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JOURNAL ARTICLE
Huayong Huang, Qiaoling Chang, Yanhui Zhou, Li Liao
BACKGROUND: Central catheter bloodstream infections (CRBSI) is a major cause of healthcare-associated infections. However, few factors are generally accepted and some studies have conflicting finding about some factors, possibly caused by limitation associated with an individual study. This study was to identify risk factors for CRBSI in intensive care units. METHODS: We searched the PubMed, Cochrane Library, Web of science and EMBASE databases and the 4 top Chinese-language databases, including WanFang data, China National Knowledge Infrastructure (CNKI), and Chinese Science and Technology Journal Database (VIP), China Biology Medicine disc (CBM) as of July 2023...
2024: PloS One
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JOURNAL ARTICLE
Gizachew Ambaw Kassie, Getahun Dendir Wolda, Beshada Zerfu Woldegeorgis, Amanuel Yosef Gebrekidan, Kirubel Eshetu Haile, Mengistu Meskele, Yordanos Sisay Asgedom
Antiretroviral therapy (ART) treatment failure remains a major public health concern, with multidimensional consequences, including an increased risk of drug resistance, compromised quality of life, and high healthcare costs. However, little is known about the outcomes of second-line ART in Ethiopia. Therefore, this systematic review and meta-analysis aimed to determine the incidence and determinants of second-line ART treatment failure. Articles published in PubMed, Google Scholar, Science Direct, and Scopus databases were systematically searched...
2024: PLOS Glob Public Health
#23
JOURNAL ARTICLE
Dong Ouyang, Yong Liang, Jinfeng Wang, Le Li, Ning Ai, Junning Feng, Shanghui Lu, Shuilin Liao, Xiaoying Liu, Shengli Xie
Existing studies have shown that the abnormal expression of microRNAs (miRNAs) usually leads to the occurrence and development of human diseases. Identifying disease-related miRNAs contributes to studying the pathogenesis of diseases at the molecular level. As traditional biological experiments are time-consuming and expensive, computational methods have been used as an effective complement to infer the potential associations between miRNAs and diseases. However, most of the existing computational methods still face three main challenges: (i) learning of high-order relations; (ii) insufficient representation learning ability; (iii) importance learning and integration of multi-view embedding representation...
April 2024: PLoS Computational Biology
#24
JOURNAL ARTICLE
Mădălina Ștefania Vulcan, Andrei-Daniel Dragne, Camelia Georgeta Badea
BACKGROUND Scleroderma is a chronic autoimmune disease characterized by angiopathy, autoimmunity, and fibrosis. One form of scleroderma, systemic sclerosis, is characterized by diffuse skin lesions and visceral involvement. Eosinophilic pleural effusion is a rare complication attributed to a large array of diseases. We present a case of a man with underlying systemic sclerosis who developed eosinophilic pleural effusion as a complication of associated Trichinella spiralis infection. CASE REPORT A 49-year-old man presented for bilateral inflammatory radio-ulnar-carpal joint pain, paresthesia of the hands and forearms and a 2-week history of right posterior aching thoracic pain and night sweats...
April 23, 2024: American Journal of Case Reports
#25
JOURNAL ARTICLE
Tracie C Harrison, Shelley A Blozis, Janiece Taylor, Nandini Mukherjee, Lucia Caudillo Ortega, Nancy Blanco, Alexandra A Garcia, Sharon A Brown
BACKGROUND: Health disparities in osteoarthritis (OA) outcomes exist both in the occurrence and treatment of functional limitation and disability for Mexican Americans. Although the effect of self-management of chronic illness is well established, studies demonstrate little attention to self-management of function or disability, despite the strong potential effect on both and, consequently, on patients' lives. OBJECTIVE: The purpose of this study pilot was to develop and test key variable relationships for a measure of disability self-management among Mexican Americans...
May 2024: Nursing Research
#26
JOURNAL ARTICLE
Lynn Rew, Natasha Slesnick, Shelli Kesler, Hyekyun Rhee
BACKGROUND: Youth who experience homelessness engage in behaviors that place them at high risk for disease and injury. Despite their health risk behaviors, these youth display psychological capital, positive attributes of hope, efficacy, resilience, and optimism that motivate them to engage in health-promoting behaviors such as safer sex. However, this array of positive psychological attributes has not been studied in this vulnerable population. OBJECTIVES: The specific aim of this analysis was to determine whether factors of psychological capital mediated the relationship between background risk factors (e...
