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https://www.readbyqxmd.com/read/28799306/scrub-typhus-the-most-common-cause-of-febrile-jaundice-in-a-tertiary-care-hospital-of-himalayan-state
#1
Jatinter Mokta, Rahul Yadav, Kiran Mokta, Prashant Panda, Asha Ranjan
BACKGROUND: Most common cause of jaundice in south east Asia is of infective etiology. Combination of fever with jaundice can cause diagnostic problem as this duo is present in many infective diseases. Timely diagnosis by simple laboratory investigations can save a lot of time and prevent morbidity and mortality. Our main aim was to determine the most common etiology of infectious jaundice in a tertiary care hospital of Himalayan state and to study their clinical profile. METHODOLOGY: This was a prospective observational study done in one year...
August 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28798859/amelioration-of-abnormalities-associated-with-the-metabolic-syndrome-by-spinacia-oleracea-spinach-consumption-and-aerobic-exercise-in-rats
#2
Vandana Panda, Kinjal Mistry, S Sudhamani, Mukesh Nandave, Shreesh Kumar Ojha
The present study evaluates the protective effects of an antioxidant-rich extract of Spinacea oleracea (NAOE) in abnormalities associated with the metabolic syndrome (MetS) in rats. HPTLC of NAOE revealed the presence of 13 total antioxidants, 14 flavonoids, and 10 phenolic acids. Rats administered with fructose (20% w/v) in drinking water for 45 days to induce abnormalities of MetS received NAOE (200 and 400 mg/kg, po), the standard drug gemfibrozil (60 mg/kg, po), aerobic exercise (AE), and a combination of NAOE 400 mg/kg and AE (NAOEAE) daily for 45 days...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28792640/inbreeding-and-inbreeding-avoidance-in-wild-giant-pandas
#3
Yibo Hu, Yonggang Nie, Wei Wei, Tianxiao Ma, Russell Van Horn, Xiaoguang Zheng, Ronald R Swaisgood, Zhixin Zhou, Wenliang Zhou, Li Yan, Zejun Zhang, Fuwen Wei
Inbreeding can have negative consequences on population and individual fitness, which could be counteracted by inbreeding avoidance mechanisms. However, the inbreeding risk and inbreeding avoidance mechanisms in endangered species are less studied. The giant panda, a solitary and threatened species, lives in many small populations and suffers from habitat fragmentation, which may aggravate the risk of inbreeding. Here, we performed long-term observations of reproductive behaviour, sampling of mother-cub pairs and large-scale genetic analyses on wild giant pandas...
August 9, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28792424/enhanced-tortuosity-for-electrolytes-in-microwave-irradiated-self-organized-carbon-doped-ni-co-hydroxide-nanocomposite-electrodes-with-higher-ni-co-atomic-ratio-and-rate-capability-for-asymmetric-supercapacitor
#4
Himanshu Sekhar Panda, Niraj Kumar, Viresh Kumar
We demonstrated a green, facile and rapid microwave-mediated process for fabricating carbon black (CB) incorporated Ni/Co hydroxide porous nanocomposite and studied the effect of various mass loading of CB on supercapacitor performance. Structure and interactions between CB and Ni/Co hydroxide are characterized by using X-Ray diffraction, Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy, which suggested the miniaturization of single phase Ni/Co hydroxide formation time. Morphology study revealed that the addition of CB in Ni/Co hydroxide develops loose network structure with well-defined architectural pores...
August 9, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28792370/molecular-diagnosis-of-rhino-orbito-cerebral-mucormycosis-from-fresh-tissue-samples
#5
Kamran Zaman, Shivaprakash Mandya Rudramurthy, Ashim Das, Naresh Panda, Prasanna Honnavar, Harsimran Kaur, Arunaloke Chakrabarti
PURPOSE: We aimed to evaluate a PCR-based technique for the diagnosis of mucormycosis and the identification of fungi from fresh tissue specimens in patients with rhino-orbito-cerebral-mucormycosis (ROCM). METHODOLOGY: Fifty cases of ROCM were included in the study. Conventional identification was performed using microscopy and culture. Molecular diagnosis was performed by amplifying the ribosomal DNA using pan-fungal ITS primers and semi-nested Mucorales-specific primers of the 18S region...
