Katharina Eisenhut, Jennifer Faber, Daniel Engels, Ramona Gerhards, Jan Lewerenz, Kathrin Doppler, Claudia Sommer, Robert Markewitz, Kim K Falk, Rosa Rössling, Harald Pruess, Carsten Finke, Jonathan Wickel, Christian Geis, Dominica Ratuszny, Lena K Pfeffer, Stefan Bittner, Johannes Piepgras, Andrea Kraft, Jaqueline Klausewitz, Brigitte Nuscher, Tania Kümpfel, Franziska S Thaler
OBJECTIVES: Neurodegeneration is considered a relevant pathophysiologic feature in neurologic disorders associated with antibodies against glutamic acid decarboxylase 65 (GAD65). In this study, we investigate surrogates of neuroaxonal damage in relation to disease duration and clinical presentation. METHODS: In a multicentric cohort of 50 patients, we measured serum neurofilament light chain (sNfL) in relation to disease duration and disease phenotypes, applied automated MRI volumetry, and analyzed clinical characteristics...
January 2024: Neurology® Neuroimmunology & Neuroinflammation