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https://www.readbyqxmd.com/read/28074147/cerebellar-ataxia-and-sensory-ganglionopathy-associated-with-light-chain-myeloma
#1
Panagiotis Zis, Dasappaiah Ganesh Rao, Bart E Wagner, Lucinda Nicholson-Goult, Nigel Hoggard, Marios Hadjivassiliou
BACKGROUND: Cerebellar ataxia with sensory ganglionopathy is a rare neurological combination that can occur in some hereditary ataxias including mitochondrial diseases and in gluten sensitivity. Individually each condition can be a classic paraneoplastic neurological syndrome. We report a patient with this combination who was diagnosed with light-chain myeloma ten years after initial presentation. CASE PRESENTATION: A 65-year-old Caucasian lady was referred to our Ataxia Clinic because of a 6-year history of progressive unsteadiness and a 2-year history of slurred speech...
2017: Cerebellum & Ataxias
https://www.readbyqxmd.com/read/28067823/biomarkers-to-monitor-gluten-free-diet-compliance-in-celiac-patients
#2
REVIEW
María de Lourdes Moreno, Alfonso Rodríguez-Herrera, Carolina Sousa, Isabel Comino
Gluten-free diet (GFD) is the only treatment for celiac disease (CD). There is a general consensus that strict GFD adherence in CD patients leads to full clinical and histological remission accompanied by improvement in quality of life and reduced long-term complications. Despite the importance of monitoring the GFD, there are no clear guidelines for assessing the outcome or for exploring its adherence. Available methods are insufficiently accurate to identify occasional gluten exposure that may cause intestinal mucosal damage...
January 6, 2017: Nutrients
https://www.readbyqxmd.com/read/28062361/redox-signaling-in-the-gastrointestinal-tract
#3
REVIEW
Salvador Pérez, Raquel Taléns-Visconti, Sergio Rius-Pérez, Isabela Finamor, Juan Sastre
Redox signaling regulates physiological self-renewal, proliferation, migration and differentiation in gastrointestinal epithelium by modulating Wnt/β-catenin and Notch signaling pathways mainly through NADPH oxidases (NOXs). In the intestine, intracellular and extracellular thiol redox status modulates the proliferative potential of epithelial cells. Furthermore, commensal bacteria contribute to intestine epithelial homeostasis through NOX1- and dual oxidase 2-derived reactive oxygen species (ROS). The loss of redox homeostasis is involved in the pathogenesis and development of a wide diversity of gastrointestinal disorders, such as Barrett's esophagus, esophageal adenocarcinoma, peptic ulcer, gastric cancer, ischemic intestinal injury, celiac disease, inflammatory bowel disease and colorectal cancer...
January 3, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28054478/world-epidemiology-of-non-celiac-gluten-sensitivity
#4
Brintha Vasagar, Jessica Cox, John T Herion, Erin Ivanoff
While the term "gluten" has become commonplace, the disorders associated with gluten still remain poorly understood. Non-celiac gluten sensitivity (NCGS), the most recently recognized of the gluten-related disorders, is arguably the most unknown. While celiac disease and wheat allergy have diagnostic algorithm, NCGS remains a diagnosis of exclusion. With no evidence-based objective diagnostic criteria or serological tests, it is difficult to diagnose and even more difficult to study epidemiologically. Studies often use varied definitions of NCGS and are difficult to compare or validate...
March 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28034662/the-perspective-of-celiac-disease-patients-on-emerging-treatment-options-and-non-celiac-gluten-sensitivity
#5
Thomas Greuter, Sandra Schmidlin, Jaqueline Lattmann, Matthias Stotz, Romina Lehmann, Jonas Zeitz, Michael Scharl, Benjamin Misselwitz, Daniel Pohl, Michael Fried, Radu Tutuian, Alessio Fasano, Alain M Schoepfer, Gerhard Rogler, Luc Biedermann, Stephan R Vavricka
BACKGROUND: Non-celiac gluten sensitivity (NCGS) and emerging treatment options are hot topics in the celiac disease (CeD) scientific literature. However, very little is known about the perspective on these issues of CeD patients. METHODS: We performed a large patient survey among unselected CeD patients in Switzerland. RESULTS: A total of 1689 patients were analyzed. 57.5% have previously heard of NCGS. 64.5% believe in the existence of this entity...
