keyword
MENU ▼
Read by QxMD icon Read
search

Conservation

keyword
https://www.readbyqxmd.com/read/29166685/-evaluation-of-inpatient-conservative-management-of-acute-subacute-and-chronic-back-pain
#1
Ingo Haase, Kilian Haase, Bernd Kladny
Background Backache is very common in the German population. It is a common reason for people to seek medical advice and specific back pain programs have been developed. The intention of this study is to evaluate the short and long term effects of conservative management of back pain in a German general hospital. Outcomes of interest were pain intensity, interference in daily functions, physical functioning and health related quality of life. Patients and Methods We examined 1010 patients with acute, subacute and chronic back pain, admitted to inpatient nonsurgical interventional therapy in a German hospital between July 2013 and July 2015...
November 22, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29166633/range-extension-and-behavioural-observations-of-the-recently-described-sheth-s-dwarf-lemur-cheirogaleus-shethi
#2
Daniel Hending, Angelo Andrianiaina, Zafimahery Rakotomalala, Sam Cotton
Sheth's dwarf lemur, Cheirogaleus shethi, is a small, recently discovered nocturnal primate endemic to northern Madagascar. Unlike many other nocturnal lemurs, C. shethi lives sympatrically with morphologically similar species of its cryptic genus, making it difficult for biologists to determine its population density and distribution. Here, we present new data and observations of this species. During a series of rapid biodiversity assessments in the SAVA region of north-eastern Madagascar, we observed C. shethi in 10 different sites, 9 of which were not previously known to harbour C...
November 23, 2017: Folia Primatologica; International Journal of Primatology
https://www.readbyqxmd.com/read/29166595/positive-and-negative-regulation-of-the-master-metabolic-regulator-mtorc1-by-two-families-of-legionella-pneumophila-effectors
#3
Justin A De Leon, Jiazhang Qiu, Christopher J Nicolai, Jessica L Counihan, Kevin C Barry, Li Xu, Rosalie E Lawrence, Brian M Castellano, Roberto Zoncu, Daniel K Nomura, Zhao-Qing Luo, Russell E Vance
All pathogens must acquire nutrients from their hosts. The intracellular bacterial pathogen Legionella pneumophila, the etiological agent of Legionnaires' disease, requires host amino acids for growth within cells. The mechanistic target of rapamycin complex 1 (mTORC1) is an evolutionarily conserved master regulator of host amino acid metabolism. Here, we identify two families of translocated L. pneumophila effector proteins that exhibit opposing effects on mTORC1 activity. The Legionella glucosyltransferase (Lgt) effector family activates mTORC1, through inhibition of host translation, whereas the SidE/SdeABC (SidE) effector family acts as mTORC1 inhibitors...
November 21, 2017: Cell Reports
https://www.readbyqxmd.com/read/29166577/cell-cycle-related-kinase-regulates-mammalian-eye-development-through-positive-and-negative-regulation-of-the-hedgehog-pathway
#4
Floria I Lupu, Jacob B Burnett, Jonathan T Eggenschwiler
Cell cycle-related kinase (CCRK) is a conserved regulator of ciliogenesis whose loss in mice leads to a wide range of developmental defects, including exencephaly, preaxial polydactyly, skeletal abnormalities, and microphthalmia. Here, we investigate the role of CCRK in mouse eye development. Ccrk mutants show dramatic patterning defects, with an expansion of the optic stalk domain into the optic cup, as well as an expansion of the retinal pigment epithelium (RPE) into neural retina (NR) territory. In addition, Ccrk mutants display a shortened optic stalk...
November 19, 2017: Developmental Biology
https://www.readbyqxmd.com/read/29166409/post-weaning-high-fat-diet-results-in-growth-cartilage-lesions-in-young-male-rats
#5
Samuel S Haysom, Mark H Vickers, Lennex H Yu, Clare M Reynolds, Elwyn C Firth, Sue R McGlashan
To determine if a high-fat diet (HF) from weaning would result in a pro-inflammatory state and affect joint cartilage, we fed male rats either HF or Chow diet post-weaning, and voluntary wheel exercise (EX) or cage only activity (SED) after 9 weeks of age. At 17 weeks body composition, plasma biomarkers and histomorphology scores of femoro-tibial cartilages of HF-SED, HF-EX, Chow-SED and Chow-EX groups were compared. Food intake and activity were not significantly different between groups. HF diet resulted in significantly higher weight gain, %fat, fat:lean ratio, and plasma leptin, insulin and TNFα concentrations, with significant interactions between diet and exercise...
