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JOURNAL ARTICLE
Cecilia Rohdin, Ingrid Ljungvall, Karin Hultin Jäderlund, Anna Svensson, Kerstin Lindblad-Toh, Jens Häggström
BACKGROUND: Pugs commonly present with thoracolumbar myelopathy, also known as pug dog myelopathy (PDM), which is clinically characterised by progressive signs involving the pelvic limbs, no apparent signs of pain and, often, incontinence. In addition to meningeal fibrosis and focal spinal cord destruction, histopathology has confirmed lymphohistiocytic infiltrates in the central nervous system (CNS) in a considerable number of pugs with PDM. Lymphohistiocytic CNS inflammation also characterises necrotising meningoencephalitis (NME) in pugs...
May 5, 2024: Veterinary Record
#2
JOURNAL ARTICLE
Jian Shi, Lin Zhu, Bang-Yi Tang, Wan-Qing Yang, Sheng-Yan Xi, Chen-Long Zhang, Peng-Fei Li, Yu-Jie Wang, Kai-Hang Guo, Jing-Ru Huang, Chen-Rui Huang, Zhou-Xin Yu, Bao-Kang Yu, Chun-Fang Zhang, Yu-Mei Zhang
Hepatocellular carcinoma (HCC) is a malignant tumor with extremely high mortality. The tumor microenvironment is the "soil" of its occurrence and development, and the inflammatory microenvironment is an important part of the "soil". Bile acid is closely related to the occurrence of HCC. Bile acid metabolism disorder is not only directly involved in the occurrence and development of HCC but also affects the inflammatory microenvironment of HCC. Yinchenhao decoction, a traditional Chinese medicine formula, can regulate bile acid metabolism and may affect the inflammatory microenvironment of HCC...
May 5, 2024: Journal of Natural Medicines
#3
JOURNAL ARTICLE
Christopher J Borgert, Lyle D Burgoon, John C Matthews
The endocrine system functions by interactions between ligands and receptors. Ligands exhibit potency for binding to and interacting with receptors. Potency is the product of affinity and efficacy. Potency and physiological concentration determine the ability of a ligand to produce physiological effects. The kinetic behavior of ligand-receptor interactions conforms to the laws of mass action. The laws of mass action define the relationship between the affinity of a ligand and the fraction of cognate receptors that it occupies at any physiological concentration...
May 5, 2024: Archives of Toxicology
#4
JOURNAL ARTICLE
Rosa De Abreu Ferreira, Sheng Zhong, Charlotte Moureaud, Michelle T Le, Adrienne Rothstein, Xiaomeng Li, Li Wang, Meenal Patwardhan
INTRODUCTION: The identification of a new adverse event (AE) caused by a drug product is one of the key activities in the pharmaceutical industry to ensure the safety profile of a drug product. Machine learning (ML) has the potential to assist with signal detection and supplement traditional pharmacovigilance (PV) surveillance methods. This pilot ML modeling study was designed to detect potential safety signals for two AbbVie products and test the model's capability of detecting safety signals earlier than humans...
May 5, 2024: Advances in Therapy
#5
JOURNAL ARTICLE
Hazim O Khalifa, Akira Watanabe, Katsuhiko Kamei
Candida parapsilosis complex has recently received special attention due to naturally occurring FKS1 polymorphism associated with high minimal inhibitory concentrations for echinocandin and the increase of clonal outbreaks of strains resistant to commonly used antifungals such as fluconazole. Despite the previous fact, little is known about the genetic mechanism associated with echinocandin resistance. Therefore, the present study was designed to investigate the mechanism of acquired echinocandin resistance in C...
May 5, 2024: Mycopathologia
#6
JOURNAL ARTICLE
Mingjie Lu, Chen Wang, Yi Zhuo, Junjiu Gou, Yingfeng Li, Jingqi Li, Xue Dong
OBJECTIVE: To compare radiomics and non-radiomics in predicting early recurrence (ER) in patients with hepatocellular carcinoma (HCC) after curative surgery. METHODS: We systematically searched PubMed and Embase databases. Studies with clear reference criteria were selected. Data were extracted and assessed for quality using the quality in prognosis studies tool (QUIPS) by two independent authors. All included radiomics studies underwent radiomics quality score (RQS) assessment...