December 7, 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28003229/case-of-coeliac-disease-presenting-in-the-psychiatry-ward
#6
Albino J Oliveira-Maia, Isabel Andrade, J Bernardo Barahona-Corrêa
We describe a case of coeliac disease that was diagnosed in the psychiatry inpatient unit of a general hospital. The patient was admitted due to suicidal behaviours and developed an agitated catatonic state while in the inpatient psychiatry unit. An extensive diagnostic study allowed for the diagnosis of coeliac disease and while her state was unresponsive to antidepressants, anxiolytics, antipsychotics and electroconvulsive therapy, the patient improved significantly when a gluten-free diet was started. While it is well known that, occasionally, gluten sensitivity and coeliac disease can present as brain gluten sensitivity, such cases are typically characterised by motor and/or cognitive symptoms and by white matter abnormalities...
December 21, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27994896/proximal-limb-weakness-in-a-patient-with-celiac-disease-copper-deficiency-gluten-sensitivity-or-both-as-the-underlying-cause
#7
J David Avila, David Lacomis
Celiac disease has been associated with several neurologic disorders which may result from micronutrient deficiencies, coexisting autoimmune conditions, or gluten sensitivity. Copper deficiency can produce multiple neurologic manifestations. Myeloneuropathy is the most common neurologic syndrome and it is often irreversible, despite copper replacement. We report the case of a 55-year-old man who presented with progressive proximal limb weakness and weight loss in the setting of untreated celiac disease without gastrointestinal symptoms...
2016: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/27941958/adherence-to-a-gluten-free-diet-in-mexican-subjects-with-gluten-related-disorders-a-high-prevalence-of-inadvertent-gluten-intake
#8
Karen Lizzette Ramírez-Cervantes, Angélica Viridiana Romero-López, Carlos Alberto Núñez-Álvarez, Luis F Uscanga-Domínguez
BACKGROUND: The rate of compliance with a gluten-free diet in patients with gluten-related disorders is unknown in most Latin American countries. OBJECTIVE: To study the adherence to a gluten-free diet of Mexican individuals with celiac disease and nonceliac gluten sensitivity at the time of their first medical and nutritional consultation at a tertiary referral center. METHODS: A cross-sectional study was performed. A specific questionnaire was used to gather information on demographics, clinical condition, and self-reported adherence to a gluten-free diet, and to determine strict compliance and intentional or inadvertent gluten consumption...
September 2016: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/27887897/nomenclature-and-diagnosis-of-gluten-related-disorders-a-position-statement-by-the-italian-association-of-hospital-gastroenterologists-and-endoscopists-aigo
#9
REVIEW
Luca Elli, Danilo Villalta, Leda Roncoroni, Donatella Barisani, Stefano Ferrero, Nicoletta Pellegrini, Maria Teresa Bardella, Flavio Valiante, Carolina Tomba, Antonio Carroccio, Massimo Bellini, Marco Soncini, Renato Cannizzaro, Gioacchino Leandro
BACKGROUND: "Gluten-related disorders" is a term that encompasses different diseases induced by the ingestion of gluten-containing food. Because of their incidence the scientific community has been intensively studying them. AIM: To support gastroenterologists with a correct nomenclature and diagnostic approach to gluten-related disorders in adulthood. METHODS: The Italian Association of Hospital Gastroenterologists and Endoscopists (AIGO) commissioned a panel of experts to prepare a position statement clarifying the nomenclature and diagnosis of gluten-related disorders, focusing on those of gastroenterological interest...
