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https://www.readbyqxmd.com/read/29913544/uterine-artery-doppler-in-screening-for-preeclampsia-and-fetal-growth-restriction
#1
Marianna Amaral Pedroso, Kirsten Rebecca Palmer, Ryan James Hodges, Fabricio da Silva Costa, Daniel Lorber Rolnik
OBJECTIVE:  To perform a comprehensive review of the current evidence on the role of uterine artery Doppler, isolated or in combination with other markers, in screening for preeclampsia (PE) and fetal growth restriction (FGR) in the general population. The review included recently published large cohort studies and randomized trials. METHODS:  A search of the literature was conducted using Medline, PubMed, MeSH and ScienceDirect. Combinations of the search terms "preeclampsia," "screening," "prediction," "Doppler," "Doppler velocimetry," "fetal growth restriction," "small for gestational age" and "uterine artery" were used...
May 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29913528/blood-pressure-and-cognitive-performance-after-a-single-administration-of-a-camphor-crataegus-combination-in-adolescents-with-low-blood-pressure
#2
Rainer Schandry, Daniela Lindauer, Matthias Mauz
Low blood pressure is rather widespread among adolescents and frequently accompanied by complaints. Two single-center, double-blinded, randomized, and placebo-controlled trials were performed with adolescent participants in the age range of 14 - 17 y having a systolic blood pressure below 118 mmHg (boys) or 110 mmHg (girls). They received a single dose of 20 drops of a fixed combination of natural D-camphor and an ethanolic extract from fresh Crataegus berries (CCC) or of an ethanolic placebo. The efficacy of CCC (commercial name Korodin) has proven its efficacy in the treatment of low blood pressure in adults of all ages, although related placebo-controlled, double-blind studies for adolescents following European (EU) pediatric regulations are lacking...
June 18, 2018: Planta Medica
https://www.readbyqxmd.com/read/29913486/prognostic-implications-of-single-sample-confirmatory-testing-for-undiagnosed-diabetes-a-prospective-cohort-study
#3
Elizabeth Selvin, Dan Wang, Kunihiro Matsushita, Morgan E Grams, Josef Coresh
Background: Current clinical definitions of diabetes require repeated blood work to confirm elevated levels of glucose or hemoglobin A1c (HbA1c) to reduce the possibility of a false-positive diagnosis. Whether 2 different tests from a single blood sample provide adequate confirmation is uncertain. Objective: To examine the prognostic performance of a single-sample confirmatory definition of undiagnosed diabetes. Design: Prospective cohort study...
June 19, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29913461/nod2-modulates-serotonin-transporter-and-interacts-with-tlr2-and-tlr4-in-intestinal-epithelial-cells
#4
Elena Layunta, Eva Latorre, Raquel Forcén, Laura Grasa, Marta Castro, Maykel A Arias, Ana I Alcalde, José Emilio Mesonero
BACKGROUND/AIMS: Serotonin (5-HT) is a chief modulator of intestinal activity. The effects of 5-HT depend on its extracellular availability, which is mainly controlled by serotonin transporter (SERT), expressed in enterocytes. On the other hand, innate immunity, mediated by Toll-like receptors (TLRs) and nucleotide oligomerization domain (NOD)-like receptors (NLRs), is known to control intestinal microbiota and maintain intestinal homeostasis. The dysregulation of the intestinal serotonergic system and innate immunity has been observed in inflammatory bowel diseases (IBD), the incidence of which has severely increased all over the world...
June 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29913450/lower-cognitive-function-in-older-patients-with-lower-muscle-strength-and-muscle-mass
#5
Romee van Dam, Jeanine M Van Ancum, Sjors Verlaan, Kira Scheerman, Carel G M Meskers, Andrea B Maier
BACKGROUND: Low muscle strength and muscle mass are associated with adverse outcomes in older hospitalized patients. The aim of this study was to assess the association between cognitive functioning and muscle strength and muscle mass in hospitalized older patients. METHODS: This prospective inception cohort included 378 patients aged 70 years or older. At admission patients were assessed for cognitive functioning by use of the Six-Item Cognitive Impairment Test (6-CIT)...
