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Propranolol er

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https://www.readbyqxmd.com/read/25629351/beta-blockers-suppress-dextrose-induced-endoplasmic-reticulum-stress-oxidative-stress-and-apoptosis-in-human-coronary-artery-endothelial-cells
#1
Michael J Haas, William Kurban, Harshit Shah, Luisa Onstead-Haas, Arshag D Mooradian
Beta blockers are known to have favorable effects on endothelial function partly because of their capacity to reduce oxidative stress. To determine whether beta blockers can also prevent dextrose-induced endoplasmic reticulum (ER) stress in addition to their antioxidative effects, human coronary artery endothelial cells and hepatocyte-derived HepG2 cells were treated with 27.5 mM dextrose for 24 hours in the presence of carvedilol (a lipophilic beta blockers with alpha blocking activity), propranolol (a lipophilic nonselective beta blockers), and atenolol (a water-soluble selective beta blockers), and ER stress, oxidative, stress and cell death were measured...
November 2016: American Journal of Therapeutics
https://www.readbyqxmd.com/read/25151873/formulation-characterization-and-clinical-evaluation-of-propranolol-hydrochloride-gel-for-transdermal-treatment-of-superficial-infantile-hemangioma
#2
RANDOMIZED CONTROLLED TRIAL
Wenhu Zhou, Shiying He, Yijun Yang, Dan Jian, Xiang Chen, Jinsong Ding
The objective of the present study is to formulate and characterize propranolol hydrochloride (PPL · HCl) gel, and to evaluate the efficacy of this formulation in transdermal treatment for superficial infantile hemangioma (IH). The transdermal PPL · HCl gel was prepared by a direct swelling method, which chose hydroxypropyl methylcellulose (HPMC) as the matrix and used terpenes plus alcohols as permeation enhancer. Permeation studies of PPL · HCl were carried out with modified Franz diffusion cells through piglet skin...
2015: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/24891937/the-quality-control-theory-of-aging
#3
Warren Ladiges
The quality control (QC) theory of aging is based on the concept that aging is the result of a reduction in QC of cellular systems designed to maintain lifelong homeostasis. Four QC systems associated with aging are 1) inadequate protein processing in a distressed endoplasmic reticulum (ER); 2) histone deacetylase (HDAC) processing of genomic histones and gene silencing; 3) suppressed AMPK nutrient sensing with inefficient energy utilization and excessive fat accumulation; and 4) beta-adrenergic receptor (BAR) signaling and environmental and emotional stress...
2014: Pathobiology of Aging & Age related Diseases
https://www.readbyqxmd.com/read/24717588/thyrotoxic-hypokalaemic-periodic-paralysis-a-rare-presentation-of-graves-disease-in-a-hispanic-patient
#4
Abhishek Matta, Jahnavi Koppala, William Gossman
A 26-year-old Hispanic man with no significant medical history presented to our emergency room with gradual onset weakness of his lower extremities. He was haemodynamically stable and examination revealed loss of motor function in his lower limbs up to the level of hips. Laboratory data revealed hypokalaemia. The patient was started on potassium supplementation and he recovered his muscle strength. Differential diagnosis included familial hypokalaemic periodic paralysis and thyrotoxic periodic paralysis (TPP)...
2014: BMJ Case Reports
https://www.readbyqxmd.com/read/24437486/activation-of-hepatic-inflammatory-pathways-by-catecholamines-is-associated-with-hepatic-insulin-resistance-in-male-ischemic-stroke-rats
#5
Ya-Yu Wang, Shih-Yi Lin, Yu-Han Chuang, Wayne Huey-Herng Sheu, Kwong-Chung Tung, Chun-Jung Chen
Patients who experience acute ischemic stroke may develop hyperglycemia, even in the absence of diabetes. In the current study we determined the effects of acute stroke on hepatic insulin signaling, TNF-α expression, endoplasmic reticulum (ER) stress, the activities of c-Jun N-terminal kinase (JNK), inhibitor κB kinase β (IKK-β), and nuclear factor-κB (NF-κB) pathways. Rats with cerebral ischemia developed higher blood glucose, and insulin levels, and insulin resistance index, as well as hepatic gluconeogenic enzyme expression compared with the sham-treated group...