August 9, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28791538/attenuation-of-neurobehavioral-and-neurochemical-abnormalities-in-animal-model-of-cognitive-deficits-of-alzheimer-s-disease-by-fermented-soybean-nanonutraceutical
#6
Vikas Kumar, Prakash Chandra Bhatt, Shruti Pathak, Bibhu Prasad Panda
The present study was performed to evaluate the efficacy of nanonutraceuticals (NN) for attenuation of neurobehavioral and neurochemical abnormalities in Alzheimer's disease. Solid-state fermentation of soybean with Bacillus subtilis was performed to produce different metabolites (nattokinase, daidzin, genistin and glycitin and menaquinone-7). Intoxication of rats with colchicine caused impairment in learning and memory which was demonstrated in neurobehavioral paradigms (Morris water maze and passive avoidance) linked with decreased activity of acetylcholinesterase (AChE)...
August 8, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28783750/virulence-of-invasive-salmonella-typhimurium-st313-in-animal-models-of-infection
#7
Girish Ramachandran, Aruna Panda, Ellen E Higginson, Eugene Ateh, Michael M Lipsky, Sunil Sen, Courtney A Matson, Jasnehta Permala-Booth, Louis J DeTolla, Sharon M Tennant
Salmonella Typhimurium sequence type (ST) 313 produces septicemia in infants in sub-Saharan Africa. Although there are known genetic and phenotypic differences between ST313 strains and gastroenteritis-associated ST19 strains, conflicting data about the in vivo virulence of ST313 strains have been reported. To resolve these differences, we tested clinical Salmonella Typhimurium ST313 and ST19 strains in murine and rhesus macaque infection models. The 50% lethal dose (LD50) was determined for three Salmonella Typhimurium ST19 and ST313 strains in mice...
August 4, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28780905/virome-comparisons-in-wild-diseased-and-healthy-captive-giant-pandas
#8
Wen Zhang, Shixing Yang, Tongling Shan, Rong Hou, Zhijian Liu, Wang Li, Lianghua Guo, Yan Wang, Peng Chen, Xiaochun Wang, Feifei Feng, Hua Wang, Chao Chen, Quan Shen, Chenglin Zhou, Xiuguo Hua, Li Cui, Xutao Deng, Zhihe Zhang, Dunwu Qi, Eric Delwart
BACKGROUND: The giant panda (Ailuropoda melanoleuca) is a vulnerable mammal herbivore living wild in central China. Viral infections have become a potential threat to the health of these endangered animals, but limited information related to these infections is available. METHODS: Using a viral metagenomic approach, we surveyed viruses in the feces, nasopharyngeal secretions, blood, and different tissues from a wild giant panda that died from an unknown disease, a healthy wild giant panda, and 46 healthy captive animals...
August 7, 2017: Microbiome
https://www.readbyqxmd.com/read/28776595/role-of-intralesional-bleomycin-sclerotherapy-as-the-sole-or-adjunct-treatment-of-superficial-ocular-adnexal-lymphatic-malformations
#9
N Bothra, L Panda, J Sheth, D Tripathy
ObjectiveTo report the role of intralesional bleomycin as sole or adjunct therapy in the management of superficial ocular adnexal lymphatic malformations.DesignRetrospective study.ParticipantsThree patients/three eyes.MethodsRetrospective chart analysis of patients receiving intralesional bleomycin sclerotherapy as sole or adjunctive treatment for superficial ocular adnexal lymphatic malformations at a single tertiary level eye care institution.ResultsDegree of clinical regression of the lesions (graded by percentage) and resolution of symptoms and signs associated with the lesions...
