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https://www.readbyqxmd.com/read/29764234/the-role-of-diet-in-the-management-of-irritable-bowel-syndrome-a-focus-on-fodmaps
#1
Russell Dolan, William D Chey, Shanti Eswaran
Irritable bowel syndrome is a common condition that negatively impacts quality of life and results in significant health care expenditures. The vast majority of IBS patients associate their symptoms with eating. Numerous randomized, controlled trials suggest that restriction of dietary FODMAPs improves overall symptoms, abdominal pain, bloating and quality of life in more than half of IBS sufferers. There is emerging data which suggests that other diets (gluten free, guided elimination diets) might also be of benefit to IBS patients...
May 15, 2018: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29761728/safety-assessment-of-hydrolyzed-wheat-protein-and-hydrolyzed-wheat-gluten-as-used-in-cosmetics
#2
Christina Burnett, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel C Liebler, James G Marks, Ronald C Shank, Thomas J Slaga, Paul W Snyder, F Alan Andersen, Bart Heldreth
The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) reviewed the product use, formulation, and safety data on hydrolyzed wheat protein and hydrolyzed wheat gluten, which function as skin- and hair-conditioning agents. The Panel determined that data from clinical and laboratory studies were sufficient to demonstrate that these ingredients will not elicit type 1 immediate hypersensitivity reactions in sensitized individuals and will not induce sensitization when the polypeptide lengths of the hydrolysates do not exceed 30 amino acids...
May 2018: International Journal of Toxicology
https://www.readbyqxmd.com/read/29736406/immune-response-to-rotavirus-and-gluten-sensitivity
#3
Antonio Puccetti, Daniele Saverino, Roberta Opri, Oretta Gabrielli, Giovanna Zanoni, Andrea Pelosi, Piera Filomena Fiore, Francesca Moretta, Claudio Lunardi, Marzia Dolcino
Rotavirus is a double-stranded RNA virus belonging to the family of Reoviridae . The virus is transmitted by the faecal-oral route and infects intestinal cells causing gastroenteritis. Rotaviruses are the main cause of severe acute diarrhoea in children less than 5 years of age worldwide. In our previous work we have shown a link between rotavirus infection and celiac disease. Nonceliac gluten sensitivity (NCGS) is emerging as new clinical entity lacking specific diagnostic biomarkers which has been reported to occur in 6-10% of the population...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29735930/efficacy-of-a-gluten-free-diet-in-the-gilles-de-la-tourette-syndrome-a-pilot-study
#4
Luis Rodrigo, Nuria Álvarez, Enrique Fernández-Bustillo, Javier Salas-Puig, Marcos Huerta, Carlos Hernández-Lahoz
The Gilles de la Tourette syndrome (GTS) and Non-Coeliac Gluten Sensitivity (NCGS) may be associated. We analyse the efficacy of a gluten-free diet (GFD) in 29 patients with GTS (23 children; six adults) in a prospective pilot study. All of them followed a GFD for one year. The Yale Global Tics Severity Scale (YGTSS), the Yale-Brown Obsessive-Compulsive Scale—Self Report (Y-BOCS) or the Children’s Yale-Brown Obsessive-Compulsive Scale—Self Report (CY-BOCS), and the Cavanna’s Quality of Life Questionnaire applied to GTS (GTS-QOL) were compared before and after the GFD; 74% of children and 50% of adults were males, not significant (NS)...
May 7, 2018: Nutrients
https://www.readbyqxmd.com/read/29704914/celiac-disease-and-non-celiac-gluten-or-wheat-sensitivity-and-health-in-later-life-a-review
#5
REVIEW
Eirini Bathrellou, Meropi D Kontogianni, Demosthenes B Panagiotakos
Celiac disease (CD) and non-gluten (or wheat) sensitivity (NCGS) are two gluten-related disorders, the treatment of which relies on dietary withdrawal of gluten (absolute and lifelong in the case of CD patients). However, these conditions differ in their pathophysiology and impact on health. CD is an autoimmune disorder of the intestine, and is associated with a wide range of disorders, pre- and post-diagnosis. Its autoimmune and inflammatory nature raises concerns about its potential effects on mortality and morbidity...