May 2024: Nursing Research
#27
JOURNAL ARTICLE
Soo Heon Kwak, Ryan B Hernandez-Cancela, Daniel A DiCorpo, David E Condon, Jordi Merino, Peitao Wu, Jennifer A Brody, Jie Yao, Xiuqing Guo, Fariba Ahmadizar, Mariah Meyer, Murat Sincan, Josep M Mercader, Sujin Lee, Jeffrey Haessler, Ha My T Vy, Zhaotong Lin, Nicole D Armstrong, Shaopeng Gu, Noah L Tsao, Leslie A Lange, Ningyuan Wang, Kerri L Wiggins, Stella Trompet, Simin Liu, Ruth J F Loos, Renae Judy, Philip H Schroeder, Natalie R Hasbani, Maxime M Bos, Alanna C Morrison, Rebecca D Jackson, Alexander P Reiner, JoAnn E Manson, Ninad S Chaudhary, Lynn K Carmichael, Yii-Der Ida Chen, Kent D Taylor, Mohsen Ghanbari, Joyce van Meurs, Achilleas N Pitsillides, Bruce M Psaty, Raymond Noordam, Ron Do, Kyong Soo Park, J Wouter Jukema, Maryam Kavousi, Adolfo Correa, Stephen S Rich, Scott M Damrauer, Catherine Hajek, Nam H Cho, Marguerite R Irvin, James S Pankow, Girish N Nadkarni, Robert Sladek, Mark O Goodarzi, Jose C Florez, Daniel I Chasman, Susan R Heckbert, Charles Kooperberg, Josée Dupuis, Rajeev Malhotra, Paul S de Vries, Ching-Ti Liu, Jerome I Rotter, James B Meigs
OBJECTIVE: To identify genetic risk factors for incident cardiovascular disease (CVD) among people with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: We conducted a multiancestry time-to-event genome-wide association study for incident CVD among people with T2D. We also tested 204 known coronary artery disease (CAD) variants for association with incident CVD. RESULTS: Among 49,230 participants with T2D, 8,956 had incident CVD events (event rate 18...
April 23, 2024: Diabetes Care
#28
JOURNAL ARTICLE
Laraine Winter, Helene Moriarty, Keith M Robinson, Benjamin E Leiby, Krista Schmidt, Christina R Whitehouse, Randel L Swanson
OBJECTIVES: Recovery from traumatic brain injury (TBI) is extremely difficult to predict, with TBI severity usually demonstrating weak predictive validity for functional or other outcomes. A possible explanation may lie in the statistical phenomenon called suppression, according to which a third variable masks the true association between predictor and outcome, making it appear weaker than it actually is. Age at injury is a strong candidate as a suppressor because of its well-established main and moderating effects on TBI outcomes...
April 17, 2024: Journal of Head Trauma Rehabilitation
#29
JOURNAL ARTICLE
C P Ranjith, Mayakannan Krishnan, Vysakh Raveendran, Lalit Chaudhari, Siddhartha Laskar
Utilising Machine Learning (ML) models to predict dosimetric parameters in pencil beam scanning proton therapy presents a promising and practical approach. The study developed Artificial Neural Network (ANN) models to predict proton beam spot size and relative positional errors using 9000 proton spot data. The irradiation log files as input variables and corresponding scintillation detector measurements as the label values. The ANN models were developed to predict six variables: spot size in the x -axis, y -axis, major axis, minor axis, and relative positional errors in the x -axis and y -axis...
April 22, 2024: Biomedical Physics & Engineering Express
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JOURNAL ARTICLE
Athanasios Tsalatsanis, Clara Dismuke-Greer, Ambuj Kumar, Jeanne Hoffman, Kimberley R Monden, Ulysses Magalang, Daniel Schwartz, Aaron M Martin, Risa Nakase-Richardson
OBJECTIVE: To assess the cost-effectiveness of alternative approaches to diagnose and treat obstructive sleep apnea (OSA) in patients with traumatic brain injury (TBI) during inpatient rehabilitation. SETTING: Data collected during the Comparison of Sleep Apnea Assessment Strategies to Maximize TBI Rehabilitation Participation and Outcome (C-SAS) clinical trial (NCT03033901) on an inpatient rehabilitation TBI cohort were used in this study. STUDY DESIGN: Decision tree analysis was used to determine the cost-effectiveness of approaches to diagnosing and treating sleep apnea...
