keyword
MENU ▼
Read by QxMD icon Read
search

Conservation

keyword
https://www.readbyqxmd.com/read/29334709/-molecular-epidemiological-study-of-human-coronavirus-oc43-in-shanghai-from-2009-2016
#1
Y J Yang, Y W Hu
Objective: To understand the epidemiological characteristics of Human coronavirus (HCoV), the patterns of emergence and circulation, and the genotype distribution of human coronavirus OC43 (HCoV-OC43) from November, 2009 to April, 2016 in Shanghai. Methods: A total of 6 059 respiratory specimens, including pharyngeal swab, sputum, nasopharyngeal aspirates and alveolar lavage fluid, as well as relative clinical data were collected from patients with acute respiratory infections from seven sentinel hospitals during November, 2009 to April, 2016 in Shanghai...
January 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29334616/preoperative-breast-magnetic-resonance-imaging-use-by-breast-density-and-family-history-of-breast-cancer
#2
Louise M Henderson, Rebecca A Hubbard, Weiwei Zhu, Julie Weiss, Karen J Wernli, Martha E Goodrich, Karla Kerlikowske, Wendy DeMartini, Elissa M Ozanne, Tracy Onega
BACKGROUND: Use of preoperative breast magnetic resonance imaging (MRI) among women with a new breast cancer has increased over the past decade. MRI use is more frequent in younger women and those with lobular carcinoma, but associations with breast density and family history of breast cancer are unknown. MATERIALS AND METHODS: Data for 3075 women ages >65 years with stage 0-III breast cancer who underwent breast conserving surgery or mastectomy from 2005 to 2010 in the Breast Cancer Surveillance Consortium were linked to administrative claims data to assess associations of preoperative MRI use with mammographic breast density and first-degree family history of breast cancer...
January 15, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29334613/reduced-mir-144-3p-expression-in-serum-and-bone-mediates-osteoporosis-pathogenesis-by-targeting-rank
#3
Chunqing Wang, Hanliang He, Yu Jiang, Liang Wang, Youjia Xu
Osteoblasts and osteoclasts are responsible for the formation and resorption of bone, respectively. An imbalance between these two processes results in a disease called osteoporosis, in which a decreased level of bone strength increases the risk of a bone fracture. MicroRNAs (miRNAs) are small non-coding RNA molecules of 18-25 nucleotides that have been previously shown to control bone metabolism by regulating osteoblast and osteoclast differentiation. In the present study, we detected the expression pattern of 10 miRNAs in patient serum samples, and identified six miRNAs altered expression in patients with osteoporosis relative to non-osteoporosis...
January 15, 2018: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/29334604/breast-conservation-therapy-versus-mastectomy-in-patients-with-t1-2n1-triple-negative-breast-cancer-pooled-analysis-of-krog-14-18-and-14-23
#4
Kyubo Kim, Hae Jin Park, Kyung Hwan Shin, Jin Ho Kim, Doo Ho Choi, Won Park, Seung Do Ahn, Su Ssan Kim, Dae Yong Kim, Tae Hyun Kim, Jin Hee Kim, Jiyoung Kim
Purpose: The aim of this study is to compare the treatment outcomes of breast conserving surgery (BCS) plus radiotherapy (RT) vs. mastectomy for patients with pT1-2N1 triple negative breast cancer (TNBC). Methods: Using two multicenter retrospective studies on breast cancer, a pooled analysis was performed among 320 patients with pT1-2N1 TNBC. All patients who underwent BCS (n=212) received whole breast RT with or without regional nodal RT, while none who underwent mastectomy (n=108) received it...