June 2018: Maturitas
https://www.readbyqxmd.com/read/29670007/prevalence-of-self-reported-gluten-related-disorders-and-adherence-to-a-gluten-free-diet-in-salvadoran-adult-population
#6
Noé Ontiveros, Cecilia Ivonne Rodríguez-Bellegarrigue, Gerardo Galicia-Rodríguez, Marcela de Jesús Vergara-Jiménez, Elia María Zepeda-Gómez, Jesús Gilberto Arámburo-Galvez, Martina Hilda Gracia-Valenzuela, Francisco Cabrera-Chávez
Gluten-related disorders are not considered of relevance at public health level in Central America. The prevalence of gluten-related disorders, and adherence to a gluten-free diet, remain unknown in the Central American region. We conducted a cross-sectional survey of the Central American population from San Salvador, El Salvador, to estimate the prevalence rates of self-reported gluten-related disorders and adherence to a gluten-free diet. 1326 individuals were surveyed. Self-reported prevalence rates were (95% Confidence Interval): gluten sensitivity 3...
April 18, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29662290/extra-intestinal-manifestations-of-non-celiac-gluten-sensitivity-an-expanding-paradigm
#7
REVIEW
Giuseppe Losurdo, Mariabeatrice Principi, Andrea Iannone, Annacinzia Amoruso, Enzo Ierardi, Alfredo Di Leo, Michele Barone
Non celiac gluten sensitivity (NCGS) is a syndrome characterized by a cohort of symptoms related to the ingestion of gluten-containing food in subjects who are not affected by celiac disease (CD) or wheat allergy. The possibility of systemic manifestations in this condition has been suggested by some reports. In most cases they are characterized by vague symptoms such as 'foggy mind', headache, fatigue, joint and muscle pain, leg or arm numbness even if more specific complaints have been described. NCGS has an immune-related background...
April 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29619556/duodenal-histological-features-in-suspected-non-celiac-gluten-sensitivity-new-insights-into-a-still-undefined-condition
#8
Barbara Zanini, Vincenzo Villanacci, Monica Marullo, Moris Cadei, Francesco Lanzarotto, Anna Bozzola, Chiara Ricci
No abstract text is available yet for this article.
April 4, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29600329/dietary-wheat-amylase-trypsin-inhibitors-exacerbate-murine-allergic-airway-inflammation
#9
Victor F Zevallos, Verena K Raker, Joachim Maxeiner, Petra Scholtes, Kerstin Steinbrink, Detlef Schuppan
BACKGROUND: Wheat amylase trypsin inhibitors (ATI) are dietary non-gluten proteins that activate the toll-like receptor 4 on myeloid cells, promoting intestinal inflammation. AIM OF THE STUDY: We investigated the effects of dietary ATI on experimental allergic airway inflammation. METHODS: Mice on a gluten and ATI-free diet (GAFD), sensitized with PBS or ovalbumin (OVA) and challenged with OVA, were compared to mice on a commercial standard chow, a gluten diet naturally containing ~ 0...
March 29, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29578652/non-celiac-gluten-sensitivity-how-its-gut-immune-activation-and-potential-dietary-management-differ-from-celiac-disease
#10
REVIEW
Vera Rotondi Aufiero, Alessio Fasano, Giuseppe Mazzarella
Non-celiac gluten sensitivity (NCGS) is a clinical entity triggered by the ingestion of gluten-containing grains leading to intestinal and/or extraintestinal symptoms that resolve once the gluten-containing foodstuff is eliminated from the diet and it is diagnosed when celiac disease (CD) and wheat allergy (WA) have been ruled out. The limited knowledge about the pathophysiology of NCGS and the lack of validated biomarkers are still major limitations for clinical studies, making it difficult to differentiate NCGS from other gluten-related disorders (GRD)...