April 18, 2024: Journal of Head Trauma Rehabilitation
#31
JOURNAL ARTICLE
Giuseppe Daniele, Andrea Tura, Alex Brocchi, Alessandro Saba, Beatrice Campi, Veronica Sancho-Bornez, Angela Dardano, Stefano Del Prato
OBJECTIVE: To explore the complementary effects of a combination of dipeptidyl peptidase 4 and sodium-glucose cotransporter 2 inhibitors added to metformin on hormonal and metabolic responses to meal ingestion. RESEARCH DESIGN AND METHODS: Forty-five patients (age 58 ± 8 years; HbA1c 58 ± 6 mmol/mol; BMI 30.7 ± 3.2 kg/m2) with type 2 diabetes uncontrolled with metformin were evaluated at baseline and 3 and 28 days after 5 mg saxagliptin (SAXA), 10 mg dapagliflozin (DAPA), or 5 mg saxagliptin plus 10 mg dapagliflozin (SAXA+DAPA) using a mixed-meal tolerance test (MMTT) spiked with dual-tracer glucose to assess glucose metabolism, insulin secretion, and sensitivity...
April 23, 2024: Diabetes Care
#32
JOURNAL ARTICLE
Emily Wiecek, Anna Kosovicheva, Zain Ahmed, Amanda Nabasaliza, Melanie Kazlas, Kimberley Chan, David G Hunter, Peter J Bex
PURPOSE: Individuals with amblyopia experience central vision deficits, including loss of visual acuity, binocular vision, and stereopsis. In this study, we examine the differences in peripheral binocular imbalance in children with anisometropic amblyopia, strabismic amblyopia, and typical binocular vision to determine if there are systematic patterns of deficits across the visual field. METHODS: This prospective cohort study recruited 12 participants with anisometropic amblyopia, 10 with strabismic amblyopia, and 10 typically sighted controls (age range, 5-18 years)...
April 1, 2024: Investigative Ophthalmology & Visual Science
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JOURNAL ARTICLE
Lukkamol Prapkree, Rianna Deringer, Catherine Coccia, Fatma Huffman, Cristina Palacios
OBJECTIVE: To determine if using the Snackability app improves snack intake among college students. PARTICIPANTS: US college students with overweight/obesity were recruited in June 2020-April 2021. METHODS: A randomized controlled trial was conducted to test the Snackability app use for 12 wk on snack scores (calculated from the app) compared to controls. We also explored the effect on diet quality (Healthy Eating Index-2015) and weight. Outcomes were compared between the intervention and the control groups at 4, 8, and 12 wk using repeated measures ANOVA...
April 23, 2024: Journal of American College Health: J of ACH
#34
JOURNAL ARTICLE
Meng Sun, Zhibin Chen, Guoyi Li, Yingfeng Weng, Yangbo Hou
Abstract： Objective: To explore the relationship between risk factors of cognitive dysfunction and blood pressure variability after acute ischemic stroke in northwest Shanghai to establish a model for early identification of high-risk groups of cognitive dysfunction and formulation of more targeted prevention and treatment measures. Methods: Spearman test was used to evaluate the correlation between blood pressure variability and Montreal Cognitive Assessment (MoCA) score in patients with acute ischemic stroke and the partial regression coefficient model was constructed based on the above independent risk factors, and the receiver operating characteristic (ROC) curve was described to analyze the relevant independent risk factors...
April 23, 2024: International Journal of Neuroscience
#35
JOURNAL ARTICLE
Sepehr Shirani, Bahman Abdi-Sargezeh, Antonio Valentin, Gonzalo Alarcon, Jordan Bird, Saeid Sanei
Identification of seizure sources in the brain is of paramount importance, particularly for drug-resistant epilepsy patients who may require surgical operation. Interictal epileptiform discharges (IEDs), which may or may not be frequent, are known to originate from seizure networks. Delayed responses (DRs) to brain electrical stimulation have been recently discovered. If DRs and IEDs come from the same location and the DRs can be accurately localized, there will be a significant step in identification of the seizure sources...