June 18, 2018: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/29913447/perioperative-anaphylaxis-including-kounis-syndrome-due-to-selective-cefazolin-allergy
#6
Inês Mota, Ângela Gaspar, Mário Morais-Almeida
BACKGROUND: Perioperative use of cefazolin has been associated with severe allergic reactions, and patients are usually labelled as allergic to penicillin afterwards. The aim of our study was to describe a group of patients with immediate reactions to cefazolin, with proven selective hypersensitivity reactions. METHODS: Systematic review of all patients followed at our drug centre with cefazolin-related reactions, between January 2012 and December 2016. All patients were investigated according to the European Network for Drug Allergy (ENDA) recommendations through skin testing (major and minor penicillin determinants, penicillin, amoxicillin, cefazolin, cefuroxime and ceftriaxone) and oral challenges tests...
June 18, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29913440/validation-of-a-new-low-cost-methanol-based-fixative-for-cervical-cytology-and-human-papillomavirus-detection
#7
Katia Ramos Moreira Leite, Thais Silva, Bruna Naum, Flavio Canavez, Juliana Canavez, Ruan Pimenta, Sabrina Reis, Luiz Heraldo Camara-Lopes
OBJECTIVE: To test the performance of a new fixative for pap smear collection for liquid-based cervical cytology, CellPreserv® and compare it with the commercially available, PreservCyt® used in the diagnosis and detection of human papillomavirus (HPV). METHODS: Seven hundred twenty five women participated in this study after signing an informed consent. The specimens were collected using a traditional device, agitated in PBS, and equally divided in both fixatives...
June 18, 2018: Acta Cytologica
https://www.readbyqxmd.com/read/29913435/assessment-of-exposure-to-air-pollution-in-children-determining-whether-wearing-a-personal-monitor-affects-physical-activity
#8
Stephanie Lovinsky-Desir, Jennifer Lawrence, Kyung Hwa Jung, Andrew G Rundle, Lori A Hoepner, Beizhan Yan, Federica Perera, Matthew S Perzanowski, Rachel L Miller, Steve N Chillrud
Personal air pollution monitoring in research studies should not interfere with usual patterns of behavior and bias results. In an urban pediatric cohort study we tested whether wearing an air monitor impacted activity time based on continuous watch-based accelerometry. The majority (71%) reported that activity while wearing the monitor mimicked normal activity. Correspondingly, variation in activity while wearing versus not wearing the monitor did not differ greatly from baseline variation in activity (P = 0...
June 15, 2018: Environmental Research
https://www.readbyqxmd.com/read/29913424/postponement-of-canine-puberty-by-neonatal-administration-of-a-long-term-release-gnrh-superagonist
#9
M Faya, C Marchetti, M Priotto, M Grisolía, F D'Francisco, C Gobello
The objective of this study was to assess the efficiency and clinical safety of postnatal administration of a GnRH agonist on canine puberty postponement. Sexual steroids and histological gonadal changes were also described. Twenty-four littermate puppies were randomly assigned to: Deslorelin acetate 18.8 mg sc (DESLO; n = 12) or Placebo: sc (PLACE; n = 12) postnatally. The dogs were clinically and endocrinologically followed up until puberty when they were gonadectomized and their gonads histomorphometrically studied...
June 2, 2018: Theriogenology
https://www.readbyqxmd.com/read/29913408/tripterine-alleviates-lps-induced-inflammatory-injury-by-up-regulation-of-mir-146a-in-hacat-cells
#10
Ying Xiong, Yanlong Yan, Yuzhu Li
BACKGROUND: Corticosteroid-dependent dermatitis (CDD) is an inflammation caused by long-term repeated inappropriate external use of corticosteroids. Tripterine is a natural product from the root of Tripterygium wilfordii Hook.f. This study aimed to explore the effect and mechanism of tripterine on LPS-induced inflammatory injury in HaCaT cells. METHODS: In this study, different concentrations (0, 1, 2, 3 and 4 μM) of tripterine and 10 μM of LPS were used to treat HaCaT cells...
