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https://www.readbyqxmd.com/read/27917035/polyglandular-autoimmune-syndrome-in-pregnancy-case-report
#1
Basilio Pecorino, Maria Cristina Teodoro, Paolo Scollo
Type III Polyglandular Autoimmune Syndrome is a multiple endocrine disorders disease determined by autoimmunity; it can be diagnosed if a patient is affected by Type 1 Diabetes Mellitus and another autoimmune disease, except Addison Disease, for example Autoimmune Hashimoto Thyroiditis or Celiac Disease. R.D., 34-year-old woman (gravida 2 para 1), was referred to the High Risk Pregnancy Outpatient Clinic at Cannizzaro Hospital in Catania at 8 weeks' gestation. She was affected from type III Polyglandular Autoimmune Disease (Type 1 Diabetes Mellitus, Autoimmune Hashimoto Thyroiditis and Celiac Disease)...
September 2016: Italian Journal of Gynaecology & Obstetrics: Official Publication of the Societa Italiana di Ginecologia e Ostetricia (SIGO)
https://www.readbyqxmd.com/read/27906802/anti-tissue-transglutaminase-normalization-post-diagnosis-in-children-with-celiac-disease
#2
Daniela Migliarese Isaac, Seema Rajani, Maryna Yaskina, Hien Q Huynh, Justine M Turner
OBJECTIVES: Limited pediatric data exist examining the trend and predictors of anti-tissue transglutaminase (atTG) normalization over time in children with celiac disease (CD). We aimed to evaluate time to normalization of atTG in children after CD diagnosis, and to assess for independent predictors impacting this duration. METHODS: A retrospective chart review was completed in pediatric CD patients diagnosed from 2007 to 2014 at the Stollery Children's Hospital Celiac Clinic (Edmonton, Alberta)...
November 30, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27906796/cardiovascular-risk-factors-in-adolescents-with-celiac-disease-a-cross-sectional-population-based-study
#3
Amit Assa, Yael Frenkel-Nir, Dorit Tzur, Lior H Katz, Raanan Shamir
BACKGROUND: Recent data have shown that adults with celiac disease (CD) may have a higher prevalence of risk factors for cardiovascular disease (CVD) compared with the general population. Thus, we aimed to investigate the association of CD with CVD risk factors at late adolescence in a cross-sectional population based study. METHODS: A total of 2,001,353 Jewish Israeli adolescents who underwent a general health examination at median age of 17.1y from 1988 to 2015 were included...
November 30, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27894748/ccr5-%C3%AE-32-gene-polymorphism-is-related-to-celiac-disease-and-autoimmune-thyroiditis-coincidence-in-patients-with-type-1-diabetes
#4
Bartosz Słomiński, Urszula Ławrynowicz, Jolanta Myśliwska, Monika Ryba-Stanisławowska, Maria Skrzypkowska, Małgorzata Myśliwiec, Agnieszka Brandt
AIM: The aim of the study was to assess the relationship between CCR5-Δ32 polymorphism and the coincidence of celiac and autoimmune thyroid diseases with type 1 diabetes mellitus (T1D) in children. METHODS: 420 children with T1D aged 15.5±3.0years and 350 healthy controls were studied. Characterization of CCR5-Δ32 genotypes (rs333) was analyzed by polymerase chain reaction (PCR). RESULTS: The allele frequency was significantly different in diabetic children as compared to the healthy controls (p<0...
November 3, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27888057/association-between-rs2294020-in-x-linked-ccdc22-and-susceptibility-to-autoimmune-diseases-with-focus-on-systemic-lupus-erythematosus
#5
Fabio D'Amico, Evangelia Skarmoutsou, Lauren J Lo, Mariagrazia Granata, Chiara Trovato, Giulio A Rossi, Chiara Bellocchi, Maurizio Marchini, Raffaella Scorza, Maria Clorinda Mazzarino, Alon Keinan
Autoimmune diseases often share common susceptibility genes. Most genetic variants associated with susceptibility to systemic lupus erythematosus are also associated with other autoimmune diseases. The X-linked variant rs2294020 is positioned in exon 7 of the CCDC22 gene. The encoded protein functions in the regulation of NF-κB, a master regulator in immune response. The aim of this study is to investigate whether the rs2294020 polymorphism may be a general susceptibility factor for autoimmunity. We evaluated case-control association between the occurrence of rs2294020 and different autoimmune diseases, including new data for systemic lupus erythematosus and previous genome-wide association studies (GWAS) (though most did not analyse the X chromosome) of psoriasis, celiac disease, Crohn's disease, ulcerative colitis, multiple sclerosis, vitiligo, type-1 diabetes, rheumatoid arthritis, and ankylosing spondylitis...
