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https://www.readbyqxmd.com/read/28339210/transition-metal-azide-and-oxidant-free-homo-and-heterocoupling-of-ambiphilic-tosylhydrazones-to-the-regioselective-triazoles-and-pyrazoles
#1
Subhankar Panda, Pradip Maity, Debasis Manna
With N-tosylhydrazone as an ambiphilic reagent, an unprecedented cyclization reaction of two identical or different tosylhydrazones has been developed to access various 4,5-disubstituted-2H-triazoles under transition metal, azide, and oxidant-free conditions. A mechanistic rationalization study led to the identification of several electronically diverse unsaturated systems for regioselective synthesis of 1- and 2-substituted 1,2,3-triazoles and pyrazoles.
March 24, 2017: Organic Letters
https://www.readbyqxmd.com/read/28337976/antiproliferative-activity-of-crocin-involves-targeting-of-microtubules-in-breast-cancer-cells
#2
Rupali R Hire, Shalini Srivastava, Melissa B Davis, Ananda Kumar Konreddy, Dulal Panda
Crocin, a component of saffron spice, is known to have an anticancer activity. However, the targets of crocin are not known. In this study, crocin was found to inhibit the proliferation of HCC70, HCC1806, HeLa and CCD1059sk cells by targeting microtubules. Crocin depolymerized both the interphase and mitotic microtubules of different cancer cells, inhibited mitosis and induced multipolar spindle formation in these cells. In vitro, crocin inhibited the assembly of pure tubulin as well as the assembly of microtubule-associated protein rich tubulin...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28337860/clinical-features-and-long-term-outcomes-of-105-granulomatosis-with-polyangiitis-patients-a-single-center-experience-from-north-india
#3
Aman Sharma, Godasi S R S N K Naidu, Manish Rathi, Roshan Verma, Manish Modi, Benzeeta Pinto, Kusum Sharma, Varun Dhir, Manphool Singhal, Mahesh Prakash, Ritambhra Nada, Naresh K Panda, Ranjana W Minz
AIM: To describe the clinical features, treatment and long-term outcomes in north Indian patients with granulomatosis with polyangiitis (GPA). METHODS: Clinical details, Birmingham Vasculitis Activity Score (BVAS-v3), laboratory data, histopathology findings, treatment details and outcomes of all consecutive patients diagnosed as having GPA between April 2005 and April 2016 were retrieved. European Vasculitis Study Group definitions were used to classify patients into localized, early systemic, generalized, severe and refractory categories...
March 24, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28334344/estimating-gene-regulatory-networks-with-pandar
#4
Daniel Schlauch, Joseph N Paulson, Albert Young, Kimberly Glass, John Quackenbush
PANDA (Passing Attributes betweenNetworks forData Assimilation) is a gene regulatory network inference method that begins with amodel of transcription factor-target gene interactions and usesmessage passing to update the network model given available transcriptomic and protein-protein interaction data. PANDA is used to estimate networks for each experimental group and the network models are then compared between groups to explore transcriptional processes that distinguish the groups. We present pandaR (bioconductor...
March 11, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28332189/technical-intelligence-and-culture-nut-cracking-in-humans-and-chimpanzees
#5
Christophe Boesch, Daša Bombjaková, Adam Boyette, Amelia Meier
OBJECTIVES: According to the technical intelligence hypothesis, humans are superior to all other animal species in understanding and using tools. However, the vast majority of comparative studies between humans and chimpanzees, both proficient tool users, have not controlled for the effects of age, prior knowledge, past experience, rearing conditions, or differences in experimental procedures. We tested whether humans are superior to chimpanzees in selecting better tools, using them more dexteriously, achieving higher performance and gaining access to more resource as predicted under the technical intelligence hypothesis...
