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https://www.readbyqxmd.com/read/29161298/controlled-placement-of-multiple-cns-cell-populations-to-create-complex-neuronal-cultures
#1
D Soscia, A Belle, N Fischer, H Enright, A Sales, J Osburn, W Benett, E Mukerjee, K Kulp, S Pannu, E Wheeler
In vitro brain-on-a-chip platforms hold promise in many areas including: drug discovery, evaluating effects of toxicants and pathogens, and disease modelling. A more accurate recapitulation of the intricate organization of the brain in vivo may require a complex in vitro system including organization of multiple neuronal cell types in an anatomically-relevant manner. Most approaches for compartmentalizing or segregating multiple cell types on microfabricated substrates use either permanent physical surface features or chemical surface functionalization...
2017: PloS One
https://www.readbyqxmd.com/read/29160478/family-resilience-and-chemical-dependency-perception-of-mental-health-professionals
#2
Sonia Regina Zerbetto, Sueli Aparecida Frari Galera, Bianca Oliveira Ruiz
OBJECTIVE: To learn the perception of health professionals from the Psychosocial Attention Center for Alcohol and Other Drugs regarding the resilience attributes that are critical to family members of psychoactive substance dependents. METHOD: A qualitative descriptive study conducted from February to May 2016, using a focus group technique for data collection. In total, 15 professionals participated in the study: 13 health professionals and two administrative professionals...
November 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29156005/abiofilm-a-resource-of-anti-biofilm-agents-and-their-potential-implications-in-targeting-antibiotic-drug-resistance
#3
Akanksha Rajput, Anamika Thakur, Shivangi Sharma, Manoj Kumar
Biofilms play an important role in the antibiotic drug resistance, which is threatening public health globally. Almost, all microbes mimic multicellular lifestyle to form biofilm by undergoing phenotypic changes to adapt adverse environmental conditions. Many anti-biofilm agents have been experimentally validated to disrupt the biofilms during last three decades. To organize this data, we developed the 'aBiofilm' resource (http://bioinfo.imtech.res.in/manojk/abiofilm/) that harbors a database, a predictor, and the data visualization modules...
November 16, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29154718/pesticide-residues-in-food-attitudes-beliefs-and-misconceptions-among-conventional-and-organic-consumers
#4
Severine Koch, Astrid Epp, Mark Lohmann, Gaby-Fleur Böl
Pesticide use and pesticide residues in foods have been the subject of controversial public discussions and media coverage in Germany. Against this background, a better understanding of public risk perceptions is needed to promote efficient public health communication. To this end, this study captures the German public's perception of pesticide residues in foods. A representative sample of the population aged 14 years and older (n = 1,004) was surveyed via computer-assisted telephone interviewing on their attitudes and knowledge with regard to pesticide residues...
November 20, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/29151606/a-spectroscopic-survey-of-orion-kl-between-41-5-and-50-ghz
#5
J R Rizzo, B Tercero, J Cernicharo
Context: The nearby massive star-forming region Orion KL is one of the richest molecular reservoirs known in our Galaxy. The region hosts newly formed protostars, and the strong interaction between their radiation and their outflows with the environment results in a series of complex chemical processes leading to a high diversity of interstellar tracers. The region is therefore one of the most frequently observed sources, and the site where many molecular species have been discovered for the first time...
September 2017: Astronomy and Astrophysics
https://www.readbyqxmd.com/read/29150402/network-science-of-biological-systems-at-different-scales-a-review
#6
REVIEW
Marko Gosak, Rene Markovič, Jurij Dolenšek, Marjan Slak Rupnik, Marko Marhl, Andraž Stožer, Matjaž Perc
Network science is today established as a backbone for description of structure and function of various physical, chemical, biological, technological, and social systems. Here we review recent advances in the study of complex biological systems that were inspired and enabled by methods of network science. First, we present research highlights ranging from determination of the molecular interaction network within a cell to studies of architectural and functional properties of brain networks and biological transportation networks...
November 3, 2017: Physics of Life Reviews
https://www.readbyqxmd.com/read/29148058/classification-of-consumer-products-under-the-eu-clp-regulation-what-to-consider-when-caring-for-contact-dermatitis-patients
#7
REVIEW
Peter Elsner
Possibly hazardous chemical substances and mixtures need to be clearly and correctly classified and labelled, in order for their hazards to be properly identified and communicated. As dermatologists may encounter cases of harm to patients induced by chemicals, such as chemical burns, and irritant and allergic contact dermatitis, it is essential for them to be aware of the EU CLP Regulation and its potential pitfalls. Manufacturers are required by CLP to classify their products according to the rules given in the CLP Regulation...
