbyqxmd.com/read/28606743/alpha1-adrenergic-receptor-blockade-in-the-vta-modulates-fear-memories-and-stress-responses
#5
Wojciech B Solecki, Klaudia Szklarczyk, Kamil Pradel, Grzegorz Dobrzański, Ryszard Przewłocki
Activity of the ventral tegmental area (VTA) and its terminals has been implicated in the Pavlovian associative learning of both stressful and rewarding stimuli. However, the role of the VTA noradrenergic signaling in fear responses remains unclear. We aimed to examine how alpha1-adrenergic receptor (α1-AR) signaling in the VTA affects conditioned fear. The role of α1-AR was assessed using the micro-infusions into the VTA of the selective antagonists (0.1-1µg/0.5µl prazosin and 1µg/0.5µl terazosin) in acquisition and expression of fear memory...
June 9, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28606630/long-term-contextual-memory-in-infant-rats-as-evidenced-by-an-ethanol-conditioned-tolerance-procedure
#6
Stefanía Castelló, Juan Carlos Molina, Carlos Arias
Conditioned tolerance can be conceptualized as a particular case of Pavlovian conditioning in which contextual cues play the role of the conditioned stimulus. Although the evidence is contradictory, it is frequently assumed that long-term contextual conditioning in pre-weanling rats is weak or even absent. This hypothesis comes from and is sustained mainly by behavioral studies that explored different contextual effects in 16-18day-old rats using a fear-conditioning paradigm, but their conclusions are stated in terms of an immature (hippocampal-dependent) declarative memory system...
June 9, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28599832/model-based-control-in-dimensional-psychiatry
#7
REVIEW
Valerie Voon, Andrea Reiter, Miriam Sebold, Stephanie Groman
We use parallel interacting goal-directed and habitual strategies to make our daily decisions. The arbitration between these strategies is relevant to inflexible repetitive behaviors in psychiatric disorders. Goal-directed control, also known as model-based control, is based on an affective outcome relying on a learned internal model to prospectively make decisions. In contrast, habit control, also known as model-free control, is based on an integration of previous reinforced learning autonomous of the current outcome value and is implicit and more efficient but at the cost of greater inflexibility...
April 23, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28591584/dorsal-ca1-hippocampal-neuronal-ensembles-encode-nicotine-reward-contextual-associations
#8
Li Xia, Stephanie K Nygard, Gabe G Sobczak, Nicholas J Hourguettes, Michael R Bruchas
Natural and drug rewards increase the motivational valence of stimuli in the environment that, through Pavlovian learning mechanisms, become conditioned stimuli that directly motivate behavior in the absence of the original unconditioned stimulus. While the hippocampus has received extensive attention for its role in learning and memory processes, less is known regarding its role in drug-reward associations. We used in vivo Ca(2+) imaging in freely moving mice during the formation of nicotine preference behavior to examine the role of the dorsal-CA1 region of the hippocampus in encoding contextual reward-seeking behavior...
June 6, 2017: Cell Reports
https://www.readbyqxmd.com/read/28588364/extinction-of-contextual-fear-with-timed-exposure-to-enriched-environment-a-differential-effect
#9
Preethi Hegde, Shane O'Mara, Thenkanidiyoor Rao Laxmi
BACKGROUND: Extinction of fear memory depends on the environmental and emotional cues. Furthermore, consolidation of extinction is also dependent on the environmental exposure. But, the relationship of the time of the exposure to a variety of environmental cues is not well known. The important region involved in facilitation of extinction of fear memory is through diversion of the flow of information leaving the lateral nucleus of amygdala. PURPOSE: The study aimed to address a question to explain how these brain regions react to environmental stimulation during the retention and extinction of fear memory...
May 2017: Annals of Neurosciences
https://www.readbyqxmd.com/read/28584876/on-the-nature-of-directed-behavior-to-drug-associated-light-cues-in-rhesus-monkeys-macaca-mulatta
#10
Mark P Reilly, Sonja I Berndt, James H Woods
The present study investigated the role of drug-paired stimuli in controlling the behavior of rhesus monkeys. Systematic observations were made with nine monkeys who had a history of drug self-administration; they had been lever pressing to produce intravenous infusions of various drugs. These observations revealed that the stimulus light co-occurring with drug infusion produced robust and cue-directed behavior such as orienting, touching and biting. Experiment 1 showed that this light-directed behavior would occur in naïve monkeys exposed to a Pavlovian pairing procedure...