2017: PloS One
https://www.readbyqxmd.com/read/29166242/dynamism-of-an-astrocyte-in-vivo-perspectives-on-identity-and-function
#6
Kira E Poskanzer, Anna V Molofsky
Astrocytes are an abundant and evolutionarily conserved central nervous system cell type. Despite decades of evidence that astrocytes are integral to neural circuit function, it seems as though astrocytic and neuronal biology continue to advance in parallel to each other, to the detriment of both. Recent advances in molecular biology and optical imaging are being applied to astrocytes in new and exciting ways but without fully considering their unique biology. From this perspective, we explore the reasons that astrocytes remain enigmatic, arguing that their responses to neuronal and environmental cues shape form and function in dynamic ways...
November 20, 2017: Annual Review of Physiology
https://www.readbyqxmd.com/read/29166224/a-reanalysis-of-occupation-and-suicide-negative-perceptions-of-the-workplace-linked-to-suicide-attempts
#7
Matt Howard, Morgan Krannitz
Suicide is the ultimate outcome of poor psychological well-being; however, there is a paucity of research examining the link between occupation and suicide, despite early academic interest and the known importance of work to our everyday lives. We propose that this body of research was abandoned prematurely, and we provide a reanalysis by integrating the Job Characteristics Model and the Conservation of Resources model with extant suicide research. Specifically, we hypothesize that work design characteristics (job autonomy, task variety, physical demands) and threats to personal resources (absence of viewing work-as-career, work-family conflict, family-work conflict, job dissatisfaction) are linked to suicide attempts via depression and suicidal ideation...
November 17, 2017: Journal of Psychology
https://www.readbyqxmd.com/read/29166154/predator-persistence-through-variability-of-resource-productivity-in-tritrophic-systems
#8
Floor H Soudijn, André M de Roos
The trophic structure of species communities depends on the energy transfer between trophic levels. Primary productivity varies strongly through time, challenging the persistence of species at higher trophic levels. Yet resource variability has mostly been studied in systems with only one or two trophic levels. We test the effect of variability in resource productivity in a tritrophic model system including a resource, a size-structured consumer, and a size-specific predator. The model complies with fundamental principles of mass conservation and the body-size dependence of individual-level energetics and predator-prey interactions...
December 2017: American Naturalist
https://www.readbyqxmd.com/read/29166127/bat-biology-genomes-and-the-bat1k-project-to-generate-chromosome-level-genomes-for-all-living-bat-species
#9
Emma Teeling, Sonja Vernes, Liliana M Davalos, David A Ray, M Thomas P Gilbert, Eugene Myers, Bat K Consortium
Bats are unique among mammals, possessing some of the rarest mammalian adaptations, including true self-powered flight, laryngeal echolocation, exceptional longevity, unique immunity, contracted genomes, and vocal learning. They provide key ecosystem services, pollinating tropical plants, dispersing seeds, and controlling insect pest populations, thus driving healthy ecosystems. They account for more than 20% of all living mammalian diversity, and their crown-group evolutionary history dates back to the Eocene...
November 20, 2017: Annual Review of Animal Biosciences
https://www.readbyqxmd.com/read/29166126/nutrient-sensing-biology-in-mammals-and-birds
#10
Eugeni Roura, Simon R Foster
Nutrient sensing mechanisms have emerged as the fringe articulating nutritional needs with dietary choices. Carbohydrate, amino acid, fatty acid, mineral, and water sensing receptors are highly conserved across mammals and birds, consisting of a repertoire of 22 genes known to date. In contrast, bitter receptors are highly divergent and have a high incidence of polymorphisms within and between mammals and birds and are involved in the adaptation of species to specific environments. In addition, the expression of nutrient sensing genes outside the oral cavity seems to mediate the required decision-making dialogue between the gut and the brain by translating exogenous chemical stimuli into neuronal inputs, and vice versa, to translate the endogenous signals relevant to the nutritional status into specific appetites and the control of feed intake...