March 23, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28325543/consensus-recommendations-on-exploring-effective-solutions-for-the-rising-cost-of-diabetes
#6
REVIEW
Shaukat M Sadikot, Ashok Kumar Das, John Wilding, Ali Siyan, Abdul Hamid Zargar, Banshi Saboo, S R Aravind, Bhavana Sosale, Sanjay Kalra, G Vijayakumar, K K Manojan, Anuj Maheshwari, Jayant K Panda, Samar Banerjee, Rajeev Chawla, Sambu Potty Vasudevan, O S Syam Sundar, Jothydev Kesavadev
Diabetes remains asymptomatic for a long period of time and its real burden gets noticed only once the complications set in. The number of individuals affected with the disease is also on the rise and more so in the low income countries. This scenario calls for urgent precautionary measures that need to be undertaken to equip ourselves to fight against this chronic disease. Individuals with financial constraints cannot afford to access even the basic treatment facilities and thus stands the most burdened. The International Diabetes Federation calls for 'Eyes on Diabetes' for the society to focus on early screening and early intervention...
March 7, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28323158/monitoring-the-end-tidal-concentration-of-sevoflurane-for-preventing-awareness-during-anesthesia-meets-panda-a-prospective-clinical-trial
#7
Jiebo Wang, Liangcheng Zhang, Qijian Huang, Guohua Wu XianfengWeng, Zhongmeng Lai, Pengtao Lin
OBJECTIVE: It was hypothesized that monitoring end-tidal sevoflurane (ETS) during endoscopic surgery could reduce the incidence of intraoperative awareness in patients undergoing general anesthesia. Herein, the incidence of intraoperative awareness and other correlative factors was recorded and compared. METHODS: Two thousand five hundred ASA I-III patients aged 18-80 years who underwent general anesthesia were randomly divided into 2 groups (n = 1250): routine care group (R) and ETS concentration group (E)...
March 16, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28320935/triad-of-human-cellular-proteins-irf2-fam111a-and-rfc3-restrict-replication-of-orthopoxvirus-spi-1-host-range-mutants
#8
Debasis Panda, Daniel J Fernandez, Madhu Lal, Eugen Buehler, Bernard Moss
Viruses and their hosts can reach balanced states of evolution ensuring mutual survival, which makes it difficult to appreciate the underlying dynamics. To uncover hidden interactions, virus mutants that have lost defense genes may be used. Deletion of the gene that encodes serine protease inhibitor 1 (SPI-1) of rabbitpox virus and vaccinia virus, two closely related orthopoxviruses, prevents their efficient replication in human cells, whereas certain other mammalian cells remain fully permissive. Our high-throughput genome-wide siRNA screen identified host factors that prevent reproduction and spread of the mutant viruses in human cells...
March 20, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28306740/metabolic-rate-of-the-red-panda-ailurus-fulgens-a-dietary-bamboo-specialist
#9
Yuxiang Fei, Rong Hou, James R Spotila, Frank V Paladino, Dunwu Qi, Zhihe Zhang
The red panda (Ailurus fulgens) has a similar diet, primarily bamboo, and shares the same habitat as the giant panda, Ailuropoda melanoleuca. There are considerable efforts underway to understand the ecology of the red panda and to increase its populations in natural reserves. Yet it is difficult to design an effective strategy for red panda reintroduction if we do not understand its basic biology. Here we report the resting metabolic rate of the red panda and find that it is higher than previously measured on animals from a zoo...
2017: PloS One
https://www.readbyqxmd.com/read/28303775/reared-apart-chinese-twins-chance-discovery-twin-based-research-twin-study-of-media-use-twin-relations-over-the-life-span-breast-feeding-opposite-sex-twins-print-and-online-media-twins-in-fashion-second-twin-pair-born-to-tennis-star-twin-primes-twin-pandas
#10
Nancy L Segal
A January 2017 reunion of 10-year-old reared-apart Chinese twin girls was captured live on ABC's morning talk show Good Morning America, and rebroadcast on their evening news program Nightline. The twins' similarities and differences, and their participation in ongoing research will be described. This story is followed by reviews of twin research concerning genetic and environmental influences on media use, twin relations across the lifespan and the breast-feeding of opposite-sex twins. Popular interest items include twins in fashion, the second twin pair born to an internationally renowned tennis star, twin primes and twin pandas...
