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Nataša Fidler Mis, Kathy Kennedy, Mary Fewtrell, Cristina Campoy, Berthold Koletzko
OBJECTIVES: Available published advice on use of incentives is limited and generally refers to short term studies without longer follow-up, predominantly conducted in developed countries. We aim to summarise published information related to the use of incentives in long-term nutrition studies involving infants, children and adolescents and the views of researchers in the field, in order to provide guidance on acceptable incentives. METHODS: We conducted a literature review and a short online survey of researchers regarding their opinions on the use of incentives in paediatric long-term (follow-up) clinical studies...
September 18, 2018: Journal of Pediatric Gastroenterology and Nutrition
Marco Di Pascoli, Silvano Fasolato, Salvatore Piano, Massimo Bolognesi, Paolo Angeli
BACKGROUND AND AIMS: In patients with liver cirrhosis, the clinical benefit of the treatment with human albumin for ascites is debated, and no data are available regarding refractory ascites. In this study, in patients with cirrhosis and refractory ascites, we assessed the effect of long-term albumin administration on emergent hospitalization and mortality. METHODS: Seventy patients with cirrhosis and refractory ascites, followed at the Unit of Internal Medicine and Hepatology, University and General Hospital of Padova, Italy, were included into the study...
September 19, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
Antonella Lezo, Teresa Capriati, Maria Immacolata Spagnuolo, Laura Lacitignola, Irina Goreva, Grazia Di Leo, Nicola Cecchi, Paolo Gandullia, Sergio Amarri, Maria Luisa Forchielli, Valeria Dipasquale, Barbara Parma, Simona Gatti, Elisa Ravaioli, Silvia Salvatore, Martina Mainetti, Lorenzo Norsa, Maristella Pellegrino, Martina Fornaro, Valentina Fiorito, Marcello Lanari, Ester Giaquinto, Elvira Verduci, Maria Elisabetta Baldassarre, Antonella Diamanti
Home Artificial Nutrition (HAN) is a safe and efficacious technique that insures children's reintegration into the family, society and school. Epidemiological data on paediatric HAN in Italy are not available. AIM: to detect the prevalence and incidence of Home Parenteral Nutrition (HPN) and Home Enteral Nutrition (HEN), either via tube or mouth, in Italy in 2016. MATERIALS AND METHODS: a specific form was sent to all registered SIGENP members and investigators of local HAN centres, inviting them to provide the requested centre's data and demographics, underlying diseases and HAN characteristics of the patients...
September 16, 2018: Nutrients
Robert S Brown, Robert E Schwartz
No abstract text is available yet for this article.
September 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Emily Adland, Gerald Jesuthasan, Louise Downs, Victoria Wharton, Gemma Wilde, Anna L McNaughton, Jane Collier, Eleanor Barnes, Paul Klenerman, Monique Andersson, Katie Jeffery, Philippa C Matthews
BACKGROUND: As direct acting antiviral (DAA) therapy is progressively rolled out for patients with hepatitis C virus (HCV) infection, careful scrutiny of HCV epidemiology, diagnostic testing, and access to care is crucial to underpin improvements in delivery of treatment, with the ultimate goal of elimination. METHODS: We retrospectively studied microbiology records from a large UK teaching hospital in order to compare the performance of HCV screening and diagnostic tests (antibody, antigen and HCV RNA detection)...
September 14, 2018: BMC Infectious Diseases
(no author information available yet)
Recognizing the importance of timely guidance regarding the rapidly evolving field of hepatitis C management, the American Association for the Study of Liver Diseases (AASLD) and the Infectious Diseases Society of America (IDSA) developed a web-based process for the expeditious formulation and dissemination of evidence-based recommendations. Launched in 2014, the hepatitis C virus (HCV) guidance website undergoes periodic updates as necessitated by availability of new therapeutic agents and/or research data...
September 12, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
The Lancet Gastroenterology Hepatology
No abstract text is available yet for this article.
October 2018: Lancet. Gastroenterology & Hepatology
The Lancet Gastroenterology Hepatology
No abstract text is available yet for this article.
