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JOURNAL ARTICLE
Ke Xie, Jessica Royer, Sara Larivière, Raul Rodriguez-Cruces, Stefan Frässle, Donna Gift Cabalo, Alexander Ngo, Jordan DeKraker, Hans Auer, Shahin Tavakol, Yifei Weng, Chifaou Abdallah, Thaera Arafat, Linda Horwood, Birgit Frauscher, Lorenzo Caciagli, Andrea Bernasconi, Neda Bernasconi, Zhiqiang Zhang, Luis Concha, Boris C Bernhardt
Temporal lobe epilepsy (TLE) is the most common pharmaco-resistant epilepsy in adults. While primarily associated with mesiotemporal pathology, recent evidence suggests that brain alterations in TLE extend beyond the paralimbic epicenter and impact macroscale function and cognitive functions, particularly memory. Using connectome-wide manifold learning and generative models of effective connectivity, we examined functional topography and directional signal flow patterns between large-scale neural circuits in TLE at rest...
April 9, 2024: Progress in Neurobiology
#2
JOURNAL ARTICLE
Hou Xueyan, Ai Qi, Song Chunming, Zhi Yu, Weng Wencai
PURPOSE: To explore white matter network topological properties changes in middle-aged and elderly patients with functional constipation (Functional Constipation, FC) by diffusion tensor imaging (DTI), and to evaluate the correlation between the abnormal changes and clinical data. METHODS: 29 FC patients and 31 age- and sex-matched healthy controls (HC) were recruited. Magnetic resonance imaging and clinical data were collected. The white matter network changes in FC patients were analyzed using deterministic fiber tracking methods, graph theory algorithms, and partial correlation analysis with clinical data...
2024: Frontiers in Neurology
#3
JOURNAL ARTICLE
Riley H Lochner, Anithachristy S Arumanayagam, Suzanne Z Powell, Joseph C Masdeu, Belen Pascual, Matthew D Cykowski
Based on the anatomic proximity, connectivity, and functional similarities between the anterior insula and amygdala, we tested the hypothesis that the anterior insula is an important focus in the progression of TDP-43 pathology in LATE-NC. Blinded to clinical and neuropathologic data, phospho-TDP (pTDP) inclusion pathology was assessed in paired anterior and posterior insula samples in 105 autopsied patients with Alzheimer disease, Lewy body disease, LATE-NC and hippocampal sclerosis (HS), amyotrophic lateral sclerosis (ALS), and other conditions...
April 9, 2024: Journal of Neuropathology and Experimental Neurology
#4
JOURNAL ARTICLE
Min Chu, Deming Jiang, Haitian Nan, Lulu Wen, Li Liu, Miao Qu, Liyong Wu
BACKGROUND: Vascular dysfunction was recently reported to be involved in the pathophysiological process of neurodegenerative diseases, but its role in sporadic behavioral variant frontotemporal dementia (bvFTD) remains unclear. The aim of this study was to systematically explore vascular dysfunction, including changes in white matter hyperintensities (WMHs) and peripheral vascular markers in bvFTD. METHODS: Thirty-two patients with bvFTD who with no vascular risk factors were enrolled in this cross-sectional study and assessed using positron emission tomography/magnetic resonance (PET/MRI) imaging, peripheral plasma vascular/inflammation markers, and neuropsychological examinations...
April 5, 2024: Alzheimer's Research & Therapy
#5
JOURNAL ARTICLE
Arina A Tagmazian, Claudia Schwarz, Catharina Lange, Esa Pitkänen, Eero Vuoksimaa
Detection and measurement of amyloid-beta (Aβ) in the brain is a key factor for early identification and diagnosis of Alzheimer's disease (AD). We aimed to develop a deep learning model to predict Aβ cerebrospinal fluid (CSF) concentration directly from amyloid PET images, independent of tracers, brain reference regions or preselected regions of interest. We used 1870 Aβ PET images and CSF measurements to train and validate a convolutional neural network ("ArcheD"). We evaluated the ArcheD performance in relation to episodic memory and the standardized uptake value ratio (SUVR) of cortical Aβ...
April 4, 2024: European Journal of Neuroscience
#6
JOURNAL ARTICLE
Agniete Kampaite, Rebecka Gustafsson, Elizabeth N York, Peter Foley, Niall J J MacDougall, Mark E Bastin, Siddharthan Chandran, Adam D Waldman, Rozanna Meijboom
Multiple Sclerosis (MS) is an autoimmune disease affecting the central nervous system, characterised by neuroinflammation and neurodegeneration. Fatigue and depression are common, debilitating, and intertwined symptoms in people with relapsing-remitting MS (pwRRMS). An increased understanding of brain changes and mechanisms underlying fatigue and depression in RRMS could lead to more effective interventions and enhancement of quality of life. To elucidate the relationship between depression and fatigue and brain connectivity in pwRRMS we conducted a systematic review...
