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https://www.readbyqxmd.com/read/28520713/combining-inferred-regulatory-and-reconstructed-metabolic-networks-enhances-phenotype-prediction-in-yeast
#1
Zhuo Wang, Samuel A Danziger, Benjamin D Heavner, Shuyi Ma, Jennifer J Smith, Song Li, Thurston Herricks, Evangelos Simeonidis, Nitin S Baliga, John D Aitchison, Nathan D Price
Gene regulatory and metabolic network models have been used successfully in many organisms, but inherent differences between them make networks difficult to integrate. Probabilistic Regulation Of Metabolism (PROM) provides a partial solution, but it does not incorporate network inference and underperforms in eukaryotes. We present an Integrated Deduced And Metabolism (IDREAM) method that combines statistically inferred Environment and Gene Regulatory Influence Network (EGRIN) models with the PROM framework to create enhanced metabolic-regulatory network models...
May 17, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28513993/patient-report-outcome-measures-in-orthopaedics
#2
REVIEW
Joel J Gagnier
Patient reported outcome measures (PROMs) are key tools when performing clinical research and PROM data are increasingly used to inform clinical decision-making, patient-centered care, health policy and more recently, reimbursement decisions. PROMs must possess particular properties before they are used. Thus purpose of this paper is to give an overview of PROMs, their definition, how their evidence can be assessed, how they should be reported in clinical research, how to choose PROMs, the types of PROMs available in orthopaedics, where these measures can be found, PROMs in orthopaedic clinical practice and what are some key next steps in this field...
May 17, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28512080/using-text-messaging-in-long-term-arthroplasty-follow-up-a-pilot-study
#3
Oliver Blocker, Alison Bullock, Rhidian Morgan-Jones, Adel Ghandour, James Richardson
BACKGROUND: Patient-reported outcome measures (PROMs) and mobile technology have the potential to change the way patients are monitored following joint replacement surgery. OBJECTIVE: The aim of this study was to determine the feasibility of text messaging to record PROMs in long-term follow-up of hip and knee arthroplasty. Our participants were 17 patients 2-years-plus post hip or knee arthroplasty attending clinic with a mobile telephone number on record. METHODS: A simple PROM (Oswestry Very Short Form) was texted to the patient...
May 16, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28505039/patient-reported-outcome-measures-in-urology
#4
Gopal L Narang, Stephanie C Pannell, Aaron A Laviana, Kathy H Y Huen, Jason Izard, Angela B Smith, Jonathan Bergman
PURPOSE OF REVIEW: Many urologic treatments have similar clinical outcomes, necessitating alternative methods to discriminate between options. Patient-reported outcome measures (PROMs) have become the new standard for evaluating the patient experience, and their use has drastically increased over the past decade. The purpose of this review is to discuss the status of PROMs in urology, highlight commonly used tools and address their future direction. RECENT FINDINGS: An increasing number of urology-specific PROMs tools have been developed and validated...
May 12, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28504863/diagnostic-accuracy-of-polymerase-chain-reaction-for-intrapartum-detection-of-group-b-streptococcus-colonization
#5
Rikke Bek Helmig, Jan Berg Gertsen
Many pregnant women are treated with antibiotics during labor to prevent transmission of group B Streptococcus (GBS, Streptococcus agalactiae) to their baby during the passage of the birth canal, and thus reducing the risk of serious infection of the newborn. Methods for intrapartum testing for GBS has been introduced to select women for whom intrapartum antibiotic prophylaxis should be offered. For such an intrapartum test to be useful in clinical practice, it has to be specific as well as sensitive. The aim of the present study is to evaluate the accuracy of the polymerase chain reaction (PCR) assay compared to an optimized culture method for GBS MATERIAL AND METHODS: In the period from 12...