October 2018: Lancet. Gastroenterology & Hepatology
Rhoia Clara Neidenbach, Eckart Lummert, Matthias Vigl, Reinhard Zachoval, Michael Fischereder, Andrea Engelhardt, Claudia Pujol, Renate Oberhoffer, Nicole Nagdyman, Peter Ewert, Michael Hauser, Harald Kaemmerer
Background: As a result of improved surgical and therapeutical management, more than 90% of patients with congenital heart disease (CHD) reach adulthood. However, the natural course of CHD is complicated by noncardiac medical problems. Aim of the study was to evaluate noncardiac comorbidities in a contemporary cohort of adults with CHD (ACHD). Methods: In a tertiary care center for ACHD, 821 consecutive patients, admitted to the outpatient clinic, were evaluated for clinically relevant noncardiac comorbidities...
August 2018: Cardiovascular Diagnosis and Therapy
Jayalakshmi Durairaj, Esha R Shanbhag, P Veena, Mamtha Gowda, Anish Keepanasseril
Wilson's disease is an autosomal recessive genetic disorder affecting copper transport leading to hepatic and/or neuropsychiatric manifestations. Changes in pregnancy can mimic certain clinical features of chronic liver disease such as spider naevi, and constraints for the use of various investigation for diagnosis pose a challenge to physicians. A high index of suspicion, multi-disciplinary team approach, use of correct non-invasive testing including viral serology, autoantibodies and copper studies and ultrasonography help to diagnose most of the pre-existing, de novo or pregnancy-specific hepatological conditions...
September 2018: Obstetric Medicine
Steven L Ciciora, Frederick W Woodley
Gastroesophageal reflux (GER) is the retrograde movement of gastric (and sometimes duodenal) contents into the esophagus. While the majority of GER is physiologic, for patients, it can be associated with symptoms. While some symptoms are merely bothersome (crying), others can be life threatening (cough, gagging, choking). The main driver of GER in infants is the frequent feedings that produce increased intra-abdominal pressure, which is known to trigger transient relaxations of the lower esophageal sphincter...
September 10, 2018: Paediatric Drugs
Dmitry Victorovich Garbuzenko, Nikolay Olegovich Arefyev, Evgeniy Leonidovich Kazachkov
Developing medicines for hemodynamic disorders that are characteristic of cirrhosis of the liver is a relevant problem in modern hepatology. The increase in hepatic vascular resistance to portal blood flow and subsequent hyperdynamic circulation underlie portal hypertension (PH) and promote its progression, despite the formation of portosystemic collaterals. Angiogenesis and vascular bed restructurization play an important role in PH pathogenesis as well. In this regard, strategic directions in the therapy for PH in cirrhosis include selectively decreasing hepatic vascular resistance while preserving or increasing portal blood flow, and correcting hyperdynamic circulation and pathological angiogenesis...
September 7, 2018: World Journal of Gastroenterology: WJG
Anna C Croce, Giovanni Bottiroli, Laura G Di Pasqua, Clarissa Berardo, Veronica Siciliano, Vittoria Rizzo, Mariapia Vairetti, Andrea Ferrigno
While it is well established that various factors can impair the production and flow of bile and lead to cholestatic disease in hepatic and extrahepatic sites, an enhanced assessment of the biomarkers of the underlying pathophysiological mechanisms is still needed to improve early diagnosis and therapeutic strategies. Hence, we investigated fluorescing endogenous biomolecules as possible intrinsic biomarkers of molecular and cellular changes in cholestasis. Spectroscopic autofluorescence (AF) analysis was performed using a fiber optic probe (366 nm excitation), under living conditions and in serum, on the livers of male Wistar rats submitted to bile duct ligation (BDL, 24, 48, and 72 h)...