2024: PloS One
#7
JOURNAL ARTICLE
Sébastien Dam, Jean-Marie Batail, Gabriel Hadrien Robert, Dominique Drapier, Pierre Maurel, Julie Coloigner
BACKGROUND: The treatment of depressive episodes is well established, with clearly demonstrated effectiveness of antidepressants and psychotherapies. However, more than one-third of depressed patients do not respond to treatment. Identifying the brain structural basis of treatment-resistant depression could prevent useless pharmacological prescriptions, adverse events, and lost therapeutic opportunities. METHODS: Using diffusion magnetic resonance imaging, we performed structural connectivity analyses on a cohort of 154 patients with mood disorder (MD) - and 77 sex- and age-matched healthy control (HC) participants...
March 27, 2024: Brain Connectivity
#8
JOURNAL ARTICLE
Xinghao Wang, Qian Chen, Yawen Liu, Jing Sun, Jia Li, Pengfei Zhao, Linkun Cai, Wenjuan Liu, Zhenghan Yang, Zhenchang Wang, Han Lv
To explore the causal relationship between age and brain health (cortical atrophy, white matter integrity, white matter hyperintensities and cerebral microbleeds in various brain regions) related multiparameter imaging features using two-sample Mendelian randomization. Age was determined as chronological age of the subject. Cortical volume, white matter micro-integrity, white matter hyperintensity volume and cerebral microbleeds of each brain region were included as phenotypes for brain health. Age and imaging of brain health related genetic data were analysed to determine the causal relationship using inverse-variance weighted model, validated by heterogeneity and horizontal pleiotropy variables...
2024: Brain communications
#9
Talita Helena Martins Sarti, Rodrigo Akira Watanabe, Glaucia Suzanna Jong-A-Liem, Juan Carlos Ahumada-Vizcaíno, Pedro José Ramiro Muiños, Felipe Magalhães, Feres Chaddad-Neto
Cavernous malformations (CMs) are rare and often oligosymptomatic vascular lesions. The main symptoms include seizure and focal neurological deficits.1-3 Depending on the symptomatology, the location, the size, and the risk factors for bleeding, like the presence of a developmental venous anomaly, it can be highly morbid. Thus, surgical resection may be considered. Deep-seated and eloquent CMs, like those in the uncus, can be challenging.4,5 In this operative video, we present a 23-year-old male adult who developed focal seizures (i...
March 19, 2024: World Neurosurgery
#10
Judy Chen, Alexander Ngo, Raúl Rodríguez-Cruces, Jessica Royer, Maria Eugenia Caligiuri, Antonio Gambardella, Luis Concha, Simon S Keller, Fernando Cendes, Clarissa L Yasuda, Marina K M Alvim, Leonardo Bonilha, Ezequiel Gleichgerrcht, Niels K Focke, Barbara Kreilkamp, Martin Domin, Felix von Podewils, Soenke Langner, Christian Rummel, Roland Wiest, Pascal Martin, Raviteja Kotikalapudi, Benjamin Bender, Terence J O'Brien, Benjamin Sinclair, Lucy Vivash, Patrick Kwan, Patricia M Desmond, Elaine Lui, Gian Marco Duma, Paolo Bonanni, Alice Ballerini, Anna Elisabetta Vaudano, Stefano Meletti, Manuela Tondelli, Saud Alhusaini, Colin P Doherty, Gianpiero L Cavalleri, Norman Delanty, Reetta Kälviäinen, Graeme D Jackson, Magdalena Kowalczyk, Mario Mascalchi, Mira Semmelroch, Rhys H Thomas, Hamid Soltanian-Zadeh, Esmaeil Davoodi-Bojd, Junsong Zhang, Matteo Lenge, Renzo Guerrini, Emanuele Bartolini, Khalid Hamandi, Sonya Foley, Theodor Rüber, Tobias Bauer, Bernd Weber, Benoit Caldairou, Chantal Depondt, Julie Absil, Sarah J A Carr, Eugenio Abela, Mark P Richardson, Orrin Devinsky, Heath Pardoe, Mariasavina Severino, Pasquale Striano, Domenico Tortora, Erik Kaestner, Sean N Hatton, Donatello Arienzo, Sjoerd B Vos, Mina Ryten, Peter N Taylor, John S Duncan, Christopher D Whelan, Marian Galovic, Gavin P Winston, Sophia I Thomopoulos, Paul M Thompson, Sanjay M Sisodiya, Angelo Labate, Carrie R McDonald, Lorenzo Caciagli, Neda Bernasconi, Andrea Bernasconi, Sara Larivière, Dewi Schrader, Boris C Bernhardt
OBJECTIVES: Temporal lobe epilepsy (TLE) is commonly associated with mesiotemporal pathology and widespread alterations of grey and white matter structures. Evidence supports a progressive condition although the temporal evolution of TLE is poorly defined. This ENIGMA-Epilepsy study utilized multimodal magnetic resonance imaging (MRI) data to investigate structural alterations in TLE patients across the adult lifespan. We charted both grey and white matter changes and explored the covariance of age-related alterations in both compartments...