November 20, 2017: Annual Review of Animal Biosciences
https://www.readbyqxmd.com/read/29166098/pulling-force-and-surface-tension-drive-membrane-fusion
#11
Xuejuan Liu, Falin Tian, Tongtao Yue, Xianren Zhang, Chongli Zhong
Despite catalyzed by fusion proteins of quite different molecular architectures, intracellular, viral, and cell-to-cell fusions are found to have the essential common features and the nearly same nature of transition states. The similarity inspires us to find a more general catalysis mechanism for membrane fusion that minimally depends on the specific structures of fusion proteins. In this work, we built a minimal model for membrane fusion, and by using dissipative particle dynamics simulations, we propose a mechanism that the pulling force generated by fusion proteins initiates the fusion process and the membrane tension regulates the subsequent fusion stages...
November 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29165886/pre-operative-features-of-non-invasive-follicular-thyroid-neoplasms-with-papillary-like-nuclear-features-an-analysis-of-their-cytological-gene-expression-classifier-and-sonographic-findings
#12
S J Song, V A LiVolsi, K Montone, Z Baloch
OBJECTIVE: To investigate the corresponding cytological diagnoses, Gene Expression Classifier (GEC) results and ultrasound features of thyroid nodules diagnosed as non-invasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP), as well as any coexisting pathology. METHODS: We performed a retrospective review of thyroid nodules histologically diagnosed as NIFTP at our institution between 1(st) April 2016 and 1(st) April 2017. The following data points were collected: demographics, nodule size, ultrasound features, cytological diagnosis, GEC results, origin of sample (in-house vs outside hospital) and any additional pathology identified in the resection specimen...
December 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29165773/laparoscopic-surgery-treatment-of-children-with-appendiceal-abscess
#13
Y-Y Yin, H-W Zhang, H Cao, H-X Zou, B-B Zhuo, Y Li, X Zhang
OBJECTIVE: To evaluate the feasibility of treatment for children with appendiceal abscess by laparoscopic surgery and investigate its superiorities to conventional treatments. PATIENTS AND METHODS: 45 children with appendiceal abscess who were treated with laparoscopic surgery from January 2011 to July 2011 were reviewed and analyzed. The age of children ranged from 7 months to 5 years. 37 children received emergency operations, among which 8 children additionally received laparoscopic surgery...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29165708/separase-prevents-genomic-instability-by-controlling-replication-fork-speed
#14
Francesco Cucco, Elisa Palumbo, Serena Camerini, Barbara D'Alessio, Valentina Quarantotti, Maria Luisa Casella, Ilaria Maria Rizzo, Dubravka Cukrov, Domenico Delia, Antonella Russo, Marco Crescenzi, Antonio Musio
Proper chromosome segregation is crucial for preserving genomic integrity, and errors in this process cause chromosome mis-segregation, which may contribute to cancer development. Sister chromatid separation is triggered by Separase, an evolutionary conserved protease that cleaves the cohesin complex, allowing the dissolution of sister chromatid cohesion. Here we provide evidence that Separase participates in genomic stability maintenance by controlling replication fork speed. We found that Separase interacted with the replication licensing factors MCM2-7, and genome-wide data showed that Separase co-localized with MCM complex and cohesin...
November 20, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29165651/functional-conservation-of-the-ama1-host-cell-invasion-ligand-between-p-falciparum-and-p-vivax-a-novel-platform-to-accelerate-vaccine-and-drug-development
#15
Damien R Drew, Paul R Sanders, Gretchen Weiss, Paul R Gilson, Brendan S Crabb, James G Beeson
P. vivax and P. falciparum malaria species have diverged significantly in receptor-ligand interactions and host-cell invasion. One protein common to both is the merozoite invasion ligand AMA1. While the general structure of AMA1 is similar between species, their sequences are divergent. Surprisingly, it was possible to genetically replace PfAMA1 with PvAMA1 in P. falciparum parasites. PvAMA1 could complement PfAMA1 function and supported efficient invasion of erythrocytes by P. falciparum. Genetically-modified P...