May 15, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28502201/prediction-of-chorioamnionitis-in-cases-of-intraamniotic-infection-by-ureaplasma-urealyticum-in-women-with-very-preterm-premature-rupture-of-membranes-or-preterm-labour
#6
Rocio Revello, María José Alcaide, Daniel Abehsera, María Martin-Camean, Mafalda Sousa E Faro Gomes, Bárbara Alonso-Luque, Jose L Bartha
OBJECTIVES: First, to determinate the frequency of chorioamnionitis and funisitis in cases of intramniotic detection of Ureaplasma urealyticum. And second, to assess the predictive capability of some biological markers in the amniotic fluid of these women to predict histological inflammation. SUBJECTS AND METHODS: We prospectively studied 20 cases of women with premature rupture of membranes or preterm labour (PROM) or preterm labour and intraamniotic detection of Ureaplasma urealyticum...
May 14, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28499767/routine-patient-reported-outcomes-as-predictors-of-psychiatric-rehospitalization
#7
Efrat Shadmi, Marc Gelkopf, Paula Garber-Epstein, Vered Baloush-Kleinman, Ronit Doudai, David Roe
OBJECTIVE: Patient reported outcome measures (PROMs) are increasingly used to measure psychiatric service consumers' progress and to provide feedback to consumers and providers. We tested whether PROMs can predict and be used to identify groups at high risk for future hospitalization. METHODS: A total of 2842 Israeli users of psychiatric rehabilitation services reported on their quality of life (QoL) and the effect of symptoms on their daily functioning. Survey data were linked with information on psychiatric hospitalization 6 and 12months after survey completion...
May 9, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28499344/the-responsiveness-and-minimal-important-change-mic-of-the-western-ontario-shoulder-instability-index-wosi-and-oxford-shoulder-instability-score-osis
#8
Just A van der Linde, Derk A van Kampen, Loes W A H van Beers, Derek F P van Deurzen, Daniël B F Saris, Caroline B Terwee
Study Design A prospective cohort study. Background Patient Reported Outcome Measurements (PROMs) are widely used to evaluate functional limitations. Considering PROMs for shoulder instability, information is lacking with regard to what constitutes a relevant change from baseline scores. Objectives To evaluate the responsiveness of the Western Ontario Shoulder Instability Index (WOSI) and the Oxford Shoulder Instability Score (OSIS) and estimate their Minimal Important Change (MIC). Methods 105 consecutive patients with shoulder instability completed five PROMs at baseline and at 6-months follow-up...
May 12, 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/28479288/a-randomized-trial-of-foley-bulb-for-labor-induction-in-premature-rupture-of-membranes-in-nulliparas-flip
#9
Jennifer Mh Amorosa, Joanne Stone, Stephanie H Factor, Whitney Booker, Meredith Newland, Angela Bianco
BACKGROUND: In premature rupture of membranes (PROM) the risk of chorioamnionitis increases with increasing duration of membrane rupture. Decreasing the time from PROM to delivery is associated with lower rates of maternal infection. The American College of Obstetricians and Gynecologists suggests that all women with PROM who do not have a contraindication to vaginal delivery have their labor induced instead of being expectantly managed. While the use of oxytocin for labor induction has been demonstrated to decrease the time to delivery when compared to expectant management, no studies have evaluated the effectiveness of cervical ripening using a Foley bulb to additionally decrease the time to delivery...
May 4, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28472109/enherv-enrichment-analysis-of-specific-human-endogenous-retrovirus-patterns-and-their-neighboring-genes
#10
Pumipat Tongyoo, Yingyos Avihingsanon, Santhitham Prom-On, Apiwat Mutirangura, Wuttichai Mhuantong, Nattiya Hirankarn
Human endogenous retroviruses (HERVs) are flanked by long terminal repeats (LTRs), which contain the regulation part of the retrovirus. Remaining HERVs constitute 7% to 8% of the present day human genome, and most have been identified as solo LTRs. The HERV sequences have been associated with several molecular functions as well as certain diseases in human, but their roles in human diseases are yet to be established. We designed EnHERV to make accessible the identified endogenous retrovirus repetitive sequences from Repbase Update (a database of eukaryotic repetitive elements) that are present in the human genome...
