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Patient reported outcome measures

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https://www.readbyqxmd.com/read/29053981/clinical-efficacy-onset-time-and-safety-of-bright-light-therapy-in-acute-bipolar-depression-as-an-adjunctive-therapy-a-randomized-controlled-trial
#1
Tian-Hang Zhou, Wei-Min Dang, Yan-Tao Ma, Chang-Qing Hu, Ning Wang, Guo-Yi Zhang, Gang Wang, Chuan Shi, Hua Zhang, Bin Guo, Shu-Zhe Zhou, Lei Feng, Shu-Xia Geng, Yu-Zhen Tong, Guan-Wen Tang, Zhong-Kai He, Long Zhen, Xin Yu
BACKGROUND: Bright light therapy (BLT) is an effective treatment for seasonal affective disorder and non- seasonal depression. The efficacy of BLT in treating patients with bipolar disorder is still unknown. AIMS: The aim of this study is to examine the efficacy, onset time and clinical safety of BLT in treating patients with acute bipolar depression as an adjunctive therapy (trial registration at ClinicalTrials.gov: NCT02009371). METHODS: This was a multi-center, single blind, randomized clinical trial...
September 25, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29053911/investigating-the-minimal-clinically-important-difference-for-snot-22-symptom-domains-in-surgically-managed-chronic-rhinosinusitis
#2
Naweed I Chowdhury, Jess C Mace, Todd E Bodner, Jeremiah A Alt, Adam S Deconde, Joshua M Levy, Timothy L Smith
BACKGROUND: Prior work has described 5 domains within the 22-item Sino-Nasal Outcomes Test (SNOT-22) that allow for stratification of symptoms into similar clusters and that can be used to direct therapy. Although the outcomes of various interventions on these symptom domains have been reported, minimal clinically important difference (MCID) values have not been investigated, which has limited clinical interpretation of these results. METHODS: This study was designed as a secondary analysis of a prospective, multi-institutional, observational cohort...
October 20, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29053898/chronic-pain-has-a-strong-impact-on-quality-of-life-in-facioscapulohumeral-muscular-dystrophy
#3
Germán Morís, Libby Wood, Roberto Fernández-Torrón, José Andrés González Coraspe, Chris Turner, David Hilton-Jones, Fiona Norwood, Tracey Willis, Matt Parton, Mark Rogers, Simon Hammans, Mark Roberts, Elizabeth Househam, Maggie Williams, Hanns Lochmüller, Teresinha Evangelista
INTRODUCTION: Earlier small case series and clinical observations reported on chronic pain playing an important role in facioscapulohumeral dystrophy (FSHD). The aim of this study was to determine the characteristics and impact of pain on quality of life (QoL) in patients with FSHD. METHODS: We analysed patient reported outcome measures collected through the UK FSHD Patient Registry. RESULTS: Of 398 patients, 88.6% reported pain at the time of study...
October 20, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29053894/french-translation-and-cross-cultural-adaptation-of-the-myotonic-dystrophy-health-index-mdhi
#4
Cynthia Gagnon, Marjolaine Tremblay, Isabelle Côté, Chad Heatwole
INTRODUCTION: Validation studies of disease-specific instruments for myotonic dystrophy type-1 (DM1) are required prior to their global use in clinical trials involving different cultures and countries. Here we translate and culturally adapt the Myotonic Dystrophy Health Index (MDHI), a disease-specific patient reported outcome measure, for a French DM1 population. METHOD: Using the ISPOR Task Force method for translation and adaptation of patient-reported outcome questionnaires, we created a French translation of the MDHI...
October 20, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29053848/is-virtual-reality-ready-for-prime-time-in-the-medical-space-a-randomized-control-trial-of-pediatric-virtual-reality-for-acute-procedural-pain-management
#5
Jeffrey I Gold, Nicole E Mahrer
Objective: To conduct a randomized control trial to evaluate the feasibility and efficacy of virtual reality (VR) compared with standard of care (SOC) for reducing pain, anxiety, and improving satisfaction associated with blood draw in children ages 10-21 years. Methods: In total, 143 triads (patients, their caregiver, and the phlebotomist) were recruited in outpatient phlebotomy at a pediatric hospital and randomized to receive either VR or SOC when undergoing routine blood draw...