March 26, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29574077/wheat-amylase-trypsin-inhibitors-exacerbate-intestinal-and-airway-allergic-immune-responses-in-humanized-mice
#11
Iris Bellinghausen, Benno Weigmann, Victor Zevallos, Joachim Maxeiner, Sonja Reißig, Ari Waisman, Detlef Schuppan, Joachim Saloga
BACKGROUND: Amylase-trypsin inhibitors (ATIs) in wheat and related cereals are potent activators of myeloid innate immune cells via engagement of TLR4. Furthermore, ATIs have been shown to serve as adjuvants in experimental intestinal inflammatory diseases. OBJECTIVE: The aim of this study was to analyze whether ATIs are also modifiers of allergic inflammation. METHODS: Therefore, CD4+ T cells from grass or birch pollen sensitized donors were stimulated with autologous allergen-pulsed dendritic cells in the presence or absence of ATIs or the control storage protein zein from corn...
March 21, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29542844/the-effect-of-a-controlled-gluten-challenge-in-a-group-of-patients-with-suspected-non-coeliac-gluten-sensitivity-a-randomized-double-blind-placebo-controlled-challenge
#12
H F Dale, J G Hatlebakk, N Hovdenak, S O Ystad, G A Lied
BACKGROUND: Non-coeliac gluten-sensitivity (NCGS) has been proposed as a new entity with unknown prevalence and mechanisms, and there is a need for a standardized procedure to confirm the diagnosis. The objective of this study was to characterize the response to an oral gluten-challenge in patients with a symptom-relief when following a gluten free-diet (GFD). METHODS: Twenty patients (14F/6M, age range: 21-62 years) with suspected NCGS, without coeliac disease and wheat-allergy, were included while on a gluten-free diet...
March 15, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29531885/translational-chemistry-meets-gluten-related-disorders
#13
REVIEW
Karen M Lammers, Maria G Herrera, Veronica I Dodero
Gluten-related disorders are a complex group of diseases that involve the activation of the immune system triggered by the ingestion of gluten. Among these, celiac disease, with a prevalence of 1 %, is the most investigated, but recently, a new pathology, named nonceliac gluten sensitivity, was reported with a general prevalence of 7 %. Finally, there other less-prevalent gluten-related diseases such as wheat allergy, gluten ataxia, and dermatitis herpetiformis (with an overall prevalence of less than 0...
March 2018: ChemistryOpen
https://www.readbyqxmd.com/read/29525696/insights-into-gliadin-supramolecular-organization-at-digestive-ph-3-0
#14
M G Herrera, D S Vazquez, R Sreij, M Drechsler, Y Hertle, T Hellweg, V I Dodero
Alpha-gliadin is a highly immunogenic protein from wheat, which is associated with many human diseases, like celiac disease and non-celiac gluten sensitivity. Because of that, gliadin solution is subject to intense biomedical research. However, the physicochemical nature of the employed gliadin solution at physiological pH is not understood. Herein, we present a supramolecular evaluation of the alpha-gliadin protein in water at pH 3.0 by dynamic light scattering (DLS), cryo-transmission electron microscopy (cryo-TEM) and small-angle-...
May 1, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29524997/exercise-lowers-threshold-and-increases-severity-but-wheat-dependent-exercise-induced-anaphylaxis-can-be-elicited-at-rest
#15
Morten J Christensen, Esben Eller, Charlotte G Mortz, Knut Brockow, Carsten Bindslev-Jensen
BACKGROUND: Wheat-dependent, exercise-induced anaphylaxis (WDEIA) is a severe form of allergy in which exercise is being considered as mandatory. The diagnosis is often complex and the clinical reproducibility low. OBJECTIVE: The aims of this study were to establish a standardized challenge method for the diagnosis of WDEIA and to investigate whether exercise is an essential trigger factor or alternatively an augmentation factor able to lower threshold and increase severity...