November 20, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29165603/all-roads-lead-to-the-vacuole-autophagic-transport-as-part-of-the-endomembrane-trafficking-network-in-plants
#16
Kamila Kalinowska, Erika Isono
Plants regulate their development and response to the changing environment by sensing and interpreting environmental signals. Intracellular trafficking pathways including endocytic-, vacuolar-, and autophagic trafficking are important for the various aspects of responses in plants. Studies in the last decade have shown that the autophagic transport pathway uses common key components of endomembrane trafficking as well as specific regulators. A number of factors previously described for their function in endosomal trafficking have been discovered to be involved in the regulation of autophagy in plants...
November 19, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29165589/ns3-helicase-from-dengue-virus-specifically-recognizes-viral-rna-sequence-to-ensure-optimal-replication
#17
Crystall M D Swarbrick, Chandrakala Basavannacharya, Kitti W K Chan, Shu-Ann Chan, Daljit Singh, Na Wei, Wint Wint Phoo, Dahai Luo, Julien Lescar, Subhash G Vasudevan
The protein-RNA interactions within the flavivirus replication complex (RC) are not fully understood. Our structure of dengue virus NS3 adenosine triphosphatase (ATPase)/helicase bound to the conserved 5' genomic RNA 5'-AGUUGUUAGUCU-3' reveals that D290 and R538 make specific interactions with G2 and G5 bases respectively. We show that single-stranded 12-mer RNA stimulates ATPase activity of NS3, however the presence of G2 and G5 leads to significantly higher activation. D290 is adjacent to the DEXH motif found in SF2 helicases like NS3 and interacts with R387, forming a molecular switch that activates the ATPase site upon RNA binding...
November 20, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29165551/evolution-and-ecology-of-plant-architecture-integrating-insights-from-the-fossil-record-extant-morphology-developmental-genetics-and-phylogenies
#18
Guillaume Chomicki, Mario Coiro, Susanne S Renner
Background: In contrast to most animals, plants have an indeterminate body plan, which allows them to add new body parts during their lifetime. A plant's realized modular construction is the result of exogenous constraints and endogenous processes. This review focuses on endogenous processes that shape plant architectures and their evolution. Scope: The phylogenetic distribution of plant growth forms across the phylogeny implies that body architectures have originated and been lost repeatedly, being shaped by a limited set of genetic pathways...
November 19, 2017: Annals of Botany
https://www.readbyqxmd.com/read/29165412/-stabilizing-effectiveness-of-orthokeratology-and-long-term-minute-concentration-atropine-therapy-in-myopia-draft-report
#19
T Yu Verzhanskaya, E P Tarutta
The rational for the study was the high prevalence of myopia in the world. According to the World Health Organization (WHO), myopia is one of the five leading causes of blindness and low vision. Of recent reports on conservative measures for the stabilization of myopia, two areas of investigation deserve attention: methods of optical correction that affect peripheral refraction, orthokeratology lenses (OKL) in particular, and pharmacotherapy. The aim of the study was to evaluate the effectiveness and safety of myopia control in pediatric patients by combining two methods - OKL wearing and instillation of extra low doses of atropine (0...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/29165399/greenhouse-gas-emissions-energy-consumption-and-economic-growth-a-panel-cointegration-analysis-for-16-asian-countries
#20
Wen-Cheng Lu
This research investigates the co-movement and causality relationships between greenhouse gas emissions, energy consumption and economic growth for 16 Asian countries over the period 1990-2012. The empirical findings suggest that in the long run, bidirectional Granger causality between energy consumption, GDP and greenhouse gas emissions and between GDP, greenhouse gas emissions and energy consumption is established. A non-linear, quadratic relationship is revealed between greenhouse gas emissions, energy consumption and economic growth, consistent with the environmental Kuznets curve for these 16 Asian countries and a subsample of the Asian new industrial economy...
November 22, 2017: International Journal of Environmental Research and Public Health
keyword
keyword
23595
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"