October 19, 2017: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29053483/sex-specific-outcomes-after-transcatheter-aortic-valve-replacement-a-review-of-the-literature
#6
Yasameen Azarbaijani, Kathryn O'Callaghan, William E Sanders, Changfu Wu, John Laschinger, Danica Marinac-Dabic, David G Strauss, Daniel A Canos, Robbert Zusterzeel
Transcatheter aortic valve replacement (TAVR) is a safe and effective therapy for aortic valve replacement in patients ineligible for or at high risk for surgery. However, outcomes after TAVR based on an individual's sex remain to be fully elucidated. We searched PUBMED and EMBASE using the keywords: 'transcatheter aortic valve replacement', 'transcatheter aortic valve implantation', 'sex differences', 'gender', 'sex characteristics' and collected information on baseline features, procedural characteristics and post-procedural outcomes in women...
October 9, 2017: Cardiology in Review
https://www.readbyqxmd.com/read/29053225/histological-outcomes-of-anal-high-grade-cytopredictions
#7
Jennifer Margaret Roberts, Fengyi Jin, Isobel Mary Poynten, Carmella Law, David James Templeton, Julia Kathleen Thurloe, Suzanne Marie Garland, Andrew Edwin Grulich, Annabelle Farnsworth, Richard John Hillman
BACKGROUND: Longitudinal studies of histological outcomes after anal cytological screening in men who have sex with men (MSM) are rare. This study measured the positive predictive values (PPVs) of each level of baseline cytological abnormality in MSM in Sydney, Australia, over a 12-month period. METHODS: The Study of the Prevention of Anal Cancer is a 3-year prospective study of the natural history of anal human papillomavirus infection in MSM at least 35 years old...
October 20, 2017: Cancer
https://www.readbyqxmd.com/read/29052519/circuit-training-enhances-function-in-patients-undergoing-total-knee-arthroplasty-a-retrospective-cohort-study
#8
Wei-Hsiu Hsu, Wei-Bin Hsu, Wun-Jer Shen, Zin-Rong Lin, Shr-Hsin Chang, Robert Wen-Wei Hsu
BACKGROUND: The number of patients receiving total knee arthroplasty (TKA) has been rising every year due to the aging population and the obesity epidemic. Post-operative rehabilitation is important for the outcome of TKA. METHODS: A series of 34 patients who underwent primary unilateral TKA was retrospectively collected and divided into either exercise group (n = 16) and control group (n = 18). The exercise group underwent a 24-week course of circuit training beginning 3 months after total knee arthroplasty (TKA)...
October 19, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29051899/surgical-treatment-of-segond-fractures-in-acute-anterior-cruciate-ligament-reconstruction
#9
Andrea Ferretti, Edoardo Monaco, Megan Rianne Wolf, Matteo Guzzini, Angelo De Carli, Daniele Mazza
BACKGROUND: The Segond fracture is an avulsion-type fracture located on the anterolateral aspect of the tibia associated with a ligament recently termed the anterolateral ligament. This injury has been described as pathognomonic for an anterior cruciate ligament (ACL) tear and is associated with a higher grade pivot shift. PURPOSE: To present and report 2-year clinical outcomes of a surgical technique for acute ACL reconstruction with fixation of a concomitant Segond fracture...
October 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29051707/efficacy-of-intra-articular-injection-of-a-newly-developed-plasma-rich-in-growth-factor-prgf-versus-hyaluronic-acid-on-pain-and-function-of-patients-with-knee-osteoarthritis-a-single-blinded-randomized-clinical-trial
#10
Seyed Ahmad Raeissadat, Seyed Mansoor Rayegani, Azadeh Gharooee Ahangar, Porya Hassan Abadi, Parviz Mojgani, Omid Gharooi Ahangar
BACKGROUND AND OBJECTIVES: Knee osteoarthritis is the most common joint disease. We aimed to compare the efficacy and safety of intra-articular injection of a newly developed plasma rich in growth factor (PRGF) versus hyaluronic acid (HA) on pain and function of patients with knee osteoarthritis. METHODS: In this single-blinded randomized clinical trial, patients with symptomatic osteoarthritis of knee were assigned to receive 2 intra-articular injections of our newly developed PRGF in 3 weeks or 3 weekly injections of HA...