January 8, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29334551/rapid-decline-of-hiv-1-dna-and-rna-in-infants-starting-very-early-art-may-pose-a-diagnostic-challenge
#5
Kirsten A Veldsman, Jean Maritz, Shahieda Isaacs, Mary Grace Katusiime, Anita Janse Van Rensburg, Barbara Laughton, John W Mellors, Mark F Cotton, Gert U van Zyl
OBJECTIVE: Birth diagnosis of HIV-1 infection offers an ideal opportunity for early antiretroviral treatment (ART) to limit HIV-1 reservoir size and limit disease progression. Although data on cellular HIV-1 DNA decay exist for children commencing treatment from 2-3 months of age, data is lacking for starting shortly after birth. DESIGN: We studied infants who initiated ART within 8 days after birth to assess HIV-1 DNA levels longitudinally. METHODS: Children were recruited from public health clinics in Cape Town where birth diagnosis of HIV-1 coupled with early ART initiation occurred...
January 13, 2018: AIDS
https://www.readbyqxmd.com/read/29334496/oxygen-in-the-critically-ill-friend-or-foe
#6
Elisa Damiani, Abele Donati, Massimo Girardis
PURPOSE OF REVIEW: To examine the potential harmful effects of hyperoxia and summarize the results of most recent clinical studies evaluating oxygen therapy in critically ill patients. RECENT FINDINGS: Excessive oxygen supplementation may have detrimental pulmonary and systemic effects because of enhanced oxidative stress and inflammation. Hyperoxia-induced lung injury includes altered surfactant protein composition, reduced mucociliary clearance and histological damage, resulting in atelectasis, reduced lung compliance and increased risk of infections...
January 12, 2018: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/29334463/torquoselective-mechanochemical-activation-of-the-staudinger-reaction-to-form-%C3%AE-lactams
#7
Dominik Marx, M Isabel Menendez
The Staudinger reaction yielding β-lactam rings via [2+2] cycloaddition is a torquoselective reaction where the stereochemistry of the product can be steered by suitable substituents. Although the mechanochemical ring-opening of β-lactams has been investigated recently, the force-assisted synthesis of this important functional four-ring motif remains unexplored. As it will be computationally demonstrated, mechanochemical activation greatly reduces the barrier of the rate limiting ring-closure step while, at the same time, preserves its torquoselectivity...
January 15, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29334414/cryptic-species-as-a-window-into-the-paradigm-shift-of-the-species-concept
#8
Cene Fišer, Christopher T Robinson, Florian Malard
The species concept is the cornerstone of biodiversity science and any paradigm shift in the delimitation of species affects many research fields. Many biologists now are embracing a new 'species' paradigm as separately evolving populations using different delimitation criteria. Individual criteria can emerge during different periods of speciation; some may never evolve. As such, a paradigm shift in the species concept relates to this inherent heterogeneity in the speciation process and species category - which is fundamentally overlooked in biodiversity research...
January 15, 2018: Molecular Ecology
https://www.readbyqxmd.com/read/29334381/the-molecular-basis-of-subtype-selectivity-of-human-kinin-g-protein-coupled-receptors
#9
Lisa Joedicke, Jiafei Mao, Georg Kuenze, Christoph Reinhart, Tejaswi Kalavacherla, Hendrik R A Jonker, Christian Richter, Harald Schwalbe, Jens Meiler, Julia Preu, Hartmut Michel, Clemens Glaubitz
G-protein-coupled receptors (GPCRs) are the most important signal transducers in higher eukaryotes. Despite considerable progress, the molecular basis of subtype-specific ligand selectivity, especially for peptide receptors, remains unknown. Here, by integrating DNP-enhanced solid-state NMR spectroscopy with advanced molecular modeling and docking, the mechanism of the subtype selectivity of human bradykinin receptors for their peptide agonists has been resolved. The conserved middle segments of the bound peptides show distinct conformations that result in different presentations of their N and C termini toward their receptors...
January 15, 2018: Nature Chemical Biology
https://www.readbyqxmd.com/read/29334364/compactness-of-viral-genomes-effect-of-disperse-and-localized-random-mutations
#10
Anže Lošdorfer Božič, Cristian Micheletti, Rudolf Podgornik, Luca Tubiana
Genomes of single-stranded RNA viruses have evolved to optimize several concurrent properties. One of them is the architecture of their genomic folds, which must not only feature precise structural elements at specific positions, but also allow for overall spatial compactness. The latter was shown to be disrupted by random synonymous mutations, a disruption which can consequently negatively affect genome encapsidation. In this study, we use three mutation schemes with different degrees of locality to mutate the genomes of phage MS2 and Brome Mosaic Virus in order to understand the observed sensitivity of the global compactness of their folds...
