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Gluten sensitivity

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https://www.readbyqxmd.com/read/28635270/understanding-the-effects-of-genotype-growing-year-and-breeding-on-tunisian-durum-wheat-allergenicity-part-2-the-celiac-disease-case
#1
Fatma Boukid, Barbara Prandi, Stefano Sforza, Rhouma Sayar, Yong Weon Seo, Mondher Mejri, Ines Yacoubi
The aim of this study was to compare immunogenic and toxic gluten peptides related to celiac disease (CD). 100 accessions of genotypes selected during the 20th century in Tunisia were in vitro digested, then analyzed by UPLC/ESI-MS technique using an isotopically labeled internal standard. The first MANOVA confirmed a high variability in the content of immunogenic and toxic peptides reflecting high genetic diversity in the germplasm released during the last century in Tunisia, consistently with PCA and clustering analysis results...
June 21, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28630805/dermatitis-herpetiformis-as-the-initial-presentation-of-primary-biliary-cholangitis-in-a-male-with-gluten-sensitivity
#2
Cyriac Philips, Rajaguru Paramaguru, Divya A Indiran, Philip Augustine
Celiac disease is commonly associated with elevated liver enzymes that normalize on a gluten-free diet. Celiac disease is rarely described in patients with primary biliary cholangitis. Dermatitis herpetiformis is the skin manifestation of the celiac disease that is very rarely associated with primary biliary cirrhosis. We present the case of a 62-year-old man who presented with severe chronic pruritus, in whom a diagnosis of primary biliary cholangitis was made initially. However, in the presence of atypical skin lesions, not confirming to chronic cholestasis, an in-depth evaluation including histopathological examination led to the diagnosis of dermatitis herpetiformis associated with gluten sensitivity...
May 14, 2017: Curēus
https://www.readbyqxmd.com/read/28582812/symptomatic-efficacy-of-buckwheat-products-in-non-celiac-gluten-sensitivity-ncgs
#3
Monicau Dinu, Donatella Macchia, Giuditta Pagliai, Anna Maria Gori, Francesca Cesari, Rossella Marcucci, Francesco Sofi, Alessandro Casini
BACKGROUND AND OBJECTIVES: Buckwheat (Fagopyrum esculentum) is a gluten-free grain with acclaimed benefi-cial effects on human health. Our aim was to assess the effect of buckwheat products on intestinal/extra-intestinal symptoms and biochemical parameters in patients with Non-Celiac Gluten Sensitivity (NCGS). METHODS AND STUDY DESIGN: A randomized, crossover trial with two intervention phases was conducted on 19 NCGS patients over a 12 week-period. The participants were assigned to consume products made from buckwheat or to maintain their normal gluten-free diet for 6 weeks in a random order...
2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28570327/gastroenterology-and-neurology
#4
Ronald F Pfeiffer
PURPOSE OF REVIEW: Just as gastrointestinal dysfunction may develop in the setting of neurologic disease, neurologic dysfunction may become evident in the setting of gastrointestinal disease. This article describes the range of neurologic features that have been described in three primary gastrointestinal diseases: celiac disease and gluten-related disorders, inflammatory bowel disease, and Whipple disease. Particular emphasis is placed on the controversial and evolving clinical picture of neurologic dysfunction in disorders of gluten sensitivity...
June 2017: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/28554285/gluten-free-food
#5
(no author information available yet)
Staple gluten-free (GF) foods have been available on prescription to patients diagnosed with gluten sensitivity enteropathies, such as coeliac disease, since the late 1960s.
May 30, 2017: Nursing Management (Harrow)
https://www.readbyqxmd.com/read/28553923/-gluten-free-diet-is-for-some-a-necessity-for-others-a-lifestyle
#6
Iben Møller Jønsson, Gitte Leth Møller, Anders Pærregaard
This review provides a brief overview of the gluten-related conditions coeliac disease (CD), wheat allergy (WA), and non-coeliac gluten sensitivity (NCGS). NCGS is a new entity which includes individuals who report symptoms when exposed to gluten and benefit from gluten-free diet, but do not have CD or WA. The concept NCGS is still controversial and a subject of considerable overdiagnosis, and consensus regarding diagnostic criteria is lacking. Furthermore, the overlap with irritable bowel syndrome is unsettled...
May 29, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28551252/food-for-thought-selecting-the-right-enzyme-for-the-digestion-of-gluten
#7
Michelle L Colgrave, Keren Byrne, Crispin A Howitt
Gluten describes a complex mixture of proteins found in wheat, rye, barley and oats that pose a health risk to people affected by conditions such as coeliac disease and non-coeliac gluten sensitivity. Complete digestion of gluten proteins is of critical importance during quantitative analysis. To this end, chymotrypsin was investigated for its ability to efficiently and reproducibly digest specific classes of gluten in barley. Using proteomics a chymotryptic peptide marker panel was elucidated and subjected to relative quantification using LC-MRM-MS...