November 22, 2016: Immunology Letters
https://www.readbyqxmd.com/read/27855231/association-of-newly-diagnosed-type-1-diabetes-and-autoimmune-pancreatitis
#6
Laila Ennazk, Ghizlane El Mghari, Nawal El Ansari
: Autoimmune pancreatitis is a new nosological entity in which a lymphocytic infiltration of the exocrine pancreas is involved. The concomitant onset of autoimmune pancreatitis and type 1 diabetes has been recently described suggesting a unique immune disturbance that compromises the pancreatic endocrine and exocrine functions. We report a case of type1 diabetes onset associated with an autoimmune pancreatitis in a young patient who seemed to present a type 2 autoimmune polyglandular syndrome...
2016: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/27847281/identification-of-pediatric-patients-with-celiac-disease-based-on-serology-and-a-classification-and-regression-tree-analysis
#7
Anna Ermarth, Matthew Bryce, Stephanie Woodward, Gregory Stoddard, Linda Book, M Kyle Jensen
BACKGROUND & AIMS: Celiac disease is detected using serology and endoscopy analyses. We used multiple statistical analyses of a geographically isolated population in the United States to determine whether a single serum screening can identify individuals with celiac disease. METHODS: We performed a retrospective study of 3555 pediatric patients (18 years old or younger) in the intermountain West region of the United States from January 1, 2008 through September 30, 2013...
November 12, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27845544/clinical-spectrum-of-celiac-disease-in-children-in-sistan-and-baluchestan-province
#8
Touran Shahraki, Ivor D Hill
BACKGROUND: The clinical manifestations of celiac disease (CD) have changed in the past decades. There are currently little data describing the initial clinical manifestations of CD in children in Iran. This study describes the initial presentation of children with suspected CD from a geographically defined region in Iran. METHOD: Medical records of children seen in 2007 - 2015 from Sistan and Baluchestan province, Iran, with suspected CD were reviewed. After obtaining TTG-IgA and IgA, subjects were divided into three groups according to presenting symptoms: GI, non-GI, and asymptomatic group...
November 2016: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/27784959/endocrine-manifestations-in-celiac-disease
#9
REVIEW
Hugh James Freeman
Celiac disease (CD) is an autoimmune small intestinal mucosal disorder that often presents with diarrhea, malabsorption and weight loss. Often, one or more associated endocrine disorders may be associated with CD. For this review, methods involved an extensive review of published English-language materials. In children and adolescents, prospective studies have demonstrated a significant relationship to insulin-dependent or type 1 diabetes, whereas in adults, autoimmune forms of thyroid disease, particularly hypothyroidism, may commonly co-exist...
October 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27730378/diagnostic-value-of-blood-tests-for-occult-causes-of-initially-idiopathic-small-fiber-polyneuropathy
#10
Magdalena Lang, Roi Treister, Anne Louise Oaklander
Small-fiber polyneuropathy (SFPN) causes non-specific symptoms including chronic pain, cardiovascular, gastrointestinal, and sweating complaints. Diagnosis is made from history and exam in patients with known risk factors such as diabetes, but objective test confirmation is recommended for patients without known risks. If tests confirm SFPN, and it is "initially idiopathic" (iiSFPN), screening for occult causes is indicated. This study's aim was to evaluate the 21 widely available, recommended blood tests to identify the most cost-effective ones and to learn about occult causes of iiSFPN...