November 17, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/29147977/are-isomeric-alkenes-used-in-species-recognition-among-neo-tropical-stingless-bees-melipona-spp
#8
Stephen J Martin, Sue Shemilt, Cândida B da S Lima, Carlos A L de Carvalho
Our understanding of the role of cuticular hydrocarbons (CHC) in recognition is based largely on temperate ant species and honey bees. The stingless bees remain relatively poorly studied, despite being the largest group of eusocial bees, comprising more than 400 species in some 60 genera. The Meliponini and Apini diverged between 80-130 Myr B.P. so the evolutionary trajectories that shaped the chemical communication systems in ants, honeybees and stingless bees may be very different. The aim of this study was to study if a unique species CHC signal existed in Neotropical stingless bees, as has been shown for many temperate species, and what compounds are involved...
November 17, 2017: Journal of Chemical Ecology
https://www.readbyqxmd.com/read/29143852/exposure-to-sublethal-ammonia-concentrations-alters-the-duration-and-intensity-of-agonistic-interactions-in-the-crayfish-orconectes-rusticus
#9
David D Edwards, Katie L Klotz, Paul A Moore
Crayfish extract information from chemical stimuli during social interactions. Commercial fertilizers increase background ammonia concentrations which may interfere with chemical communication. Background pollution can disrupt perception of chemical stimuli in three ways: masking, sensory impairment, physiological impairment or in combination. We investigated whether exposure to ammonia alters agonistic behavior. Crayfish pairs exposed to 0.9 mg/L ammonia fought for a longer duration, while crayfish exposed to 9...
November 16, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29143784/primary-cilium-dependent-signaling-mechanisms
#10
REVIEW
Rajasekharreddy Pala, Nedaa Alomari, Surya M Nauli
Primary cilia are hair-like organelles and play crucial roles in vertebrate development, organogenesis, health, and many genetic disorders. A primary cilium is a mechano-sensory organelle that responds to mechanical stimuli in the micro-environment. A cilium is also a chemosensor that senses chemical signals surrounding a cell. The overall function of a cilium is therefore to act as a communication hub to transfer extracellular signals into intracellular responses. Although intracellular calcium has been one of the most studied signaling messengers that transmit extracellular signals into the cells, calcium signaling by various ion channels remains a topic of interest in the field...
October 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29143413/bioinspired-chemical-communication-between-synthetic-nanomotors
#11
Chuanrui Chen, Xiaocong Chang, Hazhir Teymourian, Doris E Ramírez Herrera, Berta Esteban Fernández de Ávila, Xiaolong Lu, Jinxing Li, Sha He, Chengcheng Fang, Yuyan Liang, Fangzhi Mou, Jianguo Guan, Joseph Wang
While chemical communication plays a key role in diverse natural processes, the intelligent chemical communication between synthetic nanomotors remains unexplored. Here we demonstrate the design and operation of bio-inspired synthetic nanomotors capable of chemical communication among themselves that influences their propulsion behavior. The chemical message is sent from a moving 'activator' motor to a nearby 'activated' (receiver) one, and involves release of silver ions from a Janus PS/Ni/Au/Ag 'activator' motor to the 'activated' Janus SiO2/Pt nanomotor...
November 15, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29138416/plant-to-plant-communication-triggered-by-systemin-primes-anti-herbivore-resistance-in-tomato
#12
Mariangela Coppola, Pasquale Cascone, Valentina Madonna, Ilaria Di Lelio, Francesco Esposito, Concetta Avitabile, Alessandra Romanelli, Emilio Guerrieri, Alessia Vitiello, Francesco Pennacchio, Rosa Rao, Giandomenico Corrado
Plants actively respond to herbivory by inducing various defense mechanisms in both damaged (locally) and non-damaged tissues (systemically). In addition, it is currently widely accepted that plant-to-plant communication allows specific neighbors to be warned of likely incoming stress (defense priming). Systemin is a plant peptide hormone promoting the systemic response to herbivory in tomato. This 18-aa peptide is also able to induce the release of bioactive Volatile Organic Compounds, thus also promoting the interaction between the tomato and the third trophic level (e...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29136528/role-of-protein-dynamics-in-transmembrane-receptor-signalling
#13
REVIEW
Yong Wang, Katrine Bugge, Birthe B Kragelund, Kresten Lindorff-Larsen
Cells are dependent on transmembrane receptors to communicate and transform chemical and physical signals into intracellular responses. Because receptors transport 'information', conformational changes and protein dynamics play a key mechanistic role. We here review examples where experiment and computation have been used to study receptor dynamics. Recent studies on three distinct classes of receptors (G-protein coupled receptors, ligand-gated ion-channels and single-pass receptors) are highlighted to show that conformational changes across a range of time-scales and length-scales are central to function...