November 4, 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/27867394/association-of-tissue-transglutaminase-antibody-titer-with-duodenal-histological-changes-in-children-with-celiac-disease
#10
Hasan Hawamdeh, Basim Al-Zoubi, Yasameen Al Sharqi, Ayman Qasrawi, Yousef Abdelaziz, Maha Barbar
Celiac disease is usually diagnosed by demonstrating gluten enteropathy in small bowel biopsy. Celiac specific antibodies are used as an initial screening test. The goal of this study is to test the relationship of the anti-tTG titer and severity of histological changes in Jordanian children with celiac disease. Method. The medical records of 81 children who had elevated anti-tTG titer and had duodenal biopsies available were retrospectively reviewed. Result. Assessing the association of anti-tTG titer with duodenal histopathological changes, 94% of those with high anti-tTG titer (≥180 U/mL) had histological evidence of celiac disease...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27852116/non-coeliac-gluten-wheat-sensitivity-advances-in-knowledge-and-relevant-questions
#11
Umberto Volta, Giacomo Caio, Tennekoon B Karunaratne, Armin Alaedini, Roberto De Giorgio
Non-coeliac gluten/wheat sensitivity (NCG/WS) is a syndrome characterized by intestinal and extra-intestinal symptoms occurring a few hours or days after the ingestion of gluten and wheat proteins in patients testing negative for coeliac disease and wheat allergy. Areas covered: The present review deals with recent scientific acquisitions of this gluten-related syndrome, including pathogenetic mechanisms, clinical picture, symptom score, biomarkers and double-blind placebo-controlled trial for diagnosis, and treatment...
January 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27845509/anti-gliadin-antibodies-in-ncgs
#12
Maria Infantino, Francesca Meacci, Valentina Grossi, Donatella Macchia, Mariangela Manfredi
Although no biomarker has been identified to date, previous studies have reported that about 50% of patients with suspected Non Celiac Gluten Sensitivity (NCGS) had positive first generation anti- gliadin antibodies (AGAs), expecially of the IgG class. These antibodies are not specific for NCGS, being also found in CD (80-90%), autoimmune liver disorders (21.5%), connective tissue disease (9%) and IBS (20%), as well as in healthy controls (2-8%), but their finding in patients with a clinical phenotype consistent with NCGS has been regarded as an element supporting this diagnosis...
November 15, 2016: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/27834802/prevalence-and-characterization-of-self-reported-gluten-sensitivity-in-the-netherlands
#13
Tom van Gils, Petula Nijeboer, Catharina E IJssennagger, David S Sanders, Chris J J Mulder, Gerd Bouma
BACKGROUND: A growing number of individuals reports symptoms related to the ingestion of gluten-containing food in the absence of celiac disease. Yet the actual prevalence is not well established. METHODS: Between April 2015 and March 2016, unselected adults visiting marketplaces, dental practices and a university in The Netherlands were asked to complete a modified validated questionnaire for self-reported gluten sensitivity (srGS). RESULTS: Among the 785 adults enquired, two had celiac disease...
November 8, 2016: Nutrients
https://www.readbyqxmd.com/read/27808487/pathophysiology-of-non-celiac-gluten-sensitivity-where-are-we-now-in-2016
#14
Giacomo Caio, Gabriele Riegler, Marta Patturelli, Angela Facchiano, Laura DE Magistris, Anna Sapone
Non-celiac gluten sensitivity (NCGS) is the term used to describe individuals complaining of intestinal and extra-intestinal symptoms related to gluten ingestion and rapidly improving after its withdrawal, and in which both celiac disease (CD) and wheat allergy (WA) were properly ruled out. The prevalence of this condition remains unknown and a lot of questions about the possible pathogenetic mechanisms are still unclarified. It is believed that NCGS represents a heterogeneous condition with different subgroups potentially characterized by different pathogenesis, clinical history, and clinical course...
November 3, 2016: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/27801835/dietary-gluten-induced-gut-dysbiosis-is-accompanied-by-selective-upregulation-of-micrornas-with-intestinal-tight-junction-and-bacteria-binding-motifs-in-rhesus-macaque-model-of-celiac-disease
#15
Mahesh Mohan, Cheryl-Emiliane T Chow, Caitlin N Ryan, Luisa S Chan, Jason Dufour, Pyone P Aye, James Blanchard, Charles P Moehs, Karol Sestak
The composition of the gut microbiome reflects the overall health status of the host. In this study, stool samples representing the gut microbiomes from 6 gluten-sensitive (GS) captive juvenile rhesus macaques were compared with those from 6 healthy, age- and diet-matched peers. A total of 48 samples representing both groups were studied using V4 16S rRNA gene DNA analysis. Samples from GS macaques were further characterized based on type of diet administered: conventional monkey chow, i.e., wheat gluten-containing diet (GD), gluten-free diet (GFD), barley gluten-derived diet (BOMI) and reduced gluten barley-derived diet (RGB)...