December 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27727675/prevalence-and-clinical-profile-of-celiac-disease-in-patients-with-type-1-diabetes-mellitus
#11
Ranjit Singh, Manish Gutch, Madukar Mittal, Sukriti Kumar, Syed Mohd Razi
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27720243/quality-of-life-in-type-1-diabetes-and-celiac-disease-role-of-the-gluten-free-diet
#12
Anna Pham-Short, Kim C Donaghue, Geoffrey Ambler, Sarah Garnett, Maria E Craig
OBJECTIVE: To evaluate quality of life (QoL) and glycemic control in youth with type 1 diabetes (T1D) and celiac disease vs T1D only. We hypothesized that QoL scores would be lower in youth with T1D and celiac disease and those nonadherent to the gluten-free diet (GFD). STUDY DESIGN: This case control study included 35 youth with T1D and 35 with T1D  and  celiac disease matched for age, sex, diabetes duration, and hemoglobin A1c level. QoL was assessed in participants and parents using the Pediatric Quality of Life Inventory Generic Core Scale, Pediatric Quality of Life Inventory Diabetes Module...
October 5, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27670799/a-population-wide-applicable-hla-dq2-and-dq8-genotyping-using-dna-from-dried-blood-spots-and-duplex-allele-specific-qpcr-amplification
#13
Sandra Aguayo-Patrón, Lizbeth Beltrán-Sauceda, Ana María Calderón de la Barca
Genotyping of HLA-DQ2 and DQ8 haplotypes is important for diagnosis or for screening of early risk detection of celiac disease or type 1 diabetes. Usually, venous blood DNA extraction and expensive and time consuming amplification are used, that hinder population-wide studies. We assayed a friendly HLA-DQ2 and DQ8 genotyping procedure using a combination of DNA from dried blood spot (DBS) and duplex allele-specific qPCR amplification using SYBR Green. DNA was extracted using home-made buffers and compared to an extraction commercial kit...
November 2016: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/27665287/palivizumab-exposure-and-the-risk-of-autoimmune-disease-a-cross-national-cohort-study
#14
Ann Haerskjold, Marie Linder, Lonny Henriksen, Simon Francis Thomsen, Helle Kieler, Henrik Ravn, Lone Graff Stensballe
BACKGROUND: Treatment with biologic pharmaceuticals may be associated with an increased risk of immune-mediated disease. Palivizumab is a humanized monoclonal antibody designed to provide passive immunity against respiratory syncytial virus infection. Palivizumab is primarily used in preterm children known to be immunologically immature. The long-term effect of palivizumab in terms of autoimmune diseases has not yet been investigated. AIM: Our objective was to investigate whether exposure to palivizumab was associated with the development of autoimmune diseases in children...
December 2016: Paediatric Drugs
https://www.readbyqxmd.com/read/27663711/prevalence-of-celiac-disease-in-indian-children-with-type-1-diabetes
#15
Anshu Srivastava, Saurabh Chaturvedi, Preeti Dabadghao, Amrita Mathias, Umesh Shukla, Uttam Singh, Surender Kumar Yachha
BACKGROUND: Type 1 diabetes (T1D) patients are at an increased risk of having celiac disease (CD). We evaluated the prevalence and clinical profile of CD in children and adolescents with T1D and reviewed the Indian literature to determine prevalence and reasons for variability. METHODS: In this cross-sectional study, subjects with T1D were prospectively evaluated with a demographic and gastrointestinal (GI) questionnaire, human IgA-tissue transglutaminase (IgA-tTGA), and endoscopic duodenal biopsy in serology positive patients...