April 2014: Endocrinology
https://www.readbyqxmd.com/read/23955316/effect-of-lipophilicity-on-microneedle-mediated-iontophoretic-transdermal-delivery-across-human-skin-in-vitro
#6
Kasturi R Pawar, Forrest Smith, Chandra Sekhar Kolli, R Jayachandra Babu
The effect of lipophilicity of drug on the microneedle (MN)-mediated iontophoretic delivery across dermatomed human skin was studied. Beta blockers with similar pKa but varied log P values were selected as model drugs in this study. Iontophoresis (ITP) or MNs, when used independently, increased the transdermal flux of beta blockers as compared with passive delivery (PD). ITP across the MN-treated skin (MN + ITP) increased the permeation rate of all beta blockers as compared with PD (p < 0.001). The enhancement ratios (ER) for hydrophilic molecules (atenolol and sotalol) were 71- and 78-fold higher for ITP + MN as compared with PD...
October 2013: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/23314492/mechanism-of-synergistic-interactions-and-its-influence-on-drug-release-from-extended-release-matrices-manufactured-using-binary-mixtures-of-polyethylene-oxide-and-sodium-carboxymethylcellulose
#7
Dasha Palmer, Marina Levina, Dionysios Douroumis, Mohammed Maniruzzaman, David J Morgan, Thomas P Farrell, Ali R Rajabi-Siahboomi, Ali Nokhodchi
The ability of anionic polymer sodium carboxymethylcellulose to influence the release of four model cationic drugs (chlorpheniramine maleate, venlafaxine hydrochloride, propranolol hydrochloride and verapamil hydrochloride) from extended release (ER) hydrophilic matrices based on non-ionic polymer polyethylene oxide was investigated by X-ray photoelectron spectroscopy (XPS), isothermal titration calorimetry (ITC) and differential scanning calorimetry (DSC). For all studied APIs, a combination of polyethylene oxide with sodium carboxymethylcellulose produced slower drug release compared to the matrices of single polymers...
April 1, 2013: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/23054583/treatment-of-headache-in-the-elderly
#8
Linda A Hershey, Edward M Bednarczyk
Most primary headaches in the elderly are similar to those in younger patients (tension, migraine, and cluster), but there are some differences, such as late-life migraine accompaniments and hypnic headaches. Although migraine in younger persons usually presents with headache, migraine in older persons may initially appear with visual or sensory phenomena, instead of headache ("migraine accompaniments"). Hypnic headaches awaken patients from sleep, are short-lived, and occur only in the elderly. The probability of secondary headache increases steadily with age...
February 2013: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/22995391/blocking-%C3%AE-adrenergic-signaling-attenuates-reductions-in-circulating-leptin-cancellous-bone-mass-and-marrow-adiposity-seen-with-dietary-energy-restriction
#9
Kyunghwa Baek, Susan A Bloomfield
We tested whether β-adrenergic blockade attenuates bone loss and increased marrow adiposity during energy restriction (ER) and whether such an effect is associated with changes in serum leptin and leptin expression in bone and marrow tissues. Female 4-mo-old Sprague-Dawley rats were assigned into four groups (n = 10 each): two groups of 40% ER treated with vehicle (ERVEH; saline) or β-blocker (ERBB; DL-propranolol; 250 μg · kg(-1) · h(-1)) during 12 wk, and two groups of ad libitum-fed controls treated with the same two agents (CONVEH, CONBB, respectively)...
December 1, 2012: Journal of Applied Physiology
https://www.readbyqxmd.com/read/22396018/propranolol-improves-impaired-hepatic-phosphatidylinositol-3-kinase-akt-signaling-after-burn-injury
#10
Natasha C Brooks, Juquan Song, Darren Boehning, Robert Kraft, Celeste C Finnerty, David N Herndon, Marc G Jeschke
Severe burn injury is associated with induction of the hepatic endoplasmic reticulum (ER) stress response. ER stress leads to activation of c-Jun N-terminal kinase (JNK), suppression of insulin receptor signaling via phosphorylation of insulin receptor substrate 1 and subsequent insulin resistance. Marked and sustained increases in catecholamines are prominent after a burn. Here, we show that administration of propranolol, a nonselective β1/2 adrenergic receptor antagonist, attenuates ER stress and JNK activation...
2012: Molecular Medicine
https://www.readbyqxmd.com/read/22331352/endoplasmic-reticulum-potassium-hydrogen-exchanger-and-small-conductance-calcium-activated-potassium-channel-activities-are-essential-for-er-calcium-uptake-in-neurons-and-cardiomyocytes
#11
Malle Kuum, Vladimir Veksler, Joanna Liiv, Renee Ventura-Clapier, Allen Kaasik
Calcium pumping into the endoplasmic reticulum (ER) lumen is thought to be coupled to a countertransport of protons through sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA) and the members of the ClC family of chloride channels. However, pH in the ER lumen remains neutral, which suggests a mechanism responsible for proton re-entry. We studied whether cation-proton exchangers could act as routes for such a re-entry. ER Ca(2+) uptake was measured in permeabilized immortalized hypothalamic neurons, primary rat cortical neurons and mouse cardiac fibers...