November 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28545781/tests-for-serum-transglutaminase-and-endomysial-antibodies-do-not-detect-most-patients-with-celiac-disease-and-persistent-villous-atrophy-on-gluten-free-diets-a-meta-analysis
#8
Jocelyn A Silvester, Satya Kurada, Andrea Szwajcer, Ciarán P Kelly, Daniel A Leffler, Donald R Duerksen
BACKGROUND & AIMS: Tests to measure serum endomysial antibodies (EMA) and antibodies to tissue transglutaminase (tTG) were developed to screen for celiac disease in patients consuming gluten. However, they are commonly used to monitor patients on a gluten-free diet (GFD). We conducted a meta-analysis to assess the sensitivity and specificity of tTG IgA and EMA IgA assays in identifying patients with celiac disease who have persistent villous atrophy despite a GFD. METHODS: We searched PUBMED, EMBASE, BIOSIS, SCOPUS, clinicaltrials...
May 22, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28514313/clinical-and-biological-correlations-in-celiac-disease-in-children-the-prospective-single-experience-of-a-romanian-tertiary-center-a-case-control-study-strobe-compliant-study
#9
Cristina Oana Marginean, Lorena Elena Meliţ, Roxana-Cristina Mareş, Maria Oana Mărginean, Septimiu Voidăzan, Minodora Dobreanu
Celiac disease-a chronic inflammatory disease of the intestine-is triggered by gluten or associated protein consumption.The aim of our study was to assess the sensitivity, specificity of the combined anti-transglutaminase 2 (TG2)/deamidated gliadin peptide antibodies (DGP), and antiendomisium antibodies (EMA), to determine the distribution of HLA-DQ2/DQ8 for the 140 tested patients, and also to evaluate the clinical and laboratory characteristics of patients admitted with the suspicion of celiac disease (CD)...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28512643/diagnostic-and-research-aspects-of-small-intestinal-disaccharidases-in-coeliac-disease
#10
REVIEW
Tanja Šuligoj, Paul J Ciclitira, Borut Božič
Disaccharidases (DS) are brush border enzymes embedded in the microvillous membrane of small intestinal enterocytes. In untreated coeliac disease (CD), a general decrease of DS activities is seen. This manuscript reviews different aspects of DS activities in CD: their utility in the diagnosis and their application to in vitro toxicity testing. The latter has never been established in CD research. However, with the recent advances in small intestinal organoid techniques, DS might be employed as a biomarker for in vitro studies...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28508029/a-b-cell-gene-signature-correlates-with-the-extent-of-gluten-induced-intestinal-injury-in-celiac-disease
#11
Mitchell E Garber, Alok Saldanha, Joel S Parker, Wendell D Jones, Katri Kaukinen, Kaija Laurila, Marja-Leena Lähdeaho, Purvesh Khatri, Chaitan Khosla, Daniel C Adelman, Markku Mäki
BACKGROUND & AIMS: Celiac disease (CeD) provides an opportunity to study autoimmunity and the transition in immune cells as dietary gluten induces small intestinal lesions. METHODS: Seventy-three celiac disease patients on a long-term, gluten-free diet ingested a known amount of gluten daily for 6 weeks. A peripheral blood sample and intestinal biopsy specimens were taken before and 6 weeks after initiating the gluten challenge. Biopsy results were reported on a continuous numeric scale that measured the villus-height-to-crypt-depth ratio to quantify gluten-induced intestinal injury...
July 2017: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28502438/celiac-disease-and-nonceliac-gluten-sensitivity
#12
REVIEW
Runa D Watkins, Shamila Zawahir
Gluten-related disorders include celiac disease (CD), wheat allergy, and nonceliac gluten sensitivity. CD is an autoimmune enteropathy caused by damage to small intestinal mucosa when gluten is ingested in genetically susceptible individuals. Currently, the only available treatment of CD is gluten-free diet. Several potential treatments are being researched. Wheat allergy is a hypersensitivity reaction caused by IgE-mediated and/or non-IgE-mediated immune response, and can involve the gastrointestinal tract, skin, or respiratory tract...
June 2017: Pediatric Clinics of North America
https://www.readbyqxmd.com/read/28485731/differential-antibody-responses-to-gliadin-derived-indigestible-peptides-in-patients-with-schizophrenia
#13
R T McLean, P Wilson, D St Clair, C J Mustard, J Wei
Gluten consumption has previously been implicated in the development of schizophrenia while an immunological link between gluten and schizophrenia was established by the detection of circulating antibodies against gliadin, a major component of wheat gluten. Several studies have reported an increase in circulating antibodies against native gliadin molecules that are unlikely to survive degradation in the digestive system. In this study, therefore, we measured plasma immunoglobulin G (IgG) and IgA antibodies against indigestible gliadin-derived peptide antigens using an in-house enzyme-linked immunosorbent assay (ELISA) among 169 patients with schizophrenia and 236 control subjects...