2017: PloS One
https://www.readbyqxmd.com/read/28464751/minimally-important-change-measurement-error-and-responsiveness-for-the-self-reported-foot-and-ankle-score
#11
Maria C Cöster, Anna Nilsdotter, Lars Brudin, Ann Bremander
Background and purpose - Patient-reported outcome measures (PROMs) are increasingly used to evaluate results in orthopedic surgery. To enhance good responsiveness with a PROM, the minimally important change (MIC) should be established. MIC reflects the smallest measured change in score that is perceived as being relevant by the patients. We assessed MIC for the Self-reported Foot and Ankle Score (SEFAS) used in Swedish national registries. Patients and methods - Patients with forefoot disorders (n = 83) or hindfoot/ankle disorders (n = 80) completed the SEFAS before surgery and 6 months after surgery...
June 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28463151/patient-reported-outcomes-after-radiation-therapy-in-men-with-prostate-cancer-a%C3%A2-systematic-review-of-prognostic-tool-accuracy-and-validity
#12
Michael E O'Callaghan, Elspeth Raymond, Jared M Campbell, Andrew D Vincent, Kerri Beckmann, David Roder, Sue Evans, John McNeil, Jeremy Millar, John Zalcberg, Martin Borg, Kim Moretti
PURPOSE: To identify, through a systematic review, all validated tools used for the prediction of patient-reported outcome measures (PROMs) in patients being treated with radiation therapy for prostate cancer, and provide a comparative summary of accuracy and generalizability. METHODS AND MATERIALS: PubMed and EMBASE were searched from July 2007. Title/abstract screening, full text review, and critical appraisal were undertaken by 2 reviewers, whereas data extraction was performed by a single reviewer...
June 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28462655/the-effect-of-numbness-on-outcome-from-total-knee-replacement
#13
J Blackburn, V Wylde, R Greenwood, A W Blom, A Levy
INTRODUCTION Some patients report continuing pain and functional limitations after total knee replacement (TKR). While numbness around the TKR scar is common, the impact of numbness is less clear. One particular activity that could be influenced by numbness is kneeling. The aim of this study was to explore the impact of numbness around TKR scars on health related quality of life and kneeling ability. METHODS Fifty-six patients were recruited one year after primary TKR. Sensation around the knee was assessed through patient self-reporting, monofilament testing and vibration, and patients' distress was measured on a visual analogue scale...
May 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/28453454/the-effect-of-intra-articular-hyaluronate-and-tramadol-injection-on-patients-with-adhesive-capsulitis-of-the-shoulder
#14
Kyung Hee Kim, Jung-Woo Suh, Ki Young Oh
BACKGROUND: Local administration of opioids causes effective analgesia without adverse effects related to the central nervous system. After the beneficial demonstration of peripheral opioid receptors in joint synovia, intra-articular opioid injections were used for pain treatment. Clinical studies have reported the safety and efficacy of hyaluronate injection in the shoulder joint of patients with osteoarthritis, periarthritis, rotator cuff tears, and adhesive capsulitis. OBJECTIVES: To estimate the efficacy of intra-articular hyaluronate and tramadol injection for adhesive capsulitis of the shoulder compared with that of intra-articular hyaluronate injection alone...