April 2017: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/28303460/conservation-planning-beyond-giant-pandas-the-need-for-an-innovative-telecoupling-framework
#11
Fang Wang, Jianguo Liu
No abstract text is available yet for this article.
December 21, 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/28295377/time-restricted-feeding-for-prevention-and-treatment-of-cardiometabolic-disorders
#12
Girish C Melkani, Satchidananda Panda
The soaring prevalence of obesity and diabetes is associated with an increase in comorbidities, including elevated risk for cardiovascular diseases (CVD). CVDs continue to be among the leading causes of death and disability in the United States. While increased nutrition intake from an energy dense diet is known to disrupt metabolic homeostasis and contributes to the disease risk, circadian rhythm disruption is emerging as a new risk factor for CVD. Circadian rhythms coordinate cardiovascular health via temporal control of organismal metabolism and physiology...
March 10, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28283907/nanoparticles-generated-from-a-tryptophan-derivative-physical-characterization-and-anti-cancer-drug-delivery
#13
Taru Dube, Saurabh Mandal, Jiban Jyoti Panda
Surging reports of peptide-based nanosystems and their growing potency in terms of biological utility demand for the search of newer and simpler peptide-based systems that could serve as smart templates for the development of self-assembled nanostructures. Use of simple amino acids as monomeric building blocks for synthesizing ensembles of nanostructures have gained momentum in this direction with some reports focusing on the development of nanosystems from single or modified single amino acids. In this work, we have demonstrated self-assembly and nanoparticle formation ability of a single amino acid derivative, N-alpha-(9-fluorenylmethyloxycarbonyl)-N(in)-tert-butyloxycarbonyl-L-tryptophan [Fmoc-Trp(Boc)-OH]...
March 10, 2017: Amino Acids
https://www.readbyqxmd.com/read/28281076/withered-on-the-stem-is-bamboo-a-seasonally-limiting-resource-for-giant-pandas
#14
Youxu Li, Ronald R Swaisgood, Wei Wei, Yonggang Nie, Yibo Hu, Xuyu Yang, Xiaodong Gu, Zejun Zhang
In response to seasonal variation in quality and quantity of available plant biomass, herbivorous foragers may alternate among different plant resources to meet nutritional requirements. Giant pandas (Ailuropoda melanoleuca) are reliant almost exclusively on bamboo which appears omnipresent in most occupied habitat, but subtle temporal variation in bamboo quality may still govern foraging strategies, with population-level effects. In this paper, we investigated the possibility that temporal variation in the quality of this resource is involved in population regulation and examined pandas' adaptive foraging strategies in response to temporal variation in bamboo quality...
March 10, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28279127/in-silico-prediction-of-drug-resistance-due-to-s247r-mutation-of-influenza-h1n1-neuraminidase-protein
#15
Rahul Shubhra Mandal, Samiran Panda, Santasabuj Das
We present here in silico studies on antiviral drug resistance due to a novel mutation of influenza A/H1N1 neuraminidase (NA) protein. Influenza A/H1N1 virus was responsible for a recent pandemic and is currently circulating among the seasonal influenza strains. M2 and NA are the two major viral proteins related to pathogenesis in humans and have been targeted for drug designing. Among them, NA is preferred because the ligand-binding site of NA is highly conserved between different strains of influenza virus...