June 15, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29913407/the-effect-of-dichloroacetate-in-mouse-models-of-epilepsy
#11
Dylan Durie, Tanya S McDonald, Karin Borges
A recent report has found that glucose oxidation and the activity of pyruvate dehydrogenase (PDH) are reduced in the chronic stage of the pilocarpine mouse epilepsy model. This is likely caused by increased phosphorylation by PDH kinase of the E1α subunit of PDH, downregulating its activity. Inhibition of this phosphorylation has not yet been explored as a possible approach to treat epilepsy. Chronic dichloroacetate (DCA, 50 and 100 mg/kg/day) treatment was tested in acute seizure and the chronic pilocarpine models...
June 15, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29913400/soil-sterilisation-methods-for-use-in-oecd-106-how-effective-are-they
#12
Katherine Lees, Mark Fitzsimons, Jason Snape, Alan Tappin, Sean Comber
Under many circumstances chemical risk assessments for pharmaceuticals and other substances are required to differentiate between 'loss' of a chemical from the aqueous phase as a result of abiotic (sorption or precipitation reactions) or biotic (biodegradation) processes. To distinguish only abiotic processes, it is necessary to work under sterile conditions. Reported methods include poisoning the soil with sodium azide, irradiation and autoclaving. However, a key aspect of any testing is the representativeness of the matrix and so any sterilisation procedure needs to ensure that the integrity of the sample is maintained, in particular particle size distribution, pH and organic carbon partitioning potential...
June 11, 2018: Chemosphere
https://www.readbyqxmd.com/read/29913383/novel-carbazole-triazole-conjugates-as-dna-targeting-membrane-active-potentiators-against-clinical-isolated-fungi
#13
Yuan Zhang, Vijai Kumar Reddy Tangadanchu, Rammohan R Yadav Bheemanaboina, Yu Cheng, Cheng-He Zhou
A series of carbazole-triazole conjugates were designed, synthesized and characterized by IR, NMR, and HRMS spectra. Biological assay showed that most of the synthesized compounds exhibited moderate and even strong antifungal activities, especially 3,6-dibromocarbazolyl triazole 5d displayed excellent inhibitory efficacy against most of the tested fungal strains (MIC = 2-32 μg/mL) and effectively fungicidal ability towards C. albicans, C. tropicals and C. parapsilosis ATCC 22019 (MFC = 4-8 μg/mL)...
June 15, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29913380/a-scoping-review-of-suicidality-and-alexithymia-the-need-to-consider-interoception
#14
REVIEW
Steven Davey, Jamin Halberstadt, Elliot Bell, Sunny Collings
BACKGROUND: Alexithymia is a problem of emotion regulation and for this reason alone may relate to suicidality. This article investigates the evidence for a direct relationship. It explores the possibility of an additional role for interoception in future research. METHODS: A scoping review of peer-reviewed journal articles examining alexithymia and suicidality was undertaken, followed by a critical assessment of the overall state of the evidence base in relation to interoception...
June 7, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29913379/the-role-of-social-support-in-family-socio-economic-disparities-in-depressive-symptoms-during-early-pregnancy-evidence-from-a-chinese-birth-cohort
#15
Dong-Mei Wei, Shiu Lun Au Yeung, Jian-Rong He, Wan-Qing Xiao, Jin-Hua Lu, Si Tu, Nian-Nian Chen, Kin Bong Hubert Lam, Kar-Keung Cheng, Gabriel M Leung, Hui-Min Xia, C Mary Schooling, Xiu Qiu
BACKGROUND: Few studies have examined the association between a composite measure of family socio-economic position (SEP)2 and depressive symptoms among Chinese pregnant women, nor any potential underlying mechanisms which may be amenable to preventative interventions. METHODS: We investigated the association between a composite SEP measure and depressive symptoms during early pregnancy, and tested for mediation by social support and moderation by parity in the Born in Guangzhou Cohort Study (n = 12,382) using adjusted logistic regression and causal mediation analysis...