May 9, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28462999/understanding-the-catalytic-mechanism-and-the-substrate-specificity-of-an-engineered-gluten-hydrolase-by-qm-mm-molecular-dynamics-and-free-energy-simulations
#14
Jianzhuang Yao, Haixia Luo, Xia Wang
Celiac sprue, also known as gluten-sensitive enteropathy, is a chronic disease suffered by approximately 1% of the world's population. Engineered enzymes have been emerging to treat celiac disease by hydrolyzing the pathogenic peptides of gluten. For example, Kuma010 has been studied experimentally and proved to be a promising gluten hydrolase under gastric conditions. However, the detailed catalytic mechanism and the substrate specificity are still unclear. In this paper, quantum-mechanical/molecular-mechanical (QM/MM) molecular dynamics (MD) and free energy simulations were performed to determine the catalytic mechanism, the substrate specificity, and the role of the active-site residues during the reaction...
May 9, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28462603/gluten-related-disorders-certainties-questions-and-doubts
#15
Simona Valenti, Domenico Corica, Luisa Ricciardi, Claudio Romano
In the last decade, the ingestion of gluten, a heterogeneous complex of proteins present in wheat, rice, barley and probably in oats, has been associated with clinical disorders, such as celiac disease, wheat allergy and recently to non-celiac gluten sensitivity or wheat intolerance syndrome. Gluten-related disorders, which are becoming epidemiologically relevant with an estimated global prevalence of about 5%, require the exclusion of gluten from the diet. For the past 5 years, an important shift in the availability of gluten-free products, together with increased consumption in the general population, has been recorded and is estimated to be about 12-25%...
May 11, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28443584/is-the-diagnosis-of-celiac-disease-possible-without-intestinal-biopsy
#16
Maha Shomaf, Mohammad Rashid, Dana Faydi, Ahmad Halawa
BACKGROUND: Celiac disease, is defined as a state of immune mediated hyper responsiveness to dietary gluten as wheat, barley, or rye in genetically predisposed individuals, resulting in tissue damage. It affects approximately 1% of populations worldwide. The diagnosis is done by microscopic examination of small intestinal biopsy, although serologic testing for antibodies against tissue transglutaminase (tTG) and deamidated gliadin peptide can be of great advantage. It has been suggested that duodenal biopsy can be avoided in patients with high levels of tTG antibody since a relationship was found to be present between tTG antibody titers and celiac disease...
April 6, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28420279/responses-of-blood-mononucleated-cells-and-clinical-outcome-of-non-celiac-gluten-sensitive-pediatric-patients-to-various-cereal-sources-a-pilot-study
#17
Patrizia Alvisi, Luigia De Fazio, Maria Chiara Valerii, Elena Cavazza, Angela Salerno, Doriana Lacorte, Giovanni Dinelli, Enzo Spisni
Non-celiac gluten sensitivity (NCGS) is a clinical entity recently documented by the scientific community in pediatric patients. Nevertheless, its triggering mechanisms remain largely unsettled. We studied 11 children with NCGS who were diagnosed based on a clear-cut relationship between wheat consumption and development of symptoms, after excluding celiac disease (CD) and wheat allergy, matched with 18 children with active CD. Sixteen pediatric patients were also enrolled as controls. Cultured peripheral blood mononucleated cells (PBMCs) obtained from NCGS, CD and control patients were cultured in the presence of wheat proteins extracted from ancient and modern cultivars...
April 19, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/28396623/modified-mediterranean-diet-for-enrichment-of-short-chain-fatty-acids-potential-adjunctive-therapeutic-to-target-immune-and-metabolic-dysfunction-in-schizophrenia
#18
Jamie Joseph, Colin Depp, Pei-An B Shih, Kristen S Cadenhead, Geert Schmid-Schönbein
Growing interest in gut and digestive processes and their potential link to brain and peripheral based inflammation or biobehavioral phenotypes has led to an increasing number of basic and translational scientific reports focused on the role of gut microbiota within the context of neuropsychiatric disorders. However, the effect of dietary modification on specific gut metabolites, in association with immune, metabolic, and psychopathological functioning in schizophrenia spectrum disorders has not been well characterized...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28395821/interactions-between-soluble-dietary-fibers-and-wheat-gluten-in-dough-studied-by-confocal-laser-scanning-microscopy
#19
Qian Li, Rui Liu, Tao Wu, Min Zhang
Four soluble dietary fiber (SDF) fractions characterized by major components of AXs, relatively narrow molecular weight distribution, different substituted ratio, and structure-sensitive parameter (ρ) were prepared from wheat bran. The fractions were added to wheat dough to determine the interactions between the dough's network and the SDF fractions relative to their physicochemical characteristics. Furthermore, a comprehensive study focusing on the dough texture characteristic, tensile properties, thermodynamic stability, and the microstructure was conducted by performing texture profile analysis (TPA), differential scanning calorimetry (DSC), and confocal laser scanning microscopy (CLSM) experiments...
May 2017: Food Research International
https://www.readbyqxmd.com/read/28393829/-neurological-disorders-associated-with-gluten-sensitivity
#20
REVIEW
D A Degterev, I V Damulin, A I Parfenov
The review considers the pathogenetic, clinical, and therapeutic aspects of neurological disorders associated with gluten sensitivity. Gluten ataxia and polyneuropathy are most common. The clinical features of neurological disorders in patients with gluten sensitivity and the effects of a gluten-free diet are described.
2017: Terapevticheskiĭ Arkhiv
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