November 2016: Behavior Analysis (Washington, D.C.)
https://www.readbyqxmd.com/read/28561735/learning-shapes-the-aversion-and-reward-responses-of-lateral-habenula-neurons
#11
Daqing Wang, Yi Li, Qiru Feng, Qingchun Guo, Jingfeng Zhou, Minmin Luo
The lateral habenula (LHb) is believed to encode negative motivational values. It remains unknown how LHb neurons respond to various stressors and how learning shapes their responses. Here, we used fiber-photometry and electrophysiology to track LHb neuronal activity in freely-behaving mice. Bitterness, pain, and social attack by aggressors intensively excite LHb neurons. Aversive Pavlovian conditioning induced activation by the aversion-predicting cue in a few trials. The experience of social defeat also conditioned excitatory responses to previously neutral social stimuli...
May 31, 2017: ELife
https://www.readbyqxmd.com/read/28559170/integration-of-contextual-cues-into-memory-depends-on-prefrontal-n-methyl-d-aspartate-receptors
#12
Sarah Starosta, Isabelle Bartetzko, Maik C Stüttgen, Onur Güntürkün
Every learning event is embedded in a context, but not always does the context become an integral part of the memory; however, for extinction learning it usually does, resulting in context-specific conditioned responding. The neuronal mechanisms underlying contextual control have been mainly investigated for Pavlovian fear extinction with a focus on hippocampal structures. However, the initial acquisition of novel responses can be subject to contextual control as well, although the neuronal mechanisms are mostly unknown...
May 27, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28549647/pavlovian-influences-on-learning-differ-between-rats-and-mice-in-a-counter-balanced-go-nogo-judgement-bias-task
#13
Samantha Jones, Elizabeth S Paul, Peter Dayan, Emma S J Robinson, Michael Mendl
Judgement bias tests of animal affect and hence welfare assume that the animal's responses to ambiguous stimuli, which may herald positive or negative outcomes, are under instrumental control and reflect 'optimism' or 'pessimism' about what will happen. However, Pavlovian control favours responses (e.g. approach or withdrawal) according to the valence associated with a stimulus, rather than the anticipated response outcomes. Typically, positive contexts promote action and approach whilst negative contexts promote inhibition or withdrawal...
May 23, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28541285/endogenous-opioids-regulate-social-threat-learning-in-humans
#14
Jan Haaker, Jonathan Yi, Predrag Petrovic, Andreas Olsson
Many fearful expectations are shaped by observation of aversive outcomes to others. Yet, the neurochemistry regulating social learning is unknown. Previous research has shown that during direct (Pavlovian) threat learning, information about personally experienced outcomes is regulated by the release of endogenous opioids, and activity within the amygdala and periaqueductal gray (PAG). Here we report that blockade of this opioidergic circuit enhances social threat learning through observation in humans involving activity within the amygdala, midline thalamus and the PAG...
May 25, 2017: Nature Communications
https://www.readbyqxmd.com/read/28523223/transcranial-direct-current-stimulation-may-modulate-extinction-memory-in-posttraumatic-stress-disorder
#15
Mascha Van't Wout, Sharon M Longo, Madhavi K Reddy, Noah S Philip, Marguerite T Bowker, Benjamin D Greenberg
BACKGROUND: Abnormalities in fear extinction and recall are core components of posttraumatic stress disorder (PTSD). Data from animal and human studies point to a role of the ventromedial prefrontal cortex (vmPFC) in extinction learning and subsequent retention of extinction memories. Given the increasing interest in developing noninvasive brain stimulation protocols for psychopathology treatment, we piloted whether transcranial direct current stimulation (tDCS) during extinction learning, vs...