October 28, 2016: Nutrients
https://www.readbyqxmd.com/read/27799885/symptomatic-improvement-with-gluten-restriction-in-irritable-bowel-syndrome-a-prospective-randomized-double-blinded-placebo-controlled-trial
#16
Vinay G Zanwar, Sunil V Pawar, Pravir A Gambhire, Samit S Jain, Ravindra G Surude, Vinaya B Shah, Qais Q Contractor, Pravin M Rathi
BACKGROUND/AIMS: The existence of non-celiac gluten sensitivity has been debated. Indeed, the intestinal and extra-intestinal symptoms of many patients with irritable bowel syndrome (IBS) but without celiac disease or wheat allergy have been shown to improve on a gluten-free diet. Therefore, this study set out to evaluate the effects of gluten on IBS symptoms. METHODS: We performed a double-blind randomized placebo-controlled rechallenge trial in a tertiary care hospital with IBS patients who fulfilled the Rome III criteria...
October 2016: Intestinal Research
https://www.readbyqxmd.com/read/27797273/wheat-challenge-in-self-reported-gluten-sensitivity-a-comparison-of-scoring-methods
#17
Gry I Skodje, Christine Henriksen, Trude Salte, Thea Drivenes, Ieva Toleikyte, Astrid M Lovik, Marit B Veierød, Knut E A Lundin
BACKGROUND: The condition non-coeliac gluten sensitivity (NCGS) is clinically similar to coeliac disease, but lack objective diagnostic criteria. Symptom relief on gluten-free diet followed by gluten containing food challenge may confirm the condition in clinical settings. AIM: To describe the results of an open bread challenge in patients with suspected NCGS, and to compare the results with recently suggested cut-offs for symptom change. MATERIAL AND METHODS: Fifty-six patients (12 males) self-instituted on gluten-free diet with negative coeliac disease diagnostics were examined for NCGS by an open bread challenge...
February 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27792210/animal-models-to-study-non-celiac-gluten-sensitivity
#18
Plaimein Amnuaycheewa, Joseph A Murray, Eric V Marietta
Non-celiac gluten sensitivity (NCGS), sometimes known as non-celiac wheat sensitivity (NCWS), has recently received much attention, both scientific as well as from the alternative medical community. Over the past 5 years, there are over 200 publications on NCGS indexed on PubMed database, the gluten-free market has been growing bigger, and it is clear that the number of consumers who are on a gluten-free diet (GFD) possibly because of a suspicion for NCGS appears to grow even faster. Nevertheless, despite these three rising events, many questions about NCGS remain unresolved...
October 28, 2016: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/27784836/a-presumptive-case-of-gluten-sensitivity-in-a-border-terrier-a-multisystem-disorder
#19
M Lowrie, M Hadjivassiliou, D S Sanders, O A Garden
Paroxysmal gluten-sensitive dyskinesia (previously termed canine epileptoid cramping syndrome) is a condition of Border terriers in which the leading manifestation is neurological. The authors describe a case they believe to represent the first report of a Border terrier with a combination of neurological signs, atopy, positive serological results for anti-transglutaminase 2 (TG2 IgA) and anti-gliadin (AGA IgG) antibodies, and signs suggestive of gastrointestinal disease with pathological changes in the gastrointestinal tract-seemingly responsive to a gluten-free diet...
December 3, 2016: Veterinary Record
https://www.readbyqxmd.com/read/27784785/epitope-dependent-functional-effects-of-celiac-disease-autoantibodies-on-transglutaminase-2
#20
Kathrin Hnida, Jorunn Stamnaes, M Fleur du Pré, Simon Mysling, Thomas J D Jørgensen, Ludvig M Sollid, Rasmus Iversen
Transglutaminase 2 (TG2) is a Ca(2+)-dependent cross-linking enzyme involved in the pathogenesis of CD. We have previously characterized a panel of anti-TG2 mAbs generated from gut plasma cells of celiac patients and identified four epitopes (epitopes 1-4) located in the N-terminal part of TG2. Binding of the mAbs induced allosteric changes in TG2. Thus, we aimed to determine whether these mAbs could influence enzymatic activity through modulation of TG2 susceptibility to oxidative inactivation and Ca(2+) affinity...
December 2, 2016: Journal of Biological Chemistry
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