August 4, 2017: Eye
https://www.readbyqxmd.com/read/28772733/manufacturing-technology-of-composite-materials-principles-of-modification-of-polymer-composite-materials-technology-based-on-polytetrafluoroethylene
#10
Anton Panda, Kostiantyn Dyadyura, Jan Valíček, Marta Harničárová, Jozef Zajac, Vladimír Modrák, Iveta Pandová, Peter Vrábel, Ema Nováková-Marcinčínová, Zdeněk Pavelek
The results of the investigations into the technological formation of new wear-resistant polymer composites based on polytetrafluoroethylene (PTFE) filled with disperse synthetic and natural compounds are presented. The efficiency of using PTFE composites reinforced with carbon fibers depends on many factors, which influence the significant improvement of physicomechanical characteristics. The results of this research allow stating that interfacial and surface phenomena of the polymer-solid interface and composition play a decisive role in PTFE composites properties...
March 31, 2017: Materials
https://www.readbyqxmd.com/read/28772082/food-sources-of-sodium-saturated-fat-and-added-sugar-in-the-physical-activity-and-nutrition-for-diabetes-in-alberta-panda-trial
#11
Ghada Asaad, Catherine B Chan
Diabetic patients may find it difficult to achieve recommended nutrient intakes embedded within dietary guidelines. The objective of this analysis was to document total sodium, saturated fat and added sugar intake as well as the main food sources of these nutrients in Canadian adults with type 2 diabetes before and after an intervention focused on healthy eating. Participants were enrolled in a single-arm dietary intervention trial designed to improve glycemic control and adherence to dietary recommendations...
August 3, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28770139/retroperitoneal-immature-teratoma-in-a-neonate
#12
Chiranjiv Kumar, Rajpal Singh Sisodiya, Shasanka Shekhar Panda, Yogesh Kumar Sarin
We report a rare case of large immature retroperitoneal teratoma in a neonate. The diagnostic and therapeutic challenges of dealing with such a case have been discussed and the relevant literature reviewed.
April 2017: Journal of Neonatal Surgery
https://www.readbyqxmd.com/read/28768568/changes-in-urinary-androgen-concentration-indicate-that-male-giant-pandas-ailuropoda-melanoleuca-respond-to-impending-female-oestrus-during-and-outside-the-typical-spring-breeding-season
#13
Barbara L Gocinski, Katrina K Knott, Beth M Roberts, Janine L Brown, Carrie K Vance, Andrew J Kouba
Giant pandas have been described as mono-oestrus spring breeders, yet males exposed to aseasonal oestrous females in the autumn or winter exhibit breeding behaviours and interest in mating. In the present study, urinary androgens and sperm parameters were quantified for males exposed to females expressing oestrus during spring, autumn or winter to examine plasticity of reproductive seasonality in giant pandas. Monthly average androgen concentrations for two males exposed to females in either seasonal or aseasonal oestrus were greater (P<0...
August 3, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28768412/receptor-targeted-polymeric-nanostructures-capable-of-navigating-across-the-blood-brain-barrier-for-effective-delivery-of-neural-therapeutics
#14
Taru Dube, Sonika Chibh, Jibanananda Mishra, Jiban Jyoti Panda
The window of neurological maladies encompasses 600 known neurological disorders. In the last few years, an inordinate upsurge in the incidences of neuronal ailments with increased mortality rate has been witnessed globally. Despite noteworthy research in the discovery and development of neural therapeutics, brain drug delivery still encounters limited success due to meager perviousness of most of the drug molecules through the blood-brain barrier (BBB), a tight layer of endothelial cells that selectively impedes routing of the molecules across itself...
August 3, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28753516/synthesis-molecular-modeling-studies-and-bronchodilation-properties-of-nicotinonitrile-containing-compounds
#15
E A Soliman, Siva S Panda, Marian N Aziz, ElSayed M Shalaby, Nawal Mishriky, Fahmy M Asaad, Adel S Girgis
Facile synthetic pathway for nicotinonitriles 5a‒o, 7a‒i was demonstrated through reaction of ketones 4a‒k, 6a‒f with ylidenemalononitrile 3 in the presence of sodium alkoxide. Meanwhile, nucleophilic attack of amines on 2-bromonicotinonitrile 9 (obtained through reaction of propenone 8 with malononitrile, followed by bromination with bromine in acetic acid) afforded 3-pyridinecarbonitriles 11a‒d. Single crystal X-ray of compound 7i reveals the monoclinic space group C2/c with 8 molecules per unit cell...