June 5, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29913378/testing-neurophysiological-markers-related-to-fear-potentiated-startle
#16
Antonia V Seligowski, Erin Bondy, Paris Singleton, Holly K Orcutt, Kerry J Ressler, Randy P Auerbach
Fear-potentiated startle (FPS) paradigms provide insight into fear learning mechanisms that contribute to impairment among individuals with posttraumatic stress symptoms (PTSS). Electrophysiology also has provided insight into these mechanisms through the examination of event-related potentials (ERPs) such as the P100 and LPP. It remains unclear, however, whether the P100 and LPP may be related to fear learning processes within the FPS paradigm. To this end, we tested differences in ERP amplitudes for conditioned stimuli associated (CS+) and not associated (CS-) with an aversive unconditioned stimulus (US) during fear acquisition...
June 11, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29913375/versatile-graphene-biosensors-for-enhancing-human-cell-therapy
#17
REVIEW
George M Vlăsceanu, Roxana-Maria Amărandi, Mariana Ioniță, Teddy Tite, Horia Iovu, Luisa Pilan, Jorge S Burns
Technological advances in engineering and cell biology stimulate novel approaches for medical treatment, in particular cell-based therapy. The first cell-based gene therapy against cancer was recently approved by the US Food and Drug Administration. Progress in cancer diagnosis includes a blood test detecting five cancer types. Numerous stem cell phase I/II clinical trials showing safety and efficacy will soon pursue qualifying criteria for advanced therapy medicinal products (ATMP), aspiring to join the first stem-cell therapy approved by the European Medicines Agency...
May 1, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29913368/a-set-up-for-simultaneous-measurement-of-second-harmonic-generation-and-streaming-potential-and-some-test-applications
#18
Johannes Lützenkirchen, Tim Scharnweber, Tuan Ho, Alberto Striolo, Marialore Sulpizi, Ahmed Abdelmonem
We present a measurement cell that allows simultaneous measurement of second harmonic generation (SHG) and streaming potential (SP) at mineral-water interfaces with flat specimen that are suitable for non-linear optical (NLO) studies. The set-up directly yields SHG data for the interface of interest and can also be used to obtain information concerning the influence of flow on NLO signals from that interface. The streaming potential is at present measured against a reference substrate (PTFE). The properties of this inert reference can be independently determined for the same conditions...
June 15, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29913365/the-prevalence-and-correlates-of-anticoagulant-rodenticide-exposure-in-non-target-predators-and-scavengers-in-finland
#19
Elina Koivisto, Andrea Santangeli, Pertti Koivisto, Tapio Korkolainen, Timo Vuorisalo, Ilpo K Hanski, Iida Loivamaa, Sanna Koivisto
The most common rodent control method worldwide is anticoagulant rodenticides (ARs), which cause death by internal bleeding. ARs can transfer to non-target predators via secondary exposure, i.e. by consuming contaminated rodents. Here we quantify the prevalence of seven AR substances in the liver tissues of altogether 17 mammalian or avian predator or scavenger species in Finland. In addition, we identify the environmental and biological factors potentially linked to secondary AR poisoning. No previous AR screenings have been conducted in the country, despite the widespread use of ARs and their potential impacts on the high levels of the ecosystem food chain...
June 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29913361/title-quantifying-the-change-of-spasticity-after-intrathecal-baclofen-administration-a-descriptive-retrospective-analysis
#20
Thomas P Pittelkow, Markus A Bendel, Daniel R Lueders, Lisa A Beck, Matthew J Pingree, Bryan C Hoelzer
OBJECTIVES: Exploratory research quantifying the change of spasticity among patients who underwent baclofen intrathecal drug delivery system (IDDS) implantation. PATIENTS AND METHODS: 88 patients with a baclofen IDDS were identified. Patient characteristics, spasticity scores pre/post intrathecal baclofen test dose, and IDDS perioperative implantation records were collected. The primary outcome was to quantify the extent to which there was a change in Modified Ashworth Scores (MAS) pre/post-intrathecal baclofen test dose administration...
June 10, 2018: Clinical Neurology and Neurosurgery
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