April 23, 2024: IEEE Transactions on Bio-medical Engineering
#36
JOURNAL ARTICLE
Sai Zhang, Yunjie Wu, Xiaowang Zhang, Zhiyong Feng, Liang Wan, Zhiqiang Zhuang
Textbook question answering (TQA) task aims to infer answers for given questions from a multimodal context, including text and diagrams. The existing studies have aggregated intramodal semantics extracted from a single modality but have yet to capture the intermodal semantics between different modalities. A major challenge in learning intermodal semantics is maintaining lossless intramodal semantics while bridging the gap of semantics caused by heterogeneity. In this article, we propose an intermodal relation-aware heterogeneous graph network (IMR-HGN) to extract the intermodal semantics for TQA, which aggregates different modalities while learning features rather than representing them independently...
April 23, 2024: IEEE Transactions on Neural Networks and Learning Systems
#37
JOURNAL ARTICLE
Jonas Håkansson, Brooke L Quinn, Abigail L Shultz, Sharon M Swartz, Aaron J Corcoran
Studying the detailed biomechanics of flying animals requires accurate three-dimensional coordinates for key anatomical landmarks. Traditionally, this relies on manually digitizing animal videos, a labor-intensive task that scales poorly with increasing framerates and numbers of cameras. Here, we present a workflow that combines deep learning-powered automatic digitization with filtering and correction of mislabeled points using quality metrics from deep learning and 3D reconstruction. We tested our workflow using a particularly challenging scenario: bat flight...
April 23, 2024: Annals of the New York Academy of Sciences
#38
JOURNAL ARTICLE
Laura Collignon, Kenn Holmbeck, Ashley Just, Lieven Verhoye, Rodrigo Velázquez-Moctezuma, Ulrik Fahnøe, Thomas H R Carlsen, Mansun Law, Jannick Prentoe, Troels K H Scheel, Judith M Gottwein, Philip Meuleman, Jens Bukh
BACKGROUND AIMS: HCV infection continues to be a major global health burden, despite effective antiviral treatments. The urgent need for a protective vaccine is hindered by the scarcity of suitable HCV permissive animal models tractable in vaccination and challenge studies. Currently, only antibody neutralization studies in infectious cell culture systems or studies of protection by passive immunization of human-liver chimeric mice offer the possibility to evaluate the effect of vaccine-induced antibodies...
April 23, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
#39
JOURNAL ARTICLE
Amir Yari, Paniz Fasih, Mohammad Hosseini Hooshiar, Ali Goodarzi, Seyedeh Farnaz Fattahi
PURPOSE: This study aimed to assess the performance of a deep learning algorithm (YOLOv5) in detecting different mandibular fracture types in panoramic images. METHODS: This study utilized a dataset of panoramic radiographic images with mandibular fractures. The dataset was divided into training, validation, and testing sets, with 60%, 20%, and 20% of the images, respectively. An equal number of control panoramic radiographs, which did not contain any fractures, were also randomly distributed among the three sets...
April 23, 2024: Dento Maxillo Facial Radiology
#40
JOURNAL ARTICLE
Jon T Giles, Daniel H Solomon, Katherine P Liao, Pamela M Rist, Zahi A Fayad, Ahmed Tawakol, Joan M Bathon
OBJECTIVES: Rheumatoid arthritis (RA) and atherosclerosis share many common inflammatory pathways. We studied whether a multi-biomarker panel for RA disease activity (MBDA) would associate with changes in arterial inflammation in an interventional trial. METHODS: In the TARGET Trial, RA patients with active disease despite methotrexate were randomly assigned to the addition of either a TNF inhibitor or sulfasalazine+hydroxychloroquine (triple therapy). Baseline and 24-week follow-up 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography scans were assessed for change in arterial inflammation measured as the maximal arterial target-to-blood background ratio of FDG uptake in the most diseased segment of the carotid arteries or aorta (MDS-TBRmax)...
April 23, 2024: Rheumatology
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