May 5, 2024: Abdominal Radiology
#7
REVIEW
Govind Kale, Veeranjaneyulu Addepalli, Sharvari Joshi
Autism spectrum disorder is a neurodevelopmental condition marked by restricted interests and difficulty with social communication. ASD is characterized by heightened neuroinflammation and irregular neuronal connections. ASD is more frequent in male than female with male-female ratio of around 4:1. ASD affects 2.8% or 1 in 36 8-year-olds, based on the CDC's Morbidity and Mortality Weekly Report. Various factors like Environmental, Genetic, Epigenetic and Developmental factors are linked with genesis of ASD...
May 5, 2024: Molecular Biology Reports
#8
JOURNAL ARTICLE
Martin Hoenigl, David A Enoch, Dominic Wichmann, Duncan Wyncoll, Andrea Cortegiani
BACKGROUND: The global prevalence of invasive fungal infections (IFI) is increasing, particularly within Intensive Care Units (ICU), where Candida spp. and Aspergillus spp. represent the most important pathogens. Diagnosis and management of IFIs becomes progressively challenging, with increasing antifungal resistance and the emergence of rare fungal species. Through a consensus survey focused on assessing current views on how IFI should be managed, the aim of this project was to identify challenges around diagnosing and managing IFIs in the ICU...
May 5, 2024: Mycopathologia
#9
JOURNAL ARTICLE
Ondřej Fiala, Sebastiano Buti, Aristotelis Bamias, Francesco Massari, Renate Pichler, Marco Maruzzo, Enrique Grande, Ugo De Giorgi, Javier Molina-Cerrillo, Emmanuel Seront, Fabio Calabrò, Zin W Myint, Gaetano Facchini, Ray Manneh Kopp, Rossana Berardi, Jakub Kucharz, Maria Giuseppa Vitale, Alvaro Pinto, Luigi Formisano, Thomas Büttner, Carlo Messina, Fernando Sabino M Monteiro, Nicola Battelli, Ravindran Kanesvaran, Tomáš Büchler, Jindřich Kopecký, Daniele Santini, Giulia Claire Giudice, Camillo Porta, Matteo Santoni
BACKGROUND: About 20% of patients with renal cell carcinoma present with non-clear cell histology (nccRCC), encompassing various histological types. While surgery remains pivotal for localized-stage nccRCC, the role of cytoreductive nephrectomy (CN) in metastatic nccRCC is contentious. Limited data exist on the role of CN in metastatic nccRCC under current standard of care. OBJECTIVE: This retrospective study focused on the impact of upfront CN on metastatic nccRCC outcomes with first-line immune checkpoint inhibitor (IO) combinations or tyrosine kinase inhibitor (TKI) monotherapy...
May 5, 2024: Targeted Oncology
#10
JOURNAL ARTICLE
J Breuer, A M Garzinsky, A Thomas, E Nieschlag, S Kliesch, M Fedoruk, H Geyer, M Thevis
PURPOSE: Inadvertent and/or unknowing exposure to drugs and drug residues has been frequently debated in situations of so-called adverse analytical finding (AAF) in the context of sports drug testing programs. Transfer of drug residues via unprotected intercourse is a conceivable scenario but scientific data and authentic case reports are scarce. Herein, investigations into two AAFs with the peroxisome proliferator-activated receptor delta (PPARδ) agonist GW1516 are reported and discussed...
May 5, 2024: Forensic Toxicology
#11
JOURNAL ARTICLE
Joris G Heetman, Leonor J Paulino Pereira, Johannes C Kelder, Timo F W Soeterik, Lieke Wever, Jules Lavalaye, Erik J R J van der Hoeven, Marnix G E H Lam, Harm H E van Melick, Roderick C N van den Bergh
BACKGROUND: Prebiopsy magnetic resonance imaging (MRI) increases the detection rate of clinically significant prostate cancer (csPCa). Prostate-specific membrane antigen-positron emission tomography/computed tomography (PSMA PET/CT) maximum standardized uptake value (SUVmax) of the prostate may offer additional value in predicting the likelihood of csPCa in biopsy. METHODS: A single-center cohort study involving patients with biopsy-proven PCa who underwent both MRI and PSMA PET/CT between 2020 and 2021...