July 17, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28750400/a-dopamine-hypothesis-of-autism-spectrum-disorder
#16
Denis Pavăl
Autism spectrum disorder (ASD) comprises a group of neurodevelopmental disorders characterized by social deficits and stereotyped behaviors. While several theories have emerged, the pathogenesis of ASD remains unknown. Although studies report dopamine signaling abnormalities in autistic patients, a coherent dopamine hypothesis which could link neurobiology to behavior in ASD is currently lacking. In this paper, we present such a hypothesis by proposing that autistic behavior arises from dysfunctions in the midbrain dopaminergic system...
July 28, 2017: Developmental Neuroscience
https://www.readbyqxmd.com/read/28750056/fatty-binding-protein-and-galectin-of-baylisascaris-schroederi-prokaryotic-expression-and-preliminary-evaluation-of-serodiagnostic-potential
#17
Ying Sun, Yu Li, Yiran Wu, Lang Xiong, Caiwu Li, Chengdong Wang, Desheng Li, Jingchao Lan, Zhihe Zhang, Bo Jing, Xiaobing Gu, Yue Xie, Weimin Lai, Xuerong Peng, Guangyou Yang
Baylisascaris schroederi is a common parasite of captive giant pandas. The diagnosis of this ascariasis is normally carried out by a sedimentation-floatation method or PCR to detect eggs in feces, but neither method is suitable for early diagnosis. Fatty acid-binding protein (FABP) and galectin (GAL) exist in various animals and participate in important biology of parasites. Because of their good immunogenicity, they are seen as potential antigens for the diagnosis of parasitic diseases. In this study, we cloned and expressed recombinant FABP and GAL from B...
2017: PloS One
https://www.readbyqxmd.com/read/28745813/subversion-of-innate-immune-responses-by-francisella-involves-the-disruption-of-traf3-and-traf6-signaling-complexes
#18
Daniela Putzova, Swarupa Panda, Anetta Härtlova, Jiří Stulík, Nelson O Gekara
The success of pathogens depends on their ability to circumvent immune defenses. Francisella tularensis is one of the most infectious bacteria known. The remarkable virulence of Francisella is believed to be due to its capacity to evade or subvert the immune system, but how remains obscure. Here we show that Francisella triggers but concomitantly inhibits the Toll-like receptor (TLR), RIG-I-like receptor (RLR) and Cytoplasmic DNA (CDR) pathways. Francisella subverts these pathways at least in part by inhibiting K63-linked polyubiquitination and assembly of TRAF6 and TRAF3 complexes that control the transcriptional responses of PRRs...
July 26, 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/28742559/earlier-introduction-to-the-wards-are-the-medical-students-or-the-educators-too-green
#19
Nikhil Panda
No abstract text is available yet for this article.
August 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28736268/differential-connectivity-of-gene-regulatory-networks-distinguishes-corticosteroid-response-in-asthma
#20
Weiliang Qiu, Feng Guo, Kimberly Glass, Guo Cheng Yuan, John Quackenbush, Xiaobo Zhou, Kelan G Tantisira
BACKGROUND: Variations in drug response between individuals have prevented us from achieving high drug efficacy in treating many complex diseases, including asthma. Genetics plays an important role in accounting for such inter-individual variations in drug response. However, systematic approaches for addressing how genetic factors and their regulators determine variations in drug response in asthma treatment are lacking. METHODS: We used PANDA (Passing Attributes between Networks for Data Assimilations) to construct the gene regulatory networks associated with good responders and poor responders to inhaled corticosteroids based on a subset of 145 Caucasian asthmatic children who participated in the Childhood Asthma Management Cohort (CAMP)...
July 20, 2017: Journal of Allergy and Clinical Immunology
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