September 5, 2018: International Journal of Molecular Sciences
Silvia Salvatore, Antonio Ripepi, Koen Huysentruyt, Kristel van de Maele, Luana Nosetti, Massimo Agosti, Alessandro Salvatoni, Yvan Vandenplas
BACKGROUND: Guidelines are contradictory regarding the use of alginate in infants with persisting gastroesophageal reflux (GER). While The British National Institute for Health and Care (NICE) guidelines consider alginate as a treatment option, the guidelines of the European and North-American Societies for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN, NASPGHAN) do not recommend alginates. AIMS: We assessed the efficacy of alginate to reduce GER episodes in infants...
September 4, 2018: Paediatric Drugs
Krisztina Hagymási, Anna Bacsárdi, Anna Egresi, Evelin Berta, Zsolt Tulassay, Gabriella Lengyel
The community of microorganisms in the intestine, namely gut microbiome lives in symbiosis with the host, contributing to its homeostasis and influencing it simultaneously. It can be suspected that gut microbiome plays a central role in the pathophysiology of intestinal and extraintestinal diseases: determining their development, progress and complications. Recently, intestinal microbiome has become a highlighted field of interest and important topic in research, especially in hepatology. It is in the focus of relevant research as the liver is the organ which meets nutrients, bacterial components, toxins and metabolites at first, as a filter...
September 2018: Orvosi Hetilap
Jay Shah, Toluwalase Okubote, Naim Alkhouri
Nonalcoholic fatty liver disease (NAFLD) is a form of chronic liver disease that is characterized by excessive fatty infiltration of the liver in the absence of significant alcohol consumption. As in the adult population, the etiology of NAFLD in children has been attributed to genetic predilection, insulin resistance, and obesity. The prevalence of NAFLD in the pediatric population has consistently increased over the past few decades, and it is currently considered the most common chronic liver disease in children...
July 2018: Gastroenterology & Hepatology
Ewa Podgorska, Martyna Sniegocka, Marianna Mycinska, Wojciech Trybus, Ewa Trybus, Anna Kopacz-Bednarska, Olga Wiechec, Martyna Krzykawska-Serda, Martyna Elas, Teodora Krol, Krystyna Urbanska, Andrzej Slominski
Although vitamin D is included in the group of fat-soluble vitamins, it must be considered as a prohormone. Its active forms, including calcitriol, have pleiotropic effects and play an important role in the regulation of cell proliferation, differentiation and apoptosis, as well as in hormone secretion, and they demonstrate anti-cancer properties. Since calcitriol delivery can be beneficial for the organism, and Syrian golden hamsters represent a unique experimental model, we decided to investigate its toxicity in this species...
2018: Acta Biochimica Polonica
Lisa B VanWagner, Nancy Reau
No abstract text is available yet for this article.
February 2018: Clinical Liver Disease
Judy A Trieu, Mohammad Bilal, Briana Lewis, Eric Gou, Lindsay Sonstein, Sreeram Parupudi
Malnutrition is a common cause of impeding recovery in patients with acute alcoholic hepatitis (AAH). Previous reports have shown that appropriate nutritional supplementation reduce short and long-term mortality in patients with AAH. Despite these clear recommendations, the element of nutrition in AAH is often neglected. We designed a quality improvement project to evaluate and improve compliance with appropriate nutrition in patients presenting with AAH at our institution. Patients admitted with AAH between December 2015 to December 2016 were included...
August 24, 2018: Annals of Hepatology
Satoshi Ida, Yuji Kojima, Shima Hamaoka, Naohito Urawa, Jun Araki, Ryutaro Kaneko, Kazuya Murata
BACKGROUND AND AIM: We aimed to examine the validity of the Japanese version of the SARC-F questionnaire (SARC-F-J) that employs the diagnostic criteria for sarcopenia established by the Japan Society of Hepatology in patients with chronic liver disease. METHODS: Subjects were outpatients at the Department of Hepatology at the Japanese Red Cross Ise Hospital, Japan. Evaluations were performed using the following self-administered questionnaires: SARC-F-J, Tokyo Metropolitan Institute of Gerontology Index of Competence (TMIG-IC), the Japanese version of the Falls efficacy scale (FES), and Kaigo-Yobo checklist (CL)...
August 25, 2018: Journal of Gastroenterology and Hepatology
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