March 6, 2024: bioRxiv
#11
JOURNAL ARTICLE
Qi Huang, Pandeng Xie, Jian Zhou, Haoran Ding, Zhao Liu, Tianfu Li, Yuguang Guan, Mengyang Wang, Jing Wang, Pengfei Teng, Mingwang Zhu, Kaiqiang Ma, Han Wu, Guoming Luan, Feng Zhai
BACKGROUND: One-third of intractable epilepsy patients have no visually identifiable focus for neurosurgery based on imaging tests [magnetic resonance imaging (MRI)-negative cases]. Stereo-electroencephalography-guided radio-frequency thermocoagulation (SEEG-guided RF-TC) is utilized in the clinical treatment of epilepsy to lower the incidence of complications post-open surgery. OBJECTIVE: This study aimed to identify prognostic factors and long-term seizure outcomes in SEEG-guided RF-TC for patients with MRI-negative epilepsy...
2024: Therapeutic Advances in Chronic Disease
#12
JOURNAL ARTICLE
Naomi Takahashi, Yukihiro Shikama, Hikaru Kawahara, Yuma Okabe, Masayuki Kurimura, Yasuyuki Ohta
A 51-year-old man developed acute disturbances in consciousness and psychiatric symptoms one month prior to admission. He was referred and admitted to the Department of Psychiatry of our hospital and transferred to the neurology department because diffuse white matter lesions were found on his brain during MRI. 123 I-IMP-SPECT showed extensive cerebral hypoperfusion mainly in the frontal lobes. Anti-Tg, anti-TPO, and anti-NAE antibodies were positive. These findings led to a diagnosis of Hashimoto's encephalopathy...
March 22, 2024: Rinshō Shinkeigaku, Clinical Neurology
#13
JOURNAL ARTICLE
Stephen Wood, Samuel Booth, Ji Hyun Ko
Post-traumatic stress disorder (PTSD) is a highly prevalent psychological disorder characterized by intense feelings of fear or helplessness after experiencing a traumatic event. PTSD is highly comorbid with mood disorders and patients are at increased risk for suicide. The present study aimed to identify neural connectivity alterations associated with suicidal ideation (SI) in PTSD patients by using resting-state functional magnetic resonance imaging. Voxel-to-voxel intrinsic connectivity was compared between PTSD patients with no (N-SI; N = 26) and high (H-SI; N = 7) SI...
February 19, 2024: Brain Research Bulletin
#14
JOURNAL ARTICLE
Haruo Hanyu, Yumi Koyama, Kazuki Umekida, Toshimitsu Momose, Sadayoshi Watanabe, Tomohiko Sato
BACKGROUND: The underlying pathophysiology of cognitive dysfunction in oldest-old patients with Alzheimer-type dementia (AD) has not been clarified to date. We aimed to determine the factors and brain imaging features associated with cognition in oldest-old patients with AD. METHODS: We enrolled 456 consecutive outpatients with probable AD (145 men and 311 women, age range: 51-95 years). Demographic factors, such as education level, disease duration at initial visit, body mass index, comorbidities, frailty, and leisure activity, and brain imaging features, including severity of medial temporal lobe (MTL) atrophy, white matter lesions and infarcts, and frequency of posterior cerebral hypoperfusion were compared among pre-old (≤ 74 years), old (75 to 84 years), and oldest-old (≥ 85 years) subgroups...