January 15, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29334213/conservative-management-of-ovarian-fibroma-in-a-case-of-gorlin-goltz-syndrome-comorbid-with-endometriosis
#11
Sepideh Khodaverdi, Leila Nazari, Abolfazl Mehdizadeh-Kashi, Mansoureh Vahdat, Samaneh Rokhgireh, Ali Farbod, Banafsheh Tajbakhsh
Ovarian fibromas are the most common benign solid ovarian tumors, which are often difficult to diagnose preoperatively. Ovarian fibromas, especially in bilateral cases, may be cases of Gorlin-Goltz syndrome (GGS), a rare autosomal dominant disorder with predisposition to basal cell carcinomas (BCCs) and other various benign and malignant tumors. This case report describes a 25 year-old female with GGS, bilateral ovarian fibroma, endometriosis and septated uterus, which was referred to the Gynecology Clinic of Rasoul-e-Akram Hospital in October 2016...
April 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29334121/the-multipotency-to-commitment-transition-mct-in-c-elegans-implications-for-reprogramming-from-cells-to-organs
#12
REVIEW
Erik A Spickard, Pradeep M Joshi, Joel H Rothman
In animal embryos, cells transition from a multipotential state, with the capacity to adopt multiple fates, into an irreversible, committed state of differentiation. This multipotency-to-commitment transition (MCT) is evident from experiments in which cell fate is reprogrammed by transcription factors for cell-type-specific differentiation, as has been observed extensively in C. elegans. Although factors that direct differentiation into each of the three germ layer types cannot generally reprogram cells after the MCT in this animal, transcription factors for endoderm development are able to do so in multiple differentiated cell types...
January 15, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29333844/-success-in-probing-for-congenital-nasolacrimal-duct-obstruction-ten-years-experience
#13
Sofía Bravo-Beltranena, Martín A Zimmermann-Paiz
INTRODUCTION: The congenital nasolacrimal duct obstruction is a common pathology, with low morbidity, but not exempt of complications without the correct diagnosis and management. METHODS: Retrospective study from 2005 to 2015 in patients who were submitted to a probing procedure. We identified age at procedure, gender, laterality and presence or absence of success with the procedure. RESULTS: One hundred thirty-seven eyes were analyzed. The median age was 17 months and the total success rate was 85...
February 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29333837/-biodegradable-airway-stent-for-the-treatment-of-bronchial-obstruction-in-the-child-case-report
#14
Giselle Cuestas, Verónica Rodríguez, Flavia Doormann, Patricio Bellia Munzón, Gastón Bellia Munzón
Bronchial obstruction is infrequent in the child. The main cause is malacia or benign stenosis. Management alternatives range from conservative treatment to complex surgical and/or endoscopic techniques. Placement of a stent can play a key role in situations where there is no other therapeutic option. However, the ideal stent is not yet available. In the last few years, progress has been made in the development and characterization of novel biodegradable materials in order to overcome the drawbacks of traditional stents made of silicone or metal...
February 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29333782/-research-advances-on-the-molecular-mechanism-of-autophagy-regulated-by-porphyromonas-gingivalis
#15
Zhao Yan, Yu Yang, Kou Yurong
Autophagy is an intracellular conservative degradation pathway. This event has been considered as a key step in host defense against bacterial infection. However, Porphyromonas gingivalis, as one of the evidence-sufficient periodontal pathogens, can utilize self-induced autophagy to achieve persistent intracellular survival and proliferation, which enable this organism to escape from host immune surveillance. This review focuses on molecular mechanism of P. gingivalis internalization and autophagy to illuminate its pathogenesis and to further explore the relationship between P...