2017: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29051703/buprenorphine-naloxone-maintenance-therapy-an-observational-retrospective-report-on-the-effect-of-dose-on-18%C3%A2-months-retention-in-an-office-based-treatment-program
#11
Theodore V Parran, A G Mace, Yael J Dahan, Christopher A Adelman, Mykola Kolganov
CONTEXT AND OBJECTIVE: Buprenorphine has been available with few reports of the dose range necessary to adequately maintain patients. We report on the effect of 8 mg/d versus 16 mg/d of buprenorphine on long-term patient retention in office-based opioid maintenance (OBOMT). DESIGN SETTING AND PARTICIPANTS: Case series, at an urban hospital-based primary care clinic providing OBOMT to 157 opiate-dependent, low socioeconomic status, uninsured, nonhomeless patients...
2017: Substance Abuse: Research and Treatment
https://www.readbyqxmd.com/read/29051331/intravenous-zanamivir-in-hospitalized-patients-with-influenza
#12
John S Bradley, Jeffrey L Blumer, José R Romero, Marian G Michaels, Flor M Munoz, David W Kimberlin, Barbara Pahud, Roberta L DeBiasi, Go Yamamoto, Grace Roberts, Mohammad Hossain, Denise Shortino, Phillip J Yates, Bryan Adams, Amanda Peppercorn
BACKGROUND: Children with severe influenza infection may require parenteral therapy if oral or inhaled therapies are ineffective or cannot be administered. Results from a study investigating intravenous (IV) zanamivir for the treatment of hospitalized infants and children with influenza are presented. METHODS: This phase II, open-label, multicenter, single-arm study assessed the safety of investigational IV zanamivir in hospitalized children with influenza. Safety outcomes included treatment-emergent adverse events (TEAEs), clinical laboratory measurements, and vital signs...
October 19, 2017: Pediatrics
https://www.readbyqxmd.com/read/29051205/two-center-experience-in-the-endovascular-treatment-of-ruptured-and-unruptured-intracranial-aneurysms-using-the-web-device-a-retrospective-analysis
#13
J Popielski, A Berlis, W Weber, S Fischer
BACKGROUND AND PURPOSE: The safety and efficacy of the Woven EndoBridge (WEB) device for the treatment of cerebral aneurysms has been investigated in several studies. Our objective was to report the experience of 2 neurovascular centers with the WEB device in the treatment of broad-based intracranial aneurysms, including the technical feasibility and safety as well as short- and midterm angiographic and clinical follow-up-results. MATERIALS AND METHODS: We performed a retrospective analysis of all ruptured and unruptured aneurysms treated with a WEB device (WEB Single-Layer and Single-Layer Sphere) between August 2014 and February 2017...
October 19, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29051002/men-with-severe-oligospermia-appear-to-benefit-from-varicocele-repair-a-cost-effectiveness-analysis-of-assisted-reproductive-technology
#14
Justin M Dubin, Aubrey B Greer, Taylor P Kohn, Thomas A Masterson, Lunan Ji, Ranjith Ramasamy
OBJECTIVE: To evaluate the outcomes of men who underwent varicocelectomy for TMSC < 2 million and to perform a cost effectiveness analysis of IUI and IVF/ICSI after varicocelectomy. METHODS: We prospectively collected data of men with TMSC less than 2 million who underwent microsurgical subinguinal varicocelectomy. Men with azoospermia were excluded. Serum testosterone, luteinizing hormone, and follicle stimulating hormone were measured pre-operatively. Post-operative semen analysis was collected first at 3 months and then every 3 months thereafter...
October 16, 2017: Urology
https://www.readbyqxmd.com/read/29050844/monitoring-the-corrected-qt-in-the-acute-care-setting-a-comparison-of-the-12%C3%A2-lead-electrocardiogram-and-bedside-monitor
#15
James A Chenoweth, Aaron M Hougham, Daniel K Colby, Jonathan B Ford, Jordan Sandhu, Timothy E Albertson, Mark E Sutter
INTRODUCTION: Prolongation of the QT interval is a well-recognized complication associated with many commonly used medications. Emergency Department monitoring of the corrected QT (QTc) both before and after medication administration is typically performed using the 12‑lead electrocardiogram (ECG). The purpose of this study is to compare the QTc reported on the 12‑lead ECG to that reported by single brand of bedside monitor. METHODS: A convenience sample of emergency department patients over the age of 18 undergoing bedside monitoring and who had an ECG ordered by their treating physician were enrolled...