March 9, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28274156/folic-acid-ameliorates-celecoxib-cardiotoxicity-in-a-doxorubicin-heart-failure-rat-model
#16
Shafique Ahmad, Bibhu Prasad Panda, Kanchan Kohli, Mohammad Fahim, Kiran Dubey
CONTEXT: The cardiotoxic effect of selective cyclo-oxygenase-2 inhibitors is well known. While rofecoxib and valdecoxib have been withdrawn, celecoxib remains on the market. Folic acid, a naturally occurring vitamin, has been shown to reduce myocardial ischemia and post-reperfusion injury in rats. OBJECTIVE: This study examined the cardiac effects of celecoxib and folic acid on doxorubicin-induced cardiomyopathy in rats. MATERIALS AND METHODS: Cardiomyopathy was induced in male Wistar rats with six intraperitoneal injections of 2...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28267394/downregulation-of-mir-377-promotes-oral-squamous-cell-carcinoma-growth-and-migration-by-targeting-hdac9
#17
Bhawna Rastogi, Amit Kumar, Satish K Raut, Naresh K Panda, Vidya Rattan, Nainesh Joshi, Madhu Khullar
microRNAs are the post-transcriptional regulators implicated in the initiation and progression of various cancer types, including oral squamous cell carcinoma (OSCC). Here, we investigated the role of miR-377 in OSCC tumorigenesis. miR-377 expression was reduced in OSCC samples and cell line (UPCI-SCC-116), and was associated with patient survival. In vitro restoration of miR-377 repressed cell growth, induced apoptosis, and reduced cell migration. We identified HDAC9 as a target of miR-377 and found miR-377 to regulate HDAC9 and its pro-apoptotic target, NR4A1/Nur77...
March 16, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28264001/a-camera-phone-based-study-reveals-erratic-eating-pattern-and-disrupted-daily-eating-fasting-cycle-among-adults-in-india
#18
Neelu Jain Gupta, Vinod Kumar, Satchidananda Panda
The daily rhythm of feeding-fasting and meal-timing are emerging as important determinants of health. Circadian rhythm research in animal models and retrospective analyses of human nutrition data have shown that reduced length of overnight fasting or increased late night eating increases risk for metabolic diseases including obesity and diabetes. However, the daily rhythm in eating pattern in humans is rarely measured. Traditional methods to collect nutrition information through food diary and food log pay little attention to the timing of eating which may also change from day to day...
2017: PloS One
https://www.readbyqxmd.com/read/28261096/antioxidant-activities-metabolic-profiling-proximate-analysis-mineral-nutrient-composition-of-salvadora-persica-fruit-unravel-a-potential-functional-food-and-a-natural-source-of-pharmaceuticals
#19
Asha Kumari, Asish K Parida, Jaykumar Rangani, Ashok Panda
Salvadora persica is a medicinally important plant mainly used in oral hygiene. However, little attention has been given towards the nutritional prominence of this plant. This study encloses the proximate and mineral nutrient contents, amino acid composition, metabolite profiling and antioxidant potential of S. persica fruit. The ripen fruit contained substantial amount of sugars, mineral nutrients, carotenoids, polyphenols and flavonoids. The metabolic profiling of the fruit extract by GC-MS revealed a total of 22 metabolites comprising of sugars, sugar alcohols, organic acids, organic base, and aromatic silica compound...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28257198/shared-consensus-machine-learning-models-for-predicting-blood-stage-malaria-inhibition
#20
Andreas Verras, Christopher Lee Waller, Peter Gedeck, Darren Green, Thierry Kogej, Anandkumar V Raichurkar, Manoranjan Panda, Anang A Shelat, Julie A Clark, R Kiplin Guy, George Papadatos, Jeremy N Burrows
The development of new antimalarial therapies is essential and lowering the barrier of entry for the screening and discovery of new lead compound classes can spur drug development at organizations that may not have large compound screening libraries or resources to conduct high throughput screens. Machine learning models have been long established to be more robust and have a larger domain of applicability with larger training sets. Screens over multiple data sets to find compounds with potential malaria blood stage inhibitory activity have been used to generate multiple Bayesian models...
March 3, 2017: Journal of Chemical Information and Modeling
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