April 21, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28451045/-prelabour-rupture-of-membranes-prom-at-term-prognostic-factors-and-neonatal-consequences
#15
Asmama Yasmina, Amina Barakat
Prelabour rupture of membranes (PROM) at term occurs in 5 to 10% of pregnancies. It accounts for a significant proportion of neonatal morbidity and mortality. The aim of this case study was to determine the maternal and obstetric prognostic factors as well as full-term newborns outcomes in pregnancies complicated by prelabour rupture of membranes in patients hospitalized or managed at the outpatient clinic. We conducted a retrospective study of all cases of full-term infants born to mothers whose pregnancy was complicated by PROM, recorded in the neonatology department at the Children's Hospital of Rabat between 1 January and 31 July 2014...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28445314/bc-prom-validation-of-a-patient-reported-outcomes-measure-for-patients-with-breast-cancer
#16
Xiaojuan Hu, Chunsen Zhang, Yanbo Zhang
Key issues of treatment for patients with breast cancer such as patient satisfaction with treatments, compliance, and some side effects are essential for evaluating quality of life by patient-reported outcomes in clinical trials. The study aimed to develop and evaluate a specific patient-reported measure which included physical, psychological, social, and therapeutic domain for assessing the survival of patients with breast cancer.The pool of items was drafted after a theoretical revision and cognitive interviews with women with breast cancer...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28436851/synergistic-pet-and-sense-mr-image-reconstruction-using-joint-sparsity-regularization
#17
Abolfazl Mehranian, Martin Belzunce, Claudia Prieto, Alexander Hammers, Andrew Reader
In this work we propose a generalized joint sparsity regularization prior and reconstruction framework for the syner-gistic reconstruction of PET and undersampled sensitivity en-coded (SENSE) MRI data with the aim of improving image quality beyond that obtained through conventional independent recon-structions. The proposed prior improves upon the joint total vari-ation (TV) using a non-convex potential function that assigns a rel-atively lower penalty for the PET and MR gradients whose mag-nitudes are jointly large, thus permitting the preservation and for-mation of common boundaries irrespective of their relative orien-tation...
April 18, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28434005/chorioamniotic-membrane-separation-after-fetoscopic-laser-photocoagulation
#18
Mayumi Takano, Masahiko Nakata, Susumu Murata, Masahiro Sumie, Mineto Morita
INTRODUCTION: This study aimed to investigate the risk factors, incidence, and influence on the perinatal outcome of chorioamniotic membrane separation (CMS) after fetoscopic laser photocoagulation (FLP). MATERIAL AND METHODS: This retrospective study included 312 women who underwent FLP for twin-to-twin transfusion syndrome (TTTS). Clinical records were used to review obstetrical examinations, complications, operative data, ultrasonographic findings, and perinatal and neonatal follow-up data in all patients...
April 22, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28431858/third-trimester-preterm-and-term-premature-rupture-of-membranes-is-there-any-difference-in-maternal-characteristics-and-pregnancy-outcomes
#19
Ivana Chandra, Lizhou Sun
BACKGROUND: The clinical significance and management of preterm premature rupture of membranes (PPROM) remains a topic of a controversy. Although PROM is associated with a low rate of complications, PPROM may lead to significant neonatal and maternal morbidity. METHODS: We performed a retrospective study of 714 women who presented to Jiangsu Province Hospital with third trimester PPROM or PROM between January and December 2015. The data were analyzed by SPSS; the significance of maternal characteristics, and maternal and neonatal outcomes were tested using Student's t test and the χ(2) test...
April 18, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28427868/potential-palliative-care-quality-indicators-in-heart-disease-patients-a-review-of-the-literature
#20
REVIEW
Atsushi Mizuno, Mitsunori Miyashita, Akitoshi Hayashi, Fujimi Kawai, Koichiro Niwa, Akemi Utsunomiya, Shun Kohsaka, Takashi Kohno, Takeshi Yamamoto, Morimasa Takayama, Toshihisa Anzai
In spite of the increasing interest in palliative care for heart disease, data on the detailed methods of palliative care and its efficacy specifically in heart disease are still lacking. A structured PubMed literature review revealed no quality indicators of palliative care in heart disease. Therefore, we performed a narrative overview of the potential quality indicators in heart disease by reviewing previous literature concerning quality indicators in cancer patients. We summarize seven potential categories of quality indicators in heart disease: (1) presence and availability of a palliative care unit, palliative care team, and outpatient palliative care; (2) human resources such as number of skilled staff; (3) infrastructure; (4) presence and frequency of documentation or family survey; (5) patient-reported outcome measure (PROM) data and disease-specific patient quality of life such as The Kansas City Cardiomyopathy Questionnaire (KCCQ); (6) questionnaires and interviews about the quality of palliative care after death, including bereaved family surveys; and (7) admission-related outcomes such as place of death and intensive care unit length of stay...
April 17, 2017: Journal of Cardiology
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