February 1, 2012: Journal of Cell Science
https://www.readbyqxmd.com/read/21514957/%C3%AE-%C3%A2-adrenergic-activation-of-sequential-ca-2-release-from-mitochondria-and-the-endoplasmic-reticulum-and-the-subsequent-ca-2-entry-in-rodent-brown-adipocytes
#12
Ryotaro Hayato, Yoko Higure, Masako Kuba, Hiroki Nagai, Hitoshi Yamashita, Kenji Kuba
We studied how mitochondrial uncoupling by β(3)-adrenergic stimulation elicits Ca(2+) signals in rodent brown adipocytes by fluorometry of Ca(2+) concentrations ([Ca(2+)](i), [Ca(2+)](m) and [Ca(2+)](ER)) in the cytoplasm, mitochondria and the endoplasmic reticulum (ER), respectively, and mitochondrial membrane potential, using fura-2, rhod-5N, cameleon and rhodamine 123. Immunoblotting demonstrated α(1A)- and β(3)-adrenergic receptor and UCP1 in adipocytes, while RT-PCR revealed the mRNA of type 3, 7 and 9 adenylate cyclase, UCP1, UCP2, UCP3 and type 1 and 2 inositoltrisphosphate receptors...
June 2011: Cell Calcium
https://www.readbyqxmd.com/read/21235472/interactions-between-novel-terpenes-and-main-components-of-rat-and-human-skin-mechanistic-view-for-transdermal-delivery-of-propranolol-hydrochloride
#13
COMPARATIVE STUDY
Abdul Ahad, Mohammed Aqil, Kanchan Kohli, Yasmin Sultana, Mohd Mujeeb, Asgar Ali
The purpose of this study was to investigate the effectiveness and mechanism(s) of percutaneous absorption of propranolol hydrochloride (PHCL) across rat and human cadaver skin using seven novel terpenes with reference to marker terpene 1,8-cineole. In-vitro skin permeation studies were carried out via rat and human skin models. The mechanism of skin permeation of PHCL by terpenes was evaluated by FTIR, DSC, activation energy measurement and histopathological examination. Amongst the new terpenes, 1,4-cineole was found to be most effective enhancer for diffusion of PHCL through rat skin (ER=3...
March 2011: Current Drug Delivery
https://www.readbyqxmd.com/read/19889439/fate-of-beta-blocker-human-pharmaceuticals-in-surface-water-comparison-of-measured-and-simulated-concentrations-in-the-glatt-valley-watershed-switzerland
#14
COMPARATIVE STUDY
Alfredo C Alder, Christian Schaffner, Marius Majewsky, Jörg Klasmeier, Kathrin Fenner
This study focused on the occurrence and fate of four beta-blockers (atenolol, sotalol, metoprolol, propranolol) in wastewater and surface water. Measured concentrations were compared with predicted concentrations using an implementation of the geo-referenced model GREAT-ER for the Glatt Valley Watershed (Switzerland). Particularly, the question was addressed how measured and simulated data could complement each other for the exposure assessment of human pharmaceuticals and other micropollutants entering surface water through wastewater treatment plants (WWTP)...
February 2010: Water Research
https://www.readbyqxmd.com/read/19695518/-thyrotoxic-periodic-paralysis-as-a-form-of-presentation-of-primary-autoimmune-hyperthyroidism-utility-of-non-selective-beta-blockers
#15
Nuria Fuertes Zamorano, Clara Marcuello Foncillas, María Paz De Miguel Novoa, Arturo Sampedro Andrada, Rocío García Cobos, José Angel Díaz Pérez
A 40-year-old Caucasian man presented to the emergency room of our hospital with bilateral lower extremity weakness with onset 1 hour previously and concurrent hypokalemia. After dramatic clinical progression for the first 5 hours, the episode resolved once serum potassium levels were normalized. Laboratory data revealed primary hyperthyroidism, indicating a diagnosis of thyrotoxic periodic paralysis (TPP). Treatment consisted of potassium, propranolol and methimazole administration. Although the mainstay of therapy is potassium replacement, the role of propranolol in improving the acute clinical manifestations of TPP has yet to be adequately clarified...