May 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28512009/combining-d-cycloserine-with-appetitive-extinction-learning-modulates-amygdala-activity-during-recall
#16
Claudia Ebrahimi, Stefan P Koch, Eva Friedel, Ilsoray Crespo, Thomas Fydrich, Andreas Ströhle, Andreas Heinz, Florian Schlagenhauf
Appetitive Pavlovian conditioning plays a crucial role in the pathogenesis of drug addiction and conditioned reward cues can trigger craving and relapse even after long phases of abstinence. Promising preclinical work showed that the NMDA-receptor partial agonist D-cycloserine (DCS) facilitates Pavlovian extinction learning of fear and drug cues. Furthermore, DCS-augmented exposure therapy seems to be beneficial in various anxiety disorders, while the supposed working mechanism of DCS during human appetitive or aversive extinction learning is still not confirmed...
May 13, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28511979/water-and-t-maze-protocols-are-equally-efficient-methods-to-assess-spatial-memory-in-3xtg-alzheimer-s-disease-mice
#17
K E Davis, K Burnett, J Gigg
Rodent spatial memory is commonly tested using the water-maze; however, there is a potential confound of stress on learning in this behavioural paradigm. This is particularly relevant when testing spatial memory in models of neurodegeneration, such as the 3xTg mouse model for Alzheimer's disease. Here, we first confirmed that 3xTgAD mice express fear conditioning and then compared the performance of young and middle-aged mice on short-duration versions of the radial arm water-maze (RAWM) and the minimally stressful T-maze spontaneous alternation task...
May 13, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28504638/catecholaminergic-challenge-uncovers-distinct-pavlovian-and-instrumental-mechanisms-of-motivated-in-action
#18
Jennifer C Swart, Monja I Froböse, Jennifer L Cook, Dirk Em Geurts, Michael J Frank, Roshan Cools, Hanneke Em den Ouden
Catecholamines modulate the impact of motivational cues on action. Such motivational biases have been proposed to reflect cue-based, 'Pavlovian' effects. Here, we assess whether motivational biases may also arise from asymmetrical instrumental learning of active and passive responses following reward and punishment outcomes. We present a novel paradigm, allowing us to disentangle the impact of reward and punishment on instrumental learning from Pavlovian response biasing. Computational analyses showed that motivational biases reflect both Pavlovian and instrumental effects: reward and punishment cues promoted generalized (in)action in a Pavlovian manner, whereas outcomes enhanced instrumental (un)learning of chosen actions...
May 15, 2017: ELife
https://www.readbyqxmd.com/read/28499495/distraction-suppression-and-distress-endurance-diminish-the-extent-to-which-generalized-conditioned-fear-is-associated-with-maladaptive-behavioral-avoidance
#19
Christopher Hunt, Samuel E Cooper, Melissa P Hartnell, Shmuel Lissek
A central conditioning correlate of clinical anxiety is the over-generalization of Pavlovian fear to safe stimuli resembling conditioned danger cues (CS+). Though much of the pathogenic influence of such generalization may lie in the unnecessary behavioral avoidance it evokes, few studies have examined maladaptive avoidance associated with Pavlovian generalization. Lab-based assessments of this process, here referred to as instrumental avoidance from Pavlovian generalization (IAP-G), have recently begun. The current study represents a next step in this line of work by examining personality factors that may reduce maladaptive IAP-G...
April 27, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28496171/altered-balance-of-excitatory-and-inhibitory-learning-in-a-genetically-modified-mouse-model-of-glutamatergic-dysfunction-relevant-to-schizophrenia
#20
David J Sanderson, Aletheia Lee, Rolf Sprengel, Peter H Seeburg, Paul J Harrison, David M Bannerman
The GluA1 AMPAR subunit (encoded by the Gria1 gene) has been implicated in schizophrenia. Gria1 knockout in mice results in recently experienced stimuli acquiring aberrantly high salience. This suggests that GluA1 may be important for learning that is sensitive to the temporal contiguity between events. To test this, mice were trained on a Pavlovian trace conditioning procedure in which the presentation of an auditory cue and food were separated by a temporal interval. Wild-type mice initially learnt, but with prolonged training came to withhold responding during the trace-conditioned cue, responding less than for another cue that was nonreinforced...
May 11, 2017: Scientific Reports
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