October 7, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29050719/how-is-pulmonary-function-and-exercise-tolerance-affected-in-patients-with-ais-who-have-undergone-spinal-fusion
#16
Kelly A Jeans, John F Lovejoy, Lori A Karol, Anna M McClung
STUDY DESIGN: Prospectively enrolled AIS patients who underwent spinal fusion, with 2 year follow-up. OBJECTIVES: To evaluate the cardiovascular fitness and activity level in patients with AIS pre- and post-spinal fusion and to determine if initial curve magnitude or pulmonary function is predictive of exercise capacity. SUMMARY OF BACKGROUND DATA: Researchers have tried to link pulmonary function testing (PFT) to exercise capacity; the results are mixed...
November 2017: Spine Deformity
https://www.readbyqxmd.com/read/29050397/the-antimyotonic-effect-of-lamotrigine-in-non-dystrophic-myotonias-a-double-blind-randomized-study
#17
Grete Andersen, Gitte Hedermann, Nanna Witting, Morten Duno, Henning Andersen, John Vissing
Mexiletine is the only drug with proven effect for treatment of non-dystrophic myotonia, but mexiletine is expensive, has limited availability and several side effects. There is therefore a need to identify other pharmacological compounds that can alleviate myotonia in non-dystrophic myotonias. Like mexiletine, lamotrigine is a sodium channel blocker, but unlike mexiletine, lamotrigine is available, inexpensive, and well tolerated. We investigated the potential of using lamotrigine for treatment of myotonia in patients with non-dystrophic myotonias...
September 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29049672/high-mortality-in-patients-with-tracheoarterial-fistulas-clinical-experience-and-treatment-recommendations
#18
Brigitte Reger, Reiner Neu, Hans-Stefan Hofmann, Michael Ried
OBJECTIVES: A tracheoarterial fistula (TAF) is an uncommon but a critical complication of tracheostomy and represents a surgical emergency. Surgical therapy with ligation of the brachiocephalic trunk can be considered as the first choice of treatment to control massive and life-threatening haemorrhage. METHODS: We describe 3 cases of TAF in patients who had long-term placement of a tracheostomy tube and the occurrence of a severe massive haemorrhage caused by an injured brachiocephalic trunk...
July 31, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049667/when-can-computed-tomography-fissure-analysis-replace-chartis-collateral-ventilation-assessment-in-the-prediction-of-patients-with-emphysema-who-might-benefit-from-endobronchial-valve-therapy
#19
Alfonso Fiorelli, Mario Santini, Pallav Shah
A best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed was when can computed tomography-fissure analysis replace Chartis collateral ventilation assessment in the prediction of patients with emphysema who might benefit from endobronchial valve therapy? Twelve papers were chosen to answer the question. The authors, date, journal, country of publication and study type; patient group studied; relevant outcomes and results of these papers were tabulated. Five studies retrospectively compared the prognostic value of 2 methods...
September 5, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049467/updated-cost-effectiveness-assessments-of-pcsk9-inhibitors-from-the-perspectives-of-the-health-system-and-private-payers-insights-derived-from-the-fourier-trial
#20
Alejandro Arrieta, Jonathan C Hong, Rohan Khera, Salim S Virani, Harlan M Krumholz, Khurram Nasir
Importance: Preliminary cost-effectiveness analyses of proprotein convertase subtilisin/kexin type 9 inhibitor (PCSK9i) were based on benefits estimated from reductions in low-density lipoprotein cholesterol that occurred in PCSK9i trials with variable results. The recent Further Cardiovascular Outcomes Research with PCSK9 Inhibition in Subjects with Elevated Risk (FOURIER) trial provides better information about the effectiveness of the drug. Objective: To use the trial results to determine the cost-effectiveness of a PCSK9i and statin treatment strategy compared with a statin alone strategy...
October 18, 2017: JAMA Cardiology
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