February 10, 2024: Journal of the Neurological Sciences
#15
Vaclav Kremen, Vladimir Sladky, Filip Mivalt, Nicholas M Gregg, Irena Balzekas, Victoria Marks, Benjamin H Brinkmann, Brian Nils Lundstrom, Jie Cui, Erik K St Louis, Paul Croarkin, Eva C Alden, Julie Fields, Karla Crockett, Jindrich Adolf, Jordan Bilderbeek, Dora Hermes, Steven Messina, Kai J Miller, Jamie Van Gompel, Timothy Denison, Gregory A Worrell
Temporal lobe epilepsy (TLE) is a common neurological disease characterized by recurrent focal seizures. These seizures often originate from the mesial temporal limbic networks and the parahippocampal neocortex. People with TLE frequently experience comorbidities related to memory, mood, and sleep (MMS). Deep brain stimulation targeting the anterior nucleus of the thalamus (ANT-DBS) is a proven therapy for reducing TLE seizures, but the optimal stimulation parameters for improving seizures and MMS comorbidities remains unclear...
February 11, 2024: medRxiv
#16
JOURNAL ARTICLE
Chunsheng Xia, Lanlan Wang, Dong Zhang, Longfei You, Yiming Zhang, Yinbao Qi, Xiang Liu, Ruobing Qian
As a primitive driving force for biological reproduction, sexual behavior (and its associated mechanisms) is extremely complex, and orgasm plays an essential role. The limbic system plays a very important role in regulating human sexual behavior. However, it is not clear which components of the limbic system are related to orgasm sensation. We studied a rare case of spontaneous orgasmic aura in a male patient with temporal lobe epilepsy. Stereoelectroencephalography (SEEG) revealed that the right amygdala was the origin of orgasmic aura...
February 13, 2024: Acta Neurochirurgica
#17
JOURNAL ARTICLE
Qiuyang Feng, Zhiting Ren, Dongtao Wei, Cheng Liu, Xueyang Wang, Xianrui Li, Bijie Tie, Shuang Tang, Jiang Qiu
Internet addiction symptomatology(IAS) is characterized by persistent and involuntary patterns of compulsive Internet use, leading to significant impairments in both physical and mental well-being. Here, a connectome-based predictive modeling (CPM) approach was applied to decode IAS from whole-brain resting-state functional connectivity (rsFC) in healthy population. The findings showed that IAS could be predicted by the functional connectivity between prefrontal cortex with the cerebellum and limbic lobe, connections of the occipital lobe with the limbic lobe and insula lobe...
February 9, 2024: Social Cognitive and Affective Neuroscience
#18
JOURNAL ARTICLE
Laurent Tatu
ANATOMY OF MEMORY. Memory phenomena involve neuron circuits and neurogenesis processes at the microscopic level. Nevertheless, the central role played by some key structures such as the hippocampus and the limbic lobe requires a good knowledge of their macroscopic anatomy. This article summarizes an overview of the anatomical organization of these structures and of their abundant connections.
December 2023: La Revue du Praticien
#19
JOURNAL ARTICLE
Zakaria Almuwaqqat, Matthew Wittbrodt, Kasra Moazzami, Mariana Garcia, Bruno Lima, Afif Martini, Samaah Sullivan, Jonathon A Nye, Bradley D Pearce, Amit J Shah, Edmund K Waller, Viola Vaccarino, J Douglas Bremner, Arshed A Quyyumi
OBJECTIVE: Certain brain activation responses to psychological stress are associated with worse outcomes in CVD patients. We hypothesized that elevated acute psychological stress, manifesting as greater activity within neural centers for emotional regulation, mobilizes CPC from the bone marrow to the peripheral blood and predicts future cardiovascular events. METHODS: In 427 patients with stable CAD undergoing a laboratory-based mental stress (MS) test, CPCs were enumerated using flow cytometry as CD34-expressing mononuclear cells (CD34+) before and 45 min after stress...
June 14, 2023: Journal of Psychosomatic Research
#20
JOURNAL ARTICLE
Sahar Yassine, Sourour Almarouk, Ute Gschwandtner, Manon Auffret, Peter Fuhr, Marc Verin, Mahmoud Hassan
Anxiety is a common non-motor symptom in Parkinson's disease (PD) occurring in up to 31% of the patients and affecting their quality of life. Despite the high prevalence, anxiety symptoms in PD are often underdiagnosed and, therefore, undertreated. To date, functional and structural neuroimaging studies have contributed to our understanding of the motor and cognitive symptomatology of PD. Yet, the underlying pathophysiology of anxiety symptoms in PD remains largely unknown and studies on their neural correlates are missing...
January 27, 2024: Translational Psychiatry
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