September 2016: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/27642442/-serological-tests-for-celiac-disease-in-moroccan-patients-with-type-1-diabetes
#16
Asmaa Drissi Bourhanbour, Sanae Ouadghiri, Nadia Benseffaj, Malika Essakalli
Celiac disease (CD) is an autoimmune disease frequently associated with type 1 diabetes (T1D). The prevalence of CD in patients with T1D varies from 3 to 6%. The clinical manifestation of CD in patients with T1D is classified as asymptomatic in about half of cases. Our study aims to determine the frequency of anti-tissue transglutaminase autoantibodies (IgA-tTG) and anti-gliadin antibodies (AGA) in patients with type 1 diabetes in order to early recommend jejunal biopsy and establish a gluten-free diet before the onset of clinical signs and complications of celiac disease...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27639841/the-association-of-other-autoimmune-diseases-in-patients-with-autoimmune-thyroiditis-review-of-the-literature-and-report-of-a-large-series-of-patients
#17
Poupak Fallahi, Silvia Martina Ferrari, Ilaria Ruffilli, Giusy Elia, Marco Biricotti, Roberto Vita, Salvatore Benvenga, Alessandro Antonelli
We have evaluated prospectively the prevalence of other autoimmune disorders in outpatient clinic in 3069 consecutive patients with diagnosed chronic autoimmune thyroiditis (AT), with respect to two age- and sex-matched control groups: a) a control group of 1023 subjects, extracted from a random sample of the general population without thyroid disorders; b) 1023 patients with non-toxic multinodular goiter extracted from the same random sample of the general population, with similar iodine intake. The results of our study demonstrate a significant increase of the prevalence of autoimmune disorders in AT patients (with respect to both controls), for the following diseases: chronic autoimmune gastritis (CAG), vitiligo (Vit), rheumatoid arthritis, polymialgia rheumatica (Polym), celiac disease, diabetes, sjogren disease, multiple sclerosis, systemic lupus erythematosus, sarcoidosis, alopecia, psoriathic arthritis, systemic sclerosis, and HCV-related cryoglobulinemia...
September 15, 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/27633269/celiac-disease-and-the-risk-of-kidney-diseases-a-systematic-review-and-meta-analysis
#18
Karn Wijarnpreecha, Charat Thongprayoon, Panadeekarn Panjawatanan, Natanong Thamcharoen, Pavida Pachariyanon, Kiran Nakkala, Wisit Cheungpasitporn
BACKGROUND/OBJECTIVES: Previous epidemiologic studies attempting to demonstrate the risk of kidney diseases among patients with celiac disease (CD) have yielded inconsistent results. This meta-analysis was conducted with the aims to summarize all available evidence. METHODS: A literature search was performed using MEDLINE and EMBASE from inception to May 2016. Studies that provided relative risks, odd ratios, or hazard ratios examining the risk of kidney diseases among patients with CD versus individuals without CD were included...
August 24, 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/27574884/celiac-disease-and-diabetes-when-to-test-and-treat
#19
Batia Weiss, Orit Pinhas-Hamiel
Prevalence studies from around the world have established a substantial increase in the prevalence of celiac disease (CD) in patients with type 1 diabetes (T1DM). About two-thirds of patients with T1DM and CD are asymptomatic for CD at diagnosis. We aim to provide an up-to-date state of the art summary of the recommendations for serologic testing for CD in patients with T1DM, and to clarify the debate on the need for screening and interventions. We searched Medline, and Cochrane databases for studies of celiac autoimmunity and biopsy-proven CD in people with T1DM between January 1 2000 and December 1, 2015...
August 27, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27543737/frequency-of-hla-dqb1-0201-02-and-dqb1-0302-alleles-and-tissue-transglutaminase-antibody-seropositivity-in-children-with-type-1-diabetes-mellitus
#20
Thanita Thammarakcharoen, Nattiya Hirankarn, Taninee Sahakitrungruang, Thanunrat Thongmee, Pavinee Kuptawintu, Sriprapai Kanoonthong, Voranush Chongsrisawat
BACKGROUND: Patients with type 1 diabetes mellitus (T1DM) have an increased risk for celiac disease (CD). Both diseases have a common genetic susceptibility locus in the human leukocyte antigen (HLA) class II alleles. Testing for tissue transglutaminase antibodies (anti-tTG) is highly accurate for CD diagnosis. OBJECTIVE: To determine the frequency of HLA-DQB1*0201/02and DQB1*0302 alleles and anti-tTG seropositivity in children with T1DM. METHODS: Forty-six children with T1DM (male:female=24:22; mean age 12±3...
August 16, 2016: Asian Pacific Journal of Allergy and Immunology
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