November 11, 2017: Current Opinion in Structural Biology
https://www.readbyqxmd.com/read/29134798/hierarchical-self-assembly-of-a-copolymer-stabilized-coacervate-protocell
#14
Alexander F Mason, Bastiaan C Buddingh', David S Williams, Jan C M van Hest
Complex coacervate microdroplets are finding increased utility in synthetic cell applications due to their cytomimetic properties. However, their intrinsic membrane-free nature results in instability that limits their application in protocell research. Herein, we present the development of a new protocell model through the spontaneous interfacial self-assembly of copolymer molecules on biopolymer coacervate microdroplets. This hierarchical protocell model not only incorporates the favorable properties of coacervates (such as spontaneous assembly and macromolecular condensation) but also assimilates the essential features of a semipermeable copolymeric membrane (such as discretization and stabilization)...
November 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29133004/neuroendoscopic-treatment-of-cystic-craniopharyngiomas-a-case-series-with-systematic-review-of-the-literature
#15
Liverana Lauretti, Francois Yves Legninda Sop, Roberto Pallini, Eduardo Fernandez, Quintino Giorgio D'Alessandris
BACKGROUND: Total removal of craniopharyngiomas is burdened by high morbidity. In cases of a cystic or mixed craniopharyngioma, when the symptoms are caused by the cystic component of the tumor, a less invasive surgical approach aiming at cyst drainage may be recommended. Here we report our experience with intraventricular neuroendoscopy, describing our clear-cut surgical technique, and analyzing results in the context of literature data. METHODS: We reviewed the clinical data of 8 consecutive adult patients affected by cystic or mixed craniopharyngioma that were treated with intraventricular neuroendoscopy at our Institution in the last decade...
November 10, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29122454/ayurveda-formulations-a-roadmap-to-address-the-safety-concerns
#16
Kishor Patwardhan, Jigyasa Pathak, Rabinarayan Acharya
It is a matter of serious concern that the number of case reports pointing at a possible association between the clinical toxicity and the use of Ayurveda formulations is increasing significantly over the years in scientific medical literature. Though most of these cases are connected with the presence of heavy metals such as lead, mercury and arsenic in these formulations, there are also reports suggesting toxicity due to the presence of toxic chemicals of herbal origin. In the year 2008, the Government of India took an initiative of establishing the National Pharmacovigilance Programme for Ayurveda, Siddha and Unani drugs in a structured way...
November 6, 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/29121614/interaction-of-semiochemicals-with-model-lipid-membranes-a-biophysical-approach
#17
Sergio A Rodriguez, O A Pinto, Axel Hollmann
Unravelling the chemical language of insects has been the subject of intense research in the field of chemical ecology for the past five decades. Insect communication is mainly based on chemosensation due to the small body size of insects, which limits their ability to produce or perceive auditory and visual signals, especially over large distances. Chemicals involved in insect communication are called semiochemicals. These volatiles and semivolatiles compounds allow to Insects to find a mate, besides the oviposition site in reproduction and food sources...
November 2, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29120477/droplet-array-for-screening-acute-behaviour-response-to-chemicals-in-caenorhabditis-elegans
#18
G Aubry, H Lu
Caenorhabditis elegans is an excellent model organism for studying chemosensation as a significant part of its nervous system and genome are devoted to the detection of chemical cues. Studies of decision-making, learning, mating behaviour, and intraspecies communication require measuring the acute behavioural response to chemical stimulation. Such assays require precise and repeatable chemical delivery and are often arduous when performed manually. Microfluidic platforms have been developed for chemosensation studies in C...
November 9, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/29114668/an-integrative-omics-perspective-for-the-analysis-of-chemical-signals-in-ecological-interactions
#19
A E Brunetti, F Carnevale Neto, M C Vera, C Taboada, D P Pavarini, A Bauermeister, N P Lopes
All living organisms emit, detect, and respond to chemical stimuli, thus creating an almost limitless number of interactions by means of chemical signals. Technological and intellectual advances in the last two decades have enabled chemical signals analyses at several molecular levels, including gene expression, molecular diversity, and receptor affinity. These advances have also deepened our understanding of nature to encompass interactions at multiple organism levels across different taxa. This tutorial review describes the most recent analytical developments in 'omics' technologies (i...
November 8, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/29113065/lanthanide-photoluminescence-in-heterometallic-polycyanidometallate-based-coordination-networks
#20
REVIEW
Szymon Chorazy, Maciej Wyczesany, Barbara Sieklucka
Solid-state functional luminescent materials arouse an enormous scientific interest due to their diverse applications in lighting, display devices, photonics, optical communication, low energy scintillation, optical storage, light conversion, or photovoltaics. Among all types of solid luminophors, the emissive coordination polymers, especially those based on luminescent trivalent lanthanide ions, exhibit a particularly large scope of light-emitting functionalities, fruitfully investigated in the aspects of chemical sensing, display devices, and bioimaging...
November 4, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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