March 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29511548/citrulline-as-a-marker-of-intestinal-function-and-absorption-in-clinical-settings-a-systematic-review-and-meta-analysis
#16
REVIEW
Konstantinos C Fragkos, Alastair Forbes
Background: Citrulline has been described as a marker of intestinal function or absorption but evidence varies according to clinical settings. Objective: The objective of this article is to examine the evidence of plasma citrulline as a marker of intestinal function and absorption in various clinical settings. Methods: Studies were examined for p values, means and standard deviations, correlation coefficients or other metrics depicting the association of citrulline with intestinal function...
March 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29508689/a-randomised-double-blind-cross-over-trial-to-evaluate-bread-in-which-gluten-has-been-pre-digested-by-prolyl-endoprotease-treatment-in-subjects-self-reporting-benefits-of-adopting-a-gluten-free-or-low-gluten-diet
#17
Dinka Rees, Grietje Holtrop, Gemma Chope, Kim M Moar, Morven Cruickshank, Nigel Hoggard
The aim of the present study was to determine if the enzyme Aspergillus niger prolyl endoprotease (ANPEP), which degrades the immunogenic proline-rich residues in gluten peptides, can be used in the development of new wheat products, suitable for gluten-sensitive (GS) individuals. We have carried out a double-blind, randomised, cross-over trial with two groups of adults; subjects, self-reporting benefits of adopting a gluten-free or low-gluten diet (GS, n 16) and a control non-GS group (n 12). For the trial, volunteers consumed four wheat breads: normal bread, bread treated with 0·8 or 1 % ANPEP and low-protein bread made from biscuit flour...
March 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29498738/blastocystis-hominis-transmission-by-non-potable-water-a-case-report-in-italy
#18
Maria Cristina Angelici, Chiara Nardis, Riccardo Scarpelli, Paola Ade
In the reported case, a 41-year-old Italian man came to the clinician's observation reporting cramps, bloating and watery diarrhoea a few days after drinking water indicated as unpotable from a fountain in a farm area. The medical suspicion was directed at both gluten intolerance and enteric infection, eventually of waterborne origin. Gluten intolerance was investigated by intestinal biopsy and excluded, while stool analyses ruled out infective bacteriological or viral agents and parasites. Subsequently, a persistent eosinophilia was revealed and a parasitological analysis was again suggested, planning for a more sensitive molecular method...
March 2, 2018: New Microbiologica
https://www.readbyqxmd.com/read/29469015/do-celiac-disease-and-non-celiac-gluten-sensitivity-have-the-same-effects-on-reproductive-disorders
#19
REVIEW
Joanna Pieczyńska
OBJECTIVES: The wide spectrum of clinical symptoms of celiac disease (CD) is partly due to the malnourished state caused by the malabsorption of micro- and macronutrients. It has been suggested that fertility problems and obstetric complications may be a consequence of the endocrine disorders caused by selective nutrient deficiencies. The same selective nutrient deficiencies as in CD could be a reason for fertility problems in non-celiac gluten sensitivity (NCGS). The aim of this study was to investigate the effect of nutrient deficiencies in CD and NCGS on fertility problems...
April 2018: Nutrition
https://www.readbyqxmd.com/read/29429314/interpreting-tests-for-coeliac-disease
#20
Jason Tye-Din
BACKGROUND: Coeliac disease is one of most prevalent autoimmune illnesses encountered in general practice, and general practitioners have a central role in its diagnosis and follow-up. Key challenges are improving its poor rate of detection, distinguishing it from 'gluten sensitivity', and monitoring and optimising treatment to enhance long‑term outcomes. OBJECTIVE: The objective of this article is to review the evidence-based use of serology, histology and genetic testing in the diagnosis and follow-up care of adults and children with coeliac disease...
January 2018: Australian journal of general practice
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