December 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/29333706/estimating-the-footprint-of-pollution-on-coral-reefs-with-models-of-species-turnover
#16
Christopher J Brown, Richard Hamilton
Ecological communities typically change along gradients of human impact, though it is difficult to estimate the footprint of impacts for diffuse threats like pollution. Here we develop a joint model of benthic habitats on lagoonal coral reefs and use it to infer change in benthic composition along a gradient of distance from logging operations. The model estimates both changes in abundances of benthic groups and their compositional turn-over, a type of beta-diversity. We detect compositional turnover across the gradient and use the model to predict the footprint of turbidity impacts from logging...
January 15, 2018: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/29333678/supplementary-feeding-as-a-source-of-multiresistant-salmonella-in-endangered-egyptian-vultures
#17
Guillermo Blanco
Wild birds have repeatedly been highlighted as vectors in the dissemination of livestock and human pathogens. Here, the occurrence, serotypes and antimicrobial resistance of Salmonella were assessed in adult Egyptian vultures (Neophron percnopterus), to test the hypothesis that infection is associated with the consumption of swine carcasses provided at supplementary feeding stations (SFSs). Faeces of year-round resident griffon vultures (Gyps fulvus) were also tested to assess whether infection was acquired in the breeding grounds of both species or in the African wintering quarters of Egyptian vultures...
January 14, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29333606/genetic-relationships-among-vietnamese-local-pigs-investigated-using-genome-wide-snp-markers
#18
S Ishihara, A Arakawa, M Taniguchi, Q M Luu, D L Pham, B V Nguyen, S Mikawa, K Kikuchi
Vietnam is one of the most important countries for pig domestication, and a total of 26 local breeds have been reported. In the present study, genetic relationships among the various pig breeds were investigated using 90 samples collected from local pigs (15 breeds) in 15 distantly separated, distinct areas of the country and six samples from Landrace pigs in Hanoi as an out-group of a common Western breed. All samples were genotyped using the Illumina Porcine SNP60 v2 Genotyping BeadChip. We used 15 160-15 217 SNPs that showed a high degree of polymorphism in the Vietnamese breeds for identifying genetic relationships among the Vietnamese breeds...
January 15, 2018: Animal Genetics
https://www.readbyqxmd.com/read/29333477/notch-ligand-binding-assay-using-flow-cytometry
#19
Shweta Varshney, Pamela Stanley
Notch signaling is an evolutionary conserved signaling pathway that plays an indispensable role during development, and in the maintenance of homeostatic processes, in a wide variety of tissues (Kopan, 2012; Hori et al., 2013). The multifaceted roles of Notch signaling are stringently regulated at different levels. One of the most important aspects of regulation is the binding of different Notch ligands to each Notch receptor (NOTCH1-NOTCH4). Canonical ligands Delta or Serrate (in Drosophila), and Delta-like (DLL1 and DLL4) or Jagged (JAG1 and JAG2) (in mammals), are transmembrane glycoproteins...
December 5, 2017: Bio-protocol
https://www.readbyqxmd.com/read/29333425/outcomes-of-selective-surgery-in-patients-with-suspected-small-bowel-injury-from-blunt-trauma
#20
Hyoung-Chul Park, Jong Whan Kim, Min Jeong Kim, Bong Hwa Lee
Purpose: The role of initial conservative therapy with selective surgery for patients with suspected blunt bowel injury by radiologic evaluation is less clear. The aim of the study is to assess the outcomes of patients who received initial conservative therapy with selective delayed surgery, compared to emergency surgery. Methods: During this 8-year study, a total of 77 patients who were hemodynamically stable were enrolled, in which computed tomography verified suspected bowel injury from blunt trauma (mesenteric hematoma, mesenteric fat infiltration, bowel wall thickening, and free fluid without solid organ injury) was managed with either initial conservative therapy with selective delayed surgery (group A; n = 42) or emergency surgery (group B; n = 35)...
January 2018: Annals of Surgical Treatment and Research
keyword
keyword
23595
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"