May 5, 2024: Prostate
#12
JOURNAL ARTICLE
Lee Ashendorf, Susanne Withrow, Brandon E Gavett
OBJECTIVE: In dementia research, the Driving Scenes test from the Neuropsychological Assessment Battery has been shown to relate to memory, dementia diagnosis, and functional impairment. The aim of the current study was to examine Driving Scenes and its component scores, and their relationships with cognition and daily functioning, in a mixed dementia clinic sample. METHOD: One hundred U.S. military veterans between the ages of 55 and 88 were administered a full neuropsychological protocol that included Driving Scenes...
May 4, 2024: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
#13
REVIEW
Mike Zangenberg, Marie Helleberg
Leishmaniasis is transmitted by sandflies and involves cutaneous, mucocutaneous, or visceral disease. Sporadic, imported cases in Denmark emphasize the need for greater awareness. The incidence is stable with at least ten verified cases per year. Diagnostic methods include PCR- and antibody tests with a high positivity rate for PCR (17%) and a low positivity rate for antibody (1.4%). The latter should be used only when visceral disease is suspected. Immunosuppressed patients are at particular risk. Treatment strategies are chosen according to the severity of the condition, as argued in this review...
April 22, 2024: Ugeskrift for Laeger
#14
JOURNAL ARTICLE
Yang Chen, Zixuan Liu, Zhigang Wang, Ying Yi, Chunjie Yan, Wenxia Xu, Feng Zhou, Yuting Gao, Qitao Zhou, Cheng Zhang, Heng Deng
Soft on-skin electrodes play an important role in wearable technologies, requiring attributes such as wearing comfort, high conductivity, and gas permeability. However, conventional fabrication methods often compromise simplicity, cost-effectiveness, or mechanical resilience. In this study, a mechanically robust and gas-permeable on-skin electrode is presented that incorporates Flash Graphene (FG) integrated with a bioinspired armor design. FG, synthesized through Flash Joule Heating process, offers a small-sized and turbostratic arrangement that is ideal for the assembly of a conductive network with nanopore structures...
May 5, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
#15
REVIEW
Camille Schubert, Joanne Milverton, Stephen Goodall, Tracy Merlin
PURPOSE: Exome or genome sequencing (ES or GS) can identify genetic causes of otherwise unexplained congenital anomaly and perinatal death (PND) but is not routine practice. The evidence base for 'genomic autopsy' following termination of pregnancy for fetal anomaly (TOPFA) and PND has been synthesised to determine the value of this investigation. METHODS: We conducted a systematic review and meta-analysis of studies meeting pre-specified inclusion criteria, and containing ≥10 cases of TOPFA or PND (with or without major congenital abnormality), where ES or GS was conducted...
May 2, 2024: Genetics in Medicine: Official Journal of the American College of Medical Genetics
#16
JOURNAL ARTICLE
Ingela Grönbeck Lindén, Pia Andersson, Synneve Dahlin Ivanoff, Lars Gahnberg, Catharina Hägglin
OBJECTIVES: To evaluate the reliability of the new Oral Hygiene Ability Instrument (OHAI) developed to assess the cause of any inability for older adults to manage oral hygiene self-care. Oral hygiene is an important part of oral health. The inability to manage oral hygiene, combined with other risk factors, often results in poor oral health and impaired quality of life. A reliable OHAI could benefit preventive oral health care. METHODS: The preliminary OHAI uses 33 items in three parts: (I) interview, (II) clinical examination and (III) observation of oral hygiene activities...