June 2009: Endocrinología y Nutrición: órgano de la Sociedad Española de Endocrinología y Nutrición
https://www.readbyqxmd.com/read/19370290/thyrotoxic-periodic-paralysis-in-a-saudi-patient-complicated-by-life-threatening-arrhythmia
#16
Saleh Aldasouqi, Samia A Bokhari, Patan M Khan, Ali S Al-Zahrani
Thyrotoxic periodic paralysis (TPP) is rare in non-Orientals, and sporadic case reports were reported world-wide. Eight cases were reported in Arabs, including 3 Saudis. We present an additional case of TPP in a 38-year-old Saudi man, and review the literature on TPP in Arabs. Our patient presented with complete flaccid quadriplegia, 5 weeks after he was diagnosed with Graves' disease that was treated with carbimazole and propranolol. He was hyperthyroid, and his potassium was extremely low (1.5 mmol/L). During initial evaluation in the emergency room, he developed transient asystole manifested by syncope...
April 2009: Saudi Medical Journal
https://www.readbyqxmd.com/read/18445492/administration-of-angiotensin-ii-in-the-paraventricular-nucleus-protects-gastric-mucosa-from-ischemia-reperfusion-injury
#17
Yong-Mei Zhang, Er-Qing Wei, Xia Hu, Ming Xu, Yue Shi, Jian-Fu Zhang
Our previous study demonstrated that electrical stimulation of the hypothalamic paraventricular nucleus (PVN) protects against gastric ischemia-reperfusion (GI-R) injury, but it is still unknown whether angiotensin II (Ang II) in the PVN plays a role in the development of GI-R. The purpose of this study was to investigate the effect of Ang II in the PVN on GI-R injury. GI-R injury was induced in rats by clamping the celiac artery for 30 min, and then reperfusing for 30 min, 1 h, 3 h, 6 h or 24 h, respectively...
May 30, 2008: Brain Research
https://www.readbyqxmd.com/read/17567948/diacylglycerol-is-required-for-the-formation-of-copi-vesicles-in-the-golgi-to-er-transport-pathway
#18
Inés Fernández-Ulibarri, Montserrat Vilella, Francisco Lázaro-Diéguez, Elisabet Sarri, Susana E Martínez, Nuria Jiménez, Enrique Claro, Isabel Mérida, Koert N J Burger, Gustavo Egea
Diacylglycerol is necessary for trans-Golgi network (TGN) to cell surface transport, but its functional relevance in the early secretory pathway is unclear. Although depletion of diacylglycerol did not affect ER-to-Golgi transport, it led to a redistribution of the KDEL receptor to the Golgi, indicating that Golgi-to-ER transport was perturbed. Electron microscopy revealed an accumulation of COPI-coated membrane profiles close to the Golgi cisternae. Electron tomography showed that the majority of these membrane profiles originate from coated buds, indicating a block in membrane fission...
September 2007: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/17281524/rutin-induced-endothelium-dependent-vasorelaxation-in-rat-aortic-rings-and-the-underlying-mechanism
#19
Man-Li Xia, Xin-mei Zhou, Hui Yao, Hui-di Jiang, Iain C Bruce, Er-qing Wei, Qiang Xia
The aim of the present study was to determine the possible mechanism by which rutin causes vasodilatation in isolated thoracic aorta rings from the rat. The effects of rutin on rings preconstricted with phenylephrine, with or without endothelium, were determined using an organ bath technique. The mechanism was explored by measuring the effects of the nitric oxide synthase inhibitor L-N(G)-nitroarginine methyl ester (L-NAME), the guanylyl cyclase inhibitor methylene blue, the cyclooxygenase inhibitor indomethacin, the ATP-sensitive K<sup>+</sup>channel blocker glibenclamide and the beta-adrenoceptor antagonist propranolol...
2005: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/17007747/in-vitro-and-in-vivo-evaluation-of-a-novel-oral-insulin-formulation
#20
Er-li Ma, Hong Ma, Zheng Liu, Ghang-xue Zheng, Ming-xing Duan
AIM: To develop a stable self-emulsifying formulation for oral delivery of insulin. METHODS: Caco-2 cell line and diabetic beagles were used as in vitro and in vivo models to study the absorption mechanism and the hypoglycemic efficacy of the formulation. In addition, various physicochemical parameters of the formulation such as droplet size, insulin encapsulation efficiency and stability were evaluated. RESULTS: This formulation enabled changes in barrier properties of Caco-2 monolayers, as referred by transepithelial electrical resistance (TEER) and apparent permeability coefficients (P(app)) of the paracellular marker ranitidine (20-fold greater than control) but not transcellular marker propranolol, suggesting that the opening of tight junctions was involved...
October 2006: Acta Pharmacologica Sinica
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