May 5, 2024: International Journal of Dental Hygiene
#17
JOURNAL ARTICLE
Rui Chen, Xiaohu Li, Han Jia, Changjing Feng, Siting Dong, Wangyan Liu, Shushen Lin, Xiaomei Zhu, Yi Xu, Yinsu Zhu
PURPOSE: The relationship between plaque progression and pericoronary adipose tissue (PCAT) radiomics has not been comprehensively evaluated. We aim to predict plaque progression with PCAT radiomics features and evaluate their incremental value over quantitative plaque characteristics. PATIENTS AND METHODS: Between January 2009 and December 2020, 500 patients with suspected or known coronary artery disease who underwent serial coronary computed tomography angiography (CCTA) ≥2 years apart were retrospectively analyzed and randomly stratified into a training and testing data set with a ratio of 7:3...
May 3, 2024: Journal of Thoracic Imaging
#18
JOURNAL ARTICLE
Devasahayam J Christopher, Richa Gupta, Balamugesh Thangakunam, Jefferson Daniel, Surinder K Jindal, Surya Kant, Prashant N Chhajed, K B Gupta, Sahajal Dhooria, Sudhir Chaudhri, Dhruva Chaudhry, Dharmesh Patel, Ravindra Mehta, Rakesh K Chawla, Arjun Srinivasan, Arvind Kumar, Shakti K Bal, Prince James, Jebin S Roger, Avinash A Nair, S K Katiyar, Ritesh Agarwal, Raja Dhar, Ashutosh N Aggarwal, J K Samaria, Digambar Behera, Karan Madan, Raj B Singh, S K Luhadia, Nikhil Sarangdhar, George D' Souza, Amita Nene, Akhil Paul, Vimi Varghese, T V Rajagopal, M Arun, Shraddha Nair, Dhivya A Roy, Benjamin E Williams, Shona A Christopher, Dhanawade V Subodh, Nishant Sinha, Barney Isaac, Ashwin A Oliver, N Priya, Jedidiah Deva, Sujith T Chandy, Richu Bob Kurien
Pleural effusion is a common problem in our country, and most of these patients need invasive tests as they can't be evaluated by blood tests alone. The simplest of them is diagnostic pleural aspiration, and diagnostic techniques such as medical thoracoscopy are being performed more frequently than ever before. However, most physicians in India treat pleural effusion empirically, leading to delays in diagnosis, misdiagnosis and complications from wrong treatments. This situation must change, and the adoption of evidence-based protocols is urgently needed...
May 1, 2024: Lung India: Official Organ of Indian Chest Society
#19
JOURNAL ARTICLE
Giulia Gagliardini, Guia Pandolfi, Antonello Colli
Eating disorders (EDs) represent a wide range of clinical symptoms related to food intake, body image, and weight issues, and include anorexia nervosa-restricting type (AN-R), anorexia nervosa-binge-purge type (AN-BP), and bulimia nervosa (BN). The aim was to investigate the characteristics of attachment, mentalization, emotion dysregulation, and empathy in a sample of 102 patients with EDs. A sample of 102 patients and therapists completed a series of measures for the assessment of ED pathology, mentalization, empathy, and emotion dysregulation...
April 10, 2024: Journal of Nervous and Mental Disease
#20
JOURNAL ARTICLE
Zhijian Huang, Cuncan Deng, Caiqi Ma, Guirong He, Jian Tao, Lijun Zhang, Xiaoyun Hu, Yanfang Mo, Lumei Qiu, Ningfang Zhang, Chuanghua Luo, Shan Xing, Jinye Xie, Haofan Yin
OBJECTIVES: The absence of non-invasive biomarkers for the early diagnosis of colorectal cancer (CRC) has contributed to poor prognosis. Extracellular vesicles (EVs) have emerged as promising candidates for cancer monitoring using liquid biopsy. However, the complexity of EVs isolation procedures and absence of clear targets for detecting serum-derived EVs have hindered the clinical application of EVs in early CRC diagnosis. METHODS: In the discovery phase, we conducted a comprehensive 4D-DIA proteomic analysis of serum-derived EVs samples from 37 individuals, performing an initial screening of EVs surface proteins...
May 